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Seberapa Efektif Dukungan Relawan dalam Program Perawatan Paliatif?: Fenomenologi Studi Adhisty, Karolin; Maulida, Mutia Nadra; Putri, Sarahdeaz Fazzaura
Jurnal Keperawatan Vol 17 No 1 (2025): Jurnal Keperawatan: Maret 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v17i1.1822

Relawan merupakan bagian tidak terpisahkan dari sebuah tim perawatan paliatif. Relawan dalam program ini akan dilibatkan dengan pengetahuan dan keterampilannya untuk menilai dan mendukung masalah kesehatan mental, memberikan dukungan emosional, dan mengatasi tekanan emosional dan meningkatkan kualitas hidup bagi pasien dan keluarga yang mengalami penyakit kronis. Program ini membutuhkan suatu keinginan yang kuat dari para relawan sehingga keefektifan program ini bisa dirasakan manfaatnya secara luas. Tujuan penelitian ini adalah untuk mendapatkan gambaran mengenai dukungan para relawan dengan menilai kemampuan dasar yang dimiliki. Desain penelitian dengan konsep penelitian kualitatif dan fokus grup diskusi digunakan dalam bentuk fenomenologi studi. Penelitian menggunakan empat proses kerja dengan analisis data menggunakan tahapan collaizi. Hasil yang didapatkan dalam penelitian ini dapat menggambarkan dukungan para relawan yang tergambar dalam 3 tema: keterampilan relawan, keterkaitan pengetahuan dan tindakan, pengalaman relawan terkait paliatif. Program relawan dalam perawatan paliatif tentunya dapat bermanfaat untuk meneruskan perawatan paliatif pasca pengobatan di rumah sakit. Hasil ini menjadikan suatu gambaran bahwa relawan juga berperan meningkatkan kualitas hidup pasien dan keluarga dalam dimensi psikologis, sosial, dan spiritual. Program ini tentunya membutuhkan peran aktif dari para fasilitator baik fasilitas kesehatan tingkat I dan lanjut sehingga pengetahuan dan sikap yang dimiliki oleh relawan dapat terus bertumbuh.

Studi Meta-Analisis: Hubungan antara Defisiensi Vitamin D dan Penyakit Parkinson Putri, Siti Sarahdeaz Fazzaura; Irfannuddin, Irfannuddin; Murti, Krisna; Kesuma, Yudianita; Koibuchi, Noriyuki
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 9, No 1 (2023): JMK Yayasan RS.Dr.Soetomo, April 2023
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v9i1.1430

Beberapa penelitian telah dilakukan untuk mengevaluasi kadar 25(OH)D pada pasien penyakit Parkinson. Namun, hasil penelitian ini tidak konsisten. Penelitian ini melakukan meta-analisis terhadap kadar 25(OH)D pada pasien dengan penyakit Parkinson. Database PubMed digunakan untuk melakukan pencarian literatur secara sistematis. Meta-analisis dilakukan dengan menggunakan model efek acak untuk menghitung perkiraan efek gabungan. Tujuh belas artikel dimasukkan dalam penelitian ini. Meta-analisis mengungkapkan bahwa pasien dengan penyakit Parkinson memiliki kadar 25(OH)D yang lebih rendah dibandingkan dengan kontrol. Temuan dari artikel prospektif dan retrospektif sebagian besar konsisten. Besarnya respon nocebo dalam uji coba terkontrol acak yang dirancang paralel pada penyakit Parkinson sangat penting dan harus dipertimbangkan dalam interpretasi hasil keamanan dan dalam desain dan interpretasi uji klinis masa depan.

Walking as a Modality for Enhancing Physical Fitness: A Review Rachel Maya; Irfannuddin; Siti Sarahdeaz Fazzaura Putri
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.258

Walking plays a key role in maintaining overall physical fitness which is essential for good health. Physical fitness consists of two main aspects health-related and skill-related components. It is commonly measured by assessing cardiovascular endurance muscle strength muscle endurance flexibility and body composition. This review conducted a comprehensive literature search using reputable publications such as Elsevier, PubMed, PubMed Central, and other relevant sources. The search focused on peer-reviewed studies that examine the effects of walking on physical fitness. Many studies highlight walking as a simple and accessible form of exercise that offers significant benefits such as improved cardiovascular endurance muscle strength and flexibility. It is recommended to engage in at least 150 minutes of walking each week for optimal benefits. To maximize walking's impact on fitness it is crucial to maintain good posture and proper breathing techniques. In addition to physical benefits walking also promotes mental and social well-being. It is a versatile activity suitable for all ages including adolescents, adults, children, seniors, and individuals with specific health conditions or diseases. By understanding the connection between walking and fitness people can incorporate it into their daily routines to enhance overall health. Future research could focus on specific fitness aspects related to walking to develop personalized guidelines for different populations.

