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All Journal Journal of Biomedicine and Translational Research PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman The Indonesian Biomedical Journal Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Hearty : Jurnal Kesehatan Masyarakat Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL KEBIDANAN KESTRA (JKK) Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Indah Sains dan Klinis FORTE JOURNAL CHEDS: Journal of Chemistry, Education, and Science Jurnal Farmanesia Jurnal Multidisiplin Madani (MUDIMA) Formosa Journal of Sustainable Research (FJSR) JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Pengmas Kestra (JPK) Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis
Aritonang, Barita
Institut Kesehatan Medistra Lubuk Pakam
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Anti-inflammatory Activity of Clitoria ternatea L. and Hibiscus sabdariffa L. Extract Combination in Reducing VCAM-1 Levels in Atherosclerosis Harefa, Karnirius; Ritonga, Ahmad Hafizullah; Safitri, Riri; Aritonang, Barita
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol. 7 No. 1 (2024): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkf.v7i1.2300

Abstract

Atherosclerosis occurs when plaque accumulates and hardens within the arterial walls, leading to blood vessel blockages and increasing the risk of coronary heart disease (CHD). The extracts of butterfly pea (Clitoria ternatea L.) and roselle (Hibiscus sabdariffa L.) contain flavonoids that possess strong antioxidant and anti-inflammatory properties. This study aims to assess the effects of the combined extract of butterfly pea and roselle (EKTR) on atherosclerosis biomarkers such as Vascular Cell Adhesion Molecules-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), and Interleukin-6 (IL-6). The research employed a True Experimental Laboratory approach using a Post-Test Control Group Design. The subjects were 36 female Wistar rats (Rattus norvegicus L.), randomly divided into six groups through a Completely Randomized Design (CRD). Data were collected on the levels of VCAM-1, ICAM-1, and IL-6 in the serum of obese white rats, measured using an ELISA photometer. Data analysis was conducted using SPSS version 18, with statistical evaluation performed via one-way ANOVA and Tukey's post hoc test. The results showed that increasing doses of EKTR led to significant reductions in atherosclerosis biomarkers such as VCAM-1, ICAM-1, and IL-6 compared to the positive control and other groups. At a dose of 500 mg/kg BW, group F3 recorded IL-6 levels of 30.49 ± 1.60 ng/mL, VCAM-1 level of 29.42 ± 2.58 ng/mL, and ICAM-1 levels of 28.42 ± 1.72 ng/mL. In conclusion, butterfly pea and roselle, rich in flavonoids with potent antioxidant and anti-inflammatory properties, are effective as traditional remedies for reducing atherosclerosis biomarkers and for preventing and treating coronary heart disease (CHD) at an optimal dose of 500 mg/kg BW.
Formulation of Body Scrub Containing Ethanol Extract of Temulawak Rhizome (Curcuma xanthorrhiza Roxb) as a Skin Moisturizer H, Herlina; Melda Astrika Sianipar; Yaturramadhan Harahap, Hasni; Aritonang, Barita; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2650

Abstract

A body scrub is a cosmetic formulation intended to exfoliate dead skin cells and enhance skin hydration. One promising natural ingredient for body scrub formulations is the rhizome of Java turmeric (Curcuma xanthorrhiza Roxb.), which contains curcumin, a potent antioxidant known to support skin moisture retention. This study aims to evaluate the moisturizing efficacy of a body scrub formulated with Java turmeric rhizome extract. Methods: The rhizome was extracted through maceration using 96% ethanol and incorporated into body scrub formulations at concentrations of 10%, 15%, and 20%. The formulations were assessed for organoleptic characteristics, homogeneity, pH, spreadability, adhesion, oisturizing effect, and potential skin irritation on human volunteers. A commercial body scrub served as the comparator in a study involving 12 volunteers over four weeks, with applications performed once per week. Results: All Java turmeric body scrub formulations remained physically stable at room temperature and did not induce skin irritation. The physical characteristics of the formulations met standard cosmetic criteria, including consistent appearance, pH range of 6–7, spreadability between 5–7 cm, adhesion time above 4 seconds, and absence of irritation. Moisturizing effectiveness was evaluated using a skin analyzer, and data were statistically analyzed using SPSS. The p-value of 0.046 indicates that there is a significant difference between F1 and the commercial product, while for F2 and F3, there is no significant difference in moisturizing effectiveness between the temulawak formulations and the commercial product.. Among the tested formulations, the body scrub containing 20% Java turmeric extract exhibited the highest moisturizing effect. Conclusion: The body scrub formulated with Java turmeric rhizome extract, particularly at a concentration of 20%, is safe for use and shows potential as a natural moisturizing product comparable to commercial products on the market.
Reduction of BOD, COD, and TSS in Textile Wastewater Using Bentonite Activated Charcoal Adsorbent Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; H, Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2699

