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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
 426   427   428   429   430 
The Antioxidant Effect of Noni Fruits Extract on HDL and LDL Level of Wistar Rat Induced by High Fat Diet Diah Purwaningsari; Sihning EJ Tehupuring; Nita Pranitasari; Suhailah Hayaza; Lestari Dewi; Dian Ardiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14704

Abstract

Dyslipidemia is an important risk factor for myocardial infarction, cardiovascular diseases, and Nonalcoholic Fatty Liver (NAFLD) disorders. Inflammatory conditions, oxidative stress, and insulin resistance,as well as several risk factors for cardiovascular disease, are also risk factors for this disease. This study aimsto determine the effect of noni (Morinda citrifolia) extract on the improvement of dyslipidemia condition,based on the Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) level. This research is alaboratory experimental study with a post-test only control group design. Male Wistar rat (Rattus norvegicus)were divided into four groups: negative control group with no induction and treatment (K-), positive controlgroup given high-fat diet induction for 14 days (K+), noni extract treatment group given a high-fat diet anda noni extract at a dose of 100 mg/kg BB per day for 7 days (P1), and noni extract at a dose of 200 mg/kgBB per day for seven days (P2). Low Density Lipoprotein and High Density Lipoprotein serum levels weremeasured using the ELISA method. The results showed that there was a significant increase in LDL and adecrease in HDL in both treatment groups (P1 and P2) compared with K(+) group. Therefore, we concludethat noni extract (Morinda citrifolia) played a role as an antioxidant which can increase LDL and decreaseHDL serum levels in rats induced by a high fat diet.
Effect of Photoprotective Cream of Mangosteen Pericarp Extract (Garcinia Mongostana L) Against 8-OHdG After UVB Exposure On Albino Mice Dian Amelia Abdi; Nasrum Massi; Khairuddin Djawad; Sri Vitayani; Nesyana Nurmadilla
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14705

Abstract

Objective: This study aims to determine the effect of the application of mangosteen pericarp extract cream(Garcinia Mangostana L) on levels of 8-OHdG on the skin of mice after exposure to UVB.Method: The study use a pure animal experimental research design with control group. The criteria forinclution were species Swiss albino mice, aged 6 – 9 weeks, weight 20-30 g, female gender and healthy.. Thesamples that met the criteria were divided into 5 groups : UVB, Base Cream plus UVB, 3 groups mangosteenpericarp extract cream with different concentration UVB radiation in mice using a 311 nm narrowband UVB(Dermalight 1000) with the power 450 mJ/cm three times a week for 4 week. Elisa examination was carriedout before and after the experiment.Result: This study used 25 mice albino selected randomly and were divided into 5 treatment groupconsisting of 5 group : UVB alone, UVB with base cream, UVB with mangosten pericarp extract cream withconcentration of 1 %, 3 % and 5 %. The Comperative test levels of 8-OhdG between each group with PostHoc test and found It was concluded that the decrease in OhdG was greatest in group 2 followed by groups5, 4, 3, and 1 (control group), respectively.Conclution: The ELISA levels of 8-OHdG was found that there are significant difference as between thevarious treatment groups (p>0,05). However, the increasing concentration of mangosten pericarp extractcream showed decreased level of 8-OHdG.
The Effect of Nitric Oxide Supplement Intake on the Value of Hematological Examination of Health Workers Exposed to Covid-19 Didik Dwi Winarno; Abdul Rohim Tualek; Noeroel Widajati; Juliana Jalaludin; Nuh Huda; Raden Khairiyatul Afiyah; ,Firman Suryadi Rahman
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14706

