cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Syafira Dwi Cahyani
Contact Email
adminjifi@univpancasila.ac.id
Phone
+6287780957284
Journal Mail Official
syafira.ffup@univpancasila.ac.id
Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
 59   60   61   62   63 
Penentuan Kadar Flavonoid dan Aktivitas Anti-Inflamasi Ekstrak Dan Fraksi Daun Sungkai (Peronema canescens Jack) Aulena, Desi Nadya; Yani, Dwi Fitri; Mariyamah, Mariyamah; Tondi, Muhammad Lufika; Dandi, Muhammad; Wahyudin, Hafis Kiki; Raihan, Dany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1437

Abstract

The SARS-CoV-2 virus is the infectious agent that causes COVID-19, a feverish condition brought on by inflammation in the infected patient’s body. Sungkai leaf (Peronema canescens Jack) is one of the Indonesian people who rely on herbal remedies to treat COVID-19. This study aims to determine how much flavonoids are present in ethanol, ethyl acetate, and n-hexane extracts, as well as the anti-inflammatory properties of ethanol extract, ethanol fraction, and n-hexane fraction of Sungkai leaves. The procedure was performed in-vitro with a UV-Visible spectrophotometer by observing the absorption response to inhibition of denaturation of inflammatory protein. The inhibition value was then computed via linear regression, and the IC50 and IC70 values were ascertained afterward. The ethanol fraction, ethanol extract, and n-hexane fraction in this investigation had the best inhibition values (%) at a concentration of 15 ppm, corresponding to 74.27%, 54.48%, and 18.52%. The sungkai leaves ethanol fraction > n-hexane fraction > ethanol extract had the best IC50 and IC70 values. Comparatively, the ethanol extract contained the largest amounts of flavonoids, 38.782 μg/mL.
Sifat Fisika dan Kimia, Indeks Iritasi dan Aktivitas Anti-inflamasi dari Salep Minyak Atsiri Syzygium aromaticum dengan Penambahan Enhancer Alfian, Muhammad; Sugihartini, Nining; Yuliani, Sapto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1385

Abstract

This research aimed to evaluate how enhancers affect the properties of Syzygium aromaticum oil in both water-soluble and hydrocarbon bases. Physical and chemical characteristic tests, irritation index evaluations, and anti-inflammatory activity assessments were carried out to analyze the Syzygium aromaticum oil ointment. The pH tests were conducted to measure the chemical characteristics and viscosity, adhesivity, spreadability tests were conducted to measure the physical characteristics of the ointment. Rabbit-based tests were used to determine the irritation index, mice induced by crotton oil were used in anti-inflammatory activity assessments. The pH tests revealed no significant differences between both of ointments. The ointment in the water-soluble base had higher viscosity and adhesivity but lower spreadability than the ointment in the hydrocarbon base. The epidermis thickness of watersoluble and hydrocarbon-based ointments was 3.81±0.40 μm and 4.22±0.15 μm, while the number of cells with COX-2 expression was 18.24±6.51 and 21.01±5.96. The addition of enhancers did not cause any irritation in either ointment. The study concluded that the formula of Syzygium aromaticum oil in a water-soluble ointment with the addition of propylene glycol and oleic acid (70:30) as enhancers provided better physical and chemical characteristics, a lower irritation index, and higher anti-inflammatory activity compared to the hydrocarbon.
Formulasi Nanosuspensi Herbal Ekstrak Daun Cosmos caudatus Kunth., Karakterisasi, dan Pendekatan Sitotoksisitas Terhadap Sel Kanker Payudara MCF-7 Nafisa, Safira; Noor, Siti Umrah; Azkannufuus, Azkannufuus; Noviani, Yuslia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1481

