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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 16 Documents
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Search results for , issue "Vol 7 No 2 (2024)" : 16 Documents clear
Pengaruh Cotrimoxazole Terhadap Perkembangan Neural Tube Embrio Ayam Pamuji, Alifia Shafanaura; Fauziah, Cut; Tjang, Yanto Sandy; Thadeus, Maria Selvester
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.190-198

Abstract

Background In Indonesia, congenital abnormalities are still very high. Neural Tube Defect (NTD) is one of the most common congenital abnormalities. NTD occurs due to the failure of neural plate closing. One of the risk factors for NTD is folic acid deficiency. Drug use during pregnancy is one of the risk factors for congenital abnormalities. Cotrimoxazole is an anti-folate drug that still has pros and cons regarding its potential to cause NTD. Human embryonic brain development can be simulated using chicken embryos. This study aimed to determine the effect of Cotrimoxazole on the development of the chicken embryo's neural tube. Methods This study used a post-test-only control group design. The number of samples is 30 eggs and the sampling method was simple random sampling. The dose of Cotrimoxazole used was 0; 60; and 120 mg/kg per egg then the eggs were incubated for 72 hours. Data analysis was based on sample characteristics and bivariate analysis using the comparative Kruskal-Wallis test with the post-hoc test. Results In this study, 11 out of 30 eggs could be analyzed. The results were obtained by observing the number of brain vesicles. There was a significant difference in the number of brain vesicles (p= 0.046) between the study groups from the Kruskal-Wallis test. Conclusions Cotrimoxazole administration showed an effect on neural tube development of chicken embryos when compared to controls.
Analisa Kelelahan Kerja dan Usulan Perbaikan dengan Menggunakan Metode Bourdon Wiersma dan New Seven Tools Devani, Vera; Maypando, Abim Wahyu
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.179-189

Abstract

Background Employees of Public Relations work for 8 hours starting at 08.00-16.00, so it can lead to the work fatigue. Work fatigue is the condition of decreased efficiency and resilience of a person at work. Work fatigue can be caused by internal factors and external factors.The research that will be carried out is to analyze work fatigue and proposed improvements using the Bourdon Wiersma method and the New Seven Tools. Methods The method used to solve the problem is the Bourdon Wiersma method and New Seven Tools, using the Bourdon Wiersma Type Test GBT questionnaire.  The respondents were 8 employees of the Public Relations division who work using computers. The aim of this research is to determine the level of speed, level of accuracy and level of consistency before and after activities, and work fatigue. Data analysis using several tools from New Seventools, namely Relationship Diagrams and Tree Diagrams. Results Based on research, the average fatigue score for speed before work  was found that the average time speed for before work is 9.69 seconds with the value of speed interpretation (value 9, and WS = 14) including group B (Good), for after work was 10.05 seconds with a speed interpretation value (8.5, and WS = 13) including the CB class (Good Enough). The average accuracy for before work is 22.4 seconds with an interpretation accuracy value (value 5, and WS = -) including group R (Doubtful), for after work was 23 with an interpretation accuracy value (value 4.5, and WS = 7) included to group K (less). The average constant for before work was 11.58 with a constant interpretation value (value 5, and WS = -) including group R (Doubtful), for after work was 7.59 seconds with a constant interpretation value (value 5.5, and WS = 8) belongs to group R (Doubtful). Based on the Anova Test, the correlation value on the velocity variable was 0.937 with a very strong correlation level. The correlation value on the accuracy variable was 0.666 with a strong correlation level. The correlation value of the constant variable was 0.797 with a strong correlation level. Conclusions The main cause of fatigue in Public Relations employees is workload. The main cause of burnout in Public Relations employees is workload. The proposed improvement uses a Tree Diagram to reduce fatigue in Public Relations employees.
Pengaruh Pemberian Ekstrak Kecambah Kacang Hijau (Phaseolus Radiatus L.) Terhadap Kadar Katalase Pada Tikus Jantan Galur Wistar Yang Diinduksi Herbisida Paraquat Sundawa, Angga Pria; Trisnasdi, Reza Adityas; Hikmah, Annisa Nurul
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.171-178

