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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacology and Therapy Clinical and Pharmaceutical Sciences Journal
Citra Ariani Edityaningrum, Citra
Faculty Of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Formulation and Characterization of Carbamazepine Chitosan Nanoparticle Citra Ariani Edityaningrum; Ariza Nur Zulaechah; Widyasari Putranti; Dewa Ayu Arimurni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.146-154

Abstract

Background: Carbamazepine is an antiepileptic drug used to treat trigeminal neuralgia and pain associated with neurological disorders. The drug belongs to class II of the Biopharmaceutical Classification System (BCS), which has low solubility. Hence, dissolution is a rate-limiting step. Objective: This study aimed to determine the best formula for carbamazepine nanoparticles based on physical characteristics and determine the effect of chitosan and Na-TPP concentration variation on nanoparticle characterization. Methods: The carbamazepine chitosan nanoparticles were prepared using ionic gelation method with a concentration of 0.1% w/v carbamazepine and the ratio of chitosan and Na-TPP concentrations of 0.2%:0.1% (F1), 0.2%:0.2% (F2), and 0.3%:0.1% w/v (F3). The parameters evaluated included particle size, polydispersity index, zeta potential, particle morphology, and entrapment efficiency. Statistical analysis was conducted on the evaluation data using One Way ANOVA. Results: The results showed that the effect of increasing the concentration of chitosan reduced particle size (p<0.05), increased zeta potential (p<0.05), and had no effect on the value of entrapment efficiency (p>0.05). Furthermore, F3 had a particle size of 169.8±13.71 nm with a polydispersity index of 0.378±0.02, the zeta potential of +28.80±2.44 mV, entrapment efficiency of 84.3±7.50%, and spheric particle morphology which was measured using Transmission Electron Microscope (TEM). Conclusion: Therefore, F3 with the ratio of chitosan and Na-TPP concentrations of 0.3%:0.1% was the formula that provided the best characteristics of chitosan carbamazepine nanoparticles.
Chemometrics-Assisted UV-Vis Spectrophotometry for Quality Control of Pharmaceuticals: A Review Laela Hayu Nurani; Citra Ariani Edityaningrum; Irnawati Irnawati; Anggita Rosiana Putri; Anjar Windarsih; Any Guntarti; Abdul Rohman
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.74329

Abstract

Spectroscopic method in the UV-Vis region is considered the most molecular spectrometric method for content determination of a single component. However, a lot of pharmaceutical dosage forms comprise two or more components which lead to peak overlapping. Moreover, in the chemical stability test, active pharmaceutical ingredient (API) was also found along with the degradation products, impurities, and adulterant compounds. UV-Vis spectroscopy is one of the methods of choice for the determination or quantification of a single component in pharmaceutical preparations. The pharmaceutical products typically contain two or more APIs having chromophoric agents capable of absorbing UV-Vis beams and the absorbance values are summative from the absorption of each UV-Vis active compound according to the additive nature of Lambert-Beer law. The main problem for the simultaneous determination of API along with impurities and the degradation products in pharmaceutical preparations is the presence of overlapping peaks of UV-Vis spectra. The chemometrics-assisted spectroscopy is one of the analytical efforts to solve these problems. This review highlighted the application of chemometrics in combination with UV-Vis spectroscopy for the assay of API, impurities, adulteration issues and degradation products present in pharmaceutical dosage forms.
Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach Siti Rofida; Laela Hayu Nurani; Dwi Utami; Citra Ariani Edityaningrum
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27482

