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Rachmat Kosman
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Fakultas Farmasi UMI, Kampus II, Universitas Muslim Indonesia, Jl. Urip Sumohardjo Km.5, Makassar
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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ANALISIS KADAR PENGAWET NATRIUM BENZOAT PADA PRODUK MINUMAN BERKARBONASI DENGAN METODE HPLC Rahmawati, Rahmawati; Kosman, Rachmat; Effendi, Nurmaya; Ismayani, Nur
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.122 KB)

Abstract

It has been worked a research about the analysis of sodium benzoate content of carbonated beverages which is in Makassar market using High Performance Liquid Chromatography (HPLC) reverse phase. In this research, the analysis was conducted on four brands of carbonated beverages products. The results of analysis are sample A contains 47,6907 mg/kg, sample B 152,9348 mg/kg, sample C 271,4082 mg/kg, and sample D 357,3797 mg/kg of sodium benzoate. The four samples appropriate Permenkes No. 722/Menkes/Per/IX/1988 are <600 mg/kg.  Key words : Natrium Benzoate, HPLC, Carbonated Beverages
IDENTIFIKASI FLAVONOID DAUN TEH HIJAU (Camelia sinensis L. Kuntze) SECARA REAKSI WARNA DAN KROMATOGRAFI LAPIS TIPIS Afriani Kusumawati
As-Syifaa Jurnal Farmasi Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.764 KB) | DOI: 10.33096/jifa.v8i2.210

Abstract

Green tea plant (Camellia sinensis L. Kuntze) were examined in this study were taken from green tea products Cap Head Djenggot, from the area of Solo, Central Java. This plant thrives in the area of Green Tea plantation in the Solo area. For identification of the content of flavonoids in green tea leaves can be done Thin Layer Chromatography is accompanied by a color reaction.Spotting obtained detected with ammonia vapor is then observed with UV light UV 254 nm and 366 nm. In observation using a 254 nm UV light there is a blackish brown spots on the fraction of water-chloroform, the chloroform fraction of the spots are a light green color, and the n-butanol fraction contained a brown patches muda.Dengan using 366 nm UV rays are one dark brown spots on the fraction of water-chloroform, the chloroform fraction contained patches of light green color, and the n-butanol fraction contained a light brown spots.Based on data obtained from the reaction of color and Thin Layer Chromatography showed that the compound contained flavonoids in green tea leaves.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI PATCH BUKAL MUKOADHESIF ESTRAK CENGKEH (Syzygium aromaticum L.) DENGAN KOMBINASI POLIMER POLIVINIL PIROLIDON (PVP) DAN NATRIUM KARBOKSIMETIL SELULOSA (NA-CMC) TERHADAP BAKTERI Streptococcus mutans Vina Purnamasari; Iskandar Zulkarnain
As-Syifaa Jurnal Farmasi Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.272 KB) | DOI: 10.33096/jifa.v10i2.433

Abstract

Clove extract (Syzygium aromaticum) contains eugenol 70% - 85%. The clove extract is formulated in the form of mucoadhesive buccal patches. The purpose of this study was to obtain the formulation for mucoadhesive buccal patches having optimal stability that has good pharmaceutic properties and also effectively inhibits  the Streptococcus mutans bacteria. The research design used was laboratory experimental research. The mucoadhesive buccal patches with a combination of PVP and HPMC polymers made in 5 formulas based on their concentration, formula 1 1% Na-CMC concentration, formula 2 2% Na-CMC concentration, formula 3 2% PVP concentration, formula 4 3% PVP concentration, formula 5 combination of Na-CMC and PVP with concentrations of 1% and 2%. Patches obtained were tested for physical properties including organoleptic examination, surface tension, weight uniformity, thickness uniformity, folding endurance and pH patch surface. The patch is also tested for its antimicrobial power by measuring the zone of bacterial resistance. The results showed that the buccal patches of clove extract produced a dark brown color with opaque transparency, smooth surface texture with a patch weight of around 66.67 mg - 140.67 mg, standard deviation of patch thickness around ± 0.009 - ± 0.058, folding endurance more than 300 times, surface pH ranged from 6.40 - 6.60, and antimicrobial activity shows that all patch formulations can inhibit the growth of Streptococcus mutans bacteria to prevent dental caries, but the formula that has the largest inhibition zone was formula IV with a inhibition zone of about 1.667 cm.
UJI TOKSISITAS FRAKSI n-BUTANOL BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) DENGAN METODE BRINE SHRIMP LETHALITY TEST Irma Santi; Sitti Nurbaezurah
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.7 KB) | DOI: 10.33096/jifa.v5i1.73

