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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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The Effect of Pare (Momordica Charantia) L. Ethanol Extract on The Formation of Cataracts in Wistar White Rats Nur Rahayuningsih; Desi Agni Mutia; Tita Nofianti
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROCEEDINGS ICHC
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.158

Abstract

Cataract is a clouding of the lens of the eye that reduces the amount of light entering and results in impaired vision. Cataracts remain the leading cause of visual impairment and blindness worldwide. Bitter melon fruit contain flavonoids and polyphenols which have antioxidant activities. Thirty of 9 days age wistar rats was divided into six group. Normal and negative group were given 2 ml/200 g BW rats 1% of PGA orally. Positive control was given 0,0009 g/200 g BW rat of vitamin C. Test group 1, 2, and 3 (were given 0,025 g/200 g BW rats; 0,051 g/200 g BW rats; and 0,1 g/200 g BW rats bitter melon fruit ethanol extract orally, respectivelly). All of the group except Normal were inducted with 0,25 mg/200 g BW rats sodium selenit subcutaneously. Treatment was given until the rat open the eyes for the first time (± 18 days). Eyes were observed macroscopic and microscopically in all group. The ethanol extract of bitter melon (Momordica charantia L.) has preventive activity against the formation of cataracts. The negative control group and dose I included in stage IV, positive control included in stage I, dose II included in stage III and dose III included in stage II. The most effective dose which prevent the formation of eye cataracts was 0,1 g/200 g BW rats bitter melon fruit (Momordica charantia L.) ethanol extract.Keywords : Cataract, Bitter melon fruit, flavonoids
Hubungan Antara Tingkat Pengetahuan dengan Tingkat Kepatuhan Penggunaan Obat Antihipertensi di Instalasi Rawat Jalan RS UNS: Jurnal Farmasi (Journal of Pharmacy), October 2025 Ekawati, Oktavia; Hartono; Dian Anggraini, Truly
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/m9kx3655

Abstract

Hypertension is still the largest disease in Central Java Province in the first quarter of 2023 at 63%. Various efforts to reduce mortality and morbidity due to hypertension have been carried out on a massive scale. The success of treating hypertension is influenced by a number of factors. An example of factors that have an impact is the patient's level of knowledge and understanding of hypertension and patient compliance in undergoing treatment. Knowledge and understanding are very necessary for patients to understand what to do and avoid so that treatment is successful. Compliance with hypertension treatment is important to monitor blood pressure and avoid complications. The research was conducted with the aim of determining the relationship between the level of knowledge and compliance with the use of antihypertensive drugs at UNS Sukoharjo Hospital. The study carried out was a cross-sectional type of research using a questionnaire. Compliance was measured using ARMS (Adherence to Refills and Medication Scale). The sampling technique used is purposive sampling which has inclusion provisions: patients who seek treatment in January-March 2024, undergo routine examinations. The number of samples that met the inclusion and exclusion requirements was 178 patients. Data analysis carried out the Spearman rank correlation test. The study findings show that patients who have a poor level of knowledge about hypertension and its treatment are 4.5%, a sufficient level of understanding is 28.1% and a good level of understanding is 67.4%. The level of patient compliance in using antihypertensive drugs in the low category was 62.4% and in the high category was 37.6%. The results of the Spearman rank correlation test obtained a p value of 0.000 (<0.05) which has a correlation value of 0.262. This indicates that there is a relationship with weak correlation strength on the level of knowledge and compliance in using antihypertensive drugs in the outpatient installation of UNS Sukoharjo Hospital.
Optimasi Formula Sediaan Losion Ekstrak Bunga Rosella (Hibiscus sabdariffa L.) dengan Box-Behnken Design Shofiani, Della; Puspita Tanjung, Yenni; Akmal, Tubagus
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 1 (2025): Jurnal Farmasi (Journal of Pharmacy), April 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/2n52eb47

Abstract

The extract of roselle flowers contains flavonoid and phenolic components, which function as antioxidants that inhibit free radicals, proving beneficial in avoiding skin degeneration. The antioxidant properties of roselle flowers can be included into cosmetic compositions, including lotions. This study aims to create an optimal lotion formulation by adjusting the quantities of the emulsifiers Olivem®900, Cetearyl alcohol, and TEGO®Care 165. The base formula was optimized using the Box-Behnken Design as an experimental framework, facilitated by Design-Expert version 13.05.0 software. The evaluated response factors comprised pH, viscosity, and spreadability. The formulation was maintained at ambient temperature for 28 days and subsequently evaluated using GraphPad Prism version 10.4.0 software. The base optimization method utilized 15 recommended formulations, determining that the optimal base formula comprises 1.6% Olivem®900, 4.2% Cetearyl alcohol, and 9% TEGO®Care 165, achieving a desirability value of 1. The optimal formula layer derived was the foundation of the lotion including roselle flower extract. The results of the stability test analyzed statistically using the t-test showed differences in the pH test which had a significant effect (p<0.05) between the optimum formula of lotion base and the optimum formula of rosella flower extract lotion, but had no significant effect (p>0.05) on the viscosity test and the spreadability test. The results of the analysis using the t-test showed a significance value of p>0.05, which means that the preparation is statistically stable during the storage period.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Essence Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dengan Variasi Konsentrasi Butilen Glikol Freshananda Dzulhija, Aleyda; Aisiyah, Siti; Harjanti, Reslely
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/227qcj79

