cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhammad Taupik, M.Sc
Contact Email
muhammad@ung.ac.id
Phone
-
Journal Mail Official
info.jsscr@ung.ac.id
Editorial Address
-
Location
Kota gorontalo,
Gorontalo
INDONESIA
Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 17 Documents
 1   2 
Search results for , issue "Vol 5, No 2 (2023): Volume 5 Edisi 2 2023" : 17 Documents clear
Studi Penjaminan Mutu (Quality Assurance) Internal Dalam Pelayanan Kefarmasian Madania Madania; A. Mu’thi Andy Suryadi; Faramita Hiola; Rahmawati Marjun
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20359

Abstract

Pharmaceutical services in hospitals aim to improve the quality of pharmaceutical services, protect patients from irrational drug use to maintain patient safety, and ensure legal certainty for pharmacists. Quality Assurance (QA) is used in measuring service quality, whereas QA in IFRS aims to provide assurance of product quality and the quality of pharmaceutical services provided to patients. This research employs descriptive research with a cross-sectional method, and primary date are obtained from questionnaires with the framework of QA standard indicators in pharmaceutical services at the primary Installastion of Mother and Child Hospital Kasih Fatimah Kotamobagu, with five respondents. The results indicate that internal quality assurance in pharmaceutical services at the Fatimah Kotamobagu Mother and Child Hospital Kasih Fatimah Kotamobagu Pharmacy Installation was in accordance with quality assurance standards, especially in the aspects of organizational structure, quality measures, and safety assurance, as well as drug distribution with an overall value in the criteria, are (75%), moderately appropriate are (15%) and not appropriate are (10%).
Isolasi, Karakterisasi, dan Uji Antioksidan Fungi Endofit dari Tanaman Batang Kunyit (Curcuma domestica Val.,) Mahdalena Sy. Pakaya; Nur Ain Thomas; Hamsidar Hasan; Ariani H. Hutuba; Grasela Mbae
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20341

Abstract

Endophytic fungi live in mutualistic symbiosis and can produce secondary metabolites similar to their host. This research aims to isolate, characterize, and test the antioxidant activity of secondary metabolites from turmeric stems. This research is experimental research where the method used for endophytic fungi isolation is the direct planting method, and antioxidant activity is tested using qualitative and quantitative methods with DPPH (1.1-diphenyl-2-picylhydrazyl). One fungal isolate was obtained with the fungal isolate code (BK). Based on macroscopic and microscopic characterization, the BK fungal isolate indicates the Deuteromycota class's characteristics. The qualitative antioxidant test results indicate that the fraction of BK endophytic fungal isolate indicates antioxidant activity, indicated by the yellow color against a purple background on the TLC plate observed under visible light. The respective ICso values for the ethyl acetate and n-hexane fractions were 52.989 µg/ml and 89.725 µg/ml, categorized as strong antioxidants. The methanol fraction had an ICso value of 119.02 µg/ml, categorized as moderate, while the pure supernatant fraction had an ICso value of 156.86 µg/ml, categorized as weak antioxidant activity.
Uji Penyembuhan Luka Bakar Gel Enzim Bromelin Menggunakan Carbopol 940 Secara In Vivo Nur Ain Thomas; Muhammad Taupik; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Nabila Novreini Djunaidi
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20364

Abstract

Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in  burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 dengan Obat Antihipertensi Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Juliyanty Akuba; Mimi Fauziah Tahir
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.18042

Abstract

The effect caused by the use of antidiabetic and antihypertensive drugs combination needs to be considered. The treatment therapy of the patient has the potential risk of drug interactions that are beneficial or detrimental to the patient. This study aims to determine the potential drug interactions in combinations of antidiabetic and antihypertensive drugs. This research is a descriptive study with a cross-sectional design and retrospective data collection. The sample used is medical records of diabetes mellitus patients with comorbid hypertension from January to December 2021 at Batudaa Public Health Center, Gorontalo Regency. The results showed that there were more female patients than male patients. Based on this study. there were 49 female patients (70%), while the largest age group of 50-59 years included 29 patients (41,43%). Whereas, those with the highest potential for drug interactions were metformin and amlodipine, totaling 54 patients (77%). The mechanism of interaction in this study was the pharmacodynamic phase, and the potential to cause the effect was hypoglycemic through the severity of the interaction was moderate level. 
Penentuan Kadar Flavonoid Daun Rumput Knop (Hyptis capitata Jacq.) Menggunakan Spektrofotometri UV-Vis Hamsidar Hasan; A. Mu'thi Andy Suryadi; Syamsul Bahri; Ni Luh Widiastuti
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19371

Abstract

Knop grass (Hyptis capitata Jacq.) is a weed used as a tradisional medicine, especially for the leaves. Flavonoids are one of the secondary metabolites contained in the Knop Grass (Hyptis capitata Jacq.) leaves, wich function as anti-inflammatory, analgesic, antipyretic and anti-diabetic. The amount of extracted flavonoids is optimized by choosing the right extraction method, as it will determine the amount of substance that can be attracted and obtain a high content of active substansces. This research aimed to compare the flavonoid levels in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves in two different maceration methods: multilevel maceration and total maceration. Multilevel maceration employed n-hekxane, ethyl acetat and methanol solvents, while total maceration employed methanol solvent. In the meantime, the qualitative analysis in this reaserch used the color reagent test method, whereas the thin layer chromatography used the eluent, namely n-hexane : ethyl acetate with a ratio (7:3). In addition, the quantitative analysis used the UV-Vis spectrophotometry method at a maximum wavelength of 435 nm with standard quercetin as a comparison. The result signified that the average flavonoid level in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves using the multilevel maceration method was 2,9750%. The total maceration method was 4,8822%. Furthermore, the total maceration method donated the highest concentration obtained from the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves.
Skrining Fitokimia dan Uji Antioksidan Ekstrak Daun Cabai Rawit (Capsicum frutescens L.) Esti Febri Fatwami; Sri Royani
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20896

Abstract

Chili is a plant that is widely cultivated in indonesia. Chili leaves are knowon to have many health benefits. This has something to do with the content of secondary metabolites in it. This research was conducted to determine the content of secondary metabolites in chili leaves. The method used was in the form of phytochemical screening and antioxidant activity test using the DPPH method. The identification of the phytochemicals carried out included the identification of alkaloids, flavanoids, saponins, triterpenoids, quinones and phenols. The results of the phytochemical screening showed that the compounds contained in cayenne pepper leaf extract that extracted using 96% alcohol were alkaloids, flavonoids, and phenols. While the antioxidant test results on cayyenne pepper leaf extract showed an IC50 value of 78,03 µg/ml.
Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat Tri Puspita Yuliana; Hasratul Kusuma; Puspawan Hariadi; Baiq Maylinda Gemantari
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19590

Abstract

Acne is a problem caused by Propionibacterium acnes bacteria. Red watermelon rind contains lycopene compounds, antioxidants, has tannin and flavonoid compounds and is very good for skin care, free from acne, functions as an antibacterial. The purpose of this study was to formulate ethanol extract of red watermelon rind into anti-acne cream preparation and determine the inhibition zone and determine the red watermelon rind cream has the best antibacterial activity against Propionibacterium acnes bacteria. The method used in this study was experimental, extract concentration of 15%, 20%, 25%. The antibacterial activity test was conducted using the pitting method and evaluated the physical properties of the cream preparation including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results showed that the evaluation of the physical properties of the cream preparation had characteristics in accordance with the evaluation of the preparation carried out at each concentration, including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results of the antibacterial activity test of ethanol extract of red watermelon rind F1, F2, F3 are: 6.76 mm, 8.33 mm, 8.73 mm. The results of the antibacterial activity test of the cream preparation of ethanol extract of red watermelon rind F1, F2, F3 are: 4.47 mm, 6.04 mm, 8.17 mm. It can be concluded that the cream preparation of ethanol extract of red watermelon rind meets the characteristics of cream preparation stability, meets the criteria of good physical properties at concentrations of 15%, 20%, 25%, has weak to moderate category antibacterial activity against Propionibacterium acnes bacteria.
Article Review : Potensi Antioksidan Ekstrak Batang Bambu Kuning (Bambusa Sp) Sebagai Pencegahan Penyakit Asma Ardilah Ardilah; Ishmah Ulya; Sri Wahyuni; Anggi Aulia Nur Fazri; Mhd. Zaky Daniyal; Panji Ramadhani Panjaitan; Adhika Dwiputri Ilafi; Nurul Adila Damanik
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21005

Abstract

Asthma one of the most common non-communicable diseases in the world characterized by varied as well as recurrent symptoms, airflow obstruction, bronchial hyperresponsiveness, and inflammation. Asthma the most common chronic disease (4,6%), followed by golden and mood disorders (4,1%), attention deficit hyperactivity disorder (3,6%), abdominal pain (2,8%), presence (2,8%), learning disorders (2%), congenital skeletal deformities (1,6%), migraine (1,4%), morbid obesity (1,4%), and autism spectrum disorders (1,1%). Worldwide, it is estimated that around 300 million people are affected by asthma, and by 2025 the number of affected patients is growing exponentially with the addition of 100 million people affected by the condition. With the increase in asthma makes motivation and desire high to seek and find effective first-aid solutions for asthma prevention. So this solution aims to provide first aid in the prevention of asthma. In this article, the idea is given in the form of antioxidant benefits of yellow bamboo stem extract (Bambusa sp) as first aid for the prevention of asthma. Yellow bamboo stems contain antioxidants that are useful for preventing asthma. So it is hoped that this idea will have a good impact on people with asthma and be able to provide first aid for the prevention of asthma.
Isolasi Dan Identifikasi Terpenoid Fraksi Heksan Daun Premna serratifolia L. Menggunakan GC-MS Ricky Midi Candra; Isnindar Isnindar; Sri Luliana
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.15311

Abstract

Buas-buas (Premna serratifolia L.) is a plant that belongs to the Verbenaceae family. Terpenoid compounds that exist in buas-buas plants have bioactivity as medicine. Terpenoid compounds are soluble compounds in n-hexane. The purpose of this study was to isolate and identify the terpenoid compounds contained in the n-hexane fraction of buas-buas leaves using the GC-MS method. The buas-buas leaves were macerated with 96% ethanol solvent and then fractionated using a separating funnel with n-hexane as solvent. The n-hexane fraction of buas-buas leaves was isolated using column chromatography with a gradient mobile phase combination of n-hexane and ethyl acetate, then identified using the GC-MS instrument. The terpenoid compounds found in the n-hexane fraction of buas-buas leaves are estimated to be neophytadiene; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; and 2 hydroxy-4a,5-dimethyl-3-(prop-1-en-2-yl) octahydronaphthalen-1-(2H)-one.
Hubungan Self-Management Pengobatan Terhadap Kadar Gula Darah Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Di Puskesmas Umul Farida; Kumala Sari Poespita D. W; Dianty Putri Millania Paringsih
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20833

Abstract

This study aims to evaluate the relationship between the level of self-management of medication and blood glucose levels in outpatient type 2 diabetes mellitus patients at the Kediri City Health Center. The research falls under the category of quantitative research with an observational study approach, using a cross-sectional design. Diabetes mellitus (DM) is a chronic condition characterized by hyperglycemia and various metabolic abnormalities due to hormonal disorders, which can lead to long-term complications in the eyes, kidneys, nerves, and blood vessels. Data were collected using the DSME Questionnaire (Diabetes Self Management Education) to assess the level of self-management of medication.The results showed that 12 respondents (13.8%) had poor self-management of medication and poor blood glucose control. There were 14 respondents (22.2%) with moderate self-management of medication and uncontrolled blood glucose. Meanwhile, 18 respondents (28.6%) had moderate self-management and blood glucose within the normal range. A total of 31 respondents (49.2%) had moderate self-management and normal blood glucose levels. Only 12 respondents (13.8%) had good self-management and blood glucose within the normal range.The Spearman rank test results indicated a significant relationship between self-management of medication and blood glucose levels in type 2 diabetes mellitus patients. With α = 0.05, the obtained P-value was 0.000, which is smaller than 0.05. Therefore, the alternative hypothesis (H1) is accepted, while the null hypothesis (H0) is rejected. This suggests the presence of a relationship between self-management of medication and blood glucose levels, with a Spearman rank correlation coefficient of 0.598.

Page 1 of 2 | Total Record : 17

 1   2 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol 7, No 3 (2025): Volume 7 Number 3 2025 Vol 7, No 2 (2025): Volume 7 Edisi 2 2025 Vol 7, No 1 (2025): Volume 7 Edisi 1 2025 Vol 6, No 2 (2024): Volume 6 Edisi 2 2024 Vol 5, No 2 (2023): Volume 5 Edisi 2 2023 Vol 5, No 1 (2023): Volume 5 Edisi 1 2023 Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 Vol 4, No 2 (2022): Volume 4 Edisi 2 2022 Vol 4, No 1 (2022): Volume 4 Edisi 1 2022 Vol 3, No 2 (2021): Volume 3 Edisi 2 2021 Vol 3, No 1 (2021): Volume 3 Edisi 1 2021 Vol 2, No 2 (2020): Volume 2 Edisi 2 2020 Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 Vol 2, No 1 (2020): Maret 2020 Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 Vol 1, No 1 (2019): March More Issue