Abstract

Wastewater generated by the textile industry contains a variety of hazardous contaminants, including complex organic compounds, synthetic dyes, surfactants, heavy metals, and critical pollution indicators such as biochemical oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solids (TSS). This study evaluates the efficacy of a dual-adsorbent system comprising hydrochloric acid-activated bentonite and phosphoric acid-activated carbon for the removal of BOD, COD, and TSS from textile effluents. The activation processes significantly altered the physicochemical properties of both adsorbents. The moisture content of activated carbon decreased from 18% to 3.10%, while ash content was reduced from 15% to 3.05%. The iodine number, indicative of adsorption capacity, increased from 650 mg/g to 810 mg/g. Additionally, the fixed carbon content improved from 55% to 80%. Surface characterization via Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed substantial structural modifications, which enhanced the adsorption performance of the materials. Application of the combined adsorbent system resulted in substantial pollutant removal efficiencies, with reductions of 70.23% in BOD, 70.11% in COD, and 74.88% in TSS. These findings demonstrate that acid-activated bentonite and phosphoric acid-treated activated carbon represent a promising and efficient adsorptive treatment strategy for the remediation of textile wastewater.
Integration of Pharmaceutical Science in the Education of Healthy and Functional Food Preparation at SMK Negeri Pantai Labu Aritonang, Barita; Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Meilani, Debi; Wiratma, Dicky Yuswardi
JURNAL PENGMAS KESTRA (JPK) Vol. 5 No. 1 (2025): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/1p8sw386

Abstract

The modernization of lifestyle among today’s adolescents has led to significant changes in daily consumption patterns. Many teenagers tend to prefer fast food that is high in sugar, salt, and fat, but low in nutritional value. This condition may lead to various long-term health problems if not accompanied by adequate nutritional education and awareness. This community service activity aims to integrate pharmaceutical science concepts into the education of healthy and functional food preparation at SMK Negeri Pantai Labu. The implementation method consisted of several stages: initial observation of students’ knowledge and habits, delivery of interactive educational materials, hands-on practice in preparing functional food products, and evaluation through pre-test and post-test instruments. This activity involved 30 students from the culinary arts department. Evaluation results showed a significant improvement across all aspects: knowledge of healthy food increased from 55.0 to 85.3; understanding of functional food from 47.5 to 82.0; understanding of active compounds from 41.2 to 78.5; food preparation skills from 50.4 to 80.6; and awareness of food safety from 52.8 to 86.7. The average overall improvement reached 67.3%. This community service activity concludes that an educational approach based on pharmaceutical science, when applied through culinary practice, is proven to be effective in enhancing students’ competencies, not only in terms of academic knowledge and health awareness but also in fostering entrepreneurial potential in the field of local food.
Evaluation of the Effectiveness of Risk Management in Addressing Patient Safety Incidents Aritonang, Barita
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol. 7 No. 2 (2025): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7cz0f255

