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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) Jurnal Kedokteran Gigi Universitas Padjadjaran Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Kartika Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Pharmacy Reports Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Mandala of Health : A Scientific Journal Molekul: Jurnal Ilmiah Kimia Journal of Applied Science for Pharmaceuticals and Health
Fareza, Muhamad Salman
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : jurnal kimia sains dan aplikasi

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Optimizing Ultrasound-Assisted Extraction Methods of Etlingera elatior Using Response Surface Methodology for High Performance Liquid Chromatography Fingerprinting Wasito, Hendri; Ridha, Kirana Shafa; Fareza, Muhamad Salman
Jurnal Kimia Sains dan Aplikasi Vol 28, No 7 (2025): Volume 28 Issue 7 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.7.355-361

Abstract

Kecombrang flower (Etlingera elatior) is widely used in traditional medicine and contains various metabolites. High-performance liquid chromatography (HPLC) fingerprinting can be employed as an analytical technique to comprehensively reveal the metabolite profile, while ultrasound-assisted extraction (UAE) was developed to optimize metabolite extraction. This study aims to determine the optimal extraction conditions for E. elatior and apply these conditions in HPLC fingerprinting. This study utilized central composite design (CCD) and response surface methodology (RSM) to optimize the extraction of E. elatior flowers, focusing on extraction time and the simplicia-to-solvent ratio. The optimal extraction results were applied to HPLC fingerprints of the flowers, leaves, and stems of E. elatior. The chromatograms were further analyzed using chemometric methods, namely principal component analysis (PCA), partial least squares discriminant analysis (PLSDA), and hierarchical cluster analysis (HCA) to classify and interpret the variability of metabolite profiles in different parts of E. elatior. The optimal UAE conditions were determined to be a time of 46 minutes and a simplicia-to-solvent ratio of 1:25 (g/mL). Chemometric analysis revealed that the samples were well clustered, which reflects the similarity of metabolites among them. The HCA further showed that the metabolite profile of E. elatior flowers is closely related to that of the stems.
Co-Authors . Harwoko Ade Martinus Ade Martinus Afif Hariawan Pratama Agnes Yuliasari Anggraeni, Vina Juliana Aprilia, Vika Ari Asnani Ari Wahyudi Asrada, Syahdan Ayunda Tasya Hapsari Beti Pudyastuti Beti Pudyastuti Choironi, Nur Amalia Defi Srium Siagian Didin Mujahidin Dina Parika Dody Novrial Dody Novrial, Dody Dwi Utami Anjarwati Elesenda May GIta Esti Dyah Utami Esti Dyah Utami Eviyana Eviyana Fadlan, Arif Fadlan, Arif Fajar Wahyu Pribadi Febrian, Dicky Rizky Fischellya, Dafi Giri Gumelar Hanif Nasiatul Baroroh Harwoko Harwoko Hasan, Nahrul Hendri Wasito HENDRI WASITO Hening Pratiwi Irse Priyaganda Bani Musa Joko Setyono Joko Setyono Joko Setyono Kaefiyah Nurul Insani Lela Lailatul Khumaisah Mustikaningtyas, Ika Nadia Sayyidadah Aulia Nia Kurnia Sholihat Nilta Dizzania Nur Amalia Choironi Nur Amalia Choironi Nur Amalia Choironi Nuryanti Nuryanti Ponco Iswanto Putri Khaerani Cahyaningrum Putri Nur'afni Sa'adah Rehana Rehana Rehana Rehana Rehana, Rehana Ridha, Kirana Shafa Rifki Febriansah Rizka Hidayati Rizki Akbar Ramadhan Samudra, Genta Hafied Naga Sarmoko Sarmoko Sekar Cahyo Nurani Setiyabudi, Lulu Siagian, Defi Srium Siska Febdian Nitami Soenarto Soetomo Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto, Sunarto Thianti Sylviningrum Triyadi Hendra Triyadi Hendra Wijaya Triyadi Hendra Wijaya Tryandika Telaumbanua Tuti Sri Suhesti Vintya Roosalinda Permatasari Wahyu Dwi Kusdaryanto Warsinah Yuliasari, Agnes