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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol 5 No 1 (2024): February 2024" : 9 Documents clear
Formulasi dan Stabilitas Mutu Fisik Sediaan Lulur Serbuk dari Ampas Kopi Arabika (Coffea arabica) Gayo, Ubi Jalar Ungu (Ipomea batatas L) dan Rimpang Jahe (Zingiber officinale) Elfariyanti, Elfariyanti; Zarwinda, Irma; Zakaria, Nurmalia
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4383

Abstract

Scrub is a traditional cosmetic preparation that has been prescribed for generations and is used to remove dead skin cells, dirt, and open pores so that air exchange is free and the skin becomes brighter and whiter. Previous research reported that Gayo Arabica coffee grounds discarded as waste contain antibacterial and antioxidant compounds. Purple sweet potatoes are reported to contain natural antioxidants because they contain anthocyanins and beta-carotene, apart from that, ginger rhizomes are reported to be able to inhibit the growth of bacteria that cause body odor on human skin. Therefore, these three ingredients have the potential to be used as ingredients for making natural powder scrubs. This research aimed to determine the effect of the proportion of Gayo Arabica coffee grounds, purple sweet potato, and ginger rhizome on the finished product of powdered scrub preparations as seen from the stability of their physical quality. The research method used was experimental in the laboratory with a Completely Randomized Design (CRD). The powder scrub formulation is made in 3 formulas (F1, F2, and F3) by varying the ratio of the amount of Gayo Arabica coffee grounds, purple sweet potato, and ginger rhizome respectively, namely F1 (1:3:1), F2 (2:2: 1) and F3 (3:1:1). The weight of each formula is 100 g. The physical quality stability test of the powder scrub preparation was carried out on the 1st, 7th, and 14th days including organoleptics, water content, homogeneity, pH, drying time, and adhesion. The test results showed that during 2 weeks of storage, the body scrub preparations that were made had met the requirements for good physical quality. In the organoleptic test, the color, shape, and odor of the preparation did not change, the preparation was homogeneous, the pH was stable at 6.2, and the water content was stable at below 10% where the F3 formula showed the lowest water content. The results of the drying time test meet the requirements, namely a minimum of 15 minutes and the adhesion test meets the requirements, namely greater than 1 second.
Perbandingan Kadar Fenolik Total Air Rebusan dan Ekstrak Etanol Daun dan Batang Sawi Langit (Cyanthillium cinereum (L.) H.Rob) Saputri, Muharni; Yulia, Rahma; Febriani, Yessi; Ginting, Ernawaty; Amara, Saniatul; Zulkhaira, Zulkhaira; Utami, Intan Putri
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4578

Abstract

Sky mustard is one of the herbaceous plants used by the community to treat diseases such as inflammation, malaria and fever. This herbaceous plant is believed to have secondary metabolites such as phenolics which have many functions. The aim of this research was to determine the total content of phenolic compounds in leaves and stems of sky mustard greens (Cyanthillium cinereum (L.) H.Rob). This research is experimental in nature, including collecting plant material, identifying plants, cold extraction using the maceration method using ethanol and boiled water as a solvent, phytochemical screening, and determining the total phenolic content of boiled water and equivalent ethanol extract of leaves and stems (Gallic Acid Equivalent (GAE)) or gallic acid by colorimetric method using reagents Folin-ciocalteu a wavelength of 760 nm using UV-Visible spectrophotometry. The result of phytochemical screening of sky mustard leaves and stems contain alkaloids, steroids, saponins, flavonoids, tannin, glycosides and phenols. The result showed that phenol levels were greater in the leaves than in the stem the ethanol solvents attracted more phenolic compounds than boiling, and the phenol by boiling was higher at 5 minutes at 0,649 mg/g GAE. For phenolic compounds using ethanol solvent, there was a yield of 748,33 mg/g extract.
Penentuan Kadar Alkaloid Total Ektstrak Akar Bajakah (Spatholobus Littoralis Hassk) dengan Metode Spektofotometri Uv-Vis Hanifah, Nur; Daulay, Anny Sartika; Rahman, Fatur; Nasution, Haris Munandar
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4788