Abstract

Objective: Examination of the diagnostic covid-19 gold standard with real time reverse polymerase chainreaction (RT-PCR) is still limited, so that the initial hematological examination (leukocytes, lymphocytes,neutrophils, platelets, hemoglobin, and neutrophil lymphocyte ratio (NLR) plays an important role inmonitoring the course of covid-19 disease Macrophages release nitric oxide (NO) to kill parasites NOinhibits migration and adhesion of leucocytes to the endothelium. Metode: The research design used preexperimental with one group pre-post test, the total sample was 80 health workers who were exposed toCovid-19, the independent variable was the provision of NO and the dependent variable was the result ofa hematological examination (leukocytes, lymposites, platelets, neutrophils, hemoglobin and NLR). Theintervention was given NO 500 mg mixed with warm water 250 cc, given 3 times a day for 5 days, dataanalysis used the T-test with a significance value of a<0.05. Results: There is a difference in the resultsof the pre and post-test hematology giving NO to the results of the examination of leucocytes a=0.001,lymphocytes a=0.000, platelets a=0.000, neutrophils a=0.000, hemoglobin a=0.031, and NLR a=0.000.Conclusion: Giving NO to health workers exposed to Covid-19 can improve the hematology and immunesystems to fight the corona virus.
Immunotherapy Duration and Risk of Psychosocial Emotion and Risk of Attention Deficit Hyperactivity Disorder Prevalence and Relation in Allergic Rhinitis Children Dinda Anes Tunjungsari; Anang Endaryanto; Ahmad Suryawan; Ariyanto Harsono; Zahrah Hikmah; Azwin Mengindra Putera
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14707

Abstract

Background: Allergic rhinitis (AR) is the most common chronic disease in children. Allergic symptomsaffect daily activities and increase risk of psychosocial emotion and attention deficit hyperactivity disorder(ADHD). Immunotherapy has been proven in improving AR symptomsObjective: To identify prevalence of the risk of psychosocial emotion disorder and ADHD and its relationwith immunotherapy duration in AR children.Methods: A cross-sectional study was held in AR children aged 4-18 years at Allergy Immunology OutpatientClinic, Dr. Soetomo Hospital, during March 2017. Immunotherapy duration categorized into 0-6 months, 6months-1 year, 1-2 years, 2-3 years. Psychosocial emotion disorder risk assessed using Pediatric SymptomsChecklist 17 (PSC-17), scored into four different subscales: Internalizing, Externalizing, Attention, andTotal Score. ADHD risk was assessed using Abbreviated Conner’s Rating Scale (ACRS). Statistical analysisusing One-Way ANOVA and Eta test, with a value of p< 0.05 considered as significant.Results: Total of 37 children included. Based on immunotherapy duration 0-6 months, 6 months-1 year, 1-2years, and 2-3 years, prevalence risk of ADHD are 20.6%, 15.4%, 12.5%, and 12.5%, and prevalence ofpsychosocial emotion disorder risk are only in immunotherapy duration 6 months-1 year 12.5%. There wereno correlation between immunotherapy duration with risk of psychosocial emotion disorder (p = 0.945) andsignificantly correlated to ADHD (p = 0.049, r = 0.326).Conclusion: Prevalence risk of ADHD decrease as the immunotherapy duration increase and immunotherapyduration weakly correlated with risk of ADHD.
Ecological Analysis of Maternity Care in Indonesia in 2018 Dinnya Yesica Tandy; Hario Megatsari; Agung Dwi Laksono; Mursyidul Ibad
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14708

