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Abadi, Hafizhatul
Institut Kesehatan Helvetia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal Ilmiah Agribios

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FORMULASI DAN UJI ANTIDIARE SEDIAAN PATCH TRANSDERMAL EKSTRAK DAUN SENGGANI (Melastoma malabathricum L.) TERHADAP KELINCI Winata, Hanafis Sastra; Abadi, Hafizhatul; Leny, Leny; Andry, Muhammad; Ngete, Ani Florida; Yudianto, Tri; Nurjanah, Ayu; Pamungkas, Barolym Tri; Gumilar, Roni
AGRIBIOS Vol 22 No 2 (2024): November
Publisher : Program Studi Agribisnis Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36841/agribios.v22i2.5494

Abstract

One plant that has been used for traditional medicine with good results is Melastoma (Melastoma malabatricum L.). The plant known as Melastoma has three active compounds: tannins, saponins, and flavonoids. Melastoma leaves work well to cure diarrhoea. Adhesive patches with medication applied topically are called transdermal patches. Melastoma leaf extract transdermal patch formulations were utilised in this study, which employed laboratory experimental techniques. The potential of Melastoma leaf extract transdermal patch preparation formula as an antidiarrheal for rabbits was the subject of the study. Concentrations of extract: 10%, 20%, and 30%. Organoleptic testing, pH tests, weight uniformity tests, moisture tests, thickness tests, and fold resistance tests were the preparatory assessment parameters that were conducted. The characteristics of the antidiarrheal test were timing of diarrhoea occurrences, consistency of the stool, frequency of diarrhoea, and length of diarrhoea, all of which were monitored for six hours. The evaluation of the Melastoma leaf extract transdermal patch formulation demonstrated a significant difference, namely <0.05, according to the results of the ANOVA data analysis. The antidiarrheal test parameters had a significant difference between each concentration, namely <0.05, according to the findings of the ANOVA data analysis. The conclusions was possible to use a transdermal patch formulation of Melastoma leaf extract (Melastoma malabathricum L.) at a 30% concentration to prevent diarrhoea by making stools softer.
Co-Authors Adek Chan Diana, Vivi Eulis Eulis, Vivi Faadhilah Yusa Simbolon Gumilar, Roni Ignasia Amaerita Buulolo Jamiati Jamiati Khairani Fitri Khairani, Tetty Noverita Lathi Furrahmi Leny Leny, Leny Linda Hernike Napitupulu Mayang Sari Muhammad Amin Nasution Muhammad Andry Ngete, Ani Florida Nidawah Nidawah Nurjanah, Ayu Pamungkas, Barolym Tri Parhan Parhan Pricella Aqwilla Br Ginting Rani Monalisa Hutagaol Riva Rainiza Zuddin Riva Rainiza Zuddin Rumanti, Ruth Mayana Ruth Mayana Rumanti Septiana, Lilik Sipahutar, Rizki Anjani Siti Fatimah Hanum Siti Netti Ritonga Sundari, Tri Surbakti, Chemayanti Tarigan, Jacub Tetty Noverita Khairani Winata, Hanafis Sastra Yoksan Duha Yudianto, Tri Yusta Suriani Ndruru Zulmai Rani