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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication E-Dimas: Jurnal Pengabdian kepada Masyarakat Biomedical Journal of Indonesia Chimica et Natura Acta Jurnal Kesehatan Vokasional Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pengabdian Masyarakat Bumi Raflesia Medica Arteriana (Med-Art) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Indonesian Archives of Biomedical Research (InABR) INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY FASKES : Jurnal Farmasi, Kesehatan, dan Sains SULUH ABDI : Jurnal Ilmiah Pengabdian Kepada Masyarakat Scientific Journal of Pediatrics (Medical Scientific Journal) MESINA Cermin Dunia Kedokteran Proceeding UMSurabaya
Mundijo, Trisnawati
Fakultas Kedokteran Universitas Muhammadiyah Palembang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Hubungan Status Gravida dan Kehamilan Multipel dengan Derajat Keparahan Preeklampsia Fachrozi, Muhammad Fuad Arifin; Indriani, M. A. Yenny; Mundijo, Trisnawati; Purwoko, Mitayani
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 1 No. 2 (2023): Bulan November 2023 Faskes : Jurnal Farmasi, Kesehatan dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v1i3.2157

Abstract

Latar belakang: Preeklampsia adalah penyakit hipertensi yang terjadi selama kehamilan. Salah satu faktor risiko terjadinya preeklampsia pada ibu hamil adalah status gravida dan kehamilan multipel. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara status gravida dan kehamilan multipel dengan derajat keparahan preeklampsia di RSUD Palembang BARI tahun 2020-2022. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional. Populasi penelitian adalah data rekam medik pasien ibu hamil dengan preeklampsia yang melahirkan di RSUD Palembang BARI selama periode tahun 2020-2022. Sebanyak 68 sampel telah diambil dengan teknik concecutive sampling. Hasil: Sebanyak 16,2% ibu merupakan primigravida, 83,8% multigravida, 70,5% preeklampsia berat, 29,4% preeklampsia ringan, 4,4% dengan kehamilan multipel, 32,4% dengan kadar protein urine +1, 25,0% dengan kadar protein urine +2, 42,6% dengan kadar protein 3+. Hasil uji Fisher exact test didapatkan nilai p=0,155 untuk status gravida dan p=0,550 untuk kehamilan multipel. Kesimpulan dan Saran: Tidak terdapat hubungan yang signifikan antara status gravida dan kehamilan multipel dengan derajat keparahan preeklampsia di RSUD Palembang BARI.
The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Hubungan Pekerjaan Terhadap Infertilitas Pada Pria Dan Wanita Eriksyah, Aldeo; Mundijo, Trisnawati; Pratiwi, Ratih; Artanto, Ardi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.14881

Abstract

Infertilitas merupakan permasalahan sistem reproduksi yang diartikan sebagai ketidakmampuan pasangan untuk memperoleh keturunan setelah 12 bulan atau lebih melakukan yang melakukan hubungan seksual secara teratur tanpa alat kontrasepsi. Terdapat faktor risiko yang dapat menyebabkan infertilitas, salah satunya adalah pekerjaan. Hal ini dapat disebabkan oleh faktor kurang nyamannya lingkungan kerja dan terlalu berat beban kerja sehingga menyebabkan seseorang lebih memilih istirahat dan tidur seusai bekerja dibandingkan melakukan hubungan suami istri. Tujuan penelitian untuk mengetahui hubungan pekerjaan terhadap infertilitas pada pria dan wanita. Penelitian yang dilakukan merupakan penelitian kuantitatif dengan desain cross sectional. Sampel didapatkan melalui teknik purposive sampling pada sampel wanita dan total sampling pada sampel pria. Didapatkan 28 sampel pria dan 54 sampel wanita yang memenuhi kriteria penelitian. Hasil  penelitian didapatkan tidak terdapat hubungan yang bermakna antara pekerjaan terhadap infertilitas pada pria dan wanita dengan nilai p=0,747 pada pria dan p=0,572 pada wanita (p<0,05).
THE CORRELATION BETWEEN FAMILY SUPERVISION OF SCREEN TIME WITH THE INCIDENCE OF GADGET ADDICTION IN JUNIOR HIGH SCHOOL CHILDREN Salsabila, Athaya; Mundijo, Trisnawati; Kesuma, Putri zalika lailah mardiah; Awang, Zarinah Binti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.642

