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I Wayan Sutapa
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wayansutapa@fmipa.unpatti.ac.id
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Department of Chemistry, Faculty Mathematics and Natural Science, Pattimura University, Ambon, Maluku
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INDONESIA
Chemistry Indonesian Journal of Chemical Research
  • Indonesian Journal of Chemical Research (Indones.
  • Website
Published by Universitas Pattimura
ISSN : 23385359     EISSN : 26142627     DOI : 10.30598//ijcr.2021.-irm
Core Subject : Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science
Indo. J. Chem. Res. is a journal that regularly publishes primary articles covering all branches of chemistry and its sub-disciplines. Published articles consist of complete research, short communication, and review articles. The scope of published articles is not limited to inorganic chemistry, physical chemistry, organic chemistry, analytical chemistry, and biochemistry. Editors can invite articles review of authors that includes the latest developments in the field of interest of certain chemicals. A contribution is open to researchers from all countries.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 314 Documents
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The Analysis of The Absorption Capabilities of The Heavy Metal Mercury (Hg) in Mangrove Crab (Scylla serrata), Mangrove Snail (Telescopium telescopium) and Mangrove Clams (Polymesoda erosa) Irsan, Irsan; Male, Yusthinus T.; Koto, Saifuddin; Mangesa, Rosita; Ismail, Irwan; Nuraisah, Siti; Kabau, Widyawati; Banjar, Firman
Indonesian Journal of Chemical Research Vol 12 No 3 (2025): Edition for January 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.12-irs

Abstract

Mercury is a neurotoxic heavy metal with high bioaccumulation ability in aquatic biota, such as mangrove crabs (Scylla serrata), mangrove snails (Telescopium telescopium), and mangrove mussels (Polymesoda erosa), which are widely consumed by humans, and used as bioindicators of pollution. This study aimed to analyze the effect of mercury solution concentration and species differences on mercury absorption in the three biota. The method used was experimental treatment with mercury concentrations of 1 ppm, 5 ppm, 10 ppm, and control. Samples were analyzed using the AAS Cold Vapor method at the IPB Bogor Proling Laboratory. Data were analyzed descriptively and inferentially using two-way Anova with an α level of 0.05, followed by the Duncan Test if the hypothesis was accepted. Research data will be processed using SPSS 26.0 software. The results showed that mercury concentration and species differences influenced the ability to absorb mercury. Mangrove clams had the highest mercury accumulation compared to mangrove snails and mangrove crabs, especially in the 5 ppm and 10 ppm treatments. The highest mercury exposure occurred on the second day of observation.
Investigation of Pharmacokinetics, Molecular Docking, and Dynamics of Xanthomicrol-Derived Compounds Against Various Mutated Proteins in Lung Cancer Cells Kurniawan, Muhammad Akbar S; Baari, Muhamad Jalil; Sabila, Laili Cahyani; Amin, Rana Triana
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-muh

Abstract

Lung cancer remains one of the leading causes of global mortality, primarily due to drug resistance and the adverse effects of conventional therapies. Therefore, the discovery of novel compounds that are both effective and safe is crucial for the development of alternative treatments. This study employed a computational approach to evaluate the therapeutic potential of Xanthomicrol-derived compounds targeting mutated proteins commonly associated with lung cancer. Four derivatives (u1a, u2a, u3a, and u4a) were assessed using pharmacokinetic (ADMET) predictions, molecular docking, and molecular dynamics simulations against ten mutated lung cancer-related proteins (1nq1, 1x2j, 4b3z, 4j97, 5l2q, 6pwa, 6usx, 7pgk, 7pgl, and 7r7k). ADMET predictions revealed that all compounds had good gastrointestinal absorption, did not cross the blood–brain barrier, and exhibited favourable safety profiles. Among them, compound u3a showed the highest binding affinity toward seven mutated proteins, with docking scores ranging from -5.9 to -9.4 kcal/mol. Molecular dynamics simulations further supported the stability of u3a protein interactions, indicated by low RMSF values and an optimal radius of gyration. These results suggest that u3a is a promising candidate for targeted lung cancer therapy and warrants further experimental validation.
Influence Of Silica Content into Nickel/Silica Electrodeposited Composite Coating for Mechanical and Corrosion Resistant Properties Enhancement: A Review Abro, Koutouan Désiré Martial; Djassou, Adjoavi Colette; Adjoumani, Yao Joseph; Yao, Kouassi Benjamin
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-kou

