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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
 425   426   427   428   429 
The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging Cita Rosita Sigit Prakoeswa; Riyana Noor Oktaviyanti; Wisnu Triadi Nugroho; Febrina D Pratiwi; Luh Mas Rusyati; I G A A Praharsini; I G A A Elis Indira
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14694

Abstract

Background: Photoaging is a complex biologic process that affects various layers of the skin. Amnioticmembrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability toimprove clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug deliverymethods which shows promising results to improve photoaging .Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare tomicroneedling in photoaging.Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 womenreceived AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvementof pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulatedphotograph skin analyzer.Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM withfractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spotp:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in theimprovement in photoaged skins.
The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress Cita Rosita Sigit Prakoeswa; Agatha Anindhita Ayu Ardhaninggar; Riyana Noor Oktaviyanti; Irmadita Citrashanty; Maylita Sari; Menul Ayu Umborowati; Dwi Murtiastutik
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14695

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
The Impact Factors of Peripheral Diabetic Neuropathy Which is Along with Hyperglycemia, Hypercholesterolemia, and Hyperaggregation Citra Amaniah Anhar; Yetti Hernaningsih; Puspa Wardhani, Soebagijo Adi; Mohammad Saiful Ardhi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14696

Abstract

Objective: The prevalence of T2DM case in 2018 has increased by 10.9%. The majority of T2DMpatients often ignore some of the most important conditions to experience complications, which iscomplications of PDN. This study aims to analyze the dominant factors in PDF patients with hyperglycemia,hypercholesterolemia, and hyperaggregation. Material and methods: This research is a case control studyconducted from April to October 2020. The sample is 85 patients who have been confirmed to have PDNby neurologists aged 40 - 65. Sampling was conducted at several hospitals in Surabaya with a purposivesampling method. Data analysis was conducted in three stages, namely univariate analysis, bivariateanalysis and multivariate analysis. Results: 85 PDN patients who experienced hyperglycemia amountedto 81%, hypercholesterolemia 81%, and hyperaggregation 67%. The dominant factor affecting the threeconditions (hyperglycemia, hypercholeterol, and hyperagregation) in this PDN patient was a history ofhypertension with a value of p = {(0.012); (0.007); (0.001)} and also a long period of suffering from T2DMwith p value = {(0.019); (0.025); (0.041)). Meanwhile, age, gender and regularity for treatment control werenot the dominant influencing factors. Conclusion: Suffered for a long time from T2DM and a history ofhypertension are the main determinants of peripheral diabetic neuropathy which is along by hyperglycemia,hypercholesterolemia, and hyperaggregation.
Ergonomic Workstation Design for Fish Smoking Workers in the Coastal Area of Surabaya Dani Nasirul Haqi; Putri Ayuni Alayyannur
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14697

Abstract

Introduction: Workstation design should be made adjusting the workers’ anthropometry to not put additionalburden on the worker’s body. Fish smoking workers in the coastal area of Surabaya work sitting on a chairas high as their heels which cause them working with unnatural postures. This study aimed to determineergonomic workstation design for fish smoking workers in the coastal area of Surabaya.Methods: Respondents were the total population consisting of 12 male and 18 female workers. The worker’sbody was measured in a sitting position using a measuring tape. Dimensions measured included the reach ofthe thumb as measured from the back, elbow height when seated, calf height, hip width, buttock-popliteallength, and sitting height. Each dimension was calculated on the 5th and 95th percentiles to determine thesize of the ergonomic workstation.Result: Workstations were made with an adjustable concept. The size of the ergonomic workstation designfor male workers includes table width 71.93-77.57 cm, table height 51.81-55.86 cm, chair height 28.64-32.03 cm, chair width 38.66-41.84 cm, chair length 43.24-50.10 cm, and chairback height 89.21-95.46 cm.In addition, for female workers, the size of the ergonomic workstation design includes table width 60.55-68.00 cm, table height 39.21-43.57 cm, chair height 23.64-27.47 cm, chair width 29.13-34.54 cm, chairlength 35.80-39.87 cm, and chairback height 74.28-79.72 cm.Conclusion: It is necessary to make improvements to workstation of fish smoking workers in the coastalarea of Surabaya, as an attempt to make it ergonomic.
Severe Pneumonia: Etiology and Outcome in a Tertiary Hospital in Indonesia Daniel Maranatha, Mawardi; Hamzah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14698

