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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Hubungan Kepatuhan Mengkonsumsi Tablet Fe dengan Kejadian Anemia pada Ibu Hamil di Puskesmas Karang Pule 2019 Baiq Nurbaety; Nopitasari B. L.; Pamungkas C. E.
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.769

Abstract

Anemia is a problem experienced by 38.2% of pregnant women in the world in 2011. The prevalence of anemia in pregnant women in Indonesia is 37.1%. Provision of iron (Fe) tablets in the city of Mataram is still low compared to other districts in NTB where not all pregnant women get iron (Fe) tablets as many as 90 tablets (91.5%). The prevalence of pregnant women with the most anemia in 2018 is 117 people in Karang Pule Primary Health Center. This study aims to correlate the level of compliance with iron (Fe) tablets consumption with anemia in pregnant women at Karang Pule Health Center. This study used an analytic observational method with a cross sectional approach in June-August 2019. The data collected were respondents' characteristics, level of compliance using MMAS-8 questionnaires and measurement of hemoglobin levels. The research subjects were pregnant women in the working area of Karang Pule Primary Health Center who had obtained iron (Fe) tablets with 110 respondents. The data analysis used chi square test (P = 95%). Anemia occurred in 105 respondents (65.6%) and those without anemia were 55 respondents (34.4%). The level of compliance of respondents consuming Fe tablets was 24.4% with high adherence, 47.5% with moderate adherence and 28.1% with low adherence. Chi square test showed that there was no relationship between adherence to consume Fe tablets with anemia in pregnant women with a asyimp sig of 0.577.
Peningkatan Laju Pelarutan Celecoxib Menggunakan Dispersi Padat dengan Polimer HPMC yang Dikombinasi PVP dan PEG 6000 Danang Novianto Wibowo; Anita Sukmawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.887

Abstract

Celecoxib has poor solubility and categorized as Biopharmaceutical Classification System (BCS) class II drug therefore, it prepared into the solid dispersion system in order to enhance drug solubility. This study aims to determine physical characteristic and the dissolution rate of celecoxib in solid dispersion systems using Hydroxypropyl methylcellulose (HPMC) polymers combined with polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG) 6000. Celecoxib solid dispersions (CSDs) were prepared with HPMC-PVP in ratio of 1:2 and 2:1 and HPMC-PEG 6000 in ratio 1:2 and 2:1. The dissolution rate of CSDs were evaluated using dissolution method and physical characteristics were evaluated using the X-ray Powder Diffraction (XRPD). The result showed that the CSD containing HPMC-PVP 1:2 as a matrix had the highest dissolution rate (0.808 mg/cm2/minute). The dissolution rate was higher than pure celecoxib (0.400 mg / cm2 / minute). The characterisation of the crystalline degree of celecoxib solid dispersions (CSDs) using the X-ray Diffraction showed a decrease in the peak intensity of the interferance of the crystalline phase. The solid dispersion system using HPMC-PVP 1:2 could enhance the rate of dissolution of celecoxib twice highest than pure celecoxib. The highest dissolution rate value was found in celecoxib solid dispersion with 1:2 HPMC-PVP as a matrix.
Pengaruh Konsentrasi Fraksi Etil Asetat Bangle Terhadap Nilai SPF Krim Ekstrak Temugiring Anisa Lailatusy Syarifah; Andini Andini; Haritsah Alfad
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1214

Abstract

The concentration of bangle (Zingiber cassumunar) ethyl acetate fraction added in the formulation of the temugiring (Curcuma heyneana) extract cream formulation must be determined precisely since it may affect the Sun Protection Factor (SPF) value. This research aims to determine the effect of concentration variations of bangle ethyl acetate fraction on the SPF value of the temugiring extract cream. In this research, temugiring extract and bangle extract were obtained by remaceration employing ethanol, while the bangle ethyl acetate fraction was obtained by fractionation using n-hexane, ethyl acetate, methanol, and water. The bangle ethyl acetate fraction obtained was formulated in cream formulations of temugiring extract formulas 1, 2, and 3 with variations in the concentration of bangle ethyl acetate fraction 2%; 3%; and 4%. Furthermore, the SPF value was conducted using the UV-Vis spectrophotometry method. The results show that bangle ethyl acetate fraction concentration variations produced different SPF values for each cream formula. The SPF value for formulas 1, 2, and 3 was 11.466; 12.122; and 17.266. One Way ANOVA test produced a p-value of 0.037. Thus, it can be concluded that the concentration of the bangle ethyl acetate fraction would affect the SPF value in the cream temugiring extract.
Aktivitas Anti-Acne Daun Turi (Sesbania grandiflora (L.) Poir.) terhadap Propionibacterium acne Alvi Kusuma Wardani; Anna Pradiningsih; Nurul Qiyaam; Shah Iqbal Ikraman Akbar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1086