Analysis of the musculoskeletal pain risk profile through observation of work posture in minimarket employees Laeto, Arwan Bin; Putri, Siti Sarahdeaz Fazzaura; Agustine, Vania; Hasbi, Alfian; Zulissetiana, Eka Febri
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.549

Musculoskeletal pain refers to the discomfort experienced in the musculoskeletal system as a result of various pain-inducing factors. Musculoskeletal pain is a leading cause of disability and absenteeism in the workplace. The primary causes of declining health among workers include occupational injuries (29.5%), overtime (25.9%), and ergonomic factors (13.7%), significantly influence occupational health and can adversely affect organ function. The study was conducted through observational approach with a cross-sectional design and primary data collected using the Nordic Body Map (NBM) questionnaire and the Rapid Entire Body Assessment (REBA). The study population is mini market employees and sample comprises were employees who fulfil inclusion and exclusion criteria as many as 50 respondents by using non-probability sampling technique. The results of study were obtained that the majority of workers belong to the age group of under 35 years, as many as 49 individuals (98%) and more than half of the respondents are predominantly female, accounting for 52% of the total. Furthermore, the study indicates that the dominant "Very Painful" predilection criterion is most frequently reported in the back and waist of the respondents, accounting for 40% of the total respondents. Next, the majority of minimarket workers exhibit a moderate level of risk in their work posture, with 21 individuals (42%) falling into this category. Based on the results, it is recommended that respondents engage more actively in physical exercise and massage therapy.

Physical Activity Impact on Severity of Dysmenorrhea among Junior High School Students: A Cross Sectional Study Raissa Nurwany; Nadhira Tsurayya Ramadhani; Siti Sarahdeaz Fazzaura Putri; Eka Febri Zulissetiana; Arwan bin Laeto; Ardelia Bianda
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2734

Objective: This study aims to identify the prevalence of dysmenorrhea, the level of physical activity, the risk factors for dysmenorrhea and to determine the relationship between physical activity and the severity of dysmenorrhea among junior high school students. Method: This is a cross-sectional, observational analytical study on the population of adolescence, junior high school students, conducted from July to December 2023 in Palembang. Primary data were obtained using Physical Activity Questionnaire for Older Children (PAQ-C) and working ability, location, intensity, days of pain, dysmenorrhea (WaLIDD) score. Results: About 88.9% of students experienced primary dysmenorrhea, with 34.4% experiencing mild dysmenorrhea, 38.9% experiencing moderate dysmenorrhea, and 15.6% experiencing severe dysmenorrhea. The level of daily physical activity performed by the students was 43.3% low activity, 55.6% moderate activity, and 1.1% high activity. There was no significant relationship between physical activity and the degree of dysmenorrhea (p=0.459; PR=0.828; 95% CI: 0.558-1.230). Menarche age <12 years (PR=1.186), a family history of dysmenorrhea (PR=1.225), and irregular menstrual cycles (PR=1.283) are risk factors for higher degree of dysmenorrhea. Conclusion: There is no relationship between physical activity and the degree of dysmenorrhea. Female students mostly experience moderate primary dysmenorrhea, with the dominant level of physical activity being moderate. Menarche age <12 years, a family history of dysmenorrhea, and irregular menstrual cycles are risk factors for the higher degree of dysmenorrhea. Keywords: Adolescents, primary dysmenorrhea, physical activity

Walking as a Modality for Enhancing Physical Fitness : A Review Maya, Rachel; Irfannuddin, Irfannuddin; Putri, Siti Sarahdeaz Fazzaura
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10979