Abstract

Background: Patient safety incidents are a serious issue affecting healthcare quality and public trust in hospitals. Effective risk management implementation is crucial to reduce adverse events. Objective: This study aimed to evaluate the effectiveness of risk management in mitigating patient safety incidents at Granmed Hospital, Lubuk Pakam. Methods: The study was conducted from September 2023 to February 2024 using a descriptive quantitative and qualitative approach. Data were collected from 50 healthcare worker respondents via questionnaires, incident report reviews, and in-depth interviews. Results: Findings showed that 78% of respondents believed risk management systems were well implemented, especially in risk identification and analysis stages. However, incident reporting was still low (43%), due to fear of punishment and lack of training. Document analysis revealed a 27% decrease in reported incidents compared to the previous year. Conclusion: Risk management at Granmed Hospital is relatively effective in reducing patient safety incidents. Nevertheless, there is a need to improve the safety culture and develop a more transparent reporting system.
Analysis of the Effect of Quality Management System Implementation on Service Quality Aritonang, Barita
JURNAL KESMAS DAN GIZI (JKG) Vol. 7 No. 2 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/hw98wx88

Abstract

Background: Improving the quality of services in the health sector, especially in hospitals, has become one of the main concerns in various countries, including Indonesia. Quality health services are essential in creating patient satisfaction and improving the effectiveness of the health care system as a whole. Objective: This study aims to determine the extent of the relationship and influence between the variables of quality management system implementation on service quality at RSUD Dr. Pirngadi Medan City. Methods: This research is a quantitative study with an associative approach, associative research is used to test the cause-and-effect relationship between two or more variables through statistical analysis. The sample amounted to 86 respondents. Data were collected using a structured questionnaire and the outcome report was analyzed with the chi-square test at a significance level of p<0.05. Research Results: the implementation of the quality management system has a positive and significant effect on service quality at RSUD Dr. Pirngadi Medan City. The hospital needs to continue to improve the implementation of the quality management system consistently, especially in the aspects of HR training and the implementation of continuous quality audits, in order to improve the quality of services received by patients. Conclusion: hospitals need to pay attention to improving physical facilities, such as the cleanliness of treatment rooms and the provision of more modern medical equipment. With these improvements, hospitals can improve the tangible dimension of service quality, which in turn will increase overall patient satisfaction.
THE INFLUENCE OF MOTIVATION, KNOWLEDGE, AND SKILLS ON EMPLOYEE WORK SAFETY IN THE FIBER LINE UNIT AT PT. RIAU ANDALAN PULP AND PAPER PANGKALAN KERINCI Sinaga, Sri Lestari; Munthe, Novita Br Ginting; Aritonang, Barita; Sinaga, Evi Yuni Sintia
HEARTY Vol 13 No 5 (2025): OKTOBER
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i5.20975

Abstract

Occupational Safety and Health (OSH) is an important aspect in the world of work that aims to protect workers from accidents and occupational diseases. This study aims to determine the effect of motivation, knowledge, and skills on employee safety at PT. Riau Andalan Pulp and Paper Pangkalan Kerinci. The method used is quantitative descriptive with analysis of variance (ANOVA) and a sample of 64 respondents. The results show that motivation, knowledge, and skills have a significant effect on occupational safety. Knowledge has the most dominant influence. These findings indicate that improving knowledge and skills through training can strengthen the safety culture. The conclusion of this study is that motivation, knowledge, and skills have a positive and significant effect on improving occupational safety. Therefore, companies need to develop OSH training and socialization programs and create a work environment that supports compliance with safety procedures. Thus, companies can improve occupational safety and reduce the risk of accidents and occupational diseases. This research contributes to the development of effective occupational safety strategies in companies.
Butterfly Pea and Roselle Combination Extracts Reduce V-CAM, ICAM, and IL-6 Levels in High Fat Atherogenic Diet Rats Harefa, Karnirius; Ritonga, Ahmad Hafizullah; Safitri, Riri; Aritonang, Barita; Gurusinga, Rahmad; Irmayani, Irmayani; Wulan, Sri
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3361

