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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 247 Documents

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Kajian Etnofarmakologi Pemanfaatan Tanaman Obat Oleh Masyarakat Di Kecamatan Dawuan Kabupaten Subang Provinsi Jawa Barat: Ethnopharmacology Study of utilization medicinal plant by Society in Dawuan sub-district Subang Regency West Java Province Mulyani, Yani; Hasimun, Patonah; Sumarna, Rendi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Barat bertujuan untuk mengetahui jenis-jenis tumbuhan yang berkhasiat sebagai obat tradisional, bagian tumbuhan yang dapat digunakan sebagai bahan dalam pengolahan obat tradisional, cara menyiapkan, dosis yang digunakan dan cara menggunakan dalam pengobatan tradisional. Metode penelitian yang digunakan adalah survei eksploratif dan metode observatif, melalui wawancara semi-struktural dengan 81 responden menggunakan kuesioner yang meliputi nama penyakit, nama lokal tanaman, bagian tanaman yang dimanfaatkan, lokasi tumbuh dan cara membuatnya. Setiap tanaman yang digunakan untuk pengobatan dideterminasi dan dibuat herbarium. Hasil penelitian menunjukkan tanaman obat yang dimanfaatkan oleh masyarakat dan berhasil dideterminasi di Kecamatan Dawuan terdapat 40 spesies tanaman obat dari 27 famili. Famili Euforbiaceae merupakan tanaman yang paling banyak digunakan, dengan tingkat pengetahuan masyarakat tentang pemanfaatan obat sangat baik. Tanaman obat paling banyak digunakan berasal dari kebun dari bagian daun , dengan proses pengolahan dengan cara direbus dengan air dan digunakan dengan cara diminum

Pengaruh Metode Ekstraksi Terhadap Rendemen Dan Kadar Fenolik Ekstrak Tanaman Kayu Beta-Beta (Lunasia amara Blanco): (The Effect of Extraction Method on Yield Value and Phenolic Content of Beta-Beta (Lunasia amara Blanco) Bark Extract Hasnaeni, Hasnaeni; usman, suriati; Wisdawati, Wisdawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Lunasia amara Blanco bark belonging to the family Rutaceae. The research aimed to determine the effect of extraction method on yield value and phenolic content of bark extract of Lunasia amara Blanco by UV-Vis spectrophotometry. Sample was extracted by maceration, reflux, and soxhlet using methanol 70%. The extraction by maceration obtained the yield value of methanol extract of 2,352%; the reflux method of 1,611%; and the soxhlet method of 0,960%. Then the chemical content was identified by the addition of FeCl3 reagent and a blackish green color was formed positively indicating phenolic content. Afterward, phenolic identification was conducted by TLC with eluent n-hexane: ethyl acetate (2:8) containing phenolic because the Rf value was the same as the galic acid standard. The results showed that the extraction method producing the highest yield of bark extract of Lunasia amara Blanco was maceration. The phenolic content obtained by maceration was 66,548 mgGAE/g extract with 6.6548% GAE; the reflux was 73.645 mgGAE/g extract with 7.3645% GAE; and the soxhlet was 74.806 mgGAE/g extract with 7.4806% GAE.

Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C: Immunomodulatory Effects of Ethanol Extract of Melophlus sarasinorum Sponge Against Phagocytosis Activity of Macrophage Cells on Balb/C Male Mice Wahyuni, Wahyuni; Yusuf, Muhammad Ilyas; Malik, Fadhliyah; Lubis, Adryan Fristiohady; Indalifiany, Astrid; Sahidin, I
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (StimunoÂ®) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05).

Uji Daya Hambat Formula Gel Ekstrak Etanol Daun Murbei (Morus alba L.) Sebagai Anti Acne Terhadap Bakteri Propionibacterium acne.: Inhibition Test of Ethanol Extract Gel of Mulberry (Morus alba L.) Leaves as an Anti Acne on Propionibacterium acne Bacteria Aliah, Ahmad Irsyad; Wahyuni, Wahyuni; Bachri, Nurjannah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

A research on the inhibition of formula gel test ethanol extract of leaves of mulberry (Morus alba L.) as an anti-acne against bacteria Propionibacterium acne. This study uses a gel formulation made using mulberry leaf extract (Morus alba L.), which aims to determine the inhibition of antibacterial gel mulberry leaf extract (Morus alba L.) against the bacteria Propionibacterium acne. Gel made three dosage concentrations of 2%, 4% and 6%. Testing inhibition of antibacterial gel agar diffusion method. Test Antibacterial inhibition obtained by looking at the clear zone in the medium and measured using calipers. The results showed that the inhibition of antibacterial gel formulation with a concentration of 2%, 4% and 6% showing that inhibiting bacterial activity.

