cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Nursalam Hamzah
Contact Email
djps@uin-alauddin.ac.id
Phone
+6282117170860
Journal Mail Official
djps@uin-alauddin.ac.id
Editorial Address
universitas Islam Negeri Alauddin Makassar, Indonesia
Location
Kab. gowa,
Sulawesi selatan
INDONESIA
ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 10 Documents
 1 
Search results for , issue "Vol. 6 No. 1 (2023)" : 10 Documents clear
Antibacterial Activity Test of Roll on Deodorant Extract Ethanol Tamarind Seed Coat Rahim, Abdul Rahim; Salmiah; Ihsan, Ersi Arviana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37568

Abstract

Introduction: Armpit odor is one of the problems caused by bacteria, one of which is Staphylococcus aureus. The rind of the tamarind seed contains tannins and flavonoids that function as antibacterial. Aims: The purpose of this study was to formulate the ethanolic extract of tamarind seed coat into roll-on deodorant preparations and to determine the zone of inhibition from variations in the concentration of the extract. Methods: The method used is the well diffusion method and the data obtained are then analyzed using Statistical Product and Service solution (SPSS). The level of confidence used is 95% to see the significance of each evaluation of the preparation. Result: The results showed that the roll on deodorant preparation of ethanol extract of tamarind seed coat did not meet the requirements for good dispersibility, adhesion and viscosity for topical preparations in general and emulsion preparations. The pH of the preparation met the axillary skin pH he standard for topical preparations. The roll-on deodorant preparation of ethanol extract of tamarind seed cultivars was effective in inhibiting the growth of Staphylococcus aureus bacteria. Conclusion: The results of inhibition zone 3 formulations containing extracts were in the strong category and the value increased with increasing concentration of tamarind seed coat extract in the deodorant preparation.
Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes Fitrya Fitrya; Elsa Fitria Apriani; Adik Ahmadi; Dina Permata Wijaya; Khazanah Nurain
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37608

Abstract

Introduction: Artocarpus heterophyllus LMK. leaves contain flavonoids, tannins, and saponins, which have the potential to be antibacterial. Aims: This study aims to test the antibacterial activity of A. heterophyllus leaves ethanol extract, which is formulated in a gel preparation. Methods: Antibacterial testing was done on the acne-causing bacteria Propionibacterium acnes. The gel formula is designed with an extract concentration of 5, 10, or 15% with Carbopol 940 and HPMC as the bases. The antibacterial activity test was carried out using the well diffusion method. Result: The results of the study showed that the concentration of the extract affected pH, adhesive power, removability, and viscosity. Antibacterial activity tests showed that the gel of A. heterophyllus extract could inhibit Propionibacterium acnes bacteria. The higher the concentration of the extract, the greater the antibacterial activity. Conclusion: It can be concluded that the gel with an extract concentration of 15% gave the strongest antibacterial activity with an inhibition zone of 10.9 ± 1.18 mm.
: bahasa indonesia Oktariani Pramiastuti okta; Ratna Tika Nikhmatul Laili
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37703

Abstract

Introduction: Temu blenyeh (Curcuma purpurascens Blume) is a species of Curcuma belonging to the Zingiberaceae family. This plant contains secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols, which function as antimicrobials. Aims: The aims of this study was to determine the antimicrobial activity of the ethanol extract of intersection blenyeh against Streptococcus mutans and Candida albicans. Methods: The extraction process was carried out by maceration, and the antimicrobial activity test was carried out using paper disc diffusion. The negative control used in this study was 5% DMSO, while the positive control was 0.2% Chlorhexidine. Result: The results of phytochemical screening using the TLC method showed that the ethanol extract of intersection blenyeh contained flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols. The results of the antimicrobial activity test of the ethanol extract of the temu blenyeh at concentrations of 30; 40; 50; 60; and 70% against Streptococcus mutans produced an inhibition zone belonging to the medium category with an average inhibition zone value of 6.75; 7.00; 7.08; 7.16; and 8.26 mm, while Candida albicans produced an inhibition zone that belonged to the very weak category with an average inhibition zone value of 2.75; 3.16; 3.33; 3.60; and 3.67 mm. Conclusion: The conclusion of this research is that the ethanol extract of intersection blenyeh has antimicrobial activity against Streptococcus mutans and Candida albicans.
Analysis of Body Weight Profile and Toxic Symptoms of White Rats on Giving Ethanol Fraction of Rambutan Peels (Nephelium lappaceum L) Anisa Pebiansyah; Lilis Tuslinah; Ade Yeni Aprilia
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37708