Abstract

Telang flowers (Clitoria ternatea L.) contain polyphenolic compounds with the main component, anthocyanins, which have high antioxidant properties. The application of antioxidants as skin protection agents is made in the form of essence preparations. The purpose of this research is to make a preparation of ethanol extract of telang flower with varying concentrations of butylene glycol to obtain a formula with the best physical quality and stability and has antioxidant activity. The ethanol extract of telang flower was obtained from the maceration process using 70% ethanol solvent, then the essence formula was made with variations in the concentration of butylene glycol as a humectant, namely 5%; 7,5%; 10%. Physical quality test of essence preparation includes organoleptical observation, homogeneity, viscosity, pH, and stability test using Freeze-Thaw method. Testing the antioxidant activity of essence preparations using the DPPH method. The data obtained were analyzed using SPSS. The results of the research show that the ethanol extract of telang flower can be made into an essence preparation with good physical quality, where variations in the concentration of butylene glycol affect the viscosity of the preparation, namely the higher the concentration of butylene glycol, the thicker the resulting essence preparation. The formula with a concentration of 5% butylene glycol, has good physical quality, is stable in organoleptic and homogeneity and has antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals.
Bacterial Cell Wall Synthesis Inhibition Of Clerodendrum Squamatum Vahl. Phytoconstituents: A Molecular Insight Marko Jeremia Kalalo; Elly Juliana Suoth; Irma Antasionasti; Sri Sudewi; Billy Johnson Kepe; Fatimawali Fatimawali
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROCEEDINGS ICHC
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.159

Abstract

Bacterial Cell Wall (BCW) is an essential part of bacteria. Defects in BCW may lead to bacterial death due to failure in maintaining pressure and cell integrity or shape. Penicillin-Binding Protein (PBP) 2a, 1, 2, 3, and 4 are proteins responsible for Methicillin-Resistant Staphylococcus aureus (MRSA) cell wall synthesis. MRSA is a hard-to-treat bacteria due to its antibiotic resistance. Clerodendrum squamatum Vahl. leaves (CSVL) are used by North Sulawesi-Indonesian people as a medicinal plant to treat inflammation and to heal wounds. So, the present study aims to explore CSVL potential as inhibitors of MRSA cell wall synthesis using in silico approach. CSVL phytoconstituents were analyzed using Gas Chromatography-Mass Spectroscopy (GC- MS), and the chemical structures were retrieved from PubChem and docked to PBP2a, PBP1, PBP2, PBP3, and PBP4 using Pyrx-Vina. The toxicity profile of the phytoconstituents was also calculated. The results showed that CSVL interacts with PBPs with a variety of types of bonding, dominated by hydrogen bonds. The toxicity prediction showed that CSVL has a safe toxicity profile. CSVL can be a good anti-MRSA candidate due to its molecular interactions with BCW synthesis proteins.Keywords: MRSA, antibiotic resistance, medicinal plant, PBPs 
EVALUASI POLA PERESEPAN & PENGARUH RASIONALITAS ANTIBIOTIK PROFILAKSIS TERHADAP KEJADIAN INFEKSI DAERAH OPERASI PADA PASIEN BEDAH ANAK : Evaluation of Prescribing Patterns & Influence of Rationality of Prophylactic Antibiotics on the Incidence of Surgical Site Infections in Pediatric Surgery Patients Yety Lindawati, Novena; Ramadhan, Taufiq
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/yg1g2073