Abstract

Background Exposure to herbicide paraquat affects the body's organs of antioxidants that can exceed the capacity of antioxidant enzymes in the human body which causes the production of Reactive Oxygen Species (ROS). cause oxidative stress. This causes the endogenous antioxidants to decrease so prevention requires exogenous antioxidants such as mung bean sprout supplements. The effect of mung bean sprouts can reduce oxidative stress caused by the herbicide paraquat. This study aimed to determine the effect of mung bean sprout extract on catalase levels in male Wistar rats induced with paraquat herbicide. Methods This research is experimental with a posttest-only controlled Group Design. The research subjects were 25 male Wistar rats randomly divided into 5 groups, namely K1, K2, K3, K4, and K5. Groups K3, K4, and K5 were given a green bean sprout extract supplement at 21.6 mg/200 g BW/day, 43.2 mg/200 g BW/day, and 86.4 mg/200 g BW/day. 16 blood samples were taken for examination of catalase levels. Data were analyzed using the Kruskal-Wallis test. Results The mean catalase level was highest in the K1 group compared to the K3, K4, and K5 groups. The results of the Kruskal-Wallis test on catalase levels showed a significant difference between groups (p=0.000). Conclusions Supplementing green bean sprout extract with doses of 21.6 mg/200 g BW/day, 43.2 mg/200 g BW/day and 86.4 mg/200 g BW/day could increase catalase levels in male Wistar rats induced by paraquat herbicide.
Hubungan Spiritual Quotient dengan Tingkat Stres pada Mahasiswa Kedokteran di Semarang Irfandi, Nurahmat Yanisa; Widayati, Ratih; Fuad, Wijayanti
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.163-170

Abstract

Background Student medical is one major favorite where his students are confronted with various relative constraints difficult to take, like many it's a mandatory academic target resolved and prosecuted adapt from transition high school to college sure height different from facet academic, then environment social making student stressed and triggered it happened stress.  stress will raise problems for students when not managed with ok. The spiritual Quotient (SQ) is one factor that plays a role in controlling stress. Students who have a High Spiritual Quotient will be capable of controlling stress. Methods Research this characteristic quantitative, observational analysis with an approach cross-sectional. The instrument used consists of a questionnaire from the level Spiritual Quotient with the title “questionnaire spiritual intelligence” and level stress with the title "MSSQ questionnaire" and well both have been already through validity and test reliability. The analysis study use analysis bivariate with the Rank Spearman correlation test. The sample study is student-level beginning Faculty Medical Unimus class of 2021 as many as 115 of the 150 students taken with the Simple Random Sampling technique. Results Connection significant (p=0.001) and strong correlation (r=0.568) between the connection Spiritual Quotient with level stress on Unimus FK Students Class of 2021. In part, students own High Spiritual Quotient in circumstances stress moderate (55.7%), stress weight (3.5%), and stress mild (0.9%). Conclusions Increasingly tall Spiritual Quotient possessed, than the more low-level stress experienced by students level beginning class of 2021.
Pengaruh Pemberian Glukosa Oral Pra Operasi Terhadap Kadar Glukosa Darah pada Pasien Diabetes Melitus yang dilakukan operasi dengan anestesi Umum Harahap, Dhiny Yolanda; Hanafie, Achsanuddin; Lubis, Andriamuri Primaputra; Amelia, Rina
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.199-207

Abstract

Background The administration of general anesthesia during surgery can trigger the body’s stress response causing changes in regular metabolic patterns that result in hyperglycemia and ketosis. The goal of this study is to investigate how preoperative oral glucose and non-glucose administration affect patients with diabetes mellitus with blood glucose levels during surgery under general anesthesia. Methods This is a single-blind, randomized controlled trial (RCT) being carried out by the Central Surgical Installation and postoperative recovery area at Haji Adam Malik General Hospital Medan. The study sample consists of 38 patients with diabetes mellitus who underwent electively scheduled laparotomies under general anesthesia and met inclusion/exclusion criteria. For treatment group participants, mineral water containing 50 grams of glucose was administered with 400 cc. Research hypotheses were assessed using the t-test, and significant findings had p-values equal to or less than 0.05 within a confidence interval of 95%. Results The study sample had a mean age of 50.1 ± 12.73 and showed a significant effect between glucose levels before (178.47) and after (163.78) administration of maltodextrin, with a P value (0.001). No side effects were observed during or after the post-operative evaluation process conducted in this study's participants. Conclusions Patients with diabetes mellitus experience a preoperative oral glucose-induced impact on blood glucose levels.
Meningkatkan Preservasi DNA asal Saliva melalui Inaktivasi DNase I: Peran Suhu dan EDTA Yamamoto, Zulham; Sulviani, Nurul; Widjaja, Sry Suryani
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.152-162

Abstract

Background Deoxyribonuclease I (DNase I) catalyzes the cleavage of double-stranded DNA into its end products. This enzyme requires cations for its activity. In addition, DNase activity is influenced by indirect DNase inhibitors (i.e. EDTA) and temperature. EDTA is an indirect DNase I inhibitor. Therefore, DNase inactivation is crucial for DNA preservation, especially for salivary samples, and the downstream application of genetic techniques using non-blood samples. Saliva is a complex mixture contaminated with oral microbes and contains DNase which is harmful for DNA preservation. This study aims to preserve salivary DNA through temperature and EDTA treatment. Methods This is an experimental study. Salivary DNA was extracted using the spin-column method. DNA degradation assays were carried out using either 5 µL of salivary supernatant or 2.5 mg/mL of DNase I which were incubated at -20°C, 2-8°C, room temperature, 40°C, and 50°C; and added with 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA for 60 minutes. After incubation, the results were visualized using agarose gel electrophoresis. Results The average concentration of salivary DNA was 61.70 µg/mL (30.50-109.05) and the purity was 1.893 µg/mL (1.800-2.005). Incubation at -20°C, 2-8°C, and room temperature degraded salivary DNA but incubation at 40 and 50°C did not completely degrade DNA. Addition 0.125 mM, 0.25 mM, 0.5 mM, 1 mM, and 2 mM EDTA to 5 µL of salivary supernatant or 2.5 mg/mL DNase I preserved salivary DNA. Conclusions Temperature of 40 and 50°C, and 0.125 mM EDTA can inactivate DNase and preserve salivary DNA.
Emerging Threats in the Age of Pandemics: A Focus on COVID-19 and the Novel Sub-Variant EG 5 ("Eris"): Review Article Alsayed, Raghda; Thamer, Hamsa; Hameed, Seenar; Kadhom, Mohammed; Hairunisa, Nany; Amalia, Husnun; Mashabi, Yasmine; Ahmed, Dina; Mahdi, Sarah; Husain, Amani; Salman, Israa; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.262-267

Abstract

This paper draws attention to a recently identified sub-variant of SARS-CoV-2 known as EG 5, colloquially named "Eris," designated by the World Health Organization (WHO) as a variant of interest. The organization has urged nations to monitor and respond to the spread of this sub-variant since its identification on February 17, 2023. The discovery of the EG 5 variant, a sublineage of the Omicron variant, has introduced new challenges. Designated a "variant of interest" by the WHO, EG 5 carries distinctive genetic mutations, including an additional F456L amino acid mutation in the spike protein. Global prevalence has doubled, raising concerns about increased transmissibility. Although specific symptoms of EG 5 are not yet fully characterized, the variant has spread to 51 countries, with over 7,000 reported cases by August 15, 2023. The manuscript also explores the unique situation in Iraq, where, as of August 17, 2023, no EG 5 cases have been officially recorded. However, challenges such as self-treatment at. As the world grapples with the ongoing challenges of the COVID-19 pandemic, understanding the dynamics of emerging variants is crucial for effective public health responses and the development of targeted interventions.
Indek Matos-Carvalho sebagai Perbandingan dengan Indeks Diskriminan Lain pada Talasemia Beta Awal Mulyadi, Mulyadi; Mulyati, Mulyati; Ratnaningsih, Tri; Harahap, Nur Imma; Lesmana, Indra; Handayani, Niken Satuti Nur
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.208-217

Abstract

Background Microcytic hypochromic anemia is the most common type of anemia found in Beta Thalassemia Trait and Iron Deficiency Anemia, posing a diagnostic challenge due to their similar presentations. Diagnostic errors among them can lead to incorrect treatment, potentially resulting in fatal outcomes. In Indonesia HPLC (High Performance Liquid Chromatography) usage as gold standard for discrimination between these diseases are expensive. Discrimination indices offer an alternative for cheaper and effective initial screening. However, a comprehensive performance evaluation of those indices, such as Matos and Carvalho indices, alongside Mentzer index, Green and King index, England and Fraser index, RBC index, Shine and Lal index, and Srivastava index, has not been conducted in Indonesia. This study aims to determine the best discriminative performance index based on the highest Youden’s indes value between those seven indices. Methods Study consisted of 30 subjects of beta thalassemia trait and 35 subjects of iron deficiency anemia. Index calculations were performed using blood profile formulas and compared with gold standard test results to find each index sensitivity, specificity, and Youden’s index value. Results Matos and Carvalho indices exhibited superior discriminatory performance, achieving 80% sensitivity, 77.1% specificity, and a Youden's index of 57.14%. Among other indices, the RBC index demonstrated the highest sensitivity (90%), while the Green and King index excelled in specificity (97.14%). MCV and MCH values did not significantly differ between BTT and IDA groups. Conclusions The study's findings underscore the efficacy of Matos and Carvalho indices in discriminating BTT and IDA in this study population, highlighting their potential as valuable tools in initial screening efforts.
Transfusi Masif dan Tatalaksana Intensif Post Histerektomi pada Plasenta Akreta Trsitiarti, Alfi Marita; Yuliantara, Eric Edwin
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.145-151

Abstract

Background Placenta accrete remains a problem in developing countries. The incidence rate has increased over the last 30 years accompanied by the risk of maternal death. Bleeding is still the main cause of death. This rising incidence rate has increased Sectio Caesaria (SC) operations, resulting in greater treatment costs. This is due to its cost management as it requires intensive care and massive use of blood transfusions. This study aims to describe the characteristics, management, and maternal outcomes of placenta accrete spectrum cases. Methods A Cross-sectional study was conducted at Moewardi Hospital Surakarta between January 2016 and December 2021. Sample selection was based on medical records with a suspected diagnosis of PAS. A total of 121 cases of placenta accrete spectrum had been confirmed by anatomical pathology results were analyzed Assessments were carried out on maternal characteristics, risk factors, MAP score, intraoperative management, and postoperative care. Statistical analysis was carried out with a 95% confidence interval (CI), chi-square test, and odds ratio assessment using SPSS edition 23. Results Hysterectomy has more morbidity and maternal complications than conservative management in blood loss, massive transfusion, iatrogenic incident, and a long stay in the Intensive care unit. Conclusions The high rate of morbidity in the management of the placenta accrete spectrum requires comprehensive management to reduce maternal mortality.
Faktor-faktor yang Mempengaruhi Status Stunted pada Anak Usia Dua Tahun ke Bawah di Puskesmas Karya Mulia pada Tahun 2023 Wahyudi, Dery; Fahiratunnisa, Namira Alifah; Refaldi, Muhammad Wildan; Asseggaf, Syarifah Nurul Yanti Rizki Syahab
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.138-144

Abstract

Background Stunted (short stature), defined as a height-for-age condition less than two standard deviations below the median of the WHO child growth standards, is caused by inadequate nutritional intake during the first 1000 days of life. Various factors contribute to the stunted status in children. Therefore, this research focuses on factors that can be examined at primary healthcare facilities, such as public health centers, and their relationship with the stunted status in children. Objective To determine the relationship between birth weight, basic complete immunization, and vitamin A supplementation on the stunted status of children aged 12-23 months at Karya Mulia Public Health Center, Pontianak, in the year 2023. Methods This study employed an analytical design with a cross-sectional approach. A total of 86 research samples were selected using total sampling techniques that met the sample criteria. Bivariate analysis was conducted using the fisher’s exact test and chi-square test. Results The results indicate no significant relationship between birth weight (0.623), basic complete immunization (0.342), and vitamin A supplementation (0.602) on the stunted status of children aged 12-24 months at Karya Mulia Public Health Center in 2023, statistically with p-value > 0.05. Conclusions There is no relationship between birth weight, basic complete immunization status, and vitamin A supplementation on the stunted status of children aged 12-23 months at Karya Mulia Public Health Center.

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