Abstract

The research on Toxicity Test Of n-Butanol Fraction Beruwas Laut (Scaevola taccada (Gaertn.) Roxb.) Using Brine Shrimp Lethality Test Method an investigation with larvaes Artemia salina Leach as test animal which is intended to potential toxic test. Each treatment is done the replication of research 3 times of the fraction n-butanol beruwas laut concentration are 0,1 μg/ml, 1 μg/ml, 10 μg/   ml, 100 μg/ml and solvent control n-butanol by same concentration. The result is against larvae that died 24 hours after component test was given. Through the data, LC50 value of n-butanol fraction Beruwas Laut (Scaevola taccada (Gaertn.) Roxb.) was analyzed by probit analysis. This research indicated concentration of fraction n-butanol of beruwas laut (Scaevola taccada (Gaertn.) Roxb.) could kill larvae by the concentration of 0,1 μg/ml, 1 μg/ml, 10 μg/ml and 100 μg/ml. The result of probit analysis indicated that LC50 value of fraction Beruwas Laut of (Scaevola taccada (Gaertn.) Roxb.) was 12,16 ± 11,23 µg/mL. Research result and probit analysis indicated that n-butanol fraction of beruwas laut (Scaevola taccada (Gaertn.) Roxb.) toxic characteristic by LC50 value was 12,16 ± 11,23 µg/ml. On according Meyer test result explained toxic about Artemia salina Leach when extract had LC50  less of 1000 µg/mL.Key Words : Toksisitas Test, n-butanol Scaevola taccada (Gaertn.)Roxb), Brine Shrimp Lethality Test
ANALISIS AKTIVITAS ANTIOKSIDAN SEDIAAN PROPOLIS YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE FRAP (Ferric Reducing Antioxidant Power) Mamat Pratama; A. Muflihunna; Nurazizah Octaviani
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.303 KB) | DOI: 10.33096/jifa.v10i1.312

Abstract

Antioxidants are chemical compounds that can donate one or more electrons to free radical, so that free radicals that can be suppressed.This study aimed to obtain and provide scientific evidence to the public regarding the antioxidant activity in propolis liquid product circulating in Makassar. This study using FRAP (Ferric Reducing Antioxidant Power) and 96% ethanol. Free radical activity absorbance was measured with a  UV-VIS spectrophotometer at a wavelength of 710 nm and the total value of antioxidant activity was calculated based on data absorbance. The calculations show that the sample A has antioxidant activity of 0.0971 mgAAE / mg sample, the sample B has antioxidant activity of 0.0669 mgAAE / mg sample, the sample C has antioxidant activity of 0.0493 mgAAE / mg samples.
FERMENTASI UBI KAYU (Manihot utillisima Pohl) DENGAN RAGI Monascus purpureus UNTUK PRODUKSI ZAT WARNA ANGKAK Rachmat Kosman; Pirman AP; Aco Mappacanda
As-Syifaa Jurnal Farmasi Vol 2, No 1 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i1.105

Abstract

Has conducted research on the cassava (Manihot utillisima Pohl.) fermentation  with Monascus purpureus yeast to angkak essence pigmen production. This research aimed to make angkak pigmen by solid and pigmen extraction from fermentasion using Monascus purpureus. Then the wevelength is measured by using spectrophotometry UV-Vis. The result of research is 30 gram of cassava (Manihot utillisima Pohl.) fermented product obtained angkak dye with yellow dye % levels as much as 36,64%. Where the results of measurements of spectrophotometry UV-Vis showed that the maximum wevelength of 398,0 nm.Key Words : Manihot utillisima Pohl, Monascus purpureus, Angkak
AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN FRAKSI DAUN Colocacia esculenta L. DENGAN METODE KLT-BIOAUTOGRAFI DAN DIFENILPIKRIL HIDRAZIL Herwin Herwin; Muzakkir Baits; Ririn Ririn
As-Syifaa Jurnal Farmasi Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (54.392 KB) | DOI: 10.33096/jifa.v7i2.9