Abstract

Kenikir leaves (Cosmos caudatus Kunth.) contain quercetin, which has anticancer properties. To provide more effective complementary therapy for breast cancer, nanotechnology was applied to develop preparations containing kenikir leaf extract. This research aimed to formulate a nanosuspension containing kenikir leaf extract with cytotoxic activity against MCF-7 breast cancer cells. Nanosuspension of kenikir leaf extract was prepared using the ionic gelation method with 3%, 4%, and 5% PVP K-30 stabilizer. The nanosuspension formula with the highest entrapment efficiency was further characterised, including particle size, polydispersity index (PDI), zeta potential, pH, and particle morphology. Cytotoxic activity was tested against MCF-7 cells by the MTT assay. The results showed that the formula with 5% PVP has the highest entrapment efficiency value of 85.04±0.08%, a particle size of 221.9 nm, a PDI of 0.211, a zeta potential of -21.7 mV, a pH of 4.08±0.0, and a spherical morphology. The kenikir leaf extract at a concentration of 1 mg/mL inhibited the proliferation of MCF-7 cells by 23.4% (p<0.05), whereas the nanosuspension at 10 μg/mL inhibited proliferation by 23.7%. It can be concluded that kenikir leaf extract can be formulated into a nanosuspension that meets the physical criteria and has cytotoxic activity against MCF-7 cells.
Post-Market in vitro bioequivalence study of innovator and generic Gefitinib tablets: evaluation of JKN medicine quality Nurhayati, Fitri; Anggriani, Yusi; Syahruddin, Elisna; Andalucia, Rizka; Ath-Thobari, Jarir; Mulatsari, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1593

Abstract

Gefitinib is one of Tyrosine Kinase Inhibitors (TKIs), as first line therapy for Non-Small Cell Lung Cancer (NSCLC) with positive EGFR mutation. Gefitinib started to be accommodated in Jaminan Kesehatan Nasional (JKN) insurance in 2015 with the innovator gefitinib and was replaced by a generic product in middle of 2021. This research was conducted to see whether the quality of generic gefitinib equivalent to the innovator through post-market in vitro bioequivalence test. Assay method refers to previous research by Sandhya et al 2013 wih High Performance Liquid Chromatography (HPLC), while the dissolution test method is in accordance with the Food and Drug Association (FDA) 2010. We collected innovator from the official distributor and 3 batches (all batches that have been used in JKN program) of generic product from hospitals where lung cancer therapy services were provided. We evaluated the dissolution profile with similarity and unsimilarity factors and assess based on standard specification of dissolution profile that informed in innovator’s BPOM-approved brochure (avarage of 6 samples > 85% and no individual result < 75% at 45 minutes). The assay results met the requirements of ± 5% of what is stated on the label. Although dissolution profile of generic and innovator were not equal through difference and similarity factors calculation, but one batch of generics met dissolution profile standard of innovator. So, both generic and innovator drug met the standards of assay and dissolution, even though the dissolution profile were not equivalent.
Optimization of sodium starch glycolate and maltodextrin in chlorpheniramine maleate Fast Disintegrating Tablet (FDT) by factorial design Sutristio, Kezia Livianthi Kirana Budhi; Lestari, Agatha Budi Susiana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1493

Abstract

Chlorpheniramine maleate (CTM) is an antihistamine that is widely available on the market in tablet form. It needs to be formulated in the form of Fast Disintegrating Tablets (FDT) to produce a faster therapeutic effect to treat allergy symptoms, which are often irritating. The FDT contains a super disintegrant to regulate the disintegration speed of tablet and a binder to provide the ability to bind between powders. This research was conducted to obtain the effect of Sodium Starch Glycolate (SSG) as a super disintegrant and maltodextrin as a binder, and their interaction in the chlorpheniramine maleate tablet formulation. This research was categorized as true experimental designs with FDT quality parameters such as organoleptic, hardness, friability, disintegration time, wetting time, water absorption ratio, and content uniformity. The optimization method used is factorial design. Data analysis was performed using Analysis of Variance (ANOVA). Based on the data, it conclude that Sodium Starch glycolate (SSG) affects increasing hardness, increasing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. Maltodextrin, has the effect of increasing hardness, reducing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. The interaction of SSG and maltodextrin has the effect of reducing hardness, increasing friability, shortening disintegration time, shortening wetting time, and increasing the water absorption ratio.
Toxicity of Sida rhombifolia L. 96% ethanol extract based on LD50 and macropathological examination of mice's organs Aulena, Desi Nadya; Kumala, Shirly; Abdillah, Syamsudin; Rahmat, Deni; Zaidan, Sarah; Fitriyani, Dwi; Raihan, Dany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1463