Abstract

Turi (Sesbania grandiflora (L.) Poir.) is a native Indonesian plant with many benefits. One of the benefits of Turi leaves is that they can be used as antibacterial agents. Turi leaves contain several compounds with antibacterial bioactivity including tannins, flavonoids, and saponins. This study aimed to examine the activity of Turi leaf extracts against Propionibacterium acne, a bacterium that causes acne. Antibacterial activity testing was performed using the good diffusion method with three replicates. The test groups were X1, X2, and X3, which had extract concentrations of 5%, 7.5%, and 10%, respectively. The positive control group was treated with clindamycin disks. The results of measurements of the diameter of the inhibition zone showed that the mean for groups X1, X2, and X3 were 19.67 mm, 22 mm, and 23.67 mm, respectively. The positive control group was 37 mm. Based on the classifi cation of bacterial growth inhibition responses, the results of the inhibition zone diameter after deducting the good diameter × 10 mm were classifi ed as less eff ective for group X1 and weak for groups X2 and X3. The positive control group was classifi ed as strong. This study concluded that the antiacne activity of Turi leaf extracts at a concentration of less than 10% was weak when compared to the positive control.
Aktivitas Antimikroba Sabun Antiseptik Bunga Eceng Gondok (Eichhornia crassipes) dengan Basis Minyak Jelantah Nangsih Sulastri Slamet; Fihrina Mohamad; Hartati Hartati; Fadli Husain; Zulfiayu Sapiun
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1078

Abstract

Water hyacinth flowers (Eichhornia crassipes) contain antibacterial phenols, flavonoids, alkaloids, tannins, terpenoids, sterols, and glycosides that can be made into antiseptic soaps. Used cooking oil purifi ed with banana peel can be used to make soap. This study aimed to determine how to process used cooking oil, formulate and test antimicrobial antiseptic soaps using water hyacinth flower extract. The method uses antiseptic soap formulated with 10%, 15%, and 20% water hyacinth infusion. Physical, chemical, irritation, and antibacterial testing of the preparation. Used cooking oil is refined and clear, not thick. Water hyacinth flower extract can be formulated into antiseptic soap with a 1.5 cm foam height, cleaning power in criteria 3, pH in the range 9-10, water content >15%, and free alkali content of 0.6- 1.3%. Formula A (19.17 mm), B (20.01 mm), and C have strong antibacterial activity against E. coli based on the diameter of the barrier (20.13 mm). Water hyacinth flower extract and used cooking oil can be used to make antimicrobial antiseptic soap.
Penentuan Kurva Pertumbuhan dan Aktivitas Antibakteri dari Isolat Ekstrak Etil Asetat Bakteri (Te.325) terhadap Staphylococcus aureus dan Escherichia coli Alfian Syarifuddin; Ratna Wijayatri; Ichsan Feri Kurniawan; Herma Fanani Agusta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1079

Abstract

The development of infection cases and inappropriate use of antibiotics has led to cases of antibiotic resistance. An alternative to overcoming the many antibiotics that are already resistant to bacteria has led to the discovery of new antibiotics. One of the processes of discovering antibiotics is from microorganisms, namely bacteria. The exploration process for the discovery of antibiotics uses a bacterial growth phase approach, namely the stationary phase which produces secondary metabolites, one of, which are bacteria that contain antibiotic compounds. Te.325 isolate is a producer of bacterial antibiotics but The growth phase is not yet known and can be used to approach the process of obtaining antibiotics. The study was to obtain the growth phase time of the Te.325 isolate and to extract antibiotic compounds from the isolate. The determination of the growth curve is based on the weight of cell biomass and the absorbance value on UV/ Vis spectrophotometry of the culture sampled every day for 14 days of culture incubation. The results showed a log/exponential phase on 5th day and a stationary phase on 9th day. The activity test of the ethyl acetate extract was carried out using the well method with an extract concentration of 40%, which resulted in an average diameter of 8.04mm in Staphylococcus aureus and 9.035mm in Escherichia coli. The ethyl acetate extract of Te.325 has medium potency.
Formulasi Sediaan Pelembab Ekstrak Buah Melon Orange (Cucumis melo L. var. reticulatus) Dalam Bentuk Krim Mellisa Laura Mintoro; Farida Lanawati Darsono; Sumi Wijaya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1164

