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Jambura Journal of Chemistry
Published by Universitas Negeri Gorontalo
ISSN : 26563665     EISSN : 26566834     DOI : 10.34312/jambchem
Core Subject : Science,
Chemistry
Jambura Journal of Chemistry is peer-reviewed and open access journal published by Chemistry Depertment, Faculty Mathematic and Natural Science. Jam.J.Chem that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. Jambura Journal of Chemistry publish two issues (numbers) annually (February and August).
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Articles 102 Documents
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Analisis Kemiripan Obat, Prediksi Toksisitas dan Studi Molecular Docking Metabolit Sekunder Dari Streptomyces carpaticus Terhadap Protein Caspase-3 Sebagai Antikanker Leukemia Suduri, Adam; Darusman, Huda Shalahudin; Mariya, Silmi
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.26802

Abstract

Caspase-3 merupakan enzim protease yang berperan dalam proses apoptosis, dan menjadi target senyawa metabolit dalam menghambat pertumbuhan sel kanker. Tujuan penelitian adalah untuk mengetahui sifat kemiripan obat metabolit sekunder hasil produksi Streptomyces carpaticus yang diperoleh berdasarkan analisis klaster gen biosintesis pada program antiSMASH version 7.1.0, mengetahui hasil prediksi mutagenicity dan toxicity serta mengetahui hasil interaksi metabolit sekunder dengan protein Caspase-3 yang merupakan reseptor terkait sel kanker leukemia menggunakan molecular docking. Hasil analisis kemiripan obat dan prediksi ADME menunjukkan bahwa ketiga metabolit memenuhi aturan Lipinski Rule of Five dan memiliki kemiripan dengan obat. Ketiga metabolit tergolong pada Toxicity Class 5, dan memiliki sifat mutagenic inactive dengan probability Pristinol: 0.93, Raimonol: 0.91 dan Cyslabdan: 0.80 dan toxicity inactive dengan probability Pristinol: 0.75, Raimonol: 0.94 dan Cyslabdan: 0.76. Hasil studi molecular docking, analisis dan validasi situs ikatan dengan protokol penambatan ulang (redocking) ligan standar 5-[4-(1-carboxymethyl-2-OXO-propylcarbamoyl)-benzylsulfamoyl]-2-Hydroxy-Benzoic Acid memiliki nilai RMSD yaitu 0.000. Energi ikatan bebas masing-masing ligan yaitu sebesar -8,9 kkal/mol -9.2 kkal/mol, -7.0 kkal/mol, -7.1 kkal/mol, dan -7.0 kkal/mol. Hasil ini menunjukan bahwa energi ikatan hasil penambatan metabolit sekunder dengan protein Caspase-3 yang paling baik adalah metabolit cyslabdan dengan nilai ikatan bebas -7.4 kkal/mol dan jumlah interaksi 12.
Analisis Kandungan Unsur Fosfor dan Nitrogen serta Pembuatan Pupuk Organik dari Sedimen Danau Limboto Musa, Weny J.A; Pakaya, Agustina H.; Bialangi, Nurhayati; Isa, Ishak; Mohamad, Erni; Kunusa, Wiwin Rewini
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.16025