Abstract

The Indonesian people empirically use Sidaguri (Sida rhombifolia L.) in medicine, such as anti-hyperuricemia. Herbal-based treatment is currently much preferred. Drug metabolism, in general, mainly occurs in the liver, so the possibility of damage to this organ is high. This study aims to determine the acute toxicity category of 96% ethanol extract of sidaguri based on the LD50 value, changes in body weight, changes in organ weight, and macro pathology in the organs of male DDY mice in vivo. The method used in this research was experimental with a fixed dose design following the Indonesian Food and Drug Authority regulations regarding guidelines for in vivo non-clinical toxicity tests. The test group was divided into six dose groups (standard, 50, 300, 2000, 5000, and 15000 mg/kg Body of weight). Observations were made for 24 hours. Observations were continued for 14 days on death parameters, toxicity symptoms, body weight, and relative organ weights using five main organs (heart, lungs, liver, spleen, and kidneys, and pathological examination). The acute toxicity test results showed no death in all dose treatment groups. Macropathological analysis did not show abnormalities in organs in all groups of mice. LD50 value is more than 15000 mg/kg. Sidaguri 96% ethanol extract is safe and Practically non-toxic.
Public perception of COVID-19 vaccination in Banjar District, Indonesia: the role of sociodemographic factors Mardiati, Nurul; Mersa, Lina; Torizellia, Cast
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1565

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2) virus. Vaccination is one way to prevent the spread of the COVID-19 virus. One of the factors causing the low acceptance of COVID-19 vaccination in the community is the perception of COVID-19 vaccination. Socio-demographic factors such as age, gender, occupation, last degree of education, and monthly income have a substantial relationship with public perceptions of COVID-19 vaccination. The purpose of this study was to analyze public perceptions of COVID-19 vaccination. This study used an analytical observational method with a cross-sectional study design. The sample in this study used a consecutive sampling technique, totaling 400 people. The majority of respondents had a enough good perception of COVID-19 vaccination. There is a relationship between socio-demographic factors of age, occupation, last degree of education, and monthly income with people's perceptions of COVID-19.
Ionic liquid-based ultrasound-assisted extraction: a novel insights of green extraction techniques for bioactive compounds from herbal plants Aziz, Fiq'rah Lestari; Lukmanto, Donny; Iswandana, Raditya; Mu'nim, Abdul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1531

Abstract

The ionic liquid-based ultrasound-assisted extraction (ILUAE) is a non-conventional environmentally friendly extraction method. ILUAE is considered as green chemistry since ILUAE utilize ionic liquids as solvents and ultrasound-assisted extraction to extract bioactive chemicals from herbal plants. The growing popularity of ILUAE as preferred extraction method in herbal medicine is not only due to its sustainable, eco-friendly characteristics but also its improvement in extraction efficiency while maintaining the quality of extracted products. Here, we discussed and reviewed ILUAE as preferred extraction method for herbal medicines. Through discussing ILUAE’s potential, advantage against traditional extraction technique, and summarized the successful extraction of bioactive components from various herbal plants using ILUAE, we hope to showcase the technology's efficiency, selectivity, and sustainability. Finally, we discussed current limitations and future challenge for ILUAE and potential ways to address these challenges.
Evaluation of anti-acne gel of Piper crocatum leaves ethanolic extract against Propionibacterium acnes Mendra, Ni Nyoman Yudianti; Givanda, Jesi Dyah Ayu; Putra, Made Agus Sunadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1564

Abstract

The red betel leaf (Piper crocatum) exhibited antibacterial properties by inhibiting Propionibacterium acnes, known for causing acne. The study aimed to develop an anti-acne gel formulation using Piper crocatum leaves ethanolic extract and to evaluate its antibacterial efficacy against Propionibacterium acnes. The extract was formulated into three gel formulas, with concentrations of 15%, 20%, and 25%, respectively. Antibacterial activity was evaluated using the agar well diffusion method, with Clindamycin gel as the positive control. The inhibition diameter were analyzed statistically using One Way ANOVA and Post Hoc LSD tests at a 95% confidence level. The result showed that the gel met the physical test requirements. The inhibition zone of the samples was observed with an inhibition diameter of 7.98 mm, 8.06 mm, and 8.16 mm for 15%, 20%, and 30% extract of gel, respectively, compared to the positive control 27.60 mm (p < 0,05). The research findings indicate that anti-acne gel of Piper crocatum leaves ethanolic extract exhibit moderate antibacterial activity in an in vitro setting. Statistically significant differences in inhibition diameters were observed between each gel sample and positive control.
Antimicrobial activity and phytochemicals compound profile of ethanol extract Moringa leaf (Moringa oleifera) compounds by FTIR Ningsih, Arista Wahyu; Safıra, Aulia Dinda; Giovano, Andre; S.Klau, Ivan Charles
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1231

