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All Journal Journal of Islamic Pharmacy Journal of Islamic Medicine Jurnal Kesehatan Islam : Islamic Health Journal AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Bioscientist : Jurnal Ilmiah Biologi Pharmaceutical Sciences and Research (PSR) FARMASAINKES Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) PharmaCine: Journal of Pharmacy, Medical and Health Science
Rizki Rahmadi Pratama
Universitas Islam Kalimantan MAB, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11, No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Abstract

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.
Studi In Silico Senyawa 2-Hidroksi-1,4-Naftokuinon dari Daun Lawsonia inermis sebagai Inhibitor Potensial Enzim Thymidine Kinase Varicella Zoster Virus Rasida, Rima; Pratama, Rizki Rahmadi; Fauzi, Muhammad; Ardiansyah, Seno Aulia
Pharmaceutical Science and Clinical Pharmacy Vol 4 No 1 (2026): Februari 2026
Publisher : Akademi Farmasi Bumi Siliwangi

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Abstract

Lawsonia inermis L. (henna) dikenal secara tradisional di Kalimantan Selatan sebagai tanaman obat untuk perawatan cacar air. Salah satu senyawa bioaktif utama, 2-hidroksi-1,4-naftokuinon (lawsone), memiliki potensi biologis yang luas, termasuk aktivitas antivirus. Penelitian ini bertujuan mengevaluasi potensi lawsone sebagai inhibitor terhadap enzim thymidine kinase (TK) Varicella Zoster Virus (VZV) secara in silico menggunakan pendekatan docking molekuler dan prediksi ADMET. Struktur ligan dan protein diunduh dari PubChem dan PDB, diproses menggunakan AutoDock. Hasil docking menunjukkan bahwa lawsone memiliki energi pengikatan −6,92 kcal/mol dan Ki 8,45 µM, lebih baik dibanding acyclovir (−4,54 kcal/mol; Ki 469,61 µM). Analisis interaksi mengungkapkan ikatan hidrogen, elektrostatik, hidrofobik, dan π–π stacking dengan residu kunci situs aktif, memperkuat stabilitas kompleks. Prediksi ADMET menunjukkan absorpsi usus tinggi (94,28%), permeabilitas Caco-2 baik, penetrasi jaringan luas, volume distribusi lebih besar, serta metabolisme hepatik aman melalui oksidasi/hidroksilasi dan konjugasi fase II. Ekskresi lawsone lebih seimbang dengan clearance rendah, mendukung durasi aksi lebih panjang. Meski sinyal AMES positif dan potensi hepatotoksisitas terdeteksi, validasi eksperimental diperlukan sebelum pra-klinis. Kombinasi afinitas pengikatan tinggi dan profil ADMET yang menjanjikan menempatkan lawsone sebagai kandidat alami potensial untuk pengembangan terapi antivirus terhadap VZV.
Identification of Potential Anti-Blood Cancer Compounds from Centella asiatica via In Silico Approaches: Molecular Docking, ADMET Prediction, and Drug-Likeness Evaluation: Identification of Potential Anti-Blood Cancer Compounds from Centella asiatica via In Silico Approaches: Molecular Docking, ADMET Prediction, and Drug-Likeness Evaluation Syarifah Nazila Fitriani Al-Hasany; Nily Sua’ida; Rizki Rahmadi Pratama; Halimah Halimah; Nor Syipa Hayati; Muhammad Fauzi
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 7 No. 1 (2026): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v7i1.13545

Abstract

Blood cancer is a hematological malignancy characterized by abnormal proliferation of blood cells due to genetic mutations. Conventional therapies such as chemotherapy and radiotherapy often cause significant side effects, highlighting the need for safer alternatives. Natural products, including Centella asiatica, have been widely explored as potential anticancer agents. This study aimed to evaluate the binding affinity, pharmacokinetic properties, and drug-likeness of bioactive compounds from Centella asiatica using an in silico approach. Molecular docking was performed using AutoDock 1.5.6 to determine binding free energy (ΔG), followed by ADMET prediction and Lipinski’s Rule of Five evaluation. The results showed that quercetin, centellin, labiatenic acid, kaempferol, and asiatic acid exhibited binding affinities of -6.51, -4.92, -5.07, -6.16, and -6.97 kcal/mol, respectively, with asiatic acid demonstrating the strongest interaction. ADMET analysis indicated generally favorable absorption and low toxicity profiles, although variability in permeability and metabolic interactions was observed. Drug-likeness evaluation revealed that most compounds met key Lipinski parameters, with minor deviations related to lipophilicity and molecular weight. In conclusion, Centella asiatica contains promising bioactive compounds with potential anti-blood cancer activity supported by favorable pharmacokinetic and drug-likeness profiles. Further in vitro and in vivo studies are required to validate these findings.
Co-Authors Ahsana, Dina Al-Hasyimi, Said Muhammad Amelia Putri, Irena Andika Andika Anita Apriliana Ardiansyah, Seno Aulia Auliana Auliana Burhan Ma'arif Ciara Fitri Pribadi Erlianti, Karina Faisal Akhmal Muslikh Fitri Apriliany, Fitri Fuzi Maulana Ash'ari Ghina Adhila Halimah Halimah Hasniah Hasniah Indah Fajarwati, Jelita Indradewa, Rhian M. Hasan Andryanto Ma'arif, Burhan Marisca Evalina Gondokesumo Marisca Evalina Gondokesumo, Marisca Evalina Meily, Alfisyahriatunnida Melisa Intan Barliana Muhammad Fauzi Muhammad Fauzi Nily Sua’ida Nor Syipa Hayati Novi Milasari Nur Aini Nur ‘Azah Nurwijayanti Puji Rahmawati, Dwi Purwitasari, Neny Rasida, Rima Septianto, Andre Siti Lili Rizki Sari Soemarie, Yulistia Budianti Syarifah Nazila Fitriani Al-Hasany Syarifah Rugayah TIANA MILANDA Triswanto Sentat