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INDONESIA
Medical Laboratory Technology Journal
Published by Poltekkes Kemenkes Banjarmasin
ISSN : -     EISSN : 24610879     DOI : https://doi.org/10.31964/mltj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health
The aim of this journal publication is to disseminate the conceptual thoughts or ideas and research results that have achieved in the area of medical laboratory sciences. This Journal particularly focuses on the main problems in the development of the sciences of medical laboratory areas. It covers the parasitology, bacteriology, virology, hematology, clinical chemistry, toxicology, food and drink chemistry, and any sciences that cover sciences of medical laboratory area.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 8 Documents
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Search results for , issue "Vol. 10 No. 2 (2024): December" : 8 Documents clear
The Efficacy of Green Grapefruit (Vitis Vinifera L) Extracts on Reducing Blood Glucose in a Diabetic Rat Model Habibah, Nur; Rofi'ah, Lisa Khofidatur; Bekti, Heri Setiyo; Dewi, Ni Nyoman Astika; Wilankrisna, Luh Ade; Posmaningsih, Dewa Ayu Agustini
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.606

Abstract

Diabetes mellitus (DM) is a chronic disease in which the pancreas cannot produce enough insulin hormone or when the body cannot use the insulin hormones properly. Green grapes contain flavonoids, anthocyanins, tannins, phenolic acids, and resveratrol and are high in antioxidants that are beneficial in lowering blood glucose levels. This study aims to determine the effectiveness of green grapefruit (Vitis vinifera L) extract in reducing blood glucose levels in a diabetic rat model. This research is a true experiment with a post-test-only control group design, using 24 male Wistar white rats aged 8-12 weeks and weighing 130-200 grams. The rats were divided into three groups: the positive control (I), green grapefruit extract (II), and normal group (III). The results showed that green grapefruit extract effectively reduced blood glucose levels in experimental animals by a percentage of 98.4%. The Independent T-Test showed a value of ρ>0.05 (0.533), so there was no significant difference in glucose levels between green grapefruit extract and positive control. This study concludes that green grapefruit extract was effective at 98.4% in reducing blood glucose levels in the diabetic rat model, compared to the positive control. The promising results of this study need to be continued by establishing a standardized optimal dose, assessing long-term effects, and implementing clinical trials to evaluate efficacy and safety.
Analysis of COVID-19 Antibodies in Patients Who Have Been Vaccinated With Non-Vaccinated Patients with Confirmed COVID-19 Life Hutabarat, Mustika Sari H; Lubis, Agnes Felicia; Sinaga, Hotman
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.607

Abstract

COVID-19 immunization is a government initiative to prevent transmission and reduce the incidence of disease and death associated with the SARS-CoV-2 virus. Although the SARS-CoV-2 virus is no longer a significant threat, older adults with comorbidities or people who are immunosuppressed should remain vigilant by maintaining a distance of at least one meter from others, covering their mouths with their elbows when coughing or sneezing, washing their hands regularly, and wearing masks. However, many groups oppose vaccination for various reasons, including the perception that the COVID-19 vaccine is less effective and efficient in preventing SARS-CoV-2 virus infection. This study compared COVID-19 antibody titers in participants who had arrived, without mentioning the vaccine brand, with those who had not yet arrived but had a history of SARS-CoV-2 infection. This study design used a cross-sectional study; the number of samples in the study was 34, the location of this study was the Palembang Public Health Laboratory Center, and the statistical test in the study used the Independent T-test. The study results indicate that the mean antibody titer in the vaccinated group was 98.123. In contrast, in the unvaccinated group, it was 70.641, demonstrating a statistically significant difference with a p-value of 0.000. Further research suggests whether there is a relationship between antibody titers in subjects who have been vaccinated for the second and third time with a history of exposure to the COVID-19 virus.
The Analgesic Effect and Toxicity of Red and White Ginger on Mus Musculus with the Acetate Writhing Test Dewi, Vonny Khresna; Barkinah, Tut; Kirana, Rita; Rizki, Muhammad Ikhwan
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.611

