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All Journal Majalah Kedokteran Bandung JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Journal of Tropical Biodiversity and Biotechnology Dental Journal (Majalah Kedokteran Gigi) Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Al-Mashrafiyah : Jurnal Ekonomi, Keuangan, dan Perbankan Syariah ISOQUANT : Jurnal Ekonomi, Manajemen dan Akuntansi JURNAL REKAYASA Jurnal Ilmiah Edunomika (JIE) Budimas : Jurnal Pengabdian Masyarakat Conservative Dentistry Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Medfarm: Jurnal Farmasi dan Kesehatan Indian Journal of Forensic Medicine & Toxicology DedikasiMU: Journal of Community Service Journal of Multidisciplinary Applied Natural Science Jurnal Abdi Masyarakat Indonesia Jurnal Sistem Informasi Triguna Dharma (JURSI TGD) Gemilang: Jurnal Manajemen dan Akuntansi West Science Business and Management Journal of Management and Innovation Entrepreneurship (JMIE) Sadewa: Jurnal Pengabdian Masyarakat Jurnal Ekonomi, Manajemen Pariwisata dan Perhotelan
Fery Setiawan
Department Of Forensic Odontology, Institute Of Health Science Bhakti Wiyata, Kediri, East Java, Indonesia
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Journal : Journal of Multidisciplinary Applied Natural Science

 1 
The Potential of Moringa Leaf Nanoparticles (Moringa oleifera) on the Expression of TNFα, IL10, and HSP 27 in Oral Cavity Cancer Theresia Indah Budhy; Deddy Adam; Zulikran Moh Rizki Azis; Vania Syahputri; M Gandul Atik Yuliani; Muhammad Febriano Sugiarso Suwarto; Fery Setiawan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.198

Abstract

Oral cancer is currently the sixth leading malignancy in the world, with over 330,000 cases resulting in death. Several cytokines and proteins protect the survival of cancer cells, such as TNF-α, HSP27, and IL-10. Moringa oleifera is an herbal medicine with anti-cancer properties. Nanoparticles of M. oleifera have the property to be easily absorbed by water-soluble cells, so only small doses are needed to be used as anti-cancer ingredients. This research aims to prove the ability of M. oleifera nanoparticle extract against oral cancer through the expression of tumour necrosis factor α (TNF-α), heat shock protein (HSP27), and interleukin 10 (IL-10). Rat as non-human experimental subjects were divided into four groups: control group (K), treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3). Cancer induction was carried out by injecting with benzo[a]pyrene, and then M. oleifera nanoparticle extract was administered in three forms of treatment doses of 125 μg/mL (P1), 250 μg/mL (P2), and 500 μg/mL (P3). Immunohistochemical examination was analysed through TNF-α, HSP27, and IL-10’s expression. The expression of TNF-α and HSP27 between control and treatment groups was significantly different. P2 had the lowest expression of TNF-α and HSP27. The expression of IL-10 between control and treatment groups was also significantly different. P1 had the lowest expression of IL-10. M. oleifera nanoparticle extract can reduce oral cancer progression by decreasing the expression of TNF-α, HSP27, and IL-10.
Co-Authors Achmad Basori, Achmad Achmad Nurdin Himawan Acivrida Mega Charisma Acivrida Mega Charisma Acrivida Mega Charisma Agung Sosiawan Ahmad Yudianto Ahmad Yudianto Amellya Octifani Andi Syahrimayani Anis Byarwati Anis Dwi Anita Rini Anita Devi Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Arif Rahman Nurdianto Ariyanto Wibowo Aurelia, Shalsa Fadela Azis Akbar Ramadhan Azizah Fatin Hasanah Deddy Adam Dian Agustin Wahjuningrum Dimas Agung Trisliatanto Dina Ismaya Dwikora Novembri Utomo Dyah Ayu Febiyanti Dyah Irnawati Elis Anita Farida ELOK PUTRI NIMASARI Farida Anwari Farida Anwari Gandul Atik Yuliani Hendro Puspito Heni Puspitasari Heribertus Agustinus B Tena Heribertus Agustinus B Tena Heribertus Agustinus Bilo Tena Heribertus Agustinus Tena Hisnindarsyah, Hisnindarsyah Jenny Sunariani Jenny Sunariani Juni Handajani Kurniasih, Ranti Latief Mooduto, Latief Lisdrianto Hanindriyo Lusiyanti Martina Kurnia Rohmah Martina Kurnia Rohmah Martina Kurnia Rohmah Masniari Novita Moh. Khafid Muhammad Febriano Sugiarso Suwarto Niken Hilvanda Putri Nur Sayidatul Muntiah Nurdianto, Arif Rahman Reni Sumino Ria Chusnita Riawan Riyanto Riyanto Rizal Fauzi Nurdianto Rizal Fauzi Nurdianto Rizal Fauzi Nurdianto Rizaldi Patria Setyabudi Setyabudi Simon Martin Manyanza Nzilibili Siregar, Siti Julianita Slamet Santoso Sri Hartono Sri Iswati Swadheena Patro Theresia Indah Budhy Umi Farida Vania Syahputri Vera Rimbawani Sushanty Yusma Amrulloh Tri Firmansyah Yuvi Safitri Zulikran Moh Rizki Azis