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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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Formulasi Sediaan Emulgel Ekatrak Etanol 70% Daun Talas (Colocasia esculenta (L.) Schott) Dengan Variasi Konsentrasi Karbopol 940 Erni Rustiani; Septia Andini; Mareda Apriani
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROSIDING SEMINAR NASIONAL KEFARMASIAN
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.150

Abstract

Daun talas diketahui mengandung senyawa flavonoid yang berkhasiat sebagai antibakteri dan antiinflamasi. Ekstrak daun talas dibuat menjadi sediaan emulgel karena bentuk emulgel merupakan sistem penghantaran obat yang baik untuk zat aktif yang bersifat semisolid. Emulgel merupakan gabungan dari dua sediaan emulsi dan gel. Pemakaian secara topikal diharapkan mampu mencapai konsentrasi efektif pada jaringan target. Penelitian ini membuat sediaan emulgel ekstrak daun talas dengan bahan pembentuk gel (gelling agent) karbopol 940. Sebanyak empat formula dibuat dengan variasi konsentrasi karbopol 940 yaitu 0,5% (F1); 1% (F2); 1,5% (F3) dan 2%(F4). Ekstraksi daun talas menggunakan metode maserasi dengan pelarut etanol 70%. Emulgel dibuat dalam 3 tahapan yaitu tahap pembuatan emulsi, pembuatan gel dan Tahap inkorporasi (penggabungan) emulsi ke dalam gel. Hasil sediaan emulgel setelah pengujian stabilita Freeze thaw dan penyimpanan pada suhu ruangan 25-300C menunjukkan mutu yang baik berdsrkan uji organoleptik, ph, sentrifugasi dan viskositas. Sedangkan kadar flavonoid emulgel setelah 8 minggu pada formula 1 berbeda dari formula lainnya (p-value 0,001 < 0,05). Kesimpulannya bahwa pembuatan emulgel ekstrak daun talas dapat menggunakan polimer karbopol 940 (1-2%).Kata Kunci : Daun Talas, Emulgel, Karbopol 940
Formulasi Nanoemulgel Peel Off Ekstrak Buah Stroberi (Fragaria x ananassa) dan Minyak Palmarosa (Cymbopogon martinii) Sebagai Antibakteri Propionibacterium acnes Sundari, Pungky; Puspitasari, Dian; Nur Rahmawati, Aulia
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/c2q54s10

Abstract

Acne is an inflammatory skin disorder that is mostly caused by Propionibacterium acnes. Secondary metabolites such as saponins, tannins, and flavonoids in strawberries and geraniol in Palmarosa oil can function as antibacterials. To produce a more durable product and increase the solubility of Palmarosa oil, a formula was developed in the form of a nanoemulgel peel-off mask because it is easy to apply to the skin, the active ingredient is quickly penetrated, and increases the stability of the active ingredient. The research aims to determine the effect of different concentrations of strawberry fruit extract on the physical properties and antibacterial activity of the test preparation against Propionibacterium acnes. The nanoemulgel peel-off mask was formulated in 3 different concentrations of strawberry fruit extract, namely F1 = 3%, F2 = 4%, and F3 = 5%. The nanoemulgel peel-off mask preparation was made by inserting nanoemulsion into the gel. The test evaluation included the % transmittance test, nanoemulsion type, pH, organoleptic, homogeneity, adhesion, spreadability, viscosity, drying time, and Propionibacterium acnes antibacterial activity test. The results showed that the difference in concentration of Strawberry fruit extract in the nanoemulgel peel off mask preparation had a significant effect on the results of pH, viscosity, spreadability, and adhesion tests, but did not have a significant effect on the results of the Propionibacterium acnes antibacterial activity test. The concentration of 5% Strawberry fruit extract in formula 3 had the best physical properties of the preparation and the greatest antibacterial activity of Propionibacterium acnes compared to other formulas with an inhibition zone value of 12.19 ± 0.70 mm.
Activities Formulation of Jackfruit (Artocarpus Heterophyllus Lamk) and Moringa (Moringa Oleifera) Leaf on Antidiabetic in Vivo Joko Santoso; Atiek Murhayati; Irma Erinda Nur Pratiwi
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2021): PROCEEDINGS ICHC
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.161