Abstract

Background: Severe pneumonia represents a subset of life-threatening pneumonia. The mortality rate ofpatients with severe pneumonia is considerably high. This study aims to determine the etiology and outcomeof severe pneumonia.Methods: An observational prospective study was conducted from September 2017 to September 2018 onpneumonia patients in a tertiary hospital. Clinical and diagnostic evaluations were carried out to assess theseverity of the disease, etiology, comorbidities, and several other factors associated with outcomes.Results: 140 pneumonia patients were evaluated and 41 patients met the severe pneumonia criteria. Apathogen was found in 20 community-acquired pneumonia (CAP) and 13 hospital-acquired pneumonia(HAP). The most frequently isolated pathogen from the sputum culture of patients with either severe CAPor HAP was Acinetobacter baumannii. The mortality rate of severe HAP patients was higher than thatof severe CAP patients (84% vs. 65%), but the difference was nonsignificant. Most of the subjects hadcomorbidities (CAP 75%, HAP 61.6%). Procalcitonin (PCT) and C-reactive protein (CRP) levels in severeCAP were higher than those in severe HAP (PCT 7.7 vs 6.0, p=0.658; CRP 163.1 vs 93.6, p=0.580), but thedifferences were also nonsignificant.Conclusion: The most frequently isolated pathogens from the sputum culture of patients with severepneumonia were Acinetobacter baumanii, which should be considered at the time of diagnosis and empiricalantibiotic therapy. Severe pneumonia was often accompanied by comorbidities, inflammation responsesincrease in both severe CAP and HAP with a high mortality rate.
The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure David Setyo Budi; Reny I`tishom; Alphania Rahniayu; Mohammad Fathul Qorib
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14699

Abstract

Background: Disruption to healing process results on longer healing duration from the timeline. Povidoneiodine and tulle are common management in wound care. The advance of industry in health sector andthe availability of natural ingredients in Indonesia provide opportunities for developing alternatives forwound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial,and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan canmaintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potentialof turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with“post-test only control group design”. The sample consisted of 30 mice which were assigned into 5 groups.Result: All experimental groups experienced a gradual decrease in wound length. The statistical test resultsfor groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group Idid not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but ithad significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate thereduction of wound length.
Dermatoscopy in Vitiligo: Diagnosis of the Stages Davletshina Alina Y; Lomonosov Konstantin M
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14700

Abstract

The aim of the Study is to identify the main dermatoscopic patterns of vitiligo and to establish theirrelationship with the activity of the process.Materials and Methods: The study involved 63 patients with an established diagnosis of vitiligo. Therewere 34 patients with a progressive course, 11 with a stable and 18 in the repigmentation stage. All patientsunderwent dermatoscopy using a Delta 20T dermatoscope. Statistical processing of research materials wascarried out using the SPSS Statistics software package.Results. In the study, it was found that the most significant changes are manifested in the perifollicularregion. So, progressive vitiligo is characterized by perifollicular pigmentation (91.2%), an altered pigmentnetwork (97.1%), a blurred spot border (94.1%), as well as specific structures - star-shaped formations and“comet tail”. A stable vitiligo process is characterized by perifollicular depigmentation (81.8%), a sharpspot border (72.7%). For the stage of repigmentation, marginal hyperpigmentation (100%), perifolliculardepigmentation (72.2%), blurred spot border (77.8%), “pigmentation islands” (77.8%).Conclusion. For the first time, diagnostic dermatoscopic patterns of vitiligo have been developed, and theirvalue has been shown. Dermatoscopy is a promising auxiliary non-invasive tool for diagnosing vitiligo anddetermining the stage of the disease.
The Relationship between Nutritional Status and Physical Fitness in Pilot International Standard School (RSBI) at the Level of Junior High School in Padang Deri Putra; Nurlan Kusmaedi; Amung Mamun; Syafrudin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14701