Abstract

Rapid technological developments have increased the use of gadgets among children and teenagers. Devices provide benefits in the form of easy access to information, but excessive use can have negative impacts, including adding gadgets. Children aged 12-15 years are the group most vulnerable to the negative impacts of gadgets. Families, especially parents, play an important role in supervising and guiding children in using devices. This research aims to determine the relationship between family supervision of screen time and the incidence of device addiction in junior high school children. This type of research is quantitative with a cross sectional design using primary data from the community of Kelurahan 5 Ulu Palembang with 91 samples that have met the inclusion and exclusion criteria. This research sample was taken by means of consecutive sampling. The results of the statistical test obtained a P-value of 0.000, so it can be concluded that there is a correlation between family supervision of screen time and the incidence of gadget addiction in junior high school children.
Edukasi Potensi Bunga Rosella (Hibiscus sabdariffa L.) terhadap Pencegahan Bakteri Salmonella enteritidis di Cangkang Telur Mundijo, Trisnawati; Astri, Yesi; Kahar, Fania Aulia
Suluh Abdi Vol 7, No 1 (2025): SULUH ABDI
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sa.v7i1.9632

Abstract

Dalam beberapa tahun terakhir, pemanfaatan natural product semakin berkembang seiring dengan kecenderungan back to nature. Zat yang terdapat dalam bahan alam memberikan efek sinergisme sehingga memiliki kemampuan dalam mencegah beberapa masalah kesehatan. Salah satu kekayaan hayati Indonesiabdengan khasiat yang dimiliki yaitu tanaman Rosella (Hibiscus sabdariffa L.). Masyarakat desa Pulau Panggung dan muara dua, kabupaten Muara Enim secara turun menurun telah memanfaatkan tanaman Rosella. Tidak hanya sebagai tanaman hidup yang berfungsi sebagai pagar di pekarangan, namun juga sebagai salah satu kebiasaan dengan mengkonsumsinya sebagai teh dari bunga yang diseduh dalam air panas. Kebiasaan ini dilakukan masyarakat khususnya saat musim panen di kebun. Masyarakat mempercayai bahwa dengan mengkonsumsi teh bunga Rosella, kesehatan mereka akan terjaga selama musim panen. Selain itu, literatur hasil penelitian telah banyak melaporkan bahwa tanaman Rosella memiliki banyak khasiat bagi kesehatan manusia karena memiliki kandungan zat berupa flavonoid, saponin, tanin dan alkaloid yang salah satunya berperan dalam menghambat dan mengeliminasi pertumbuhan bakteri. Etnofarmaka yang terdapat dalam tanaman Rosella ini perlu disampaikan  kepada masyarakat seiring dengan kebiasaan masyarakat dalam memanfaatkan Rosella sehingga diperlukan edukasi terkait manfaat yang terdapat dalam tanaman Rosella khususnya sebagai antibakteri.
Identification of Secondary Metabolites in Ethyl Acetate Extract of Ki Encok Plant Roots (Plumbago zeylanica Linn) and In Silico Cytotoxicity Activity Purwoko, Mitayani; Mundijo, Trisnawati; Astri, Yesi; Rohani, Siti
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50815

Abstract

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, tested in silico using the CB-Dock2 software, and evaluated for drug-likeness with SwissADME. Qualitative phytochemical tests indicate the presence of alkaloid and tannin compounds. The GC-MS test showed the presence of Plumbagin, Gamma sitosterol, and 4-ethoxybenzaldehyde. In the in silico test, docking between Gamma sitosterol, Plumbagin, and 4-ethoxybenzaldehyde with the target protein Caspase-3 has free binding energies of -8.5, -7.0, and -6.1. The Gamma sitosterol-Caspase-3 complex shows the best free-binding energy among the three ligands. Further in vitro or in vivo studies are needed to assess whether the interaction between Gamma sitosterol and Caspase-3 is inhibition or activation.
Network Pharmacology of Ki Encok (Plumbago zeylanica Linn) Plant as A Treatment for Osteoarthritis Purwoko, Mitayani; Mundijo, Trisnawati; Widyadi, Yoshiko
Chimica et Natura Acta Vol 13, No 3 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n3.61349