Abstrak: Berjalan kaki berperan penting dalam menjaga kebugaran jasmani yang krusial bagi kesehatan. Kebugaran jasmani terdiri atas dua komponen utama, yaitu kesehatan dan keterampilan. Kebugaran umumnya diukur melalui penilaian daya tahan kardiorespirasi, kekuatan otot, kelenturan, dan komposisi tubuh. Tinjauan ini melakukan penelusuran literatur komprehensif menggunakan publikasi terkemuka seperti Elsevier, PubMed, dan sumber relevan lainnya. Penelusuran ini berfokus pada penelitian yang telah melalui telaah sejawat mengenai dampak berjalan kaki terhadap kebugaran. Banyak penelitian menunjukkan bahwa berjalan kaki adalah olahraga sederhana dan mudah diakses, serta memberikan manfaat signifikan, seperti peningkatan daya tahan kardiorespirasi, kekuatan otot, dan kelenturan. Disarankan berjalan kaki 150 menit per minggu guna memperoleh manfaat optimal. Untuk memaksimalkan manfaatnya, diperlukan postur tubuh yang benar dan teknik pernapasan baik. Selain manfaat fisik, berjalan kaki juga meningkatkan kesejahteraan mental dan sosial. Aktivitas ini fleksibel dan sesuai untuk berbagai kelompok usia, termasuk individu dengan kondisi kesehatan tertentu. Memahami hubungan antara berjalan kaki dan kebugaran membantu masyarakat mengintegrasikan aktivitas ini guna meningkatkan kesehatan. Penelitian di masa depan dapat berfokus pada aspek kebugaran tertentu untuk mengembangkan pedoman yang lebih tepat bagi berbagai kelompok masyarakat.

Integration of Molecular Factors Influencing VCAM-1 Expression in Vascular Inflammation and Atherosclerosis: A Narrative Review Nur Asini; Taufik Indrajaya; Irfannuddin; Siti Sarahdeaz Fazzaura Putri
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i2.1676

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a vascular adhesion molecule that plays a crucial role in vascular inflammation, endothelial dysfunction, and the development of atherosclerosis. Increased VCAM-1 expression occurs in response to various inflammatory stimuli and cellular stressors that involve the activation of specific molecular signaling pathways. Various factors such as chronic inflammation, oxidative stress, activation of the Nuclear Factor-kappa B (NF-κB) pathway, the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway, obesity, leptin resistance, genetic factors, and changes in vascular hemodynamics are known to contribute to increased VCAM-1 expression. This study aims to analyze various factors that influence VCAM-1 changes molecularly using a narrative review method. Article searches were conducted through the PubMed, Scopus, and Google Scholar databases using the keywords "VCAM-1", "NF-κB", "oxidative stress", "LEPR", "leptin resistance", "endothelial dysfunction", and "atherosclerosis". The articles used were published between 2020 and 2026, relevant to the research topic, and available in full text. The review results indicate that NF-κB activation is the primary mechanism of VCAM-1 elevation triggered by pro-inflammatory cytokines, increased reactive oxygen species (ROS), leptin resistance, and LEPR activation via the JAK-STAT pathway. Furthermore, genetic factors such as LEPR polymorphisms and epigenetic mechanisms also contribute to increased vascular inflammation and VCAM-1 expression. Thus, VCAM-1 has great potential as a biomarker of vascular inflammation and a therapeutic target in cardiovascular disease, particularly atherosclerosis.

Walking as a Modality for Enhancing Physical Fitness : A Review Rachel Maya; Irfannuddin Irfannuddin; Siti Sarahdeaz Fazzaura Putri
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10979

Abstrak: Berjalan kaki berperan penting dalam menjaga kebugaran jasmani yang krusial bagi kesehatan. Kebugaran jasmani terdiri atas dua komponen utama, yaitu kesehatan dan keterampilan. Kebugaran umumnya diukur melalui penilaian daya tahan kardiorespirasi, kekuatan otot, kelenturan, dan komposisi tubuh. Tinjauan ini melakukan penelusuran literatur komprehensif menggunakan publikasi terkemuka seperti Elsevier, PubMed, dan sumber relevan lainnya. Penelusuran ini berfokus pada penelitian yang telah melalui telaah sejawat mengenai dampak berjalan kaki terhadap kebugaran. Banyak penelitian menunjukkan bahwa berjalan kaki adalah olahraga sederhana dan mudah diakses, serta memberikan manfaat signifikan, seperti peningkatan daya tahan kardiorespirasi, kekuatan otot, dan kelenturan. Disarankan berjalan kaki 150 menit per minggu guna memperoleh manfaat optimal. Untuk memaksimalkan manfaatnya, diperlukan postur tubuh yang benar dan teknik pernapasan baik. Selain manfaat fisik, berjalan kaki juga meningkatkan kesejahteraan mental dan sosial. Aktivitas ini fleksibel dan sesuai untuk berbagai kelompok usia, termasuk individu dengan kondisi kesehatan tertentu. Memahami hubungan antara berjalan kaki dan kebugaran membantu masyarakat mengintegrasikan aktivitas ini guna meningkatkan kesehatan. Penelitian di masa depan dapat berfokus pada aspek kebugaran tertentu untuk mengembangkan pedoman yang lebih tepat bagi berbagai kelompok masyarakat.

