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All Journal Catimore: Jurnal Pengabdian Kepada Masyarakat The International Journal of Tropical Veterinary and Biomedical Research Jurnal Medika Veterinaria
Ferdian, Riyan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Jurnal Medika Veterinaria

 1 
Screening of Bioactive Compounds of Gambir leaf (Uncaria gambir Roxb) as Antibiofilm Againts the Glucosyltransferase of Streptococus mutans Enzyme Khalid, Idham; Sari, Dea Kurnia; Bakri, Muttaqien; Daniel, Daniel; Frengki, Frengki; Makmur, Ali; Riandi, Lian Varis; Ferdian, Riyan; Amiruddin, Amiruddin
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.43265

Abstract

The use of natural ingredients in dental care, such as manginang which has become part of the Minang community culture, is considered an alternative dental care that must be created to overcome the negative impacts of dental care made from artificial materials. The core of this study is to change the manginang tradition towards logical verification through screening of bioactive compounds of gambir leaves (Uncaria gambir Roxb.) as antibiofilms against Streptococcus mutans. This study was conducted using an in silico strategy approach with the help of computer programs such as MOE v.09 and Chimera 1.13.1, as well as the Way2Drug site, protein information bank, and protox_ii. This study began with the collection of ligand information from the writing, followed by transformation into 2D and 3D designs. Other antibiofilm actions were decided using the QSAR procedure through the website (http://www.way2drug.com/PASSOnline/predict.php). The selected antibiofilm compounds were then followed by observing their affinity for the receptor (pdb id. 3AIB) using an atomic docking strategy. Finally, the ligand damage profile was observed to anticipate. The results of this study indicate that of the 41 identified gambir leaf compounds, there are 20 compounds that have the potential to have antibiofilm effects with quinnic acid having the highest score (Pa 0.703), while the compound with the strongest affinity for the receptor is chlorogenic acid with an affinity score (Gbinding) of -16.03 kcal/mol and an average of low toxicity (level IV-VI). However, of the 20 bioactive compounds of gambir leaves, only 5 compounds are predicted to have the same potential as the -maltose control.
Treatment Of Prolapsus Bulbus Oculi In Domestic Cats Sukma, Zahwa Tamara; Darmawi, Darmawi; Sayuti, Arman; Amiruddin, Amiruddin; Syafruddin, Syafruddin; Daud, Razali; Erwin, Erwin; Panjaitan, Budianto; Ferdian, Riyan; Zamzami, Rumi Sahara; Usrina, Nora; Akmal, Muslim; Balqis, Ummu
Jurnal Medika Veterinaria Vol 19, No 1 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i1.37430

Abstract

Bulbus oculi prolapse is a condition characterized by the protrusion of the eyeball from the eye socket, which can be caused by various factors such as trauma, elevated intraocular pressure, and abnormalities in the eye muscles. This case study aimed to examine the treatment of bulbus oculi prolapse in domestic cats. A female calico cat named Mici presented with a chronic left eye injury that had become infected, leading to inflammation and persistent ocular discharge. The cats body weight was 0.7 kg, and its temperature was 38.2C. Surgical treatment was performed using an enucleation technique. The procedure involved an incision along the mid-anterior eyelid, extending to the lower eyelid. Dissection was carried out to expose the bulbus oculi, which was then ligated and excised. The eyelid margins were sutured using simple interrupted sutures. Postoperatively, the cat was administered antibiotics and antihistamines.
Clinical Outcomes of Autologous Serum Eye Drops in Treating Corneal Ulceration in a Domestic Cat: A Case Base Study Eka Putri, Rahmi; Hilmi, Mulkiah; Rahmi, Ulfa; Zamzami, Rumi Sahara; Etriwati, Etriwati; Erwin, Erwin; Sugito, Sugito; Syah, Nada Yulian; Ferdian, Riyan; Sari, Wahyu Eka; Safitri, Jessica Anggun
Jurnal Medika Veterinaria Vol 19, No 2 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i2.46171

Abstract

Corneal ulceration is a frequent ophthalmic disorder in domestic cats that can cause ocular discomfort, visual impairment, and serious complications if left untreated. Conventional medical management often provides limited support for epithelial regeneration, leading to the need for alternative therapeutic options. This case study reports the clinical outcome of using autologous serum eye drops (ASEDs) in the treatment of corneal ulceration in a domestic cat. A cat presented with severe epiphora, conjunctival hyperemia, and a centrally located corneal ulcer confirmed by fluorescein staining. Autologous serum was prepared by weekly collection of 6 mL of blood from the dorsalis antebrachii vein, followed by centrifugation and aliquoting into sterile eye drop bottles stored at 4 C. The serum was applied topically twice daily, accompanied by supportive therapy consisting of vitamin A supplementation, multivitamin injections, and an Elizabethan collar to prevent self-trauma. Clinical scoring (03) was used to monitor epiphora, conjunctival hyperemia, and corneal opacity over the treatment period. Marked improvement was observed within 14 days: epiphora and conjunctival hyperemia resolved completely, while corneal opacity improved from moderate to mild, with fluorescein staining becoming negative, indicating complete epithelial closure. No adverse effects were recorded during therapy. This case highlights the potential of autologous serum eye drops as a safe and effective adjunct treatment for feline corneal ulceration, warranting further investigation in larger cohorts to establish standardized protocols for veterinary ophthalmology
Co-Authors Abdullah Hamzah, Abdullah Amiruddin Amiruddin Arman Sayuti Awaluddin Awaluddin budianto panjaitan Daniel Daniel Darmawi . Erwin Erwin Etriwati E Frengki Frengki, Frengki Hasyimi, Adyar Hilmi, Mulkiah Idham Khalid Jessica Anggun Safitri M Hasan Makmur, Ali Masitta Tanjung Muhammad Hasan Muslim Akmal Muttaqien Bakri, Muttaqien Nanda Yulian Syah Nora Usrina NURLIANA NURLIANA Nursal Nursal, Nursal Rahmi Eka Putri Rahmi, Ulfa Rasyida Ulfa Razali Daud Riandi, Lian Varis Rizki, Maurina Sari, Dea Kurnia Sari, Wahyu Eka Sugito - Sukma, Zahwa Tamara Syafruddin Syafruddin Syah, Nada Yulian Ummu Balqis Yulian Syah, Nanda Zamzami, Rumi Sahara