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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia METAMORFOSA Journal of Biological Sciences Indonesian Journal of Tropical and Infectious Disease Agrimeta: Agrimeta: Jurnal Pertanian Berbasis Keseimbangan Ekosistem The Indonesian Biomedical Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) WIDYA LAKSANA INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Media Sains Indian Journal of Forensic Medicine & Toxicology Quimica : Jurnal Kimia Sains dan Terapan Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Seminar Nasional Aplikasi Iptek (SINAPTEK) Jurnal Kesehatan Terpadu JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) DEDIKASI : Jurnal Pengabdian Kepada Masyarakat Paradharma: Jurnal Aplikasi IPTEK Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Permatasari, Anak Agung Ayu Putri
Universitas Dhyana Pura
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : The Indonesian Biomedical Journal

 1 
Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets I Gede Widhiantara; Anak Agung Ayu Putri Permatasari; I Wayan Rosiana; Putu Angga Wiradana; Luh Putu Widiastini; I Made Jawi
The Indonesian Biomedical Journal Vol 13, No 4 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i4.1694

Abstract

BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet
Role of HIF-1, Siah-1 and SKN-1 in Inducing Adiposity for Caenorhabditis elegans under Hypoxic Conditions I Gede Widhiantara; Anak Agung Ayu Putri Permatasari; I Wayan Rosiana; I Wayan Putu Sutirtayasa; Ferbian Milas Siswanto
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.1007

Abstract

BACKGROUND: Hypoxia has been shown to be able to induce adiposity. However, the mechanism and factors involved in this effect still remains unclear. Hence, we sought to investigate the role of oxygensensitive factors regarding hypoxia-induced adiposity in nematode Caenorhabditis elegans.METHODS: The C. elegans were grown on nematode growth medium (NGM) agar plates seeded with Escherichia coli OP50 at 20°C. The ratio of width/body length was measured using the morphometry analysis. Fat accumulation was examined using Sudan Black methods. Protein levels of sterol binding protein (SBP)-1 were assessed by immunoblotting. Lifespan assay was performed at 20°C and was monitored every two days.RESULTS: The results showed that of all mutant used, only hif-1 mutant which did not experience an increase in the ratio of width/body length (p>0.05) and fat accumulation (p>0.05), indicating that hypoxia-inducible factors (HIF)-1 plays an important role in the pathogenesis of hypoxia-induced adiposity. Both siah-1 and skn-1 mutants experienced SBP-1 protein elevation (p<0.05), and increased fat-6 mRNA expression (p<0.05) which were not experienced by a hif-1 mutant (p>0.05) further supporting that HIF-1 acts as an upstream regulator fromSBP-1.CONCLUSION: In general, the results of this study provide evidences of the involvement of the transcription factor HIF-1 in inducing adiposity under the hypoxic conditions. However, we did not find the involvement of seven in absentia homolog-1 (Siah-1) and skinhead-1 (SKN-1).KEYWORDS: hypoxia, adiposity, fat, HIF-1, Siah-1, SKN-1, C. elegans
Co-Authors Adnyana, Gabriel Firsta Anggraeni, Ni Kadek Irma Aris Jatmiko Bagus Komang Satriyasa Buu, Ani Wini Chela Krisna Denata Desyandri Desyandri Dewi, Ni Putu Eny Sulistya Dylla Hanggaeni Dyah Puspaningrum Elok Faiqotus Zahro Ferbian Milas Siswanto Hasanah, Nina Huawatun Herdiansyah, Mochammad Aqilah I Gede Arya Sena I Gede Putu Eka Budiyasa I Gede Widhiantara I Gusti Ayu Agung Tania Devianitha I Made Endra Puniawan I Made Gde Sudyadnyana Sandhika I Made Jawi I Made Murna I Made Wisnu Adhi Putra I Wayan Putu Sutirta Yasa I Wayan Rosiana Kusala, Muhammad Khaliim Jati Kusala Luh Putu Widiastini Mochammad Aqilah Herdiansyah Ni Kadek Dwipayani Lestari NI KADEK YUNITA SARI Ni Luh Sunarsih Ni Luh Utari Sumadewi Ni Putu Widya Astuti Ni Wayan Deswiniyanti Novaria Sari Dewi Panjaitan Panjaitan, Novaria Sari Dewi Panjaitan, Novaria Sari Dewi Panjaitan Permatasari, Anak Agung Ayu Putri Permatasari Putu Angga Wiradana Putu Eka Sudaryatma PUTU INDAH LESTARI Rahmadi Prasetijo Razaq, Imanuddin Rizky, Istiqomah Novia Sari, Ni Kadek Yunita Sari Sri Puji Astuti Wahyuningsih Sumadewi, Ni Luh Utari Teguh Hari Sucipto, Teguh Hari Wiartini, Ni Wayan Ayu Wiartini Widhiantar, I Gede a Win Darmanto