Aktivitas Antioksidan Ekstrak Etanol Buah, Daun, Batang Dan Rimpang Pada Tanaman Wualae (Etlingera Elatior (Jack) R.M Smith) (RECTRACTED): Antioxidant Activity of Ethanol Extract of Fruits, Leaves, Stems and Rhizome of Wualae (Etlingera elatior (Jack) R.M Smith) (RECTRACTED) Jabbar, Asriullah; Wahyuni, Wahyuni; Malaka, Muh Hajrul; Apriliani, Apriliani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

This paper is retracted by editor because it has been published in another journal Wualae (Etlingera elatior (Jack) R.M Smith) is one of the plants in the Zingiberaceae family, widely used in medicine ranging from rhizomes, fruits, and flowers. Empirically Wualae are usually used by people for treating skin diseases, flavoring food, a natural soap, and in Southeast Sulawesi, it is used to treat typhoid fever. This study aims to examine the antioxidant activity of Wualae (Etlingera elatior) plant. The plant extracts were extracted by maceration method, antioxidant activity test was performed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that ethanol extracts of fruits, leaves, stems and rhizomes of Wualae (Etlingera elatior) has the potential antioxidant activity with the IC50 values of 72.518 mg/L, 99.890 mg/L, 52.345 mg/L and 58.638 mg/L, respectively. and Vitamin C has IC50 value of 3,787 mg/L.

Analisis Profil Bobot Badan Tikus dan Gejala Toksis Pada Pemberian Ekstrak Etanol Daun Parang Romang (Boehmeria virgata) Terhadap Tikus Putih (Rattus novergicus): Analysis Profile of Body Weight and Toxic Symptom of Rats In The Administration of Ethanol Extract Parang Roman Leaves (Boehmeria virgata) To Male White Rats (Rattus novergicus Magfirah, Magfirah; Christin, Vidya
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Traditional medicine is part of the Indonesian cultural heritage which has been used for generations and for centuries, but in general its safety has not been supported by adequate research. One of them is a parangromang which is empirically used by Makassar tribal healers as an antitumor. This study aims to determine theprofile Of body weight and toxic symptoms after 24 hours to 14 days including skinand fur changes, tremors and seizures, comaof rats in the administration of ethanol extract parang romang. White rats were divided randomly into 4 groups: group one was given 0.5% NaCMC, groups of two, three and four were given extract at a dose of 175 mg / KgBB, 550 mg / KgBB and 1750 mg / KgBB for 14 days, the bodyweights of rats on days 0, 7 and 14 days and toxic symptoms after 24 hours to 14 days.The results showed ethanol extract of parang romang leaves 550 mg / KgBB had an effect on increasing body weight of rats and there were no changes in skin and fur, spasms, tremor, coma and death. It can be concluded that the ethanol extract of parang romang leaves has a significant effect on increasing the weight profile of male white rats and there are no toxic symptoms.

Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan (Rattus Novergicus) Model Hiperkolesterolemia-Diabetes: Effectiveness of Ethanol Extract of Avocado Seeds (Persea americana mill.) on Blood Glucose Levels of Male White Rat (Rattus novergicus) Hipercolesterolemia-diabetes Model Patala, Recky; Dewi, Niluh Puspita; Pasaribu, Meilinda Handayani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to a deficiency of insulin secretion or when insulin resistance occurs. Herbal medicine is one alternative method that can be used to control blood glucose levels and prevent complications of diabetes mellitus. One of the medicinal plants is avocado seeds (Persea americana Mill.) The active compounds contained in avocado seeds that have antidiabetic activity are flavonoids, alkaloids, tannins and saponins. This study aims to determine the content of secondary metabolites in the extract of avocado seed, the effect of extract of avocado seed and the dose of extract of avocado seed that is effective in lowering blood glucose levels. This research was a laboratory experiment using a modified randomized controlled pretest and posttest group design. Test animals used were 30 rats which were divided into six treatment groups, namely normal control, negative control, positive control, a dose of 250, 300 and 350 mg/kg groups. The results showed that extract of avocado seed contained secondary metabolites: flavonoids, alkaloids, saponins, and tanins;extract of avocado seed gave effect to decrease blood glucose levels; extract of avocado seed with a dose of 350 mg/kg was effective in lowering blood glucose levelswith an avarage decrease of 99,8 mg/dL.