Abstract

The aim of the research to determine the antibacterial and antioxidant activity of Colocacia esculenta fraction leaves derive from Pare-Pare South Sulawesi in using TLC- Bioautography and diphenilpycril Hydroxil. Screening antibacterial activity test of the Colocacia esculenta fraction leaves exhibited in concentration 1% active on pathogenic bacteria Salmonella thypi. Based on either antibacterial and antioxidant activities by TLC-Bioautography showed that fraction at Rf 0.70 value active on bacteria Salmonella thypi and antioxidant active as well. Identification of active chemical compound showed flavonoid compound using Iodium-KI and antimo (III) clorida as reagent.
FORMULASI SARI BUAH TOMAT VARIETAS APEL (Lycopersicum esculentum Mill Pyriforme) SEBAGAI KRIM MASKER A. Muflihunna
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.077 KB) | DOI: 10.33096/jifa.v4i1.137

Abstract

An research has been done about formulation of tomato essence (Lycopersicum esculentum Mill) as a Cream Mask by using variation concentration of nonionic emulgator (polysorbat 20 and sorbitan monostearic) that were  formula A (concentration 4%), formula B (concentration 3%), and formula C (concentration 2%). There aim of investigation was to determine the Formulation which has an optimum stability. Stability evaluation has done by observation of organoleptic, creaming volume, dispersed globule, viscosity and yield value, and emulsion type determination before and after stress condition at 50C and 350C for 10 cycles. Observation’s result shown that there wasn’t change before and after stress condition of orgenoleptic, creaming volume, emulsion type, rheology type before and after stress condition. Statistic analyse result of parameter viscosity and yield value by means of random black design shown that formula B (concentration 3%) obtained apparent indifferent in dispersed globule, viscosity and yield value between before and after stress condition. The conclusion that cream mask has the most optimal stability is that by formula B (concentration 3%).Key Words : Formulation, Cream Mask, Tomato essence
UJI EFEK ANTIINFLAMASI EKSTRAK n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb) PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI DENGAN KARAGEN Sitti Amirah; Rahmawati Rahmawati; Safriani Rahman; Franita Achmad
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.1 KB) | DOI: 10.33096/jifa.v6i2.49

Abstract

This research about antiinflammation effect from n-hexane extract of Beruwas Laut leaves (Scaevola taccada (Gaertn.) Roxb.) in male mice (Mus musculus) was conducted, the aim was assay the antiinflammation effect of Beruwas Laut leaves done extract based on decrease in edema volume of foot palm male mice. This research using 15 male mice that evaluated and divided into 5 groups that each group has 3 mice. In group I, diclofenac sodium as the compare administrated. In groups II, III, dan IV,  n-hexane Extract of Beruwas Laut leaves in concentration of 2,5%, 5% and 7,5% administrated. In group V, 1% Na-CMC as negative control administrated. Induction carried out by injection 1% w/v carrageen 0,1 ml subcutan on the feet palm of mice. One hour later each group administered the preparation test 1 ml/30 gBW orally. The measurement of edema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between induction and antiinflammation effect analysed. Result indicated variety with n-hexane extract of Beruwas Laut leaves have the antiinflammation effect at concentration 7,5%. Key Word : Antiinflammation, Scaevola taccada (Gaertn.) Roxb, Mice, n-Hexane.
EFEK ANTIHIPERKOLESTEROLEMIA KITIN CANGKANG UDANG WINDU (Penaeus monodon) SECARA INVIVO PADA KELINCI (Oryctolagus cuniculus) Muammar Fawwaz
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (38.446 KB) | DOI: 10.33096/jifa.v5i1.64

Abstract

The reasearch test effect anthypercholesterolemia Chytosan Windu Shrimp Shell with aimed to know the effect to decrease the total blood cholesterol degree on adult rabbit. These research include 3 group, namely 1 group of control and 2 groups of examined namely chytosan 5% and 10% w/v. The observation applied with measure of the total blood cholesterol degree on adult rabbit before induction of cholesterol, then inducted of cholesterol as long as 7 days, then observed  cholesterol degree, and then its gived chytosan 400 mg/kgBB (5%w/v) and 800 mg/kgBB (10%w/v) at the 8th and  measured again of the total blood cholesterol degree after examined Chytosan at concentration 400 mg/kgBB (5%w/v) dan 800 mg/kgBB (10%w/v), conduct decreasing of total blood cholesterol degree on adult rabbit. Key Word : Antihypercholestrolemia, Penaeus monodo, Oryctolagus cuniculus, Invivo

Page 8 of 40 | Total Record : 397

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