Abstract

Policies that encourage maternity care to health care facilities are an important effort to reduce maternalmortality rates. This study aims to analyze the factors related to maternity care coverage in Indonesia. Theecological analysis was conducted using secondary data from the Ministry of Health of the Republic ofIndonesia report in 2018. All provinces were taken as samples. In addition to coverage of childbirth in healthcare facilities as the dependent variable, there were 6 independent variables analyzed in this study, namelypercentage of poor families, a ratio of primary health care/100,000 population, a ratio of hospital/100,000population, a ratio of gynecologist/100,000 population, a ratio of midwife/100,000 population, andcoverage of health insurance ownership. Data were analyzed using cross-tabulation. The results show thepercentage of poor families tends to have a negative relationship with maternity care coverage. Besides,four other variables were found to tend to have a positive relationship with maternity care coverage, namelythe ratio of primary health care/100,000 population, the ratio of hospital/100,000 population, the ratio ofgynecologist/100,000 population, and coverage of health insurance ownership. Meanwhile, the ratio of themidwife/100,000 population was found to have no relationship with maternity care coverage in Indonesia. Itwas concluded that 5 variables show the tendency of the relationship with maternity care coverage in healthcare facilities in Indonesia.
Ketogenic Diet Slows Down Weight Gain in Juvenile Mus musculus with Benzopyrene as Cancer Inducer Dita Mega Utami; Lilik Herawati; Reny I’tishom; Mohammad Anam Al-Ari; Muhammad Miftahussurur; Purwo Sri Rejeki
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14709

Abstract

Objective: This study aims to analyze the ketogenic diet that slows down weight gain in juvenile Musmusculus induced with benzopyrene (BZP). Method: Thirty-six female mice (Mus musculus), 6-8 weeks old,weighted 15-25 grams were divided into six groups randomly. K1 (negative control, standard diet) inducedwith oleum olivarum, while K2 (positive control, standard diet), P1 (ketogenic diet 1), P2 (ketogenic diet 2),P3 (ketogenic diet 3) and P4 (ketogenic diet 4) induced with BZP subcutaneously in the right breast at a doseof 0.3mg/20gBB/day for 14 days. The ketogenic diet was given for the next 28 days. Data were analyzedusing the ANOVA and post hoc LSD test. Results: After 42 days, the ketogenic diet mice experiencedslower weight gain (p=0.000) because BZP induced neurotoxicity and the administration of the ketogenicdiet in juvenile mice induced neurohormonal changes. The ketogenic diet increased ketone plasma level(p=0.000) and reduced blood glucose levels (p=0.002) due to nutritional ketosis state. Conclusions: Theketogenic diet with fat:protein ratio 60:30 slows down weight gain, increased ketone levels and decreasedblood glucose levels in juvenile mice with BZP as cancer inducer.
Molecular Detection of Toxoplasma gondii in Helix pomatia in Wasit Province Iraq Duaa Abdul Khaliq AL-Quraishy; Altamemy A. K. Aakool
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14710

Abstract

DNA of a total of 96 samples of (32) enteric, (32) gastric and (32) pod of Helix pomatia has been obtainedthrough the use of the Genomic DNA Extraction kit and tested by the use of the Real time PCR and specificset of the primers and probe for the detection of the Toxoplasma gondii B1 gene. Six enteric samples and only2 gastric samples have been positive while the others have been negative, that result indicates the presenceof the T. gondii in that snail species, and based upon those results infection can either be acquired from thecontaminated environment or as a result of consuming the grass that has been contaminated with parasiteoocysts. The negative result of pod samples may be due to the failure of filtration the infectious stages ofparasites into the organs that close contacts with environment or inability of the parasites in surviving inthose organs.
New Insight in the Using of Core Needle Biopsy As First Line in Preoperative Diagnosis of Thyroid Nodule Eaman Suud Khalifa; Ayser Hameed Latif
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14711

Abstract

Background: The diagnosis of thyroid nodule by core needle biopsy is different from post resection samplesbecause of difficulties in applying histological criteria for both samples due to limitation in core needlebiopsy sample .Objective: To assess the utility of core needle biopsy in diagnosis of thyroid nodule.Material and Method: We use core needle biopsy as first line method instead of fine needle aspirationand to reach final diagnosis after resection sample . Core needle biopsy results were divided to six groups)unsatisfactory, benign, indeterminate, follicular neoplasm, suspicious for malignancy and malignant)according to The Bethesda system for reporting thyroid cytopathology (1,2,3) .Result : A total of 45 thyroid nodules taken from 45 patients (30 female and 15 male) . Malignant changeswere seen in 19 nodules after surgery and 26 after core needle biopsy. Benign nodules were diagnosed in 11cases after surgery and in 12 cases after core needle biopsy . Final diagnoses were concluded for 34 nodules(76%). Twenty one nodules were diagnosed as malignant nodules and 13 nodules were diagnosed as benignnodules .Conclusions: Core needle biopsy is reliable and valuable tool for the diagnosis of thyroid nodule and canbeen used as an alternative to fine needle aspirate especially in patients with inconclusive results .
Species Composition and Seasonal Activity of Phlebotominae Sand Flies in Kuhdasht City, Lorestan Province, Iran Ebrahim Hosseini-Fard; Aref Salehzadeh; Amir Hossein Maghsood; Behroz Davari; Amir-Hossein Zahirnia
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14712

Abstract

Background: leishmaniasis causes ninth largest burden among infectious diseases and has been known forseveral hundred years in Iran. Phlebotominae sand flies are proven vectors of leishmaniasis and some otherinfectious diseases such as sand fly fever, summer meningitis, vesicular stomatitis, Carri ?on’s disease andChandipura virus encephalitis to human and animals.Aim: To reveal the species diversity and distribution of leishmaniasis vectors, the present study wasconducted with the aim of investigating the fauna and monthly activity of sand flies of Kuhdasht.Methodology: This cross-sectional descriptive study was done on sand flies distribution and seasonalactivity in Kuhdasht city. Using sticky traps and light traps sand flies were collected during activity seasonfrom the end of March to mid-December, 2016.Results: During 8 months of study, totally 4455 sand flies (4157 with sticky trap and 298 with light trap) werecollected. Sandflies include a collection of 7 species composed of Phlebotomus (Phlebotomus) papatasi, P(Paraphlebotomus) sergenti, P (Paraphlebotomus) alexandri, P (Adlerius) halpensis, P (Paraphlebotomus)caucasicus, P (Phlebotomus) salehi and Sergentomyia (Sergentomia) antenata. Activity of sand flies startedin late May and continued until the end of November. Phlebotomus papatasi, P. sergenti and P. alexandriwere three prevalent species in studied areas and two activity peaks were recorded in the end of June and inearly-September.Conclusions: Regarding the presence of proven vectors of leishmaniasis in studied areas and neighboringwith important foci of cutaneous leishmaniasis, monitoring the status of vectors and epidemiology of thedisease in the city and suburb of the Kuhdasht is very important in the prevention of forming a new focusof leishmaniasis.
Therapeutic Effect of Gum Arabic on some Biochemical Parameters in Nephrotoxic Albino rats Eman Aboud Hussein; Husham Qassim Mohammed
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14713

Abstract

The aim of the current study is to evaluate some biochemical parameters in rats treated with gentamicinto induce nephrotoxicity . The experimental study was conducted using 42 healthy adult male rat weighing250-300 grams . The results showed a significant increase (P?0.05) in the levels of urea and creatinine inthe blood serum, an increase in the activity of liver enzymes AST, ALT, ALP and a significant decrease inthe concentration of albumin in adult male rats injected with gentamicin (80 mg / kg IP daily for 10 Days)to induce nephrotoxicity compared to control group. The results showed a significant increase (P?0.05)in the concentration of urea and creatinine in the blood serum and a significant increase (P?0.05) in theactivity of liver enzymes AST, ALT, ALP, and albumin concentration in (untreated induced nephrotoxicity)compared with (control group). The results showed a significant decrease (P?0.05) in the levels of ureaand creatinine in the blood serum and a significant decrease (P?0.05) in the activity of liver enzymes AST,ALT, ALP, kidney weight and a significant increase (P?0.05) in albumin concentration, from the inducednephrotoxicity group treated with (15% w / v / day) Gum Arabic compared to the untreated nephrotoxicgroup, but the values In all treated groups were less than the control group. The present study concluded thatthe induced nephrotoxicity group treated with Gum Arabic showed improvement in some biochemical andhematological parameters associated mainly with nephrotoxicity

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