Abstract

The Bajakah tampala tree (Spatholobus littoral hassk) is a native plant from the interior of the forests in Kalimantan, especially Central Kalimantan. This plant is a plant that stretches or grows and grows abundantly in the interior of the forest. The Bajakah plant is known to the people of Kalimantan as a medicinal plant and can cure various diseases, including diarrhea, rheumatism, and cancer. The aim of this research was to determine the alkaloid content of bajakah root extract in various concentrations. The research method was carried out experimentally, with the independent variable being an ethanol extract of bajakah roots with concentrations of 50, 70, and 96%. Meanwhile, the dependent variables are the characteristics of simplicia, the secondary metabolite content of Bajakah root ethanol extract, and the determination of the total alkaloid content of Bajakah root extract. Bajakah root simplicia extract is made with 96, 70, and 50% ethanol solvents. The parameters used in this study include water content, total ash content, acid insoluble ash content, water soluble extract content, ethanol soluble extract content, and secondary metabolite content, including alkaloids, tannins, flavonoids, saponins, steroids, and terpenoids, by conducting phytochemical screening. , making a standard caffeine solution, determining the maximum wavelength of caffeine, measuring the caffeine calibration curve, and determining the total alkaloid content of Bajakah root extract. The results of the phytochemical screening showed that Bajakah root was positive for containing alkaloid compounds, saponins, tannins, flavonoids, steroids, and terpenoids. And the results obtained from Bajakah root plants obtained from Central Kalimantan were a 96% ethanol concentration of 1.66797 ± 0.7088 mg/gram, a 70% ethanol concentration of 1.6679 ± 0.1124 mg/gram, and a 50% ethanol concentration of 0.46981 ± 1.0656 mg/gram
The Effect of Non-pharmacological Therapy with Soy Milk on the Reduction of Primary Dysmenorrhea Pain in Adolescent Girls Fitriani, Rani; Setiana, Eva Mesi
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4821

Abstract

Dysmenorrhea is a detrimental condition for many women, significantly impacting the health-related quality of life. Non-pharmacological interventions, such as warm compress, balanced nutrition, and adequate rest, play a crucial role as strategies. Particularly, the consumption of high-calcium foods, such as soy, is recognized as an effective solution. This research adopts a Quasi-Experimental design with a Pretest Posttest approach and Control Group Design, involving 10 female students in each group. Statistical analysis employs Paired Sample T-Test and Independent T-test. The research findings reveal a p-value of 0.000, rejecting the null hypothesis (H0), indicating a significant difference in the reduction of dysmenorrhea pain scale after the administration of soy milk and health education intervention (HEI) in adolescent girls at MA Walisongo, North Lampung. The discussion emphasizes the role of calcium in alleviating muscle tension, including the uterine muscles, and the presence of isoflavones in soy that can reduce dysmenorrhea. In conclusion, soy milk has a positive influence on reducing primary dysmenorrhea pain in adolescent girls at MA Walisongo, North Lampung.
The Influence of the Combination of Acupressure on the Meridian Point P6 and Peppermint Aromatherapy Inhalation on the Reduction of Nausea and Vomiting Frequency in First-Trimester Pregnant Women Sari, Atika Kurnia; Setianingsih, Setianingsih
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4823

Abstract

Nausea and vomiting disorders during pregnancy, particularly in the first trimester, often impact the quality of life for pregnant women, with 50-90% of cases occurring during this period. Besides affecting maternal health, these disorders also influence fetal growth and development. Management can be achieved through pharmacological and non-pharmacological methods, including the combination of acupressure at Meridian Point P6 and inhalation of peppermint aromatherapy.This research aims to evaluate the impact of this combination on reducing the frequency of nausea and vomiting in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung. Utilizing a quasi-experimental method, involving 12 first-trimester pregnant women experiencing nausea and vomiting at the mentioned hospital, the study results demonstrate that the combination of acupressure and peppermint aromatherapy significantly reduces the frequency of these symptoms. Statistical analysis using the paired t-test yields a p-value of 0.012. In conclusion, this combination proves effective in addressing nausea and vomiting issues in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung, offering new insights into non-pharmacological options for improving the well-being of pregnant women.
The Combination of Pakcoy Juice (Brassica Rapa L.) and Antihypertensive Medication in Reducing Blood Pressure in Pregnant Women with Hypertension Ardini, Weda Ayu; Irayani, Fahrul
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4834

Abstract

Hypertension in pregnant women ranks as the second highest cause of Chronic Kidney Disease (CKD). Hypertension is defined as a minimum diastolic blood pressure of 90 mmHg and a minimum systolic blood pressure of 140 mmHg, with an increase in diastolic and systolic pressure of at least 15 mmHg and 30 mmHg, respectively. This study aims to evaluate the impact of a combination of Pakcoy juice (Brassica rapa L) and antihypertensive medication on blood pressure in pregnant women with hypertension.Using a quasi-experimental design with a One Group Pre-Test – Post-Test without a control group, the study involved 14 pregnant women with hypertension at the Gunung Sugih Community Health Center from January to June 2023 as the population. The results of data analysis indicate a significant influence (p value 0.000 < α: 0.05) on the reduction of blood pressure after the administration of antihypertensive medication and Pakcoy juice.The discussion emphasizes that Pakcoy juice is effective as a supplement to antihypertensive medication due to its natural content of potassium, calcium, and magnesium, which can reduce blood pressure. Consuming 4,700 milligrams of potassium per day is known to lower blood pressure caused by high sodium intake. In conclusion, the combination of Pakcoy juice and antihypertensive medication has a positive effect of 19% on reducing blood pressure in pregnant women with hypertension at the Gunung Sugih Community Health Center, with a recommendation for health education outreach to prevent hypertension cases in pregnant women.
Analisis GC-MS Minyak Atsiri dan Uji Antioksidan Kulit Jeruk Manis (Citrus sinensis) Sebagai Lip Balm Nurmala, Nurmala; Syarifah, Syarifah; Nilsya, Nilsya; Melisa, Melisa; Dina, Dina; Ayu, Ayu; Chairunnisa, Chairunnisa
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4850

