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All Journal Jurnal Delima Harapan JURNAL FARMASIMED (JFM) Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Anna Fitriawati
Universitas Duta Bangsa Surakarta
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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

 1 
AKTIVIITAS ANTIOKSIDAN ANTIHIPERLIPIDEMIA DAN ANTIHIPERTENSI DARI EKSTRAK ETANOL DAUN KEDABU (Sonneratia ovata. Backer) Raharjo, Danang; Fitriawati, Anna; Aminnulloh, Muhhamad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2245

Abstract

Kedabu (Sonneratia ovata. Backer) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. The flavonoid content in the kedabu plant includes sonnerphenolic, vanillin, (-)-(R)-nyasol, (-)-(R)-4’-O-methylnyasol, maslinic acid, lingueresinol and gallic acid. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This study aims to examine the potential of kedabu leaf extract as an antioxidant, antihypertensive and antihyperlipidemic agent tested in vitro. Antioxidant testing was carried out using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6sulfonate) method, antihypertension testing was carried out by inhibiting Angiotensin converting enzyme and antihyperlipidemia testing was carried out by inhibiting the lipase enzyme. The results of the study showed that the total flavonoid content was 38.248 ± 0.142 mgQE / g with an antioxidant capacity with an IC50 value of 28.30 ± 0.558 ppm. From the Angiotensin converting enzyme inhibition and lipase enzyme inhibition tests, the IC50 values ​​were 44.851 ± 0.130 ppm and 39.133 ± 0.889 ppm, respectively. Based on these results, the kedabu leaf extract showed antihypertensive and antihyperlipidemia activities by inhibiting the activity of Angiotensin converting enzyme and lipase enzymes.
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anisa Fadilah Kumala Putri Bagas Ardiyantoro Bangkit Riska P Bryan Dwi Multi Danang Raharjo Dwi S, Anita Emin Karoba Endang Suciati Hasna Afifah, Diyana Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Luthfiyanti, Niken Muhammad Abdul Azis Nia Kurniati Ningrum, Della Puspita ningsih, endang wahyu Nurul Fatimah Olga Nordeka, Marcela P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Riska P, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Tanoyo, William Toyang, Gresilia Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana