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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 237 Documents
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Potential of Flavonoids from Cat's Whiskers Plant (Orthosiphon Stamineus) as Antidiabetic Candidates through Inhibition of Tyrosine Phosphatase 1B and Aldose Reductase Proteins Adi Budi Ramadhan, Adi Budi Ramadhan; Galih Hamdani Riansyah; Saeful Amin
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2654

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired regulation of blood glucose levels. The enzymes Protein Tyrosine Phosphatase 1B (PTP1B) and Aldose Reductase are known to play significant roles in the development of insulin resistance and diabetes-related complications. This study aims to evaluate the potential of flavonoid compounds from Orthosiphon stamineus as dual inhibitors of these enzymes through an in silico approach. The research involved phytochemical screening of flavonoids reported in O. stamineus, followed by molecular docking and validation using PyRx software on the crystal structures of PTP1B (PDB ID: 1AAX) and Aldose Reductase (PDB ID: 1AH3). Docking validation was performed via redocking of native ligands, yielding RMSD values < 2 Å. Ligand-protein interactions were analyzed using Discovery Studio, while pharmacokinetic and toxicity predictions were carried out using SwissADME, pkCSM, and ProTox-II. Docking results revealed that sinensetin and salvigenin exhibited the highest binding affinities to PTP1B and Aldose Reductase, with binding energies of -9.4 and -8.4 kcal/mol, respectively. These compounds formed strong interactions with key residues at the active sites of the enzymes, indicating their potential as effective inhibitors. Pharmacokinetic evaluation showed that most compounds complied with Lipinski’s rule of five and demonstrated favorable ADME profiles, including good absorption and potential blood-brain barrier penetration. Toxicity analysis indicated that the candidate compounds were non-toxic (toxicity class III–IV) and safe for oral administration. Flavonoid compounds from O. stamineus, particularly sinensetin and salvigenin, demonstrated strong potential as dual inhibitors of PTP1B and Aldose Reductase. This study supports further development of O. stamineus flavonoids as natural multitarget therapeutic agents for the management of diabetes mellitus.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Acute Toxicity Evaluation of Mango (Mangifera indica L.) Leaf and Peel Extracts on Zebrafish (Danio rerio) Embryos Lusi Agus Setiani; Zaldy Rusli; Dinda Sabina Oktavia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2682

Abstract

Mangiferin is the main flavonoid compound found in Mangifera indica L. (mango), known for its antioxidant and anti-inflammatory activities. In addition to the leaves, secondary metabolites such as alkaloids, flavonoids, and triterpenoids are also present in mango peels, contributing to their antibacterial properties. This study aimed to evaluate the acute toxicity of mango leaf and peel extracts using the Zebrafish Embryo Acute Toxicity Test (ZFET). The test was conducted over a 96-hour post-fertilization (hpf) period using zebrafish (Danio rerio) embryos exposed to five different concentrations of the extracts: 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm, along with an internal control using embryo water. Observed parameters included mortality rate and morphological abnormalities such as pericardial edema, yolk sac edema, spinal deformities, and tail malformations. Probit regression analysis revealed LC?? values of 156.133 ppm for mango leaf extract and 160.353 ppm for mango peel extract at 96 hpf. According to the EPA toxicity classification, both extracts fall into the practically non-toxic category. These findings provide preliminary evidence that mango leaf and peel extracts are relatively safe and have potential for further development into natural product-based formulations. However, additional research is required to support their clinical applications and long-term toxicological profiles.
Testing The Effectiveness of An Ethanol Extract Gel Preparation of Kelakai Leaves (Stenochlaena palustris (Burm.F.) Bedd.) on Reducing The Extent of Burns in Male White Rats (Rattus novergicus) Syarifuddin, Aminah; Novandi Purba; Yayuk Rahayu Suyudi; Elliya Siswanti; Syahfitri, Wilda Dani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2685

Abstract

The wound healing process is essential for restoring body tissue to its original integrity or normal function. This process involves several stages, including the inflammatory, proliferative, and maturation phases. Both internal and external factors play a role in accelerating wound healing. Kelakai leaves are traditionally used as a topical treatment for burns in gel form, as they are safe for use, non-toxic, and do not cause harmful side effects. The most significant effect was observed with the gel formulation containing 15% w/w kelakai leaf extract, which was able to reduce burn wound area by 13.75%. This demonstrates the effectiveness of kelakai leaf extract gel (Stenochlaena palustris (Burm. F.) Bedd.) in the wound healing process. Therefore, the gel has the potential to reduce the extent of burn injuries.The aim of this study was to analyze the effect of various concentrations of ethanol-based kelakai leaf extract gel. As an effort to reduce burn wound area, this research included several stages, starting from the collection of materials and equipment, plant identification, research procedures, to the extraction process of kelakai leaf simplicia using maceration. This was followed by phytochemical screening and gel formulation at concentrations of 5%, 10%, and 15%, which were then tested for effectiveness on male white rats. The data were analyzed using ANOVA with a significance level of p < 0.050. The findings indicate that the gel containing kelakai leaf extract has a significant effect in reducing the burn wound area in rats.
Reduction of BOD, COD, and TSS in Textile Wastewater Using Bentonite Activated Charcoal Adsorbent Aritonang, Barita; Ritonga, Ahmad Hafizullah; Harefa, Karnirius; H, Herlina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2699

Abstract

Wastewater generated by the textile industry contains a variety of hazardous contaminants, including complex organic compounds, synthetic dyes, surfactants, heavy metals, and critical pollution indicators such as biochemical oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solids (TSS). This study evaluates the efficacy of a dual-adsorbent system comprising hydrochloric acid-activated bentonite and phosphoric acid-activated carbon for the removal of BOD, COD, and TSS from textile effluents. The activation processes significantly altered the physicochemical properties of both adsorbents. The moisture content of activated carbon decreased from 18% to 3.10%, while ash content was reduced from 15% to 3.05%. The iodine number, indicative of adsorption capacity, increased from 650 mg/g to 810 mg/g. Additionally, the fixed carbon content improved from 55% to 80%. Surface characterization via Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed substantial structural modifications, which enhanced the adsorption performance of the materials. Application of the combined adsorbent system resulted in substantial pollutant removal efficiencies, with reductions of 70.23% in BOD, 70.11% in COD, and 74.88% in TSS. These findings demonstrate that acid-activated bentonite and phosphoric acid-treated activated carbon represent a promising and efficient adsorptive treatment strategy for the remediation of textile wastewater.
The Effect of Laban Leaf Ethanol Extract Cream (Vitex pinnata) on Wound Healing on Male White Rats (Rattus norvegicus) Wistar Strain Simorangkir, Delisma Marsauli; Evi Depiana; Masria Sianipar; Chindy Umaya; Gratia Apulina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2713

Abstract

Wound healing is a process that involves the restoration of injured or dead tissue and replacing it with new tissue through the process of cell regeneration. Although the wounds that occur tend to be mild, they need to be treated immediately to avoid infection that will hinder the healing process, even causing dangerous diseases. Therefore, natural product-based treatments have been explored naturally because of their ability to provide optimal wound healing effects to patients such as laban leaves (Vitex pinnata). The method used in this study was a laboratory experiment that began with the manufacture of extracts, cream formulations, and testing of wound healing activity. The test animals, male white rats of the Wistar strain, were divided into 5 groups for different treatments. Wound healing activity was measured by observing the diameter of the wound and healing time, and analyzed statistically using the One Way Anova method. The results showed that the preparation of ethanol extract cream of laban leaves (Vitex pinnata) was effective in accelerating the healing of cuts in male white rats at a concentration of 25% which was almost the same as the positive control. The conclusion of this study shows that the ethanol extract of laban leaves (Vitex pinnata) can be formulated into an effective cream preparation for wound healing, with a concentration of 25% as the most optimal concentration.
Evaluation of Fondaparinux Use on Kidney Function in Hospitalized COVID-19 Patients with Decreased eGFR Putri Nurhidayah, Eka; Didik Hasmono; Ruddy Hartono
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2731

Abstract

Background: The COVID-19 pandemic has resulted in increased hospitalization rates among patients with multisystem complications, including coagulation disorders and decreased renal function. Fondaparinux, a synthetic anticoagulant with a lower risk of thrombocytopenia, is often used as an alternative to heparin. However, its use in patients with reduced glomerular filtration rate (eGFR) remains debatable, as its elimination is dependent on renal function. Objective: This study aims to evaluate the impact of fondaparinux on renal function, specifically examining changes in eGFR and serum creatinine levels in COVID-19 patients with impaired renal function during treatment at Bhayangkara South Surabaya Hospital. Methods: This research employed a retrospective observational quantitative approach, involving COVID-19 patients who received fondaparinux at the inpatient facility of Bhayangkara Hospital from June 2020 to October 2021. Data were collected from the medical records of patients during their hospitalization, including fondaparinux dosage and eGFR and serum creatinine values, as well as other relevant clinical parameters. Statistical analysis using the Wilcoxon test was conducted to assess significant differences in serum creatinine and eGFR values following fondaparinux administration. Results: Of the 535 patients analyzed, 56 medical records met the inclusion criteria. The results of the Wilcoxon test analysis showed that there was a significant increase in eGFR (p-value 0.012, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%), a substantial decrease in SCr (p-value 0.035, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%) based on each degree of COVID-19 severity. Conclusion: The use of fondaparinux may improve kidney function, as indicated by significant decrease in serum creatinine and an increase in eGFR. Furthermore, no bleeding incidents were observed during the use of fondaparinux.
Association of Pharmacist-Provided Medication Counselingwith Adherence in Outpatients Samran
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/p6jqac58