Abstract

Moringa plants are known in various parts of the world as a type of vegetable plant that is rich in nutrients and has multiple properties, one of which is as an antimicrobial. This research was conducted to test the antimicrobial inhibition of Moringa leaf decoction and ethanol extract against the growth of Escherichia coli and Aspergillus niger. The antimicrobial test in this study used the Disc diffusion method using various concentrations, including 25%, 50%, 75%, and 100%. There were two test samples, Moringa leaf decoction and ethanol extract using the maceration method with 96% ethanol solvent. In addition to the test group, there was also a control group, namely a positive control using chloramphenicol and ketoconazole antibiotics, negative control using aquadest as a decoction solvent, and DMSO as an extraction solvent. The ethanol extract was identified by the FTIR method. The results showed that Moringa leaf decoction and Moringa leaf ethanol extract could be used as antibacterial. Inhibition zones on Escherichia coli bacteria produced at concentrations of 25%, 50%, and 75% had a weak zone of inhibition category for both decoction and ethanol extract of Moringa leaves. Meanwhile, at a concentration of 100%, the decoction has a weak zone of inhibition and 100% ethanol extract of Moringa leaves can inhibit 8.25 mm which is included in the medium category. The inhibition zones of the fungus Aspergillus niger produced at concentrations of 25%, 50%, 75%, and 100% had no inhibition on both the decoction and ethanol extract of Moringa leaves. From the analysis of functional groups using the FTIR method, it can be predicted that in the Moringa leaf extract with methanol as solvent there are groups of phenolic compounds or flavonoids.

Page 61 of 68 | Total Record : 680

 59   60   61   62   63 

Filter by Year

2003 2025


Reset
Filter By Issues
All Issue Vol 23 No 2 (2025): JIFI Vol 23 No 1 (2025): JIFI Vol 22 No 2 (2024): JIFI Vol 22 No 1 (2024): JIFI Vol 21 No 2 (2023): JIFI Vol 21 No 1 (2023): JIFI Vol 20 No 2 (2022): JIFI Vol 20 No 1 (2022): JIFI Vol 19 No 2 (2021): JIFI Vol 19 No 1 (2021): JIFI Vol 18 No 2 (2020): JIFI Vol 18 No 1 (2020): JIFI Vol 17 No 2 (2019): JIFI Vol 17 No 1 (2019): JIFI Vol 16 No 2 (2018): JIFI Vol 16 No 1 (2018): JIFI Vol 15 No 2 (2017): JIFI Vol 15 No 1 (2017): JIFI Vol 14 No 2 (2016): JIFI Vol 14 No 1 (2016): JIFI Vol 13 No 2 (2015): JIFI Vol 13 No 1 (2015): JIFI Vol 12 No 2 (2014): JIFI Vol 12 No 1 (2014): JIFI Vol 11 No 2 (2013): JIFI Vol 11 No 1 (2013): JIFI Vol 10 No 2 (2012): JIFI Vol 10 No 1 (2012): JIFI Vol 9 No 2 (2011): JIFI Vol 9 No 1 (2011): JIFI Vol 8 No 2 (2010): JIFI Vol 8 No 1 (2010): JIFI Vol 7 No 2 (2009): JIFI Vol 7 No 1 (2009): JIFI Vol 6 No 2 (2008): JIFI Vol 6 No 1 (2008): JIFI Vol 5 No 2 (2007): JIFI Vol 5 No 1 (2007): JIFI Vol 4 No 2 (2006): JIFI Vol 4 No 1 (2006): JIFI Vol 3 No 2 (2005): JIFI Vol 3 No 1 (2005): JIFI Vol 2 No 2 (2004): JIFI Vol 2 No 1 (2004): JIFI Vol 1 No 2 (2003): JIFI Vol 1 No 1 (2003): JIFI More Issue