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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya E-Dimas: Jurnal Pengabdian kepada Masyarakat Biomedical Journal of Indonesia Chimica et Natura Acta Jurnal Kesehatan Vokasional Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Medica Arteriana (Med-Art) Indonesian Archives of Biomedical Research (InABR) INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY FASKES : Jurnal Farmasi, Kesehatan, dan Sains SULUH ABDI : Jurnal Ilmiah Pengabdian Kepada Masyarakat (Medical Scientific Journal) MESINA
Mundijo, Trisnawati
Departemen Biologi Kedokteran, Fakultas Kedokteran, Universitas Muhammadiyah Palembang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Hubungan Pekerjaan Terhadap Infertilitas Pada Pria Dan Wanita Eriksyah, Aldeo; Mundijo, Trisnawati; Pratiwi, Ratih; Artanto, Ardi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.14881

Abstract

Infertilitas merupakan permasalahan sistem reproduksi yang diartikan sebagai ketidakmampuan pasangan untuk memperoleh keturunan setelah 12 bulan atau lebih melakukan yang melakukan hubungan seksual secara teratur tanpa alat kontrasepsi. Terdapat faktor risiko yang dapat menyebabkan infertilitas, salah satunya adalah pekerjaan. Hal ini dapat disebabkan oleh faktor kurang nyamannya lingkungan kerja dan terlalu berat beban kerja sehingga menyebabkan seseorang lebih memilih istirahat dan tidur seusai bekerja dibandingkan melakukan hubungan suami istri. Tujuan penelitian untuk mengetahui hubungan pekerjaan terhadap infertilitas pada pria dan wanita. Penelitian yang dilakukan merupakan penelitian kuantitatif dengan desain cross sectional. Sampel didapatkan melalui teknik purposive sampling pada sampel wanita dan total sampling pada sampel pria. Didapatkan 28 sampel pria dan 54 sampel wanita yang memenuhi kriteria penelitian. Hasil  penelitian didapatkan tidak terdapat hubungan yang bermakna antara pekerjaan terhadap infertilitas pada pria dan wanita dengan nilai p=0,747 pada pria dan p=0,572 pada wanita (p<0,05).
THE CORRELATION BETWEEN FAMILY SUPERVISION OF SCREEN TIME WITH THE INCIDENCE OF GADGET ADDICTION IN JUNIOR HIGH SCHOOL CHILDREN Salsabila, Athaya; Mundijo, Trisnawati; Kesuma, Putri zalika lailah mardiah; Awang, Zarinah Binti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.642

Abstract

Rapid technological developments have increased the use of gadgets among children and teenagers. Devices provide benefits in the form of easy access to information, but excessive use can have negative impacts, including adding gadgets. Children aged 12-15 years are the group most vulnerable to the negative impacts of gadgets. Families, especially parents, play an important role in supervising and guiding children in using devices. This research aims to determine the relationship between family supervision of screen time and the incidence of device addiction in junior high school children. This type of research is quantitative with a cross sectional design using primary data from the community of Kelurahan 5 Ulu Palembang with 91 samples that have met the inclusion and exclusion criteria. This research sample was taken by means of consecutive sampling. The results of the statistical test obtained a P-value of 0.000, so it can be concluded that there is a correlation between family supervision of screen time and the incidence of gadget addiction in junior high school children.
Edukasi Potensi Bunga Rosella (Hibiscus sabdariffa L.) terhadap Pencegahan Bakteri Salmonella enteritidis di Cangkang Telur Mundijo, Trisnawati; Astri, Yesi; Kahar, Fania Aulia
Suluh Abdi Vol 7, No 1 (2025): SULUH ABDI
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sa.v7i1.9632