Abstract

Cervical cancer is one of the second-leading causes of death in women. The discovery of cancer drug candidates continues to be carried out due to the resistance that occurs in cervical cancer therapy. Plant metabolite compounds are one of the sources used to explore new drug candidates. Red ginger rhizome is a candidate plant that has anti-cervical cancer activity. This study aims to determine the cytotoxicity of an ethanol extract of red ginger rhizomes on the growth of HeLa cancer cells and predict anti-proliferative activity via the jak2/stat3 and hedgehog pathways. The sample (red ginger rhizome simplicia) was extracted by remaceration using 75% ethanol. The MTT assay method is used to test the cytotoxicity and anti-proliferation of metabolite compounds using Autodock 4.2 software. The receptors used in the jak2, stat3, and smo pathways were obtained from the Protein Data Bank with the codes 6VGL, 6NUQ, and 5L7I, respectively. The ethanol extract produced is a thick yellowish brown extract with an aromatic smell and spicy taste, with an extract yield of 18.63% w/w. 75% ethanol extract of red ginger rhizomes has cytotoxic activity in HeLa cancer with an IC50 of 104.22 ± 6.18 µg/mL and an IC50 of cisplatin of 38.61 ± 3.66. Prediction of antiproliferative activity via the jak2 pathway shows a binding energy and Ki value of -7.47 kcal/mol, -7.48 kcal/mol, and 3.33 uM, 3.27 uM, as shown by alpha-cedrol and beta-eudesmol compounds. The highest inhibition on the stat3 and smo pathways was shown by the beta compound eudesmol, with binding energy and Ki values of -6.05 kcal/mol, -7.57 kcal/mol, and 36.48 uM, respectively; 2.81 uM.
THE APOPTOSIS INDUCTION OF Zingiber oficinale ETHANOLIC EXTRACT-Treated HeLa (HUMAN CERVICAL CANCER) CELLS AND ACTIVE COMPOUND PROFILING USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY Laela Hayu Nurani; Siti Rofida; Dwi Utami; Citra Ariani Edityaningrum; Any Guntarti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1059

Abstract

Cervical cancer accounts for the highest percentage of cancer-related deaths in Indonesia, accounting for nearly 60% of all cancer cases.  Therefore, research into the anticancer mechanisms needs to be conducted.  The ethanolic extract of Zingiber officinale (EEZO) contains zingiberene, a chemical known for its anticancer activity. Understanding the mechanism underlying the apoptosis-inducing effects is crucial. This study aimed to elucidate the apoptotic pathway and analyze the gas chromatography/mass spectrometry (GC/MS) profile of EEZO cells. The research commenced with the maceration of Zingiber officinale rhizomes using 75% ethanol to obtain EEZO. Apoptosis assays were conducted on both a negative control group and an EEZO-treated group of HeLa cells (cervical cancer cells). The apoptotic mechanism was evaluated using forward scattered light-side scattered light (FSC-SSC), fluorescein isothiocyanate (FTIC), and phycoerythrin (PE) flow cytometry. Apoptotic results were analyzed by comparing the control and EEZO samples, which revealed the number of viable cells, apoptotic cells, and cells in the sub-G1 phase. The major constituent of EEZO, which is expected to be a potent apoptosis inducer, was detected using GC/MS. The FSC-SSC results indicated a lower number of viable cells in the EEZO-exposed group than in the control group. FTIC results demonstrated that EEZO significantly increased apoptotic cell death, increasing from 68 to 1537 cells. PE flow cytometry revealed an elevated sub-G1 cell population, indicating the induction of apoptosis by EEZO. GC/MS analysis revealed five dominant components in EEZO, which had the potential to induce apoptosis: L-borneol, zingiberene, farnesol, beta-sesquiphellandrene, and alpha-curcumene ...  
Analisis Profil Minyak Atsiri Daun Kayu Putih (Melaleuca leucadendra L.) dan Produk di Pasaran Irfan, Nawwar; Nurani, Laela Hayu; Guntarti, Any; Salamah, Nina; Edityaningrum, Citra Ariani
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5785

Abstract

Minyak kayu putih merupakan salah satu minyak atsiri yang biasa digunakan dalam sehari-hari. Produksi dalam negeri hanya dapat memproduksi minyak kayu putih 650 ton/tahun dari permintaan kebutuhan dalam negeri dalam setahun sebesar 3.500 ton sehingga memacu pemalsuan. Penelitian ini bertujuan untuk membandingkan profil minyak kayu putih hasil destilasi dengan minyak kayu putih yang ada di pasaran berdasarkan mutu Standar Nasional Indonesia (SNI). Destilasi minyak atsiri dilakukan dengan 5 kg daun kayu putih menggunakan metode destilasi uap air selama 3 hari didapatkan rendemen sebesar 2,32%. Minyak kayu putih hasil destilasi dan minyak produk A, B dan C dilakukan pengujian profil minyak berdasarkan SNI 06-3954-2006 meliputi warna, bau, bobot jenis, indeks bias, kelarutan dalam etanol 70%, dan profil KLT. Hasil pengamatan organoleptis minyak hasil destilasi, produk A, B, dan C memiliki perbedaan warna, bobot jenis, dan kelarutan dalam etanol 70% serta tidak ada perbedaan bau dan indeks bias. Hasil penelitian menunjukkan adanya perbedaan profil minyak produk A, B, dan C yang tidak memenuhi SNI pada pengujian bobot jenis pada produk C. KLT dengan menggunakan fase diam silika gel GF254 dan fase gerak Toluen (100%). Profil KLT pada produk C tidak terlihat noda yang sama dengan standar eucalyptol yang diperlihatkan oleh minyak lainnya. Keywords: Analisis profil, Minyak kayu putih, SNI 06-3954-2006
Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro Aristiani, Windy; Desvita, Widea Rossi; Khayatulisma, Dika; Edityaningrum, Citra Ariani; Guntarti, Any; Nurani, Laela Hayu
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10887