Abstract

Introdiction: Rambutan peel (Nephelium lappaceum L) contains antioxidant compounds like flavonoids such as anthocyanins. The high antioxidant activity causes the high utilization of rambutan peel for treatment, but its side effects on the body are unknown. Aims: This study aimed to analyze the effect of giving rambutan rind ethanol fraction on body weight and toxic symptoms in white rats. Methods: The test was carried out using the OECD 425 method in which there were three treatment groups, each consisting of 5 test animals that were given the preparation orally. Treatment 1 was only given 1% CMC Na for 14 days; treatment 2 was given the ethanol fraction of rambutan peel 400 mg/200 g BW which was observed every 30 minutes for 4 hours, then up to 48 hours, then every day for up to 14 days. If there is none, it is continued with treatment 3, which is given the ethanol fraction of rambutan peel 1000 mg/200 g BW for 14 days. Symptoms of acute animal toxicity were observed for 14 days in that treatment. Result: The results showed that the ethanol fraction of rambutan peel doses of 400 mg/200 g BW and 1000 mg/200 g BW had a significant effect (p=0.017) in increasing the body weight profile of white rats, and there were no signs of acute toxicity in each treatment group. Conclusion: The dose of the ethanol fraction of rambutan peel 400 mg/200 g BW is the best, with an increased body weight of 25.17%.
The Potential of α- glucosidase Inhibition from Endophytic Fungi Associated in Portulaca oleracea L Siska; Asriani Suhaenah; Saripa Indira Syahraini Latuconsina
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38049

Abstract

Introduction: The discovery of endophytic microbes, which are microorganisms that reside within plant tissues and can produce bioactive compounds with similar properties to their host plants, is one possible solution to this issue. Endophytic fungi are capable of manufacturing antibacterial, antifungal, antiviral, anticancer, antimalarial, and antidiabetic agents. Portulaca oleracea L. is a weed that has spread globally. Portulaca oleracea L.has been utilized as a nutritious and medicinal plant for countless centuries. Aims: This study seeks to assess the antidiabetic potential of the endophytic fungi Portulaca oleracea L. Methods: In this study, isolation, macroscopic testing, fermentation, and antidiabetic activity testing were conducted using the alpha-glucosidase method. Twelve isolates with macroscopically distinct characteristics were obtained from of isolating the endophytic fungi. The procedure then advances to the fermentation and ethyl acetate extraction phases. Result: The results showed that there was inhibition of the α-glucosidase enzyme in hydrolyzing substrates into glucose by secondary metabolite extracts of fungi associated with the plant Portulaca oleracea L. with the highest percentage inhibition on the lab scale in the 12th isolate (83.92%). Conclusion: This measurement gives good results as an α-glucosidase inhibitor, so its potential as a source of antidiabetic drug substances is very high.
Effectiveness Of Cassia alata L Leaf Extract Decrease Blood Glucose Level On Streptozotocin-Induced Male White Rats Niluh Puspita Dewi; Febry Grasela Aula; Indah Kurnia Utami; Ayu Wulandari; Rezky Yanuarty; Wayan Wirawan
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38400

Abstract

Introduction: Diabetes mellitus (DM) is a condition in which the body either fails to produce enough insulin at the right time or fails to use it properly. Aims: The goal of this study is to show how Cassia alata L. leaf extract affects blood glucose levels in streptozotocin-induced diabetic rats. Methods: Cassia alata L. leaves therapy is an alternative treatment for DM. In this investigation, laboratory techniques were employed. Streptozotocin was administered intraperitoneally to mice at a dose of 40 mg/kg body weight initially. Except that they produce normal controls. Six groups of 30 rats each received treatment with Cassia alata L. leaf extract at doses of 500 mg/kg body weight, 600 mg/kg body weight, and 700 mg/kg body weight in addition to the usual control group. Trial outcome data were first examined using one-way ANOVA to confirm differences between treatments and then put through the DUNCAN trial. Result: As a result, it was discovered that secondary metabolites of alkaloids, flavonoids, saponins, and tannins were present in the ethanol extract of Cassia alata L. leaves. A dose of 700 mg/kg body weight is an effective blood sugar-lowering dose, with an average reduction of 121 mg/dl. Conclusion: Ethanol extract from Cassia alata L. leaves has this effect.
Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves Magfirah Magfirah; Indah Kurnia Utami; I Dewa Ayu Nurllya K.D; Niluh Puspita Dewi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38469

Abstract

Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmittance, drug loading, emulsification time, particle size, index polydispersity, zeta potential, dissolution test, Scanning electron microscopy (SEM ) and validation of the analysis method including linearity, precision, accuracy, LOD, and LOQ. Result: The results showed the ratio of surfactant, co-surfactant, and olive oil which produced the optimum formula for SNEDDS, namely 26 ml; 17.5 ml; and 6.5 ml,% transmittance 85.90, drug loading 45.36, emulsification time for AGF, AIF, and aqua dest was 15-16 seconds, particle size 404.1 nm, index polydispersity 0.840, zeta potential -31.4 mV, dissolution test 92.13%, SEM in the form of spherical chunks, and the result of the validation test of the analytical method with a linearity of r = 0.9902, precision 0.436%, accuracy 103.738%, LOD 1.87 µ / ml and LOQ 5.57 µ / ml. SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant provide optimal nanoemulsion characteristics and validation of the analytical method meets the requirements. Conclusion: Formula 1 SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant is an optimal formula that provides good nanoemulsion characteristics and validation of analytical methods meets the requirements
Physical Characteristics and Shelf Life Estimation Of Instant Powder Drink Made from The Combination Of Yellow Sweet Potatoes and Red Beans Chaidir Masyhuri Majiding; Muhammad Nuzul Azhim Ash Siddiq; Fahrul Rozi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38633

Abstract

Introdiction: In this modern era, people demand everything fast and practical. Likewise, in terms of food or beverage, people tend to prefer instant products. Instant products are food or beverage products that are easy to serve or consume in a relatively short time, such as instant powdered drinks. The physical characteristics of instant products can be interpreted as the essential properties of their ingredients in addition to chemical and biochemical properties. The physical characteristics are needed to develop instant products that are useful for producing quality food or beverage products. Aims: Instant powder drink product from the combination of yellow sweet potatoes and red beans need to be analyzed for their physical characteristics through yield, water absorption, solubility, viscosity, and shelf life. Result: The results of the analysis showed that the instant powder drink product combination of yellow sweet potato and red bean had a yield of 30.40%, a water absorption capacity of 4.98 ml, a solubility of 63.42%, and a viscosity of 14.80 cp. At the same time, the shelf life of this product is based on the assumption of average storage temperature in Indonesia (around 28ºC-38ºC), which is approximately 5 months of shelf life. Conclusion: Based on the results of the analysis, instant powder drink products have fairly good product stability and the product can be stored at room temperature or refrigerator
Xenograft Models for Preclinical Assessment of Anticancer Therapies: A Comprehensive Review Ebrahim sadaqa; Muhammad Ikhlas Arsul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38677

Abstract

Introduction: Xenograft models play a pivotal role in preclinical studies for assessing the efficacy of anticancer medications. In this comprehensive review, we present an overview of current advancements and future prospects in xenograft research, focusing on their significance in guiding drug development and clinical translation. Aim: Our aim is to conduct an in-depth review of xenograft models, their utility in evaluating anticancer drug effectiveness and ultimately improve patient outcomes. Methods We conducted an in-depth literature search using databases such as ScienceDirect, Google Scholar and PubMed with keywords including "xenograft model, cancer CDX PDX." We then reviewed and analyzed relevant studies that utilized xenograft models in order to highlight key findings and contributions made through such models. Results: Our analysis showcases the essential role of xenograft models in assessing the efficacy of anticancer drugs. We discuss the benefits and limitations of these models, emphasizing their importance in guiding drug development and clinical decision-making. Conclusion: Xenograft models remain invaluable tools in preclinical cancer research despite their inherent limitations, with researchers continually striving to refine and enhance these models to ensure their reliability in an ever-evolving field of cancer therapeutics. Utilizing xenograft models allows researchers to evaluate anticancer drug activity more accurately while striving for improved patient outcomes.
Formulation and Antibacterial Activity of Porang (Amorphophallus muelleri Blume) Extract Gel Against Propionibacterium acne Nurshalati Tahar; Dwi Wahyuni; Rabiatul Adawiyah; Khaerani; Munifah Wahyuddin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38744

Abstract

Introduction: The increase in bacterial resistance to antibiotics provides an opportunity to obtain antibacterial compounds from natural ingredients. Porang is a plant belonging to the Araceae family that has potential against Propionibacterium acne. Aims: This study aims to determine the effectiveness of the preparation of porang tuber extract gel against Propionibacterium acne. Methods: The porang were extraction by maceration using ethanol. The extract porang were made gel with various concentration and evaluation their stability and antibacterial activity using disc diffusion method. Result: The hedonic test showed no significant differenece each of formula and stable during storage in two weeks. On the other hand, only formula F2 and F3 can inhibit of Propionibacterium acnee. Conclusion: The porang extract can made of gel and good stability. The formula F2 and F3 have antibacterial activity.

Page 1 of 1 | Total Record : 10

 1 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol. 8 No.1 (2025) Vol. 7 No. 1 (2024) Vol. 6 No. 2 (2023) Vol. 6 No. 1 (2023) Vol 5 No 2 (2022) Vol 5 No 1 (2022) Vol 4 No 2 (2021) Vol 4 No 1 (2021) Vol 3 No 2 (2020) Vol 3 No 1 (2020) Vol 2 No 2 (2019) Vol 2 No 1 (2019) Vol 1 No 2 (2018) Vol 1 No 1 (2018) More Issue