Abstract

Sedimen merupakan bahan organik dan anorganik yang dapat mempengaruhi kualitas air. Sedimen biasanya mengandung Fosfor dan Nitrogen. Fosfor dan Nitrogen merupakan unsur hara makro yang diperlukan dalam proses pertumbuhan tanaman. Penelitian ini bertujuan untuk mengetahui kandungan fosfor (P) dan nitrogen (N) pada sedimen danau limboto maupun pupuk organik yang dibuat serta pengaruh pupuk organik terhadap tanaman kangkung darat. Analisis kandungan fosfor (P) menggunakan metode Spektrofotometer Uv-Vis. Sementara untuk kandungan nitrogen (N) menggunakan metode kjedhal. Untuk pengaplikasiannya dilakukan pada tanaman kangkung darat. Hasil yang diperoleh menunjukkan bahwa pada 3 sampel sedimen danau limboto untuk kandungan fosfor (P) dan Nitrogen (N) tergolong sangat tinggi. Kandungan fosfor (P) masing-masing sebesar titik 1= 0,48%, titik 2 = 0,45%, titik 3 = 0,44% dan kandungan nitrogen (N) sebesar titik 1= 12,35%, titik 2 = 13,7%, titik 3 = 17,85%. Sementara itu, pupuk organik yang dibuat, kualitas fisiknya memenuhi standar yaitu berwarna coklat kehitaman, berbau tanah dan teksturnya tidak menggumpal. Untuk hasil uji kadar fosfor (P) dan nitrogen (N) pada pupuk organik diperoleh masing-masing sebesar 22,675% dan 1,76%. Pada pengaplikasian pupuk organik, Tanaman kangkung darat mengalami perkembangan dalam setiap minggu setelah tanam (mst) baik tinggi maupun jumlah daunnya.
Ekstrak Getah Merkubung (Macaranga gigantea) Sebagai Inhibitor Korosi Yang Ramah Lingkungan Pada Baja Lunak Dalam Media Air Gambut Prasetio, Muhamad Reza; Pradina, Armitha Dea; Gusti, Diah Riski; Susanto, Nindita Clourisa Amaris
Jambura Journal of Chemistry Vol 7, No 1 (2025): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i1.15714

Abstract

Pemanfaatan baja lunak dalam industri sebagai alat kontruksi dan transportasi karena baja memiliki banyak manfaat antara lain kokoh, mudah digunakan dan sederhana. Namun, baja rentan terkena korosi karena berinteraksi dengan kondisi lingkungan asam, alkali , dan lingkungan agresif lainnya. Ekstrak getah merkubung (Macaranga gigantea) dipilih sebagai inhibitor korosi karena mengandung senyawa metabolit sekunder, salah satunya yaitu tanin. Tujuan dari penelitian ini untuk manganalisis pengaruh konsentrasi ekstrak terhadap laju korosi, efisiensi dalam media air gambut. Metode pengujian yaitu metode kehilangan berat, dimana laju korosi tertinggi pada suhu 333 K dengan konsentrasi 0,5 g/L adalah 0,555 g/cm^2.jam. Sedangkan nilai efisiensi sebesar 67,196 % pada suhu 333 K dengan konsentrasi 2,5 g/L. Analisis yang digunakan pada penelitian ini yaitu Analisis Scanning Electron Microscopy/ Energy Dispersive X-Ray (SEM-EDX) dan Analisis Fouriere Transformi Infra Red (FTIR).
Bioaktivitas Ekstrak Daun Namnam (Cynometra cauliflora L.) Terhadap Antidiabetes Secara In Vitro Anliza, Syarah; Rachmawati, Nurmeily
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.13379

Abstract

Every day our bodies produce free radicals and every organism has a natural defense system to reduce free radicals. In a healthy state the amount of antioxidants in the body can balancing the amount of free radicals. However, in certain circumstances it can interfere with the body's defense against free radicals. This situation underlies the occurrence of various diseases caused by radicals, one of which is non-communicable (degenerative) diseases. Many therapies are available for the treatment of diabetes, do not completely cure the disease but cause many side effects. Namnam plant is predict to have the ability as an anti-diabetic agent. The purpose of this study was to determine the in vitro bioactivity of Namnam leaves extract against antidiabetic. This research conducted extraction, phytochemical test, total phenol test, total flavonoid test, and in vitro -glucosidase enzyme inhibition test as an antidiabetic. The results of the study showed that the ethanol extract produced secondary metabolites, namely flavonoids and steroids. The results of the α-glucosidase inhibition test resulted in an IC50 value of 30,89 ppm. The comparison that has been used is acarbose which produces IC50 of 0.22 ppm. Ethanol extract and ethyl acetate extract have inhibitory ability due to the presence of flavonoid and steroid compounds contained in the extract
Comparative Studies on Proximate and In Vitro Anti-Inflammatory Activities Turmeric Methanol Extract In Albino Wistar Rats Adio, Waheed Sakariyau; Salawudeen, Wahab; Adesola, Ridwan Olamilekan; Adisa, Azeez Soliu; Obunadike, Chizoba Victory
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.16385