Abstract

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.
The Hepatoprotective Effect of Moringa oleifera Leaves on Male Wistar Rat Induced Streptozotocin-Nicotinamide Bachri, Moch Saiful; Nurani, Laela Hayu; Edityaningrum, Citra Ariani; Ma'ruf, Muhammad; Sulistyorini, Dwi Agustin; Amelia, Rizki; Hidayati, Sholihatil; Sulistyawati, Rini; Guntarti, Any
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90806

Abstract

Diabetes mellitus is a disease characterized by uncontrolled increases in blood sugar levels, which can cause complications in the liver. Disorder liver disease can be seen from the increasing SGOT, SGPT activity, and the number of necrosis cells in the liver. Moringa leaves contain the flavonoid quercetin with antidiabetic and antioxidant activity. This research aimed to determine the effect of administering the ethyl acetate fraction of Moringa leaves on SGOT activity, SGPT, and liver histopathology in rat induced by streptozotocin and nicotinamide. Moringa leaves macerated with 80% ethanol and fractionated with ethyl acetate were used. The research subjects were 30 rats divided into six groups. The rats were induced with streptozotocin at a dose of 65 mg/kgBW and nicotinamide 100 mg/kgBW for five days, then treated for ten days. Serum SGOT and SGPT activity were measured using a Microlab 300 Semi-Automated at a wavelength of 340 nm. Histopathological observations were carried out when the rats were dislocated, their livers were taken, and then preparations were made using Hematoxylin Eosin (HE) staining. Data were analyzed using the SPSS One Way ANOVA method, followed by the Tukey test with a confidence level of 95%. The results of the study showed that administration of Ethyl Acetate Fraction of Moringa oleifera (EA-MO) could reduce the levels of SGOT, SGPT, and the number of liver necrosis cells in rats induced by streptozotocin and nicotinamide.
AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET Nurani, Laela Hayu; Guntarti, Any; Milanie, Rida Dwi; Gandjar, Ibnu Gholib; Rais, Ichwan Ridwan; Prasasti, Dian; Edityaningrum, Citra Ariani
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10523

Abstract

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.
MEKANISME KO-KEMOTERAPI EKSTRAK ROSELLA (Hibiscus sabdariffa. L) DENGAN DOXORUBICIN PADA SEL KANKER SERVIKS (HeLa) SECARA IN VITRO Daud, Intan; Hayu Nurani, Laela; Bachri, Moch. Saiful; Ariani Edityaningrum, Citra; Ma’ruf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2158

Abstract

Cervical cancer caused by exposure to Human Papilloma Virus (HPV) through sexual intercourse can be treated with Doxorubicin. Doxorubicin shows side effects so it needs to be combined with co-chemotherapy. Rosella (Hibiscus sabdariffa L.) The main content of anthocyanins is cytotoxic to HeLa cells.  The purpose of this study was to find co-chemotherapy combination of Doxorubicin and Rosella extract with apoptosis mechanism and Rosella antiproliferation.  The research method starts from the maceration process of Rosella petals using 96% ethanol. Cytotoxic test method, antiproliferation test, apoptosis, and combination test with MTT method using HeLa cells. The result of cytotoxic test showed IC50 of Rosella extract was 32.3 ± 2.15 µg/mL and IC50 of Doxorubicin was 2.68 ± 0.09 µg/mL. The antiproliferation test results in the control cell doubling time of 28.25 ± 0.21 hours while the concentration of Rosella extract at levels of 32.3; 16.15; and 8.08 µg/mL doubling time of 53.23 ± 0.20 hours, 39.02 ± 0.19 hours and 46.74 ± 0.23 hours so that it shows the inhibition of cell multiplication growth. The IC results show the combination of 4.04 µg/mL Rosella Flower Extract and 2.67 µg/mL Doxorubicin which is 0.0013 can be interpreted as a very strong synergistic effect (0.0013 ≤ 0.1). So it can be concluded the combination of ethanol extract Rosella flowers has antiproliferation properties through the mechanism of delaying the doubling time.
Formulasi Fast Disintegrating Tablet Ekstrak Etanol Daun Salam dengan Kombinasi Crospovidone dan Croscarmellose Sodium sebagai Superdisintegrants Putranti, Widyasari; Edityaningrum, Citra Ariani; Prastyaningrum, Endah; Widiyastuti, Lina
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.3.285-295.2021