Abstract

Background: patient medication adherence is critical for therapeutic success. Pharmacist-provided medication counseling can enhance patients' understanding and adherence to treatment regimens. Objective: this study aimed to assess the relationship between pharmacist-provided counseling and medication adherence among outpatients at RSU. Sembiring Delitua. Research Methods: a quantitative study with a cross-sectional design was conducted. A total of 100 outpatients were selected using purposive sampling. Data were collected using a structured questionnaire evaluating counseling quality and adherence through the MMAS-8 scale. The Chi-square test was used for statistical analysis at a significance level of p<0.05. Results: Sixty percent of patients reported receiving counseling, but only 21% received complete counseling. Medication adherence levels showed that 42% had high adherence. Statistical analysis revealed a significant association between medication counseling and adherence (p=0.002), where patients receiving counseling had higher adherence rates. Conclusion: pharmacist-led medication counseling is significantly associated with higher medication adherence among patients. Hospitals are advised to improve the quality and coverage of medication counseling through continuous pharmacist training and the use of supplementary educational media.
Evaluation and Characterization of Caryophyllene Nanoemulsion Preparations from Clove Oil (Syzigium aromaticum) Eriska Agustin; Martavinus, Whilly
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/zz7g4329

Abstract

The clove plant (Syzygium aromaticum) is a plant from the Myrtaceae family. Clove plants can be found in various countries, including Indonesia. The contents of the clove plant have been studied to have beneficial pharmacological effects, one of which is the caryophyllene content in the clove plant which has antioxidant, antibacterial, etc. activities. This research aims to create a formula and evaluate the physical characteristics of a karyophyllene nanoemulsion preparation from clove oil. The method for making nanoemulsion preparations is made into three formulas with varying concentrations of karyophyllene compounds as active substances, namely F0 (0%), F1 (0.5%), and F2 (1%). Evaluation of the preparation includes organoleptic tests, pH tests, particle morphology tests, stability tests, and nanoemulsion globule size tests. The results showed that the nanoemulsion preparations of caryophyllene compounds F0, F1, and F2 had globule sizes of 82 ± 1.45 nm, 95 ± 2.67 nm, 89 ± 1.46 nm on day 1, while on day 28 the globule sizes were 99±2.87 nm, 116±2.56 nm, and 121±1.56 nm. The nanoemulsion preparation is clear white, semi-thick, and has a distinctive aroma. The morphology of the nanoemulsion globules is spherical and homogeneous. All three nanoemulsion formulations demonstrated good physical stability, as indicated by the absence of precipitation, phase separation, and turbidity, as well as pH values within the acceptable range for nanoemulsion systems, despite a slight increase in globule size observed over the 28-day storage period.
From Laboratory to Algorithm: The Role of Computational Methods in New Drug Design Discovery in the Digital Era Fajarini, Syifa Rizkia; Amin, Saeful; Ansyirohanisa; Beni Maulana Habib; Muhammad Rahmat Darmawan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8f4xh746

Abstract

In the digital era, the integration of computational methods in drug discovery has revolutionized laboratory practices, enhancing efficiency and accuracy in drug development. This article provides a comprehensive review of the crucial role of computational technology in accelerating the discovery of new drug compounds, highlighting its impact on the effectiveness and success of pharmaceutical development. Traditional drug discovery methods often require extensive time and high costs, with relatively low success rates in clinical trials. To address these challenges, various computational approaches, such as Molecular Docking, Quantitative Structure-Activity Relationship (QSAR), and machine learning, have been widely adopted in the pharmaceutical industry. This study employs a systematic approach to explore different computational techniques and their applications in identifying potential drug candidates. Findings indicate that computational tools significantly expedite the drug development process, reduce costs, and improve the success rates of clinical trials. The conclusion emphasizes the importance of leveraging computational technology as an innovative strategy in pharmaceutical research and development, ultimately accelerating the discovery of safer and more effective therapies. Keywords: Computation, Drug Discovery, Digital Era, QSAR, Molecular Docking.

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