Abstract

BACKGROUND: Atherosclerosis, driven by inflammation and oxidative stress, increases the risk of coronary heart disease (CHD). Flavonoids in butterfly pea and roselle are known for their potent antioxidant and anti-inflammatory properties. While their individual effects on cardiovascular health have been studied, no studies have explored the combined impact on atherosclerosis biomarkers, including vascular cell adhesion molecules (VCAM)-1, intercellular adhesion molecule (ICAM)-1, and interleukin (IL)-6. Therefore, this study was performed to evaluate the synergistic effects of butterfly pea and roselle combination extracts (BPRCE) on these biomarkers.METHODS: A study with a post-test control group design using 36 male white rats was performed. The rats were randomly assigned to 6 groups; 1 group was fed with standard feed, while 5 groups were fed with a high-fat atherogenic diet (HFAD) to create atherosclerosis rat models. The HFAD rats were given either no treatment, sodium carboxymethylcellulose (Na-CMC), 300, 400, or 500 mg/kgBW BPRCE. Serum levels of VCAM-1, ICAM-1, and IL-6 of rats were measured using enzyme-linked immunosorbent assay (ELISA) methods.RESULTS: Increasing doses of BPRCE resulted in a significant reduction in VCAM-1, ICAM-1, and IL-6 compared to the other groups. The group with the highest dose, 500 mg/kgBW BPRCE, showed the greatest reduction of VCAM-1 level (32.73±3.57 pg/mL), ICAM-1 level (5.68±1.17 ng/mL), and IL-6 levels (21.49±4.62 pg/mL).CONCLUSION: Administration of BPRCE in atherosclerosis rats model reduces VCAM-1, ICAM-1, and IL-6 in a dose-dependent manner. This study showed that using BPRCE as a traditional remedy for preventing and treating CHD at an optimal dose of 500 mg/kgBW might be a potential future application in reducing atherosclerosis biomarkers.KEYWORDS: VCAM-1, ICAM-1, IL-6, butterfly pea, rosella, atherosclerosis
SINTESIS DAN KARAKTERISASI ARANG AKTIF DARI KULIT JENGKOL SEBAGAI ADSORBEN TERHADAP KADAR BOD, COD, TSS PADA LIMBAH CAIR INDUSTRI TAHU Hestina, Hestina; Gultom, Erdiana; Sijabat, Salomo; Aritonang, Barita
CHEDS: Journal of Chemistry, Education, and Science Vol 6, No 2 (2022)
Publisher : Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/cheds.v6i2.6183

Abstract

Limbah cair industri tahu yang mencemari lingkungan dilakukan pengolahan limbah dengan metode adsorpsi menggunakan arang aktif sebagai adsorben. Penelitian ini bertujuan untuk menurunkan kadar BOD, COD dan TSS pada limbah cair tahu menggunakan arang aktif sebelum dan sesudah diaktivasi dengan H3PO4 konsentrasi 7%. Pembuatan arang aktif dari kulit jengkol telah berhasil dibuat dan sudah memenuhi persyaratan yang ditetapkan SNI 06–3730-1995, diperoleh kadar air sebesar 3,03 %, kadar abu sebesar 2,87 % dan daya serap iodin sebesar 543 mg/L. Analisis spektrum FT-IR arang aktif kulit jengkol memiliki gugus O-H hidroksil, C=O karbonil dan C-O eter. Analisis morfologi permukaan arang aktif memiliki pori-pori dan luas area permukaan yang besar. Limbah cair industri tahu sebelum diadsorpsi dengan arang aktif memiliki kadar yang melebihi nilai ambang batas yaitu, BOD 768 mg/L, COD 745 mg/L dan TSS 752 mg/L. Setelah dilakukan proses adsorpsi menggunakan arang aktif sebagai adsorben kadar BOD, COD dan TSS menjadi turun. Penambahan arang aktif yang tidak diaktivasi dengan H3PO4, kedalam limbah cair tahu diperoleh kadar BOD 100 mg/L, setelah diaktivasi turun menjadi 50 mg/L, kadar COD 200 mg/L, setelah diaktivasi turun menjadi 100 mg/L, kadar TSS 100 mg/L, setelah diaktivasi turun menjadi 65 mg/L. Kesimpulan hasil penelitian kadar BOD, COD dan TSS pada limbah cair industri tahu pasca penambahan arang aktif sebelum dan sesudah diaktivasi memenuhi peraturan Menteri Lingkungan Hidup Republik Indonesia Nomor 5 Tahun  2014. Nilai ambang batas yang diizinkan untuk kadar BOD 150 mg/L, COD 300 mg/L, dan TSS 200 mg/L.
Factors Associated with Community Perception of Public Safety Center  (PSC) in Silinda District, Serdang Bedagai Regency Saragih, Eriani Senaya; Barita Aritonang; Sri Melda Bangun
JURNAL KESMAS DAN GIZI (JKG) Vol. 8 No. 1 (2025): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/swqre992