Abstract

All throughout the world, turmeric has attracted the interest of scientists and medical specialists. The goal of this study was to pinpoint turmeric methanol extract's immediate proximate and anti-inflammatory activities. A spectrophotometric approach was used to choose the phytochemical screens (both qualitative and quantitative). The recent approach (standard method) was used to research the anti-inflammatory effects and proximate components of turmeric. The qualitative phytochemical screening revealed a substantial amount of turbid alkaloid (++) but no steroid (-). Phenol (151.34±1.01 mg/100g) had the highest concentration (5.83%), while flavonoid (22.30±0.62 mg/100g) had the lowest (5.83%), according to the quantitative screening. The anti-inflammatory activity of the turmeric methanol extract in the treated groups (150, 300, and 600 mg/kg body weight) and the positive control group demonstrated a valuable value (inhibitory values). Paw thickness was also significantly different (reduced) between the 600 mg/kg and positive control groups promising anti-inflammatory effects. These findings demonstrated that inflammation can be treated using turmeric's anti-inflammatory and adjuvant capabilities.
Roles of Polysaccharide Gums in the Food and Beverage Industries: A Review Abdulrazaq, Opeyemi Olabode; Olabode, Ponmile Akeem; Obunadike, Chizoba Victory; Ogunsanmi, Ayomide Oluwaseyi; Muhammed, Zahradeen; Lawal, Isah Abdulshakur; Yakubu, Yussif Yunusah
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.16001

Abstract

Polysaccharides have been used in the food business for a variety of beneficial purposes over the years. The food and beverage businesses must satisfy customer demands while using natural components that perform their technological functions in processed foods. This puts them in increasingly difficult situations. Polysaccharides have numerous useful food uses as stabilizers, thickening agents, and emulsifiers that could be used as additives in the relevant food sectors. In the context of food industry innovation, this review discusses understanding regarding the functions and uses of polysaccharide gums.
Identifikasi Gugus Fungsi Senyawa Hasil Ekstraksi Limbah Kulit Batang Sagu (Metroxylon sagu Rottb L.) dengan Deep Eutectic Solvents Oksalin Menggunakan Spektroskopi FT-IR Hamdani, Ulfah Zakiyah; Mustawinar, Besse Helmi; Yanti, Rosmalah; Hamdani, Nurul Fuady Adhalia
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.23252

Abstract

FT-IR spectrum analysis of sago bark waste extract (Metroxylon sagu Rottb L.) which was extracted using deep eutectic solvents (DES) Choline Chloride-Oxalic Acid (Oxaline) has been conducted. DES synthesis was carried out by stirring a number of constituent masses according to the molar ratio at 600 rpm while heating at 60°C. The variation in the molar ratio of DES Oxaline constituents applied were 1:1; 1:1.5; 1:2 and 1:4. Extraction of sago bark waste was carried out by 30 minutes sonication of sago bark waste powder with DES Oxaline solvent at 50W. The sonication results were then centrifuged at 4000 rpm for 35 minutes. The residue was obtained from centrifuge filtration using 1μm filter paper. The synthesized DES Oxaline and its residues were analyzed using FT-IR spectrometry. DES Oxaline which was successfully synthesized were molar ratios of 1:1; 1:1.5 and 1:2. The yield of sago bark waste extracted were 66%; 66% and 62% for 1:1 molar ratio; 1:1.5 and 1:2 respectively. FT-IR spectrum analysis showed that the functional groups of Choline Chloride and Oxalic Acid are depicted in the IR spectrum of Oxaline DES. The residue spectrum analysis stated that the majority of functional groups were representative of lignin.
Isolasi, Karakterisasi dan Uji Daya Hambat Mikroba Endofit Tanaman Lidah Mertua (Sansevieria trifasciata) terhadap Bakteri Escherichia Coli dan Staphylococcus Aureus Pakaya, Mahdalena Sy.; Abas, Siti Nur Rahmatiya; Thomas, Nur Ain
Jambura Journal of Chemistry Vol 7, No 1 (2025): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i1.12436

