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All Journal Majalah Obat Tradisional Raheema Chemistry Indonesian Journal of Chemical Research Jurnal Mandala Pharmacon Indonesia Pharmaceutical Sciences and Research (PSR) Sewagati: Jurnal Pengabdian Masyarakat Indonesia Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Academic Hospital Journal Harmoni Sosial : Jurnal Pengabdian Dan Solidaritas Masyarakat Jurnal Inovasi dan Terapan Pengabdian Masyarakat Fundamentum: Jurnal Pengabdian Multidisiplin
Dermawan, Abdurraafi Maududi
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Formulation and Characterization of Uncaria gambir (U. gambir) Extract Cream as an Anti-Psoriasis Candidate: In Silico and In Vitro Studies Abidin, Khoirul Rista; Nurhidayattulloh, Ariffialdi; Siregar, Febrina; Dermawan, Abdurrafi Maududi; Dwisari, Fath; Oktaviria, Oktaviria; Suchi, Suchi; Indriani, Melly; Putri, Firda Aulia; Prasetyaningsi, Hernyati; Shofia, Shofia
Indonesian Journal of Chemical Research Vol 13 No 3 (2026): Edition for January 2026
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2026.13-kho

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder in which oxidative stress and COX-2–mediated pathways contribute to disease progression. Conventional topical therapies, particularly corticosteroids, are effective but associated with adverse effects and limited mechanistic targeting. Objective: This study investigated Uncaria gambir (U. gambir) extract as a natural anti-psoriasis candidate in a topical cream formulation through phytochemical, antioxidant, in silico, and physicochemical evaluations. Methods: The extract was screened for phenolic and flavonoid content and evaluated for DPPH radical scavenging activity (IC₅₀). Molecular docking of catechin against the COX-2 receptor was performed using quercetin as a reference. Cream formulations containing varying extract concentrations were assessed for pH, spreadability, and adhesiveness. Results: U. gambir extract exhibited very strong antioxidant activity (IC₅₀ = 6.84 ppm), falling within the range of highly active antioxidants, although less potent than vitamin C. Catechin showed stable COX-2 binding (−4.76 kcal/mol). The 4.5% cream formulation (F2) demonstrated optimal properties, with a skin-compatible pH (~7.5) and good spreadability (~5.5 cm). Conclusion: U. gambir extract shows promising potential as a natural topical agent targeting oxidative stress and inflammation in psoriasis, supporting further in vivo and clinical validation.
Antibacterial Activity of Bajakah Tampala (Spatholobus littoralis Hassk.) Methanol Extract in Roll-On Deodorant against Staphylococcus epidermidis Dwisari, Fath; Dermawan, Abdurraafi' Maududi; Rahma, Nur Atika; Tjoadri, Tessa Nathalia; Abidin, Khoirul Rista
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.865

Abstract

Body malodor results from the bacterial breakdown of apocrine gland secretions, with Staphylococcus epidermidis identified as a key contributor. Conventional deodorants often rely on synthetic compounds that may cause skin irritation or pose long-term health risks. This study aimed to formulate and assess an antibacterial roll-on deodorant containing methanolic extract of Spatholobus littoralis Hassk., a Kalimantan-native medicinal plant known for its antibacterial properties. The extract, prepared via maceration, was incorporated into a multiphase emulsion base comprising zinc ricinoleate, aluminum potassium sulfate, Carbopol 940, triethanolamine, Lexemul CS20, BHT, and phenoxyethanol. The formulations were evaluated for their physicochemical characteristics—pH, spreadability, adhesiveness, and homogeneity—as well as antibacterial activity against S. epidermidis using the disc diffusion assay. The extract-containing formulations (F1–F3) exhibited a beige color, herbal aroma, and uniform texture. The pH values (4.12–4.35) were within the dermally acceptable range. The spreadability varied from 4.59 to 4.81?cm, while the adhesiveness ranged from 0.34?s to 5.25?min, indicating favorable application and retention properties. Antibacterial testing showed inhibition zones of 10.40–12.37?mm, comparable to a commercial control (p?>?0.05). These findings suggest that S. littoralis extract is a potential natural, skin-compatible antibacterial agent for topical deodorant applications
Comparison of The Effectiveness of Intermittent and Continuous Pantoprazole Therapy in Peptic Ulcer Disease Bleeding Wirastuti, Ade; Molidia, Sri Rahmat; Salsabela, Salsabela; Anisya, Kharina; Deisberanda, Fortunata Saesarria; Aqsa, Kathina Deswi; Ajwad, Muhammad Nur; Dermawan, Abdurraafi' Maududi; Fakhruddin, Fakhruddin; Rommy, Rommy
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.115539

Abstract

Background:  Peptic ulcer disease with melena is commonly encountered in clinical practice. Pantoprazole is widely used to control bleeding and heal ulcers, but there is still debate regarding the effectiveness of intermittent bolus administration compared to continuous infusion.Objective: To review and evaluate the literature on the comparative effectiveness of pantoprazole administered via intermittent bolus versus continuous infusion.Methods: This study employed a narrative literature review design. Literature searches were conducted in the PubMed, Google Scholar, ProQuest, and Sage Journals databases for publications from 2020 to 2025 using the keywords: “pantoprazole,” “continuous infusion,” “intermittent bolus,” “effectiveness,” “bleeding,” and “peptic ulcer disease”.Result: Four articles met the inclusion criteria. Two studies reported no significant difference between intermittent bolus and continuous infusion administration. One study found that intermittent bolus administration was associated with a shorter length of stay, whereas another recommended continuous infusion for patients at high risk of upper gastrointestinal bleeding. There was heterogeneity in study design and reported outcomes.Conclusion: There is no significant difference between continuous infusion and intermittent bolus administration of pantoprazole; given the limited number and quality of studies, further research is needed.
Co-Authors Abidin, Khoirul Rista Ade Wirastuti, Ade Afriani, Natia Ajwad, Muhammad Nur Amalia, Puspa Anisya, Kharina Aqsa, Kathina Deswi Azmi, Khulul Deisberanda, Fortunata Saesarria Fakhruddin Fakhruddin Fath Dwisari Fitri Khotimatus Sa'adah Indri Kusharyanti Indriani, Melly Julianti, Elin Jumadilah, Rahmi Liza Pratiwi Molidia, Sri Rahmat Nurhidayattulloh, Ariffialdi Nurza Wahyuningsih Oktaviria, Oktaviria Prasetyaningsi, Hernyati Purwanti, Desi Asih Putra, Masteria Yunovilsa Putri, Firda Aulia Rahma, Nur Atika Ramadhani, Natasya Intan Rommy, Rommy Salsabela, Salsabela Samsiah Samsiah Shofia, Shofia Siregar, Febrina Suchi, Suchi Tjoadri, Tessa Nathalia Tri Utari