Abstract

One of the plants in Indonesia used by the community to treat gout or Osteoarthritis (OA) is the Ki Encok plant (Plumbago zeylanica Linn). However, it is currently unknown what active substances play a role in the therapy process for gout or OA and what the pathway is. This study aimed to predict the pharmacological mechanism of the active content of Encok leaves against OA disease. This study used an in silico experimental test. The content of active plant substances was extracted from IMPPAT and KNAPSACK. Then, the target proteins of all these active substances were searched for, including target proteins involved in OA disease, through the GeneCards database. Common targets were then analyzed using the STRING database. Pathways involved in OA therapy by P. zeylanica Linn were analyzed using Gene Ontology. The active substances P. zeylanica plant are 52 components with 163 protein targets. Proteins involved in the pathogenesis of OA were found to be 5,394 proteins. Common targets were found to be 100 proteins. After being analyzed based on degree, the top 10 common targets that may play a role are ALB, TNF, INS, AKT1, TP53, IL6, PPARG, ESR1, HIF1A, and JUN. The active compounds contained in P. zeylanica with target proteins that match OA are D-glucose, vanillic acid, beta-stigmasterol, isoorientin, and lupeol.
Hubungan Tipe Kepribadian Ekstrover dan Introver dengan Prokrastinasi Akademik Mahasiswa Kedokteran: Penelitian Kesuma, Putri Zalika Laila Mardiah; Febriani, Ratika; Mundijo , Trisnawati; Ramadhani, Adelia
Cermin Dunia Kedokteran Vol 53 No 01 (2026): Januari 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i01.1702

Abstract

Background: Academic procrastination refers to the act of postponing the completion of crucial and scheduled tasks. This research seeks the relationship between personality types (introvert and extrovert) and academic procrastination. Methods: A quantitative descriptive approach with a cross-sectional design. The participants include students from the Faculty of Medicine (FK) at Muhammadiyah University (UM) in Palembang, from the 2020 and 2021 cohorts; 127 individuals fulfilled the inclusion and exclusion criteria. The sampling technique was a total sampling. The tools used in this study were the Eysenck personality questionnaire (EPQ) and the active procrastination scale (APS). Results: A sum of 83 respondents (65.4%) displayed an extrovert personality, while 44 respondents (34.6%) showed an introvert personality; 114 respondents (89.8%) demonstrated low levels of academic procrastination behavior, whereas 13 respondents (10.2%) reported high levels of academic procrastination. A bivariate analysis showed that the relationship between personality type and academic procrastination had a p-value of 0.765 (p > 0.05). Conclusion: No significant correlation between personality type and academic procrastination among medical students from the 2020 and 2021 cohorts at FK UM Palembang. Additional research is required to investigate other factors that may lead to academic procrastination in medical students.
EKSPLORASI POLA SIDIK JARI DAN SUDUT AXIAL TRIRADIUS DIGITAL (ATD) PADA ANAK RETARDASI MENTAL DI PALEMBANG Trisnawati Mundijo; Vonny Alfanda
PROCEEDING UMSURABAYA 2018
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dermatoglifi adalah ilmu yang mempelajari pola sidik jari, jumlah sulur dan jumlah triradius yang perkembangannya diatur oleh genetik. Beberapa kelainan kromosom atau genetik mempengaruhi fenotip dermatoglifi diantaranya pada retardasi  mental. Penelitian ini  merupakan penelitian deskriptif yang bertujuan untuk mengeksplorasi  bagaimana pola sidik jari dan sudut ATD yang khas pada anak retardasi mental di Palembang. Sampel penelitian berjumlah 78 orang didapatkan dari Yayasan Pembinaan AnakCacat Palembang dan Yayasan Bina Autis Mandiri Palembang dengan cara total sampling. Data penelitian diambil dengan cara pengolesan lipstik pada sepuluh jari tangan untuk identifikasi pola sidik jari dan penempelan palmar kanan dan kiri pada bantalan cap untuk menghitung besar sudut ATD di lembar observasi. Hasil penelitian didapatkan peningkatan frekuensi pola ulnar loop (58,3%) dan penurunan pada pola accidental whorl (0,8%). Sedangkan untuk sudut ATD didapatkan hasil tertinggi pada kategori normal yaitu sudut 35o-50o, pada tangan kanan dan kiri masing-masing sebesar 76,9% dan 75,6%.
Family Support Domains and Quality of Social Interaction in School-Aged Children with Autism Spectrum Disorder: A Cross-Sectional Study in Palembang, Indonesia Ahmad Fadhil Kurnia; Trisnawati; Yuni Fitrianti; Hazian Hamzah
Scientific Journal of Pediatrics Vol. 3 No. 2 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v3i2.268

