Article Per Year (5 Year)
p-Index From 2021 - 2026
2.906
P-Index
This Author published in this journals
All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) Jurnal Kedokteran Gigi Universitas Padjadjaran Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Kartika Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Pharmacy Reports Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Mandala of Health : A Scientific Journal Molekul: Jurnal Ilmiah Kimia Journal of Applied Science for Pharmaceuticals and Health
Fareza, Muhamad Salman
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Pharmacy Reports

 1 
Evaluation of natural compounds as VEGFR-2 inhibitors for breast cancer therapy: insights from molecular docking and drug-likeness analysis Aprilia, Vika; Sarmoko; Fareza, Muhamad Salman; Baroroh, Hanif Nasiatul; Choironi, Nur Amalia
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.82

Abstract

Breast cancer remains one of the most common cancers worldwide, with VEGFR-2 (KDR) playing a key role in tumor angiogenesis. Inhibiting VEGFR-2 is a promising therapeutic strategy. Natural compounds are increasingly studied for their potential to inhibit VEGFR-2. This study aims to assess the binding affinity of 11 natural compounds (andrographolide, alpha-mangostin, pinostrobin, pinocembrin, ethyl-p-methoxycinnamate (EPMS), xanthorrhizol, galangin, gamma-mangostin, curcumin, cinnamaldehyde, and alashanoid B) to the VEGFR-2 protein through molecular docking and Lipinski's rule analysis, identifying promising candidates for breast cancer treatment. Molecular docking simulations were performed for 11 compounds and sunitinib as a control, with binding energies and interactions analyzed. The compounds were also evaluated for drug-likeness using Lipinski’s rule of five. Curcumin showed the highest binding affinity to VEGFR-2 with a binding energy of -9.9 kcal/mol, surpassing sunitinib (-9.4 kcal/mol). Key interactions were observed with active site residues Cys919 and Asp1046. All tested compounds met the criteria for oral bioavailability per Lipinski’s rules. Curcumin demonstrates potential as a VEGFR-2 inhibitor due to its favorable binding affinity and drug-like properties. Enhancing curcumin’s bioavailability is recommended for effective therapeutic application.
Co-Authors . Harwoko Ade Martinus Ade Martinus Afif Hariawan Pratama Agnes Yuliasari Anggraeni, Vina Juliana Aprilia, Vika Ari Asnani Ari Wahyudi Asrada, Syahdan Ayunda Tasya Hapsari Beti Pudyastuti Beti Pudyastuti Choironi, Nur Amalia Defi Srium Siagian Didin Mujahidin Dina Parika Dody Novrial Dody Novrial, Dody Dwi Utami Anjarwati Elesenda May GIta Esti Dyah Utami Esti Dyah Utami Eviyana Eviyana Fadlan, Arif Fadlan, Arif Fajar Wahyu Pribadi Febrian, Dicky Rizky Fischellya, Dafi Giri Gumelar Hanif Nasiatul Baroroh Harwoko Harwoko Hasan, Nahrul HENDRI WASITO Hendri Wasito Hening Pratiwi Irse Priyaganda Bani Musa Joko Setyono Joko Setyono Joko Setyono Kaefiyah Nurul Insani Lela Lailatul Khumaisah Mustikaningtyas, Ika Nadia Sayyidadah Aulia Nia Kurnia Sholihat Nilta Dizzania Nur Amalia Choironi Nur Amalia Choironi Nur Amalia Choironi Nuryanti Nuryanti Ponco Iswanto Putri Khaerani Cahyaningrum Putri Nur'afni Sa'adah Rehana Rehana Rehana Rehana Rehana, Rehana Ridha, Kirana Shafa Rifki Febriansah Rizka Hidayati Rizki Akbar Ramadhan Samudra, Genta Hafied Naga Sarmoko Sarmoko Sekar Cahyo Nurani Setiyabudi, Lulu Siagian, Defi Srium Siska Febdian Nitami Soenarto Soetomo Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto, Sunarto Thianti Sylviningrum Triyadi Hendra Triyadi Hendra Wijaya Triyadi Hendra Wijaya Tryandika Telaumbanua Tuti Sri Suhesti Vintya Roosalinda Permatasari Wahyu Dwi Kusdaryanto Warsinah Yuliasari, Agnes