Abstract

Mikroba endofit merupakan mikroorganisme yang hidup pada jaringan tanaman tanpa merusak atau mengganggu kelangsungan hidup dari tanaman tersebut. Selain dapat membantu proses metabolisme, mikroba endofit juga dapat menghasilkan senyawa metabolit sekunder yang sama seperti inangnya. Penelitian ini bertujuan untuk mengisolasi mikroba endofit yang terdapat pada tanaman lidah mertua (Sansevieria trifasciata) dan menguji daya hambat mikroba endofit tersebut terhadap bakteri patogen Escherichia coli dan Staphylococcus aureus. Metode yang digunakan pada tahap isolasi adalah metode tanam langsung sehingga dapat terlihat jelas mikroba endofit yang keluar dari jaringan tumbuhan; tahap karakterisasi secara makroskopik dan mikroskopik; tahap uji daya hambat menggunakan metode difusi cakram (Kirby-Bauer). Jumlah mikroba yang berhasil diisolasi sebanyak 4 isolat; A1 dan A2 (isolat bakteri), B1 dan B2 (isolat jamur). Berdasarkan hasil karakterisasi secara makroskopik dan mikroskopis, keempat mikroba tersebut menunjukkan karakteristik yang berbeda. Hasil uji daya hambat berdasarkan diameter zona bening menunjukkan rata-rata zona hambat dengan kategori lemah-sedang terhadap kedua bakteri patogen. Hasil uji daya hambat oleh mirkoba endofit terhadap kedua bakteri patogen dianalisis secara One Way Anova dengan taraf kepercayaan 99% (α=0,01). Hasil analisis data menujukkan bahwa kedua bakteri patogen Escherichia coli dan Staphylococcus aureus sama-sama dapat dihambat pertumbuhannya oleh mikroba endofit dengan karena p=0,704 (sig.a).
Fermentasi Jerami Padi Dengan Berbagai Probiotik Terhadap Kandungan Selulosa, Hemiselulosa Dan Lignin Bahri, Syamsul
Jambura Journal of Chemistry Vol 7, No 1 (2025): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i1.20502

Abstract

ABSTRACT Utilization of rice straw is one way of addressing the demand for ruminant feed, and requires management before it is used for livestock through suffering. This study aims to determine the content of cellulose, hemicellulose and lignin fermented rice straw with various probiotics This research aimed to determine the contents of cellulose, hemicellulose, and lignin in rice straw fermented with various probiotics. It employed a completely randomized design (CRD) with five treatments and three replications. The treatments consisted of: PO = 90% rice straw + 10% concentrate, P1 = 90% rice straw + 10% concentrate + Bio EM+ probiotic, P2 = 90% rice straw + 10% concentrate + starbio probiotic, P3 = 90% rice straw + 10% concentrate + win prob probiotic, P4 = 90% rice straw + 10% concentrate + a combination of probiotics (Bio EM+, starbio and win prob). Furthermore, the parameters measured were the contents of cellulose, hemicellulose, and lignin. The findings depicted that the treatment had a highly significant effect (P
Analisis Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Batang Alpukat Mentega (Persea Americana Mill) Chusnah, Hudallil; Hafshah, Mutista
Jambura Journal of Chemistry Vol 7, No 1 (2025): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i1.21182

Abstract

Lack of physical activity, fast food products, and increased stress due to work pressures are all dangers that might induce unnoticed changes in the body that can lead to degenerative diseases. The existence of free radicals, which can cause cancer and damage cells in the body, might trigger the emergence of degenerative disorders. Antioxidants can help to prevent degenerative disorders caused by the presence of free radicals. The purpose of this study is to investigate the yield percentage, secondary metabolite chemicals, and the IC50 value of the antioxidant activity of butter avocado stem bark (Persea americana Mill). The maceration method is used in the extraction of avocado butter bark. The obtained extraction results give as much as. Flavonoids, tannins, saponins, and alkaloids are among the secondary metabolites found in butter avocado stem bark. The antioxidant activity was then determined using the DPPH (2,2-diphenyl-1-picryhidrazil) technique. The ethanol extract of avocado butter stem bark exhibited an IC50 value of 137.81 ppm, indicating that it was a natural product with moderate antioxidant activity that may be exploited as a natural antioxidant source.

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