Abstract

Introduction: Autism spectrum disorder (ASD) affects approximately one in 100 children worldwide, and family support is a modifiable determinant of pediatric social functioning, yet the contribution of distinct family-support domains to social-interaction quality remains poorly characterized in Indonesian children. We quantified the association between five Friedman-framework family-support domains (emotional, informational, reward, instrumental, social/network) and social-interaction quality. Methods: In a cross-sectional analytical study at Sekolah Luar Biasa Negeri Pembina Palembang during November–December 2024, 36 of 40 eligible caregivers of children with ASD aged 7–12 years (mean 9.9 years, 91.7% male) completed Friedman's family-support inventory and the Indonesian Autism Social Skills Profile (ASSP). Spearman correlations with Fisher-z-derived confidence intervals, multivariable logistic regression, receiver-operating-characteristic (ROC) discriminative-performance analysis, and pre-specified subgroup analyses were performed. Results: Social interaction was moderate in 58.3%, low in 25.0%, and high in 16.7%. Network/social support showed the strongest correlation with ASSP score (ρ = 0.654, 95% CI 0.413–0.808, p < 0.001), and in multivariable regression remained the only independent predictor of non-low quality (adjusted OR 6.42, 95% CI 1.48–27.83, p = 0.013; Nagelkerke R² = 0.547). The composite family-support score discriminated low from non-low quality with AUC = 0.832 (95% CI 0.701–0.963; Youden cut-off ≈ 85, sensitivity 0.78, specificity 0.81). Conclusion: Network/social support is the predominant family-support component shaping social-interaction quality in Indonesian children with ASD, supporting pediatric primary-care screening focused on caregiver social connectedness.
Co-Authors Agnes Melianti Agustine, Asmar Dwi Ahmad Fadhil Kurnia Artanto, Ardi Awang, Zarinah Binti Chairani, Liza Dhiya Ridha Shafira Eriksyah, Aldeo Fachrozi, Muhammad Fuad Arifin Fadhil Rizki Martha Fadhilah Jasmine Shahab Febiyolan, Febiyolan Ghea Lingga Septiareni Hazian Hamzah Ilyasa, Muhammad Alfredo Indriani, M. A. Yenny Isma Yulianti Kahar, Fania Aulia Kesuma, Putri zalika lailah mardiah KHM Arsyad, KHM Laila M.K, Putri Zalika Malika Zilda Mirawati Mirawati Mitayani Purwoko, Mitayani Mutia Mutmainnah Nafatilana, Dinda Nur Fatimah Pramayastri, Vina Putri Erlyn Putria, Sinta Julia Liona Radiana Dhewayani Antarianto Ramadhani, Adelia Ratih Pratiwi Ratika Febriani Rezky, Monica Rosita, Yanti Sabrina, Siti Salsabila, Athaya Sari, Fanny Rahma Silvana, Rista Siti Rohani Suarni, Ertati Suciandari, Altiara Risky Suciandari, Altiara Risky Vonny Alfanda Widyadi, Yoshiko Wijaya, Otchi Putri Yesi Astri Yuni Fitrianti Yurnadi Yurnadi