Abstract

Based on data from the World Health Organization in 2020, the incidence of dysmenorrhea was 1,769,425 (90%) women who suffered from dysmenorrhea, with 10-16% suffering from severe dysmenorrhea. The problem of pain is very disruptive to activities, so prevention and treatment of pain must be a concern. Ginger is a natural ingredient that grows in South Kalimantan and is empirically used to treat pain. The study aimed to determine the analgesic effects and toxicity of red and white ginger from Banjarmasin and Banjar Regency. The nutrient content profile of the soil where the ginger grew was analyzed, and it was determined by nitrogen content, cation exchange capacity, and soil pH. The content of active compound groups was analyzed using specific reagents to determine the presence of active compounds. Determination of total phenolic levels using a colorimetric method using a UV-Vis spectrophotometer. The instant ginger formula was optimized with organoleptic test result parameters. Acute toxicity tests using male Wistar rats with observations for 14 days. Analgesic tests were conducted on Mus musculus using the acetic acid writhing test. The results showed that the highest nitrogen (1,34%), cation exchange capacity (29.22 me/100 g), and soil pH levels (6,89) were in the soil where the ginger samples from Banjar Regency grew. The chemical compound content in all gingers contained the same phenolics, flavonoids, tannins, saponins, and terpenoids. The levels of marker compounds in succession from Banjarmasin red ginger, Banjarmasin white ginger, Banjar Regency red ginger, and Banjar Regency white ginger were 7.43%, 6.26%, 8.52%, and 7.12%, respectively. The results of formula optimization showed that all gingers had a sweet and spicy taste, a distinctive odor, powder form, and a reddish-brown color in red ginger and pale yellow in white ginger. The toxicity test results showed that at doses of 300 mg/Kg BW and 2000 mg/Kg BW, there was no toxic effect on the administration of ginger extract. Analgesic activity showed that all gingers had an analgesic effect at a dose of 200 mg/Kg BW. The analgesic effects from the strongest to the lowest were red ginger from Banjar Regency, red ginger from Banjarmasin, white ginger from Banjar Regency, and white ginger from Banjarmasin. This study concludes that red ginger from Banjar Regency has the most potent analgesic activity and no toxicity for all ginger.
The Relationship of Plasmodium sp Density to Platelet Count and Hemoglobin Levels in Malaria Patients at Bhayangkara Hospital TK I Pusdokkes Police Kramat Jati, Indonesia Inderiati, Dewi; Oktapıa, Nısa; Nida, Wadhatun; Zuraida, Zuraida; Hariutami, Desi
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.613

Abstract

Malaria is an acute and chronic disease. Globally, as many as 247 million positive cases of malaria were reported in 84 malaria-endemic countries. Indonesia is a malaria-endemic country with a total of 443,530 cases with a malaria prevalence of 89% reported from Papua province. This study examined the correlation between Plasmodium sp density platelet count and hemoglobin levels. The type of research used in this study was observational analytics with a cross-sectional study approach design. The sample and population in this study were malaria-positive patients who had their platelet count and hemoglobin levels checked as recorded in the report from Bhayangkara Hospital Tk I Pusdokkes Polri Kramat Jati, Indonesia, namely using medical record data from months January to December a total of 54 samples with data analysis in this study using descriptive univariate analysis and bivariate analysis using the Fisher Exact test. This study showed that the density of Plasmodium sp with the number of platelets had a significant result, namely 0.088, which indicates that the density of Plasmodium sp does not affect the platelet count. In contrast, the density of Plasmodium sp with hemoglobin levels had a significant result, namely 0.023, which indicated a lower Hb level of malaria sufferers. The higher the level of Plasmodium density.
The Potential of Probiotics from West Sumatra, Indonesia on Low-Density Lipoprotein and Interleukin-6 Levels with Dyslipidemia Ridwan, Rhinie Uphita; Putranto, Wachid; Nuhriwangsa, Adi Magna Patriadi
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.618

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by abnormal elevations or reductions in one or more lipid fractions within the plasma. This condition is a critical component of both metabolic syndrome and cardiovascular disease (CVD). This study aims to see the potential of curd administration on Low-Density Lipoprotein (LDL) and Interleukin-6 (IL-6) levels in dyslipidemia patients. This study is an experimental study with a pre-post test control group design consisting of a control group and a treatment group totaling 42 people taken randomly at the DR Drs M Hatta Bukittinggi Brain Hospital in June and July 2024. In the three groups, LDL and IL-6 examinations were carried out and measured before and after curd for 14 days. Treatment group 1 was given curd as much as 150 grams, treatment group 2 was given curd as much as 200 grams, given 1x a day, and the control group was not given curd. Data analysis was performed using the Wilcoxon statistical test and paired t-test. Results: There was no significant difference in LDL (p=0.360) and IL-6 (p=0.932) levels after giving curd for 14 days. However, there was a decrease in LDL and IL-6 levels after giving curd for 14 days. Conclusion: The results showed that giving curd for 14 days in the treatment group 1 (150gram) and treatment 2 (200gram) can reduce LDL and IL-6 levels. Consuming probiotics for 14 days can reduce LDL and IL-6 levels.
Analysis of Serum Creatinine Levels, Blood Pressure and Grade of Hypertension of Chronic Disease Management Program Participants Tanjung, Asbar; Nurhidayah, Ika; Maulidayanti, Sharfina; Br Situmorang, Ing Mayfa
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.619