Abstract

Dalam beberapa tahun terakhir, pemanfaatan natural product semakin berkembang seiring dengan kecenderungan back to nature. Zat yang terdapat dalam bahan alam memberikan efek sinergisme sehingga memiliki kemampuan dalam mencegah beberapa masalah kesehatan. Salah satu kekayaan hayati Indonesiabdengan khasiat yang dimiliki yaitu tanaman Rosella (Hibiscus sabdariffa L.). Masyarakat desa Pulau Panggung dan muara dua, kabupaten Muara Enim secara turun menurun telah memanfaatkan tanaman Rosella. Tidak hanya sebagai tanaman hidup yang berfungsi sebagai pagar di pekarangan, namun juga sebagai salah satu kebiasaan dengan mengkonsumsinya sebagai teh dari bunga yang diseduh dalam air panas. Kebiasaan ini dilakukan masyarakat khususnya saat musim panen di kebun. Masyarakat mempercayai bahwa dengan mengkonsumsi teh bunga Rosella, kesehatan mereka akan terjaga selama musim panen. Selain itu, literatur hasil penelitian telah banyak melaporkan bahwa tanaman Rosella memiliki banyak khasiat bagi kesehatan manusia karena memiliki kandungan zat berupa flavonoid, saponin, tanin dan alkaloid yang salah satunya berperan dalam menghambat dan mengeliminasi pertumbuhan bakteri. Etnofarmaka yang terdapat dalam tanaman Rosella ini perlu disampaikan  kepada masyarakat seiring dengan kebiasaan masyarakat dalam memanfaatkan Rosella sehingga diperlukan edukasi terkait manfaat yang terdapat dalam tanaman Rosella khususnya sebagai antibakteri.
Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Network Pharmacology of Ki Encok (Plumbago zeylanica Linn) Plant as A Treatment for Osteoarthritis Purwoko, Mitayani; Mundijo, Trisnawati; Widyadi, Yoshiko
Chimica et Natura Acta Vol 13, No 3 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n3.61349

Abstract

One of the plants in Indonesia used by the community to treat gout or Osteoarthritis (OA) is the Ki Encok plant (Plumbago zeylanica Linn). However, it is currently unknown what active substances play a role in the therapy process for gout or OA and what the pathway is. This study aimed to predict the pharmacological mechanism of the active content of Encok leaves against OA disease. This study used an in silico experimental test. The content of active plant substances was extracted from IMPPAT and KNAPSACK. Then, the target proteins of all these active substances were searched for, including target proteins involved in OA disease, through the GeneCards database. Common targets were then analyzed using the STRING database. Pathways involved in OA therapy by P. zeylanica Linn were analyzed using Gene Ontology. The active substances P. zeylanica plant are 52 components with 163 protein targets. Proteins involved in the pathogenesis of OA were found to be 5,394 proteins. Common targets were found to be 100 proteins. After being analyzed based on degree, the top 10 common targets that may play a role are ALB, TNF, INS, AKT1, TP53, IL6, PPARG, ESR1, HIF1A, and JUN. The active compounds contained in P. zeylanica with target proteins that match OA are D-glucose, vanillic acid, beta-stigmasterol, isoorientin, and lupeol.
Co-Authors Agustine, Asmar Dwi Artanto, Ardi Awang, Zarinah Binti Chairani, Liza Eriksyah, Aldeo Fachrozi, Muhammad Fuad Arifin Febiyolan, Febiyolan Ghea Lingga Septiareni Ilyasa, Muhammad Alfredo Indriani, M. A. Yenny Kahar, Fania Aulia Kesuma, Putri zalika lailah mardiah KHM Arsyad, KHM Martha, Fadhil Rizki Melianti, Agnes Mirawati Mirawati Mitayani Mitayani Mitayani Purwoko, Mitayani Mutia Mutmainnah Nafatilana, Dinda Pramayastri, Vina Putria, Sinta Julia Liona Radiana Dhewayani Antarianto Ratih Pratiwi Rezky, Monica Rosita, Yanti Sabrina, Siti Salsabila, Athaya Sari, Fanny Rahma Silvana, Rista Siti Rohani Suarni, Ertati Suciandari, Altiara Risky Suciandari, Altiara Risky Widyadi, Yoshiko Wijaya, Otchi Putri Yesi Astri Yesi Astri Yurnadi Yurnadi Zilda, Malika