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Formulasi dan Uji Aktifitas Antikutu Kepala (Pediculus humanus capitis) Sediaan Sampo Minyak Sereh Wangi (Citronella oil): Formulation and Test of Anti-Head Lice Activity (Pediculus humanus capitis) Citronella Oil Shampoo Preparation (Citronella oil) nesa agistia; Nofriyanti Nofriyanti; Ratna Sari Dewi
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3578

One of the problems that reduce a person's confidence is pediculosis. Natural ingredients used as anti-lice are citronella oil (Citronella oil), citronella oil contains citronellal compounds. This study aims to obtain a shampoo preparation that has anti-head lice activity. Citronella oil is formulated in several concentrations, namely 5% (FI), 7.5% (FII) and 10% (FIII). Evaluation of shampoo preparations included organoleptic examination, pH, homogeneity, foam height, irritation, cleaning power, freeze and thaw and anti-lice activity. Data analysis used the One Way ANOVA statistical test to see the comparison formula against the time of tick death. Based on the evaluation of the preparations, it was found that the shampoo had a thick liquid consistency, white in color, had a distinctive smell of citronella oil and no phase separation, pH 5.62-5.69, homogeneous, good cleaning power test, non-irritating, stable, anti-lice activity test FI = 6.24 minutes, FII = 5.38 minutes, FIII = 3.68 minutes, there was a significant difference (p<0.05) between the formulas on the time of tick death.

Evaluasi Karakteristik Fisik dan Uji Iritasi Akut Dermal Sediaan Losion yang Mengandung Senyawa (E)–1–(2–Hidroksifenil)–3–(4–Metoksifenil)prop–2–en–1–on nesa agistia; Ferdy Firmansyah; Ihsan Ikhtiarudin; Selvi Rahmawati
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7798

Chalcones are secondary metabolites belonging to the flavonoid class that exhibit sunscreen activity. The chalcone analog (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one has the potential to be developed as an active ingredient in sunscreen formulations. In this study, the compound was formulated into an oil-in-water (O/W) lotion at three different active ingredient concentrations, namely F1 (0.1%), F2 (0.3%), and F3 (0.5%). The formulations were subsequently evaluated for their physical properties and acute dermal irritation in vivo using experimental animals. The physical evaluation demonstrated that all lotion formulations were homogeneous, had a pH of 6.90, exhibited an oil-in-water emulsion type, possessed a viscosity of 8,866 cps, showed pseudoplastic thixotropic flow behavior, and had a spreadability of 6.25 cm. Furthermore, no significant changes in the physical properties were observed after 8 weeks of storage. The acute dermal irritation test revealed that all formulations had an irritation index of 0, indicating a very slight irritation response. These findings demonstrate that all lotion formulations met the required quality criteria for lotion preparations and were well tolerated, supporting their potential as safe topical sunscreen formulations.

Formulasi dan Uji Aktivitas Serum Spray Gel Minyak Adas (Feoniculum Vulgare Mill.) terhadap Bakteri Propionibacterium Acnes Nesa Agistia; Nofriyanti .; Erniza Pratiwi; Mifza Azizah
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 5 No 1 (2026): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v5i1.2449

Acne is a prevalent dermatological condition primarily caused by the bacterium Propionibacterium acnes. Antibiotics are used in acne therapy; however, increasing bacterial resistance has been reported in numerous studies. Fennel (Foeniculum vulgare Mill.) essential oil is known to exhibit antibacterial properties, mainly due to its active constituents, anethole and fenchone. This study aimed to develop a pharmaceutically stable serum spray gel formulation containing fennel essential oil and to evaluate its anti-acne activity. Fennel essential oil was formulated into serum spray gel preparations at concentrations of 10%, 15%, and 20%. The formulations were evaluated for organoleptic characteristics, pH, homogeneity, viscosity, flow behavior, adhesiveness, physical stability, spray pattern, and antibacterial activity.The results demonstrated that all serum spray gel formulations exhibited good physical stability, as indicated by acceptable organoleptic properties, homogeneity, pH values, viscosity, flow behavior, adhesiveness, stability, and spray patterns. One-way analysis of variance (ANOVA) revealed a statistically significant difference (p < 0.05) among the formulations in terms of antibacterial activity, as measured by the diameter of the inhibition zones. Post hoc Tukey analysis showed that the 10% fennel essential oil formulation exhibited the highest antibacterial activity, with an inhibition zone diameter of 23.6 mm, which was classified as strong antibacterial activity.

Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Deni Anggraini; Nesa Agistia; Armon Fernando; Amanda Yulia; Dira Repuja
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.

Optimization of the Essential Oil Toner Formula from Kaffir Lime Peel (Citrus hystrix DC.) and Evaluation of Its Antibacterial Activity against Propionibacterium acnes Nesa Agistia; Alfina Nadia; Wira Noviana Suhery
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26887

Acne is a multifactorial skin disease of the pilosebaceous unit. It is a complex inflammatory condition, in which one of the contributing factors is infection by Propionibacterium acnes, which plays a central role in its pathogenesis. Lime peel essential oil is rich in limonene (approximately 32%), which is known for its potent antibacterial activity. This study aims to evaluate the interactive effects of surfactant and co-surfactant concentrations on key physicochemical parameters—namely pH and percentage transmittance- while also identifying the optimal formulation, as well as assessing its physical stability and antibacterial performance. Using a factorial experimental design, Tween 80 (20–25%) and propylene glycol (15–20%) demonstrated interactive effects on the measured responses. Higher concentrations of Tween 80 and propylene glycol resulted in increased pH and percentage transmittance of the toner. Among the variables, Tween 80 was found to be the most influential factor affecting the responses. The optimized toner formulation consisted of 25% Tween 80 and 20% propylene glycol. Verification of the optimal formula using a one-sample t-test showed no significant difference between the predicted values (obtained from Design-Expert) and the experimental results for pH and percentage transmittance, as indicated by a Sig. (2-tailed) value of > 0.05. These results indicate excellent clarity and an ideal pH profile; however, a decrease in pH was observed after 8 weeks of storage. In addition, the incorporation of 15% lime peel essential oil exhibited antibacterial activity, producing an inhibition zone of 21.1 mm against P. acnes.

Optimization of the Essential Oil Toner Formula from Kaffir Lime Peel (Citrus hystrix DC.) and Evaluation of Its Antibacterial Activity against Propionibacterium acnes Nesa Agistia; Alfina Nadia; Wira Noviana Suhery
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26887

Acne is a multifactorial skin disease of the pilosebaceous unit. It is a complex inflammatory condition, in which one of the contributing factors is infection by Propionibacterium acnes, which plays a central role in its pathogenesis. Lime peel essential oil is rich in limonene (approximately 32%), which is known for its potent antibacterial activity. This study aims to evaluate the interactive effects of surfactant and co-surfactant concentrations on key physicochemical parameters—namely pH and percentage transmittance- while also identifying the optimal formulation, as well as assessing its physical stability and antibacterial performance. Using a factorial experimental design, Tween 80 (20–25%) and propylene glycol (15–20%) demonstrated interactive effects on the measured responses. Higher concentrations of Tween 80 and propylene glycol resulted in increased pH and percentage transmittance of the toner. Among the variables, Tween 80 was found to be the most influential factor affecting the responses. The optimized toner formulation consisted of 25% Tween 80 and 20% propylene glycol. Verification of the optimal formula using a one-sample t-test showed no significant difference between the predicted values (obtained from Design-Expert) and the experimental results for pH and percentage transmittance, as indicated by a Sig. (2-tailed) value of > 0.05. These results indicate excellent clarity and an ideal pH profile; however, a decrease in pH was observed after 8 weeks of storage. In addition, the incorporation of 15% lime peel essential oil exhibited antibacterial activity, producing an inhibition zone of 21.1 mm against P. acnes.

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