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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Kesehatan Tambusai Journal of Experimental and Clinical Pharmacy (JECP) Pharmademica: Jurnal Kefarmasian dan Gizi Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Pengabdian Masyarakat dan Riset Pendidikan Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Rohmana, Vivin Marwiyati
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A Pola Pengobatan dan Efek Samping Terapi Hormonal pada Pasien Kanker Payudara di RSUD Dr. Moewardi Surakarta Luthfiyanti, Niken; Rohmana, Vivin Marwiyati; Khusain, Muhammad Fuad Zidane
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.137

Abstract

Breast cancer is one of the most prevalent malignancies in women and remains a leading cause of cancer-related mortality. One of the main treatment modalities for hormone receptor–positive breast cancer is Adjuvant Endocrine Therapy (AET), particularly tamoxifen, either as monotherapy or in combination. This study aimed to evaluate patient characteristics, treatment patterns of hormonal and chemotherapy regimens, as well as adverse drug reactions (ADRs) among breast cancer patients at Dr. Moewardi General Hospital, Surakarta. This study employed a cross-sectional design with purposive sampling. A total of 64 breast cancer patients who had received tamoxifen therapy for at least one month were included. Data were collected from medical records and questionnaires, and analyzed using the Chi-Square test to determine associations between variables. The results showed that most patients were <50 years old (60.9%) and diagnosed at advanced stages (III–IV, 57.8%). The most frequent treatment was a combination of chemotherapy and hormonal therapy (51.6%), while hormonal therapy alone was administered in 48.4% of patients. The most commonly prescribed chemotherapy regimen was Cyclophosphamide & Epirubicin, whereas the most frequent hormonal regimen was Tamoxifen + Zoladex. Bivariate analysis indicated significant associations between age and treatment type, as well as between cancer stage and treatment type (p<0,05). However, no significant associations were found between age, stage, or type of therapy and ADRs (p>0.05). The most commonly reported adverse effects were fatigue, hot flushes, nausea, and bone/joint pain, with a small proportion reporting endometrial cancer.
Co-Authors 'Arifah, Zainul A, Ferlinda Ayu Ambararum, Tiara Rizki Aprilia Puteri Santika Ardiantoro, Bagas Artini, Kusumaningtyas Siwi Bagas Ardiyantoro Danang Raharjo Febriani, Tiffany Aisya Handayani, Sri Insani, Fitri Nur iska olivia, anggun Kharisma Jayak Pratama Khusain, Muhammad Fuad Zidane Kusumasedya, Willyana Pratiwi Listyani, Tiara Ajeng Luthfiyanti, Niken Mahendra, Andika Dwi Monica Permata, Bangkit Riska Phiapresia, Safara Zulfa Pratama, Kharisma Jayak Puspita Sari, Mawar Dela Raden Mohamad Herdian Bhakti Rahmadona, Salsa Permata Rahmat Hidayat Rahmatillah, Annie Rianto, Yeta Pradina Ainun Rosmala Dewi Saputra, Rizka Wahyu Sari, Silvia Mega Kusuma Septian Maulid Wicahco Septiarini, Anita Dwi Tantri Dwi Lestari Tiara Dhea Febryana Wardani, Tatiana Siska Yustina Esha Maunia Chantika