Abstract

The Public Safety Center  (PSC) serves as a rapid, precise, and careful response facility for communities in emergency situations, providing 24/7 services. This study aims to identify factors related to community perception of PSC in Silinda District, Serdang Bedagai Regency. Using a quantitative method with a cross-sectional design. The population in this study consists of all residents in Silinda District, Serdang Bedagai Regency, totaling 5,055 people. The sampling technique used in this study is purposive sampling. the study found that Education has the most significant influence on community perception of PSC, With P value = 0,000 and EXp(B) = 192,893. This indicates that individuals with higher education tend to have a more positive perception of PSC. The analysis concludes that Education and Knowledge are factors related to community perception of PSC in Silinda District. The conclusion is that public perception of the Public Safety Center  (PSC) is influenced by several factors. There is no significant relationship between the age variable and public perception of the PSC. However, there is a significant relationship between the level of education and public knowledge and their perception of the PSC, indicating that the higher a person's education and knowledge, the more positive their perception of PSC services. Meanwhile, variables related to needs such as information, facilities and infrastructure, and healthcare personnel do not show a significant relationship with public perception. It is recommended to increase awareness and knowledge about PSC and its role in enhancing safety and security.
Co-Authors Ahmad Hafizullah Ritonga Asvia Rahayu Badriani, Nurainun Chatarina Umbul Wahyuni Cut Masyitah Thaib Cut masyithah Debi Meilani Desideria Yosepha Ginting Dicky Yuswardi Wiratma Eka Margareta Sinaga Eka Margareth Erawati, Suci Erdiana Gultom Erdiana Gultom Erdiana Gultom Gultom, Erdiana Harahap, Hasni Yaturramadhan Hasni Yaturramadhan Harahap Hendri Faisal Herlina Herlina , Herlina Herlina . Herlina H Herlina Herlina Hermansyah Aziz Hestina . Hestina Hestina Hestina, Hestina Imel Santika Irmayani Irmayani Karnirius Harefa Karo-Karo, Julyenni Khairiah, Khairiah Lenny Novita Liver Iman Putra Zai Mala Sari, Nur Melda Astrika Sianipar Munthe, Novita Br Ginting Nova Florentina Nova Florentina Nova Florentina Ambarwati Novesar Jamarun Panjaitan, Delita Pitriani, Pitriani Putri, Gusliani Eka Rahmad Gurusinga Rahmad Gurusinga RAMAWATI, NURVITA Riah Ukur Ginting, Riah Ukur Rima Anggeraini Riri Safitri Rotua Sumihar Sitorus Salomo Sijabat Saragih, Eriani Senaya Siagian, Ernita Siahaan, Enzo W.B Sijabat, Salomo Simanjuntak, Putri Nuraimun Sinaga, Eka M Sinaga, Evi Yuni Sintia Sinaga, Sri Lestari Sitepu, Rahmadani Sitorus, Elly Sri Melda Bangun Sri Ulina Sri Wulan, Sri Suarnikan Hulu Supartiningsih - - Syarifuddin, Shofian Syukri Arief Tamrin Tamrin Widyaningsih, Fadlilah Yanti, Rahma Yaturramadhan Harahap, Hasni Yosi Darmirani Yossy Silalahi Yulidar Laila Safitri Yunita Sari