Abstract

Pengembangan formulasi ekstrak daun Salam (Syzygium polyanthum W.) sebagai antihiperlipidemia yang mampu hancur cepat setelah diletakkan di atas lidah sangat diperlukan untuk mempercepat onset obat dan memberikan kenyamanan terutama pada pasien hiperlipidemia usia lanjut yang sulit menelan obat. Tujuan dari penelitian ini untuk mengetahui komposisi perbandingan superdisintegrants crospovidone dan croscarmellose sodium yang mampu menghasilkan sifat fisik Fast Disintegrating Tablet (FDT) yang optimum. Pembuatan FDT menggunakan metode granulasi basah dengan variasi konsentrasi crospovidone dan croscarmellose sodium dalam rentang 2%-5%. Hasil uji sifat fisik FDT dianalisis menggunakan metode Simplex Lattice Design (SLD) program Design Expert 10.1.). Kombinasi kedua superdisintegrants dapat mempengaruhi respon sifat fisik yaitu mampu menurunkan kekerasan, waktu disintegrasi, waktu pembasahan dan meningkatkan kerapuhan FDT ekstrak daun salam. Formula optimum didapat pada kombinasi crospovidone dan croscarmellose sodium dengan perbandingan 25 mg : 10 mg dalam setiap 500 mg tablet. Formula optimum tersebut memiliki kekerasan 4,21 kg, kerapuhan 0,52%, waktu pembasahan 106,65 detik, dan waktu hancur 55,73 detik. Hasil analisis dengan one sample t-test menunjukkan persamaan SLD valid digunakan untuk menyusun formula yang memberikan parameter-parameter optimum FDT.
Co-Authors Abdul Rohman Agitohutomo, Muhammad Aisyah, Vani Akrom, Akrom Aldri Frinaldi Anggita Rosiana Putri Anjar Windarsih Annas Binarjo Any Guntarti Any Guntarti Any Guntarti Arimurni, Dewa Ayu Aristiani, Windi Aristiani, Windy Ariza Nur Zulaechah Artika Tri Oktafiani Azizah, Siwi Nur Azzahra, Fara Daud, Intan Dian Prasasti Dwi Utami Endah Prastyaningrum Feby Zulien Hardi Astuti Witasari HENI RACHMAWATI Hidayati, Sholihatil Ibnu Gholib Gandjar Ibnu Gholib Gandjar Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ichwan Ridwan Rais Irfan, Nawwar Irnawati Irnawati Khairun Nisa Khairurrizki, Amanda Khayatulisma, Dika Kintoko, Kintoko Laela Hayu Nurani Lalu Muhammad Irham Lina Widiyastuti Maulida, Khansa Syahira Milanie, Rida Dwi Moch Saiful Bachri Moch. Saiful Bachri Monika, Tika Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Niken Pratiwi, Niken Nina Salamah Nisa, Salsabila Naura Nur Ismiyati Prastyaningrum, Endah Rini Sulistyawati Rizki Amelia Siti Fatmawati Fatimah, Siti Fatmawati Siti Rofida Sri Mulyaningsih Ste, Luay Banna Sugiyanto - Sulistyorini, Dwi Agustin Tantri Sofia Fauziah Tika Monika Tika Monika, Tika Utari, Dina Vani Aisyah Widea Rossi Desvita Widiyastuti, Lina Widyasari Putranti Wihasty Nur Istyqomah Zahirah, Nadrah Adinda Zainab Zainab