Abstract

The ratio cost/efficiency of electrodeposited composite coating has boosted the development of this method in the last decades. Thus, electrodeposited nickel with silica particles as reinforcement was successfully designed and the conditions to increase particles in the composite are better understood. Those composites' morphological, mechanical, and corrosion properties as a function of the embedded silica particles were also investigated. In this review, the last findings about nickel/silica preparations and their properties are specifically summarized. Data collected here indicate that silica particles entrapment depends on current density, particle load in the bath, particle surface modification, and hydrodynamics. The presence of silica particles in the composite led to the refinement of the nickel grain and consequently enhanced the mechanical and corrosion properties.
Fatty Acid and Amino Acid Profile of Mancadu Clam (Atrina vexillum) in Waai Village Salamony, Meilita; Sohilait, Hanoch Julianus; Telussa, Ivonne
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-mei

Abstract

Mancadu clam (Atrina Vexillum) is a food source for Maluku coastel communities with high nutritional value and contains various bioactive components, including fatty acids and amino acids. This study analyzed the content of fatty acids and amino acids in mancadu clams (Atrina Vexillum) in Waai village. Fatty acid analysis was carried out through a maceration extraction process with the Shaking Incubator method and transesterification using the microwave. Amino acid analysis was carried out by hydrolysis for 12 hours. The results of the research, the fatty acids of mancadu clams contain 7 fatty acid components, consisting of 2 saturated fatty acids, namely hexadecanoic or methyl palmitate, which is the most significant component (17.61%) and heptadecanoic acid (13.43%). Unsaturated fatty acids are hydrosinnamic acid (15.01%), 5,8,11,14- eicosatetranoic acid/omega-6 fatty acid (7.2%), octadecanoic acid (6.65%), 9-Octadecanoic acid (5.1%) and 8,11-eicosadinoic acid or FUPA (4.68%). The results of amino acid analysis of mancadu clams (Atrina Vexillum) on 18 amino acids obtained 6 types of essential amino acids namely leucine, valine, isoleucine, threonine, methionine and arginine which the largest compound from acid hydrolysis (1150.94 mg/Kg). There are 7 types of nonessential amino acids: glutamic acid, alanine, serine, glycine, aspartic acid, and proline.
Understanding the Impact of Curing Duration on Characteristics of Durian Extract-Based Solid Soap Imani, Nadya Alfa Cahaya; Pribadi, Meidwiarta Cahya; Irsyada, Muhamad Zakky; Kusumaningrum, Maharani; Asri, Sarwi; Ardhiansyah, Hanif
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-nad

Abstract

This study aims to understand the effect of curing duration on the characteristics of durian extract-based solid soap. Durian extract-based soap has unique properties that can be affected by the curing process, namely the duration of drying and maturation of the soap after manufacture. In this study, soap was produced using durian extract as the main ingredient, with curing time variations ranging from 2 weeks to 6 weeks. During the curing process, the water content in the soap decreased, and the saponification reaction between alkali and free fatty acids from durian extract took place further. The characteristics of the soap analyzed included hardness, pH, free fatty acid content, and foam durability and quality. The results showed that the soap became more challenging as the curing time increased, with a more stable pH and lower free fatty acid content. In addition, the durability of the soap increased, and the foam quality became more optimal. Longer curing durations were also associated with increased stability and safety of the resulting soap. This study provides new insights into the development of durian extract-based soap. It can be used as a reference to improve the quality of natural soap products through proper curing process management.
Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment Azkiyah, Dina; Syahbirin, Gustini; Firdayani, Firdayani; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-din

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease distinguished by disrupted glucose metabolism, causing elevated blood sugar levels. One of the latest therapeutic strategies involves inhibiting dipeptidyl peptidase-4 (DPP-4) to regulate glucose metabolism. Emodin, a bioactive compound, has shown potential as a DPP-4 inhibitor, but its efficacy requires further research. This study aims to identify and assess emodin and its derivatives as potential DPP-4 inhibitors through a comprehensive in silico and in vitro analysis. Molecular docking analysis revealed that 3-ρ-toluoyl emodin (ρTE) had the lowest binding energy (-111.4 kcal/mol) among the tested compounds. Furthermore, in vitro testing showed consistent results in silico, indicating that ρTE had significant inhibitory activity with an IC50 value of 1.37 μM. Pharmacokinetic and physicochemical evaluations confirmed ρTE’s potential as a safe antidiabetic drug candidate. The research findings indicate that ρTE holds potential as a promising drug candidate for further development.
Optimizing Photovoltaic Performance in p-Cu2O/n-TiO2 Heterojunction Solar Cells: The Impact of Annealing Temperature, Layer Thickness, and Carbon Doping Pakpahan, Sarinah; Gultom, Rimawanto
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-sar