Abstract

Infeksi daerah operasi (IDO) merupakan salah satu infeksi terkait pelayanan kesehatan yang paling banyak ditemukan, dengan insidensi mencapai satu dari 3 pasien yang menjalani operasi. Pemberian antibiotik perlu dilakukan secara rasional untuk memaksimalkan efikasi serta mencegah perkembangan resistensi antimikroba. Penelitian terkait IDO pada pasien bedah anak akan dapat membantu para pemangku kebijakan untuk menentukan langkah yang paling efektif dalam pencegahan IDO. Penelitian ini adalah penelitian observasional analitik dengan rancangan kohort retrospektif, yang melibatkan rekam medik pasien anak yang menjalani prosedur bedah invasif pada periode 1 Juli hingga 31 Desember 2023 di Rumah Sakit Ortopedi Prof. Dr. R. Soeharso Surakarta. Variabel yang diamati dalam penelitian ini adalah rasionalitas dari terapi antibiotik profilaksis yang diberikan kepada pasien bedah anak, dan luaran klinis berupa kejadian IDO. Rasionalitas antibiotik profilaksis dinilai dengan algoritma Gyssens, mengacu pada seri tatalaksana pencegahan IDO yang diterbitkan oleh POP-NeoPed Study Group dan tatalaksana antibiotik profilaksis oleh American Society of Health-System Pharmacists (ASHP). Luaran klinis berupa kejadian IDO ditentukan dengan kriteria yang disusun oleh CDC. Data dari 268 terapi antibiotik profilaksis pada pasien bedah anak, terdapat 33 terapi (12,31 %) yang masuk ke dalam kategori VI (data tidak lengkap), 94 terapi (35,07 %) yang masuk ke dalam kategori V (tidak ada indikasi pemberian antibiotik), 2 terapi (0,75 %) yang masuk ke dalam kategori IVd (ada antibiotik lain yang spektrumnya lebih sempit), 125 terapi (46,64 %) yang masuk ke dalam kategori IIa (tidak tepat dosis), dan 14 terapi (5,22 %) yang masuk ke dalam kategori I (tidak tepat waktu pemberian).
Formulasi dan Uji Sun Protection Factor (SPF) SediaanKrim Ekstrak Etanol 70% Daging Buah Labu Kuning (Curcubita Maxima Durch) Secara In Vitro Ayu Sonia Cahyani; Agitya Resti Erwiyani
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROSIDING SEMINAR NASIONAL KEFARMASIAN
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.149

Abstract

Kosmetik perawatan kulit wajah yang banyak digunakan tersedia dalam berbagai bentuk, salah satunya yaitu bentuk sediaan krim. Kandungan flavonoid buah labu kuningmemiliki potensi dari labu kuning sebagai antioksidan dan tabir surya dimanfaatkan dalam bentuk sediaan krim yang sangat praktis penggunaannya. Efektivitas sediaan dalam melindungi kulitdari radiasi sinar UV biasanya dinyatakan dengan nilai SPF. Tujuan dari penelitian ini yaitu untuk mengevaluasi sifat fisik sediaan krim ekstrak etanol 70% daging buah labu kuning (Cucurbita maxima D.) dengan konsentrasi berbeda dan penentuan nilai Sun Protection Factor (SPF) secara in vitro menggunakan spektrofotometri UV-Vis. Penelitian ini menggunakan metode eksperimental. Daging buah labu kuning (Cucurbita maxima D.) yang telah dilakukan ekstraksi menggunakan metode maserasi kemudian dilanjutkan pembuatan formulasi krim dan penentuan nilai Sun Protection Factor (SPF) secara in vitro dengan metode Mansur dan A.J. Petro. Hasil uji sifat fisik sediaan krim memenuhi persyaratan sediaan krim yang baik kecuali pada uji daya sebar karena kurang dari 5-7 cm. Nilai SPF sediaan krim pada formula basis(0%), formula I (5%), formula II (10%) dan formula III (15%) memiliki rerata nilai SPF 0,59±0,225 (tidak memiliki efektivitas tabir surya), 2,83±1,164 (minimal), 4,43±0,266 (sedang), 6,98±0,099 (ekstra) berdasarkan perhitungan Mansur dan 1,28±0,132 (bukan merupakan tabir surya), 3,80±2,003 (minimal), 7,55±0,913 (minimal), 25,22±1,493 (sedang) berdasar perhitungan A.J. Petro. Sediaan krim ekstrak etanol 70% daging buah labu kuning dengan konsentrasi 0%, 5%, 10% dan 15% memiliki sifat fisik yang kurang baik, pada uji daya sebar tidak masuk kriteria krim yang baik 5-7 cm. Peningkatan konsentrasi ekstrak etanol 70% daging buah labu kuning memberikan nilai SPF yang berbeda.Kata Kunci : Krim, Daging buah labu kuning, SPF
Kajian Literatur: Aplikasi Metode Ekstraksi Modern Untuk Mengekstraksi Senyawa Fenolik dari Bahan Alam Firdiyansyah, Moh. Rofiqi; Sindu Sakti, Aditya; Wulan Kusumo, Djati; Saiful Amin, Muhammad
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/s6cgpw74