The Effect of Maternal Separation on Anxiety Behavior in of White Mice (Mus Musculus L.) Male Swiss Webster Strain Budi Santoso; Siti Sarahdeaz Fazzaura Putri; Eka Febri Zulissetiana; Alfian Hasbi; Alvita Putri Luthfiyyah; Nada Triastuti
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.241

Introduction. Maternal separation (MS) is a commonly utilized model of early-life stress to explain the influence on brain development and psychological behavior. MS has been demonstrated to elevate the likelihood of developing anxiety disorders as a consequence of alterations in hypothalamic- pituitary-adrenal (HPA) functionality and neurotransmitter levels. This study aimed to evaluate the impact of maternal separation (MS) duration on anxiety behavior in male Swiss Webster strain white mice (Mus musculus L.). Methods. The study used a true experimental method with a posttest- only control group design. A total of 28 male mice aged 2 days were randomly assigned to one of four groups: a control group that did not undergo maternal separation (MS) and three MS treatment groups with a duration of 2 hours, 4 hours, and 6 hours per day for 21 days. Anxiety behavior was evaluated using the Elevated Plus Maze (EPM), with the number and duration of entries into the closed and open arms serving as the primary analysis metrics. The data were analyzed using one-way ANOVA and post-hoc LSD statistical tests. The duration of MS significantly impacted the anxiety behavior of the mice. Results. The MS groups of 2, 4 and 6 hours demonstrated a notable increase in the number and duration of entries into the closed arm in comparison to the control group (p < 0.05), which is indicative of increased anxiety. In contrast, the number of entries into the open arm decreased in the 6 h MS group compared to the control. Conclusion. The results indicated that MS negatively affected the anxiety behavior of mice, with longer duration exacerbating the trend.

Integration of Molecular Factors Influencing VCAM-1 Expression in Vascular Inflammation and Atherosclerosis: A Systematic Review of In Vitro Studies Asini, Nur; Indrajaya, Taufik; Irfannuddin, Irfannuddin; Putri, Siti Sarahdeaz Fazzaura
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.12

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a vascular adhesion molecule that plays a crucial role in vascular inflammation, endothelial dysfunction, and the development of atherosclerosis. Increased VCAM-1 expression occurs in response to various inflammatory stimuli and cellular stressors that involve the activation of specific molecular signaling pathways. Various factors such as chronic inflammation, oxidative stress, activation of the Nuclear Factor-kappa B (NF-κB) pathway, the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway, obesity, leptin resistance, genetic factors, and changes in vascular hemodynamics are known to contribute to increased VCAM-1 expression. This study aims to analyze various factors that influence VCAM-1 changes molecularly using a narrative review method. Article searches were conducted through the PubMed, Scopus, and Google Scholar databases using the keywords "VCAM-1", "NF-κB", "oxidative stress", "LEPR", "leptin resistance", "endothelial dysfunction", and "atherosclerosis". The articles used were published between 2020 and 2026, relevant to the research topic, and available in full text. The review results indicate that NF-κB activation is the primary mechanism of VCAM-1 elevation triggered by pro-inflammatory cytokines, increased reactive oxygen species (ROS), leptin resistance, and LEPR activation via the JAK-STAT pathway. Furthermore, genetic factors such as LEPR polymorphisms and epigenetic mechanisms also contribute to increased vascular inflammation and VCAM-1 expression. Thus, VCAM-1 has great potential as a biomarker of vascular inflammation and a therapeutic target in cardiovascular disease, particularly atherosclerosis.

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