Abstract

Antioxidants are chemicals that can inhibit or stop other molecules from oxidizing. Antioxidants can be found in the fruit known as sweet orange (Citrus sinensis). Orange peel essential oil is utilized in processed foods, medicines, cosmetics, and aromatherapy in the medical field. Therefore, the objective of this study was to identify the chemical content and antioxidant potential of sweet orange peel to be used as a lip balm. Processing sweet orange peel, steam distillation of essential oil, GC-MS analysis, formulating lip balm preparation, assessing lip balm preparation, and measuring antioxidant activity using a spectrophotometer and DPPH technique, were part of this study. Essential oil from sweet orange peel (Citrus sinensis L.) was analyzed using GC-MS (Gas Chromatography - Mass Spectroscopy), and the results obtained in this study were 1.4 - Cyclohexadiene, 1 - methyl. The lip balm formulation containing essential oil was evaluated as the most preferred formulation. The IC50 value of sweet orange peel essential oil was determined to be 85.2595386 ppm, which converts the antioxidant to strong.
Uji Cemaran Coliform Menggunakan Uji MPN pada Air Sumur Gali, Sumur Bor dan PDAM Fatimah, Cut; Safriana, Safriana; Andriani, Sindy
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4955

Abstract

Physical, biological, and chemical parameters form the environmental health quality standards for water media used for sanitary hygiene needs. These parameters must be checked periodically by the laws and regulations contained in the Minister of Health Regulation Number 32 of 2017. One of these requirements is the MPN limit, which is a maximum total Coliform count of 50 colonies per 100 milliliters and requires the absence of Escherichia coli. This study was to ascertain whether PDAM water, borehole, and dug well water in the Cinta Rakyat Village area of Percut Sei Tuan Deli Serdang were contaminated by Escherichia coli and the MPN Coliform index. A 3:3:3 tube series consisting of a prediction test using Lactose Broth (LB) media, a confirmation test using Brilliant Green Lactose Broth (BGLB) media, and a complementary test using Eosin media was used to conduct a microbiological contamination test using the Most Probable Number (MPN) Coliform method. Gram stain with methylene blue agar (EMBA). Six water samples from dug wells, six from boreholes, and one PDAM water sample from the homeowner's residence were used for testing. The samples were randomly selected. The findings showed that two well water samples - ASGD 1 with 75 colonies/100 mL and ASGD 6 with 75 colonies/100 mL - exceeded the total Coliform limit. Six samples taken from dug wells were positive for fecal coliform. The colony count for ASGD 1 was 15/100 mL, ASGD 2 was 7/100 mL, ASGD 3 was 7/100 mL, ASGD 4 was 15/100 mL, ASGD 5 was 4/100 mL, and ASGD 6 was 20/100 mL. Two samples from boreholes were positive for fecal coliform. There were 4 colonies/100 mL for ASBD 2 and 7 colonies/100 mL for ASBD 4. PDAM water samples did not contain non-fecal coliforms and fecal coliforms.
Formulasi dan Uji Aktivitas Antioksidan dengan Metode DPPH dari Minuman Sari Buah Cempedak (Artocarpus Integer) Menggunakan Spektrofotometri UV-Vis Sumardi, Sumardi; Zebua, Nilsya Febrika; Ulpah, Ulpah
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4966

Abstract

As chempedak fruit is only used fresh in the community, it is easily affected by mechanical, chemical, and microbiological factors and decays quickly. Therefore, fruit processing becomes very important to extend the shelf life of the fruit. Making juices, syrups, and juice products with a long shelf life is one of the selected ways of fruit utilization. The preparation of cempedak fruit juice as an antioxidant is the objective of this study. This is a summary of the article to help the reader quickly ascertain the purpose of the study according to the research needs. Fruit juice is a drinkable liquid obtained by squeezing or filtering the pulp. Cempedak juice drink formulas were tested for antioxidant activity in water, sugar, and CMC as part of the formula optimization process using SLD (simple lattice design) and respondent polling. Seven cempedak juice drink formulas with concentrations of 80 µg/mL, 60 µg/mL, 40 µg/mL, and 20 µg/mL were shown to have antioxidant capacity based on the results. The IC50 readings of the seven cempedak juice drink formulas are as follows: 7.948 µg/mL, 2.048 µg/mL, 3.085 µg/mL, 0.435 µg/mL, 11.057 µg/mL, 3.388 µg/mL, and 2.726 µg/mL, all of which were considered very strong. The audience found high popularity in the optimal formula made with a mixture of water, sugar, and CMC addition in the hedonic test, which measured responses to taste, aroma, and color. The highest pH of 4 was achieved in the pH 7 test of the Cempedak juice drink recipe. The homogeneity and cycling test results showed that the beverage formulation could be integrated into the drink.

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