Abstract

Indonesia is one of the countries with the highest number of cases of hypertension in the world; the predominant patient is the elderly. In some patients with hypertension, increased blood pressure causes impaired salt and creatinine excretion, resulting in poor kidney function. A chronic disease management program is a health care system with a proactive-integrative approach to prevent further complications. The research objective is to analyze serum creatinine levels, blood pressure, and hypertension grade and determine the relationship between serum creatinine and blood pressure in chronic disease management program participants. The study subjects, 73 participants with hypertension, were obtained by purposive sampling. Patient data and hypertension grade were obtained from medical records; an auto chemistry analyzer analyzed serum creatinine. Data were analyzed using the Pearson correlation test using SPSS. Participants with hypertension fall into the elderly age (60-69 years), totalling 31 (42%); pre-elderly age (45–59 years) includes 28 (38%); and high-risk elderly age (>70 years) includes 14 (19%). Most of the participants (40 participants) fell into hypertension stage II, followed by hypertension stage I (25 participants), and only 8 participants fell into the elevated category. The mean serum creatinine of participants with Elevated blood pressure criteria was 0.89±0.178, Hypertension grade I 0.91±0.322, and hypertension grade II 0.99±0.269, illustrating a trend of increasing serum creatinine levels due to higher blood pressure criteria. Pearson correlation test shows a significant correlation between both systolic blood pressure with serum creatinine levels (p<0.05, r=0.2) and diastolic blood pressure with serum creatinine levels (p=0.007, r=0.342). There was a trend of increasing serum creatinine levels corresponding to the hypertension grade in participants. Blood pressure was significantly correlated with serum creatinine, clearly confirming that an increase in blood pressure may followed by an increase in serum creatinine.
Kato Katz against Floatation Technique Comparison for Intestinal Helminth Detection of Elementary School Children in Swamp Wetland Area, South Kalimantan, Indonesia Rifqoh, Rifqoh; Cahyono, Jujuk Anton; Kustiningsih, Yayuk
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.620

Abstract

Intestinal helminth infections are the most widespread of the world's neglected tropical diseases, primarily affecting morbidity in school-age children. Early and accurate intestinal helminth detection is important to determine an effective treatment for reducing morbidity. This research objective is to compare intestinal worm infections in elementary school children in swampy wetland areas using the Kato-Katz method and Flotation techniques. Two hundred ninety-six elementary school children in Danau Panggang Swamp-wetland, 6-13 years old, were examined for intestinal helminth eggs in no-preservative feces using microscopies Kato Katz and Floatation. The result of Kato Katz was a total egg counting per gram feces of Ascaris lumbricoides 23-92/gr feces Trichuris trichiura 23-207/gr feces and Fasciolopsis buski 23-69/gr feces, while the results of Floatation only Ascaris lumbricoides 10-50/gr feces Trichuris trichiura 20-90/gr feces. The percentage of intestinal helminth infection by Kato Katz was 31,76% (94 samples), which is higher than by the Floatation was 25,34% (75 samples). The Wilcoxon statistical test obtained a significance value of 0.001, which shows p<α (α=0.05); there is a significant difference between the results of the quantitative examination of intestinal worm eggs between the Kato Katz and Floatation technique. It is recommended that Kato Katz's performance testing be continued compared to PCR methods and a wider sample area.
Catechin Isolates from Gambir (Uncaria gambir Roxb) Maintain Glucose Homeostasis in Diabetic Model Rat Rita, Rauza Sukma; Yetti, Husna; Santoso, Putra; Afriani, Nita
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.621

Abstract

The prevalence of diabetes mellitus is rising globally. Oxidative stress, which can result from hyperglycemia in diabetes, might have negative consequences. An antioxidant is needed to prevent hyperglycemia. Cathechin isolates are derived from gambir, which has many antioxidants. This study examines catechin isolates from gambir (Uncaria gambir Roxb.) effect on glucose homeostasis in rats induced by alloxan. For this experiment, 35 male rats were employed. Male rats were given alloxan (150 mg/BW, IP), and after 72 hours, blood glucose levels were assessed. If blood glucose levels exceeded 200 mg/dl, three oral catechin isolates were administered (T1=10 mg/kg/day, T2=20 mg/kg/day, and T3=40 mg/kg/day). Following blood collection on the experiment's last day, fasting blood glucose, glucagon and insulin levels were measured. Catechin isolates decreased blood glucose levels in all treatment groups compared to the positive control group (T1 = 150.750 ± 14.359 mg/dl; T2 = 159.750 ± 15.434 mg/dl, and T3 = 153.375 ± 20.207 mg/dl vs 385 ± 60.989 mg/dl) significantly (p value-0.05). A decrease in glucagon serum level was also observed in the treatment group vs positive control (T1: 193.855 ± 36.009 pg/ml, T2 = 286.689 ± 20.313 pg/ml, and T3 = 319.462 ± 30.060 pg/ml vs  529.825 ± 74.279 pg/ml), significantly. Catechine isolates in the T3 group showed an increase in insulin serum level compared to the positive control group significantly (T3 = 216.640 ± 38.230 µIU/ml vs 69.833 ± 3.071 µIU/ml). In conclusion, catechin isolates from gambir decreased blood glucose levels by reducing glucagon and increasing insulin serum levels.

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