Abstract

This study analyzes the photoresponse behavior and optimizing the efficiency of p-Cu₂O/n-TiO₂ heterojunction solar cells. The impact of annealing temperature, layered thickness, and carbon doping on the optical and electrical characteristics of the solar cells was investigated. The findings reveal that the annealing temperature continuously affects the optical absorption and energy gap of Cu2O, with the best performance at 250°C. Increasing the layer thickness of Cu2O resulted in further improvement in absorption and efficiency. It was also found that doping carbon into TiO2 lowered the energy gap, increasing efficiency. The maximum efficiency of 0.003593% was obtained with carbon-doped TiO2. This work guides optimizing the design of heterojunction solar cells for better photovoltaic performance.
Synthesis, Microstructure, Optical Properties, and Sensitive Amoxicillin Detection of Carbon Dots Lubis, Yuni Aldriani; Gea, Saharman; Lubis, Muhammad Frassetia; Pai, Woei Wu Larry; Marpongahtun, Marpongahtun
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-yun

Abstract

The detection of amoxicillin has been successfully carried out using C-dot fluorescence probes made from d-glucose and urea. The fluorescence probe has an intense bright blue emission under UV light at 395 nm and and depends on the excitation and depends on the excitation. Raman studies successfully showed a D peak at 1381 cm-1 and a G peak at 1586 cm-1 associated with graphitic and amorphous structures. The absorption peaks in UV-vis spectroscopy confirm transitions at 275 nm (π → π*) and 322 nm (n → π*) with the presence of conjugated C=C and carbonyl (C=O) functional groups. The results of the fluorescence test show a bright blue color, with its intensity measured at an excitation of 365 nm. This can be attributed to nitrogen incorporation on the surface of the C-dots derived from urea, resulting in a quantum yield of 54%. This fluorescence probe is highly sensitive in detecting amoxicillin, as evidenced by the successful detection of AMX at concentrations of 10–30 μM and a resulting LOD of 5.75443×10−7 nM. The microstructure shows a uniform size of C-dot nanoparticles, and C-dot modeling was created. C-dot probes have an LOD of 5.75443×10−7 nM, indicating high sensitivity in detecting AMX.
Evaluation of Lead (Pb) Bioaccumulation Levels by sea grass (Enhalus acoroides) at Tulehu Village Port Mariwy, Abraham; Manuhutu, Julita B.; Tuhalauruw, Debby E.
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-mar

Abstract

This research aims to study the level of heavy metal Pb bioaccumulation by sea grass (Enhalus acoroides) in the waters of Tulehu Village, Central Maluku Regency, where the type of particles and Pb content in sediment, roots and leaves are important variables for studying the accumulation and translocation of Pb metal ions by sea grass. Lead (Pb) content in sediment, roots and leaves of sea grass was measured using an atomic absorption spectrophotometer. The ability to accumulate and translocate lead (Pb) in sea grass (Enhalus acoroides) is known from the BCF (bioconcentration factor) and TF (translocation factor) values. The results of the study showed that the type of sediment particle grains at point I was 2.92% gravel, 86.67% sand, 26.67% mud, the size of sediment grains at point II was 16.67% gravel, 82.94% sand, 2.35% mud, and the size of sediment grains at point III was 19.77%, 64.58% sand, 1.04% mud. The Pb metal content produced at point I ranged from 4.80 mg/kg, point II ranged from 4.85 mg/kg and point III ranged from 4.44 mg/kg. The BCF values obtained at points I, II, and III were respectively 0.55; 2.20; 2.12.
Optimization Of Hydrolysis Of Gayam Peel Waste Using The Acid Method Into Glucose Sani, Sani; Wirayudha, Umar; Rofiq, Ainur; Suprihatin, Suprihatin
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-uma

Abstract

This study aims to optimize the hydrolysis process of gayam fruit peel waste using the acid method to produce glucose, which serves as a raw material for bioethanol production. Gayam peel waste contains a high amount of cellulose, which can be converted into glucose through acid hydrolysis. The process began with a delignification step using an 8% NaOH solution at 80°C for 60 minutes to reduce the lignin content. This was followed by hydrolysis using hydrochloric acid (HCl) with varying concentrations (1, 2, 3, 4, and 5 N) and durations (90, 120, 150, 180, and 210 minutes). Optimization was performed using the Response Surface Methodology (RSM) with Minitab 18 software. The RSM results indicated that the highest glucose yield was achieved at a 5 N HCl concentration and 156.67 minutes of hydrolysis time, with a predicted glucose content of 24.37%. Validation using UV-Vis spectrophotometry and the Nelson-Somogyi method showed an actual glucose content of 4.7217% or 47.217 ppm. These findings demonstrate that gayam fruit peel waste can be efficiently converted into reducing sugars and holds significant potential as an environmentally friendly raw material for bioethanol production.

Page 29 of 32 | Total Record : 314

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