Abstract

The problem of this research is the low of level of physical fitness of students of Pilot International StandardSchool (SMP level) in Padang. It happened because of lack of nutrional status and physical activity.The purpose of this research is to reveal the correlation between nutrional status and physical activity,individually and in group. This research is Quantitative Reaearch that used correlational technique continuedby counting the contribution of independent variables to dependent variables. The accessible population ofthis research was all male students (448) of RSBI school in Padang, academic year 2011/2012. The sampleof this research was 67 students or 15% of accessible population by using proportional technique of randomsampling. The instrument of this research to measure physical fitness (Y) was Multistage Running Test(Tes MRT) ; Nutrional Status (X1) with the measure of weight and age converted to Classification Tableof Society Nutritional Status, Directorate of Community Nutrition, Department of Health of Republic ofIndonesia 1999 ; and Psysical Activity (X2) with questionaire. The results of the research are: (1).Thereis a significant relationship between nutrional status and physical fitness and contributed for 12.00% . (2).There is a significant relationship between physical activity and physical fitness and contributed for 26.00%.(3). There is a significant relationship between nutritional status and physical activity and contributed for29.00%. Thus, it can be concluded that increasing the psysical fitness of RSBI students in Padang can bedone by increasing Nutrional Status and Psysical Activity individually and in group.
Comparison the Serum Level of Paraoxonase Activity in Frequent Relapse and Infrequent Relapse Patients with Nephrotic Syndrome Dhuha A. Hussain; Sinan A. Ibrahim; Raid J. Mohamed
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14702

Abstract

Nephrotic syndrome (NS) is distinguished by heavy proteinuria (urine protein:creatinine ratio ?2000 mg/gor ?300 mg/dL, or 3+ protein on urine dipstick), hypoalbuminemia (?2.5 g/dL), and edema. Leakage ofmassive amounts of serum proteins into the urine leads to a hypercoagulable state, a higher rate of infectiousdisease, and the dysregulation of fluid balance. Idiopathic nephrotic syndrome (INS)is one of the most common renal problems in children encountered in day-to-day nephrology practices.The present study was aimed to evaluate the oxidant/ antioxidant status by measuring paraoxonase (PON)activities as well as total antioxidant capacity in steroid sensitive nephrotic syndrome (frequent and infrequentrelapse) and compares it with healthy control children . Paraoxonase activity by spectrophotometer in threegroups consisted of age and sex matched (30) patients with Frequent relapse nephrotic syndrome FRNS ,(30) patients with infrequent relapse nephrotic syndrome (IFRNS) and (30) healthy control children. Theserum level of paraoxonase activity in infrequent relapse group was 101.61±43.0 IU which far less thanfrequent relapse group (160.44±44.22 IU) or controls (228.35±32.35 IU) with highly significant differences.Of note, the difference between control group and frequent relapse group was highly significant.
Effect of Cyanide on the Liver Histological and Biochemical Status Dhurgam Jameel Mohamed; Ghusoon G Al- Janabi; Abbas Natroud Bashi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14703

Abstract

The biochemical and histological response of the rats following dosed on the potassium cyanide wasexamined in this study, about 36 rats were randomly divided into sex groups ; G0 which considers the controlgroup, G1 oral dosed with potassium cyanide concentration 500ppm (500U/L), G2 dosed with concentration1000ppm (1g/L), waiting for a long time 21 days before anatomy the animal. G3, G4, and G5 dosed with2000ppm, 2500ppm, and 3000ppm, respectively to study the effect of high dose concentration on the liverhistology, liver enzyme and lipid profile and determined LD50 (lethal dose), and LC50 (lethal concentration).After anatomy, the animal experiment to study the liver histological and determine the effect of potassiumcyanide concentration on the liver enzymes such as HDL, triglyceride, and cholesterol, compared the resultwith the control group and previous studies . The study indicated the presence of a significant increase (P?0.05) in ALP in the G1 , a non-significant increase (P? 0.05) in the G2 , the G3 and G4 groups suffered froma significant increase (P? 0.05) while the G5 group suffered from a non-significant decrease (P? 0.05) incomparison with G0. The present study also showed that there was a significant increase (P ? 0.05) in GPT inthe G1 , G2 , G3 , G4 in comparison with G0. The study also indicated the presence of a significant increase(P ? 0.05) in GOT In the G1 , G2 and G3 compared to the G0.

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