Ekstrak Hibiscus rosa-sinensis L. Memperbaiki Kadar Glukosa Darah Puasa dan Jumlah Sel Mast pada Model Tikus Diabetes Terinfeksi Mycobacterium tuberculosis: Hibiscus rosa-sinensis L. Extract Improves Fasting Blood Glucose Levels and Number of Mast Cells in Diabetic Rat Model that Infected with Mycobacterium tuberculosis Pakaya, David; Dewi, Marzela; Antari, Arlita Leniseptaria; Saraswati, Indah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Background: The condition of hyperglycemia in Diabetes mellitus (DM) causes a disruption of the function of phagocytes that can facilitate M. tuberculosis infection. Immunostimulant from natural ingredients can help improve the condition of hyperglycemia an immune function. Objective: To analyze the effect of Hibiscus rosa-sinensis L. extract on fasting blood glucose level and the number of mast cell in TB-DM mouse model. Methods: This experimental study used 27 male Wistar rats, 8 weeks of age, 200-230 g weight, divided into 3 groups, K: Normal control group, P1: TB-positive mouse group P2: Group rat TB-DM + Hibiscus rosa-sinensis L extract dose 250 mg/kgBW and 3 time measurement of H + 7 DM, H + 14 DM and H + 21 DM. TB-DM model mice were prepared with the administration of nicotinamide (NA) 100 mg/kgBW and streptozotocin (STZ) 65 mg/Kg BW, TB agent 1.5 x 105 CFU. Fasting blood glucose levels were measured by GOD-PAP method and Pulmonary tissue is excised, made in paraffin blocks and stained with blue Toluidine to count the mast cells. Results: There was an improvement in the mean fasting blood glucose levels in the group treated with the Hibiscus rosa-sinensis L. extract of 250 mg/kgBW compared to the TB-DM group without extract therapy followed by decreased the number of mast cell. Conclusion: Hibiscus rosa-sinensis L. extract. improves fasting blood glucose levels and decreases the number of mast cell of TB-DM rat model.

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes: Ethanol Extract of Some Cowpea (Vigna unguiculata (L.) Walp) Leaves: Morphometry Study of Pancreatic Islet of Diabetic Rat Model Solehah, Puput Octaviani; Tarusu, Fikhta Agnesya; Tandi, Joni; Dewi, Niluh Puspita; Ratih Lintin, Gabriella Bamba; Fitriana, Yuli; Pakaya, David
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5Î¼m thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8Â±156.3) and lowest in group A (67.2 Â±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

Toksisitas Ekstrak Etanol dan Ekstrak Air dari Daun Jotang Kuda (Synedrella nodiflora (L.) Gaertn.), Daun Gandarusa (Justicia Gendarussa Burm.F.), dan Daun Pulutan (Urena lobata L.) dengan Brine Shrimp Lethality Test: Toxicity of Ethanol Extract and Water Extract of Synedrella nodiflora(L.) Gaertn. Leaves, Justicia gendarussa Burm.f. Leaves, and Urena lobata L. Leaves with Brine Shrimp Lethality Test Widodo, Agustinus; Khumaidi, Akhmad; A. Lasongke, Putri Faradila
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Jotang kuda (Synedrella nodiflora (L.) Gaertn.), gandarusa (Justicia gendarussa Burm.f.) and pulutan (Urena lobata L.) leaves are used by several tribes in Central Sulawesi for the treatment of cancer. This study aims to determine the value of LC50 (Lethal Concentration 50) of ethanol and water extracts from the S. nodiflora, J. gendarussa and U. lobata leaves and identify the class of chemical compounds contained in extracts with the highest toxicity. The ethanol extract was obtained by the maceration method using ethanol 96% and the water extract was obtained by the infusionmethod. The extract toxicity test was carried out byBrine Shrimp Lethality Test (BSLT) and dentification test was carried out by Thin Layer Chromatography (TLC). The toxicity test results (LC50) of 96% ethanol extract and water extract of S. nodiflora leaves were 395.60 Î¼g/ml and 109.25 Î¼g/ml; J. gendarussa leaves 713.34 Î¼g/ml and 18.02 Î¼g/ml; and U.lobata leaves 188.38 Î¼g/ml and 85.37 Î¼g/ml, respectively. The results of identification showed that the water extract of the J. gendarussa leaves containing alkaloids, flavonoids, phenolics, saponins, and steroids-terpenoids. The results of this study indicated that the extracts of S. nodiflora leaves, J. gendarussa leaves, and U. lobata leaves are potential to be developed as anticancer.

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Muhammad Sulaiman Zubair

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jurnalgalenika.farmasiuntad@gmail.com

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Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

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Sulawesi tengah

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Home Page

OAI Link

Editorial Team

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Contact Name Muhammad Sulaiman Zubair

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Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

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Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA