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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan Jurnal Teknologi Industri Pertanian JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kesehatan Masyarakat Buletin Iptek Tanaman Pangan agriTECH Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat AGRISAINTIFIKA Jurnal Ilmu-ilmu Pertanian Jurnal Aplikasi Teknologi Pangan CERIA (Cerdas Energik Responsif Inovatif Adaptif) Jurnal Mutu Pangan : Indonesian Journal of Food Quality Jurnal Pembelajaran dan Biologi Nukleus Jurnal Fakultas Teknik UNISA Kuningan Makara Journal of Science Media Bina Ilmiah Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Lilis Nuraida
Departemen Ilmu Dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Kampus IPB Darmaga Bogor 16680
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Media Bina Ilmiah

 1 
SUPLEMENTASI BEKATUL BERAS HITAM UNTUK MENGHAMBAT PERKEMBANGAN KANKER KOLON MELALUI PENGHAMBATAN PROLIFERASI DAN PENINGKATAN APOPTOSIS PADA MENCIT BALB/C Yeni Kurniati; Slamet Budijanto; Lilis Nuraida; Fitriya Nur Annisa Dewi; Safrida, Safrida
Media Bina Ilmiah Vol. 18 No. 10: Mei 2024
Publisher : LPSDI Bina Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33758/mbi.v18i10.806

Abstract

Colon cancer is one of the degenerative diseases caused of death after lung and breast cancer. One of the food ingredients that potentially inhibites the occurrence of colon cancer is black rice bran. The aim of this study was to found the effect of black rice bran on apoptosis and cell proliferation on BALB/c mice. In this study, BALB/c mice were divided into three groups, they are normal group (K-), AOM/DSS induced tumor group (K+), and feeding black rice bran with induction of AOM/DSS (BRB). At the end of the study, all mice were terminated and the presence of nodule were analysed in colon tissue used imageJ application. The expression of caspase-3, caspase-8, and PCNA were analysed in colon tissue used q-RT PCR. The data obtained by analyzes of variance (ANOVA) and continued by Tukey HD different test at 5% level. Administration of BRB significantly decreased the expression of PCNA in comparison with that of control mice (K+) (0.58 ± 0.09 vs 5.22 ± 0.80). The expression of caspase 3 (0.91 ± 0.20) and caspase 8 (0.36 ± 0.15) of BRB significantly increased comparasion with control mice K+. Our results thus indicated that black rice bran performed to suppresed proliferation and induced apoptosis
Co-Authors . EFRIWATI . Hana Afifah Zahra Agista Alam, Syah Khalif Amor Tresna Karyawati, Amor Tresna Anja Meryandini Antonius Suwanto Antung Sima Firlieyanti Antung Sima Firlieyanti Apriliana W. Hartanti Ardiansyah . Arimah Arimah Bambang Pontjo Priosoeryanto Betty Jenie Sri Laksmi Betty Sri Laksmi Betty Sri Laksmi Jenie Betty Sri Laksmi Jenie Budi Nurtama Cece Sumantri Cynthia Rizka Riani Dahrul Syah Dede R. Adawiyah Dede Robiatul Adawiyah Denny Agustin Desty Gitapratiwi Desty Gitapratiwi Dewi, Fitriya Nur Annisa Dewi, Retno Anggrina Khalistha Dian Herawati Dias Erfan Dodik Briawan Donna Fujie Rahaditha Utami Dreitsohn Franklyn Purba Eko Hari Purnomo Emmawati, Aswita Endang Prangdimurti Epi Taufik Fadlillah, Hendry Noer Faleh Setia Budi Farida, Eko Fenny Larasati Firat Meiyasa Gayuh Rahayu Hana - - Hana . Hana . Hanifah Nuryani Lioe Haqqifizta Ratihwulan Harsi D. Kusumaningrum Hendry Noer Fadlillah Iffa Illiyya Fatma Irma Isnafia Arief Jamal Zamrudi Madaniyah, Siti Maggy T. Suhartono Maggy Thenawidjaja Suhartono Mahara, Fenny Amilia Mochammad Sriduresta Soenarno NASRIANTI SYAM, NASRIANTI Ni Nyoman Puspawati Nur Rita Mardiana Nurbety Tarigan Nurdin, Qamariyah Nuri Andarwulan Nurwulan Purnasari Pika Mustika Purwiyatno Hariyadi Puspo Edi Giriwono Qamariyah Nurdin Raini Panjaitan Ratih Dewanti -Hariyadi Ria Noviar Triana Rina Ningtyas Safrida Safrida Siti - Winarti Siti Madanijah Siti Madaniyah Siti Nurjanah Slamet Budijanto Sri Budiarti Poerwanto Sri Rini Dwiari Suci Apsari Pebrianti Sutrisno Koswara TATI NURHAYATI Tio, Yohana Tania Tita Rialita Tjahja Muhandri Ummul Khayrah Uswatun Hasanah Utami, Donna Fujie Rahaditha Widya Aprilita Minamilail Winiati P Rahayu Winiati P Rahayu Winiati P. Rahayu Winiati P. Rahayu Winiati Pudji Rahayu Yati Maryati Yati Maryati Yeni Kurniati Yeni Kurniati Yeni Restiani Yuli Sukmawati YULIN LESTARI Zamrudi, Jamal Zulaikhah Zulaikhah Zulaikhah Zulaikhah Zulaikhah Zulaikhah, Zulaikhah