Abstract

Environmental factors such as extreme sunlight may disrupt skin’s moisture balance and cause the skin to dry out. Therefore, skincare products such as moisturisers are highly needed. In this study, orange melon (Cucumis melo L. var. reticulatus) was added to increase the value of the moisturiser product. Orange melon contains sucrose as the moisturising substance and antioxidant substance which helps to normalize the skin. The extraction process was carried out using juicer. The fruit extract was used at 10% (FI), 20% (FII), and 30% (FIII). This study aims to know the impact of increasing orange melon extract concentration on the physical characteristics of cream and its moisturising effect and antioxidant activity as well as the best formula. The evaluations consisted of physical characteristics, moisturising effect, and antioxidant test with DPPH method. The statistical results showed that the increase in extract concentration significantly affect the physical characteristics (pH, viscosity, spreadibility, ease of removal, adhesivity) and moisturising effect of the creams. Increasing extract concentration would cause a significant increase in the moisturising effect of creams containing synthetic humectants. The best formula which fulfilled the requirements of physical characteristics and effectiveness test, while possessing antioxidant effect was F2 (20% orange melon extract).
Analisis Natrium Siklamat pada Kue Telur Gabus yang Beredar di Pasar Ir Soekarno Sukoharjo Ronal Tolkhah; Makhabbah Jamilatun; Dewi Saraswati Fadhillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1225

Abstract

Cork egg cake is a traditional cake famous for its sweet taste. Sodium cyclamate is a sweetener that is added to snacks, one of which is cork egg cake. Excess sodium cyclamates can trigger cancer development. The Head of the National Food and Drug Agency of the Republic of Indonesia issued regulation number 4 of 2014 concerning the maximum limit for the use of food additives. The sweetener in the snack food category was 250 mg/kg. This study was conducted to determine the level of sodium cyclamate in cork egg cakes circulating in Ir. Soekarno Sukoharjo market. The type of research was quantitative with a descriptive research design. The method used in this research was qualitative analysis using the precipitation method and quantitative analysis using UV-Vis spectrophotometry. Qualitative analysis showed that samples B and C were positive for sodium cyclamate. The results of the quantitative analysis showed that the average levels of sodium cyclamate in cork egg cakes B and C were 1.02 mg/kg and 1.03 mg/kg. The concentrations of the two samples were still below the limit requirements of BPOM No. 4 in 2014.
Analisis Efektivitas Biaya Seftriakson sebagai Antibiotik Profilaksis Pada Seksio Sesarea: Dosis Tunggal Versus Dosis Berulang Bayu Pertiwi; Hesty Utami Ramadaniati; Prih Sarnianto; Dwirani Amelia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1084

Abstract

The provision of single-dose prophylactic antibiotics within 30 to 60 minutes before caesarean has been highly recommended, yet its implementation in hospitals varies considerably. This research aimed to analyze the cost-effectiveness of prophylactic antibiotics given a single dose versus multiple doses during caesarean section surgery. A retrospective observational study with a crosssectional design involved pregnant women undergoing caesarean section and receiving a ceftriaxone single dose before surgery (Group 1) versus those receiving multiple ceftriaxone doses (Group 2). The study calculated direct medical costs (hospital perspective), with surgical site infection (SSI) as the effectiveness parameter. The chi-square test was used to compare SSI between the two groups. There were 806 patients (group 1) and A total of 250 patients (Group 2) met the inclusion criteria. Analysis of total cost revealed no significant difference between both groups (approximately IDR 13,000,000/patient), yet patients receiving prolonged Ceftriaxone were associated with significantly higher antibiotic costs (p-0.000). The study documented 1.2% SSI in Group 1 and 0.8% in Group 2 (p=0.742). Calculation of the incremental cost-effectiveness ratio found that an extra IDR 3,278,000 was needed to provide additional success to prevent SSI by administering multiple doses of ceftriaxone. In conclusion, a single dose prophylactic antibiotic provides comparable efficacy to a multiple-dose regimen, but at a lower cost.
Optimalisasi Produksi Fikosianin pada Sianobakteria Laut BTM 11 dan Uji Aktivitas Antioksidannya Baso Didik Hikmawan; Swastika Praharyawan; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1198

Abstract

Phycocyanin (PC)-producing cyanobacteria has shown many pharmaceutical applications, the main one is the antioxidant properties. Biosynthesis of PC-producing cyanobacteria is affected by many factors like nitrogen availability and light intensity during cultivation. This study aims to analyze the optimum concentration of nitrogen and light intensity during the cultivation of PC biosynthesis of marine cyanobacteria BTM 11 and identify its antioxidant properties This study was an experimental laboratory method and the PC level was determined through the variation of sodium nitrate (NaNO3) as a source of nitrogen dissolved in media and using different light intensities. The most optimum nitrogen and light intensity values of PC were measured by its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical capture method. Data was analyzed by one-way ANOVA and the post-hoc Duncan to see whether p<0.05. The result showed that there was a significant difference in the PC level that was cultivated with the variation of NaNO3 concentrations. The highest PC level was observed in media containing 525 mg of NaNO3 and the optimum light intensity of 4500 lux. The result of the antioxidant activity assay showed that the BTM11’s PC’s antioxidant activity had its IC50 at 91.89 μg/mL and the IC50 of ascorbic acid was 2.39 μg/mL

Page 55 of 73 | Total Record : 721

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