Abstract

Phenolic compounds are phytochemicals obtained from plants as a response to stress. This compound has benefits as an antioxidant. Moreover, these compounds have an important role in preventing and treating several disorders such as atherosclerosis, brain dysfunction, diabetes mellitus, and cancer. Obtaining phenolic compounds from natural products, required an extraction method. A modern extraction method is an extraction process using several high technological instruments, to obtain high-yield extract in a short time. This review article performed to summarizes several modern extraction methods that can applied to extract phenolic compounds from natural products. The process of preparing this article was carried out comprehensively using various databases such as Google Scholar, Pubmed, Science Direct, Portal Garuda, NCBI, and BMC, using the keywords "Phenolic Compounds", "Microwave Assisted Extraction", "Enzyme Assisted Extraction", "High Hydrotastic Pressure Extraction”, “Ultrasonic Assisted Extraction”, “Pressure Liquid Extraction”, “Pressure Extraction Fluid”, and “Modern Extraction Methods”. The results show that the most optimal extraction method to extract total phenolics contents was using Microwave Assisted Extraction (MAE) method at 600 watts for 4 minutes using ethanol 70%, this procedure can produce 199.4 mgGAE/g total phenolics contents from the Pomegranate peel plant (Punica granatum L).
The Influence of Education with Audio-Visual Media on Adolescent Knowledge Level in Kaligentong Village, Gladagsari, Boyolali, Central Java About Preventing of COVID-19 Transmission Eka Pratiwi; Lusia Murtisiwi
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROCEEDINGS ICHC
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.160

Abstract

In early 2020, the World Health Organization announced Corona Virus Disease-19 (COVID-19) had become a global pandemic. The spread of COVID-19 is very fast and widespread because it is transmitted human to human. Knowledge about preventing the transmission of COVID-19 is very important to reduce the increase in spread of COVID-19, including among adolescents. This study aims to analyse the influence of education with audio-visual media on the level of knowledge of adolescents in Kaligentong Village, Gladagsari, Boyolali regency, Central Java about preventing the transmission of COVID-19. This is a quasi-experimental study with a non-randomized pretest-posttest design with control group. Sampling was done by purposive sampling. The data collection technique was carried out using a questionnaire that was given online using Google form. Respondents in this study were adolescents aged 15-24 years and unmarried, as many as 82 respondents who were divided into two groups, namely the control group and the intervention group. Data were analysed by Wilcoxon, Mann Whitney and intervention effect tests. The results on this study indicate the influence of education through audio-visual media on the level of knowledge of adolescents in Kaligentong Village, Gladagsari, Boyolali about preventing the transmission of COVID-19 with an effect size of 72,3% and shows a significant difference between the experimental group and the control group.Keywords: COVID-19 prevention, adolescents, education, audio-visual media, level of knowledge
EVALUASI RASIONALITAS PENGGUNAAN ANTIHIPERTENSI PADA PASIEN RAWAT JALAN DI KLINIK HABIL SYIFA MEDIKA: Evaluation of The Rationality of The Use of Antihypertensive In Outpatients at The Habil Syifa Medika Clinic Ayu Safitri, Winda; Saryanti, Dwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/4t8bm846

Abstract

Hipertensi ialah suatu keadaan tekanan darah yang melebihi 140/90 mmHg. Jumlah penderita hipertensi terus mengalami peningkatan oleh karena itu, kemungkinan ketidakrasionalan penggunaan obat antihipertensi turut mengalami peningkatan. Tujuan dilakukan kajian ini agar dapat mengetahui karakteristik pasien dan rasionalitas penggunaan obat antihipertensi di Klinik Habil Syifa Medika tahun 2024. Kajian ini berwujud penelitian deskriptif dengan memakai data retrospektif yakni lembar rekam medis pasien hipertensi tahun 2024. Sampel penelitian yang diperoleh 137 rekam medis pasien hipertensi diambil dengan menerapkan teknik purposive sampling memakai kriteria inklusi serta ekslusi yang sudah ditetapkan. Data yang didapat yaitu karakteristik pengobatan yang dibandingkan dengan literatur PERHI 2019 mengenai “Pedoman Pelayanan Kefarmasian Pada Hipertensi”, serta penatalaksanaan terapi hipertensi. Data yang disajikan berbentuk tabel serta persentase. Hasil kajian ini yaitu obat antihipertensi yang banyak dipakai yaitu dari monoterapi golongan obat CCBs yaitu amlodipin (70%). Rasionalitas penggunaan obat antihipertensi pada pasien hipertensi yaitu tepat indikasi (100%), tepat dosis (87,6%)

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