Abstract

Indonesia ranks sixth in the world for the highest prevalence of diabetes after China, India, the United States, Brazil, and Mexico. The prevalence of people with diabetes in Indonesia tends to increase, where in 2007 it was 5.7% and in 2013 it was 6.9%. In 2045, the number is estimated to be 16.7 million people with diabetes aged 20-79 years. Jackfruit leaves (Artocarpus heterophyllus Lamk) contain phytochemical compounds, active compounds of flavonoids, tannins, saponins, alkaloids, polyphenols, steroids, where these compounds can reduce blood glucose levels. Jackfruit leaves and Moringa leaves contain flavonoids, tannins, alkaloids, triterpenoids, saponins, and reducing sugars showed that flavonoids have a hypoglycemic effect. Objective To evaluate the activity of the jackfruit and moringa leaf formulations against antidiabetic in vivo. Methods The research used experimental methods with a post test design laboratory research approach where this study was divided into 5 experimental groups, each group consisting of 5 test animals. Results: Tests for blood sugar levels in rats were Group I (ENK 200mg/kgBW) of 110.30 mg/dL, Group II (ENK 400mg/kgBW) of 100.50 mg/dL, Group III (ENK 800mg/KgBW) of 95.50 mg/dL, Group IV (Glibenclamide 150mg/KgBW) of 120, 30 mg/dL and Group V (Aquadest) of 190.30 mg/dL. Conclusion: The effective dose and activity as antidiabetic is group III ( ENK 800mg) because it can reduce blood sugar levels by 95.50 mg/dL compared to other groups.Keywords: Jackfruit leaves, Moringa and Antidiabetes
UJI AKTIVITAS GEL EKSTRAK ETANOL HERBA SELEDRI (Apium graveolens) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH: Activity Test of Celery Herb (Apium graveolens) Ethanolic Extract Gel on Incised Wound Healing in White Rats Mudzakkiroh, Alfiyah Syamsiyatun; Andriani, Disa; Kusuma, Eka Wisnu
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/h6kkt006

Abstract

Luka sayat merupakan luka terbuka yang umum terjadi akibat benda tajam. Penanganan yang lambat dapat meningkatkan risiko infeksi dan memperpanjang waktu penyembuhan. Penggunaan bahan alam seperti seledri (Apium graveolens) menjadi alternatif yang diminati karena kandungan flavonoid, saponin, dan tanin yang memiliki aktivitas mempercepat regenerasi jaringan. Penelitian ini bertujuan untuk mengetahui aktivitas penyembuhan luka sayat sediaan gel ekstrak etanol herba seledri pada tikus putih jantan (Rattus norvegicus). Gel dibuat dalam tiga konsentrasi ekstrak seledri yaitu 1% (F1), 3% (F2), dan 5% (F3). Evaluasi meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas. Aktivitas penyembuhan luka diuji berdasarkan pengukuran panjang luka secara harian hingga sembuh, kemudian dianalisis secara statistik menggunakan SPSS. Hasil penelitian menunjukkan bahwa semua formula memenuhi parameter uji fisik dan dinyatakan stabil secara organoleptis, pH, daya sebar, daya lekat, dan viskositas. Formula 3 memberikan waktu penyembuhan tercepat dengan tidak berbeda signifikan dibanding kontrol positif.
Antibacterial Activity of Extract 96% Purple Leaf Graptophyllum pictum and Stingless Bee Honey Ointment Against Pseudomonas aeruginosa Nofariyanto, Haris; Wijayatri, Ratna; Sakti Wahyuningtyas, Eka; Handayani, Estrin; Wahyu Hidayat, Imron; Oktaviyani, Tiwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 14 No. 2 (2025): Jurnal Farmasi (Journal of Pharmacy), October 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/t68y9480

Abstract

Penggunaan antibiotik konvensional sering kali kurang efektif karena bakteri dapat membentuk biofilm yang mempersulit pengobatan. Penelitian mengenai terapi alternatif menggunakan bahan alami yang memiliki aktivitas antibakteri semakin berkembang. Salah satu bahan alami yang menjanjikan adalah ekstrak daun ungu Graptophyllum pictum (L.). Tanaman ini telah digunakan secara tradisional dalam pengobatan di Asia Tenggara dan mengandung senyawa bioaktif seperti flavonoid, alkaloid, dan terpenoid yang berfungsi sebagai agen antibakteri. Selain itu, madu lebah klanceng juga memiliki sifat antibakteri karena mengandung senyawa seperti hidrogen peroksida, flavonoid, dan asam fenolat. Penelitian ini bertujuan untuk mengetahui efektivitas salep yang mengandung ekstrak Graptophyllum pictum (L.) dan madu lebah klanceng terhadap Pseudomonas aeruginosa. Tiga formula salep diuji berdasarkan diameter zona hambat, yaitu: F1 dengan hambatan 23,42 mm (konsentrasi tinggi), F2 dengan hambatan 14,10 mm (konsentrasi sedang), dan F3 dengan hambatan 13,12 mm (konsentrasi rendah). Hasil penelitian menunjukkan bahwa formula F1 memiliki daya hambat terbesar terhadap P. aeruginosa, diikuti oleh F2 dan F3. Formula dengan konsentrasi lebih tinggi menunjukkan potensi antibakteri yang lebih kuat. Hasil ini menunjukkan bahwa kombinasi ekstrak Graptophyllum pictum (L.) dan madu lebah klanceng, terutama pada konsentrasi tinggi, berpotensi menjadi agen antibakteri yang efektif untuk mencegah infeksi luka.
Uji Aktivitas Penurunan Kadar Glukosa Ekstrak Daun Bayam Merah (Amaranthus tricolor L.) Secara In Vitro Rahma Putri Yulia, Ita; Ingrid Anggraini, Devina
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/shhhdz63

Abstract

Red spinach leaves are a plant that is rich in fiber and antioxidants which can be used to lower blood glucose levels. Some secondary metabolites that play a role include flavonoids and phenols. The aim of this research was to determine whether red spinach leaf extract (Amaranthus tricolor L) has the potential to lower glucose levels in vitro and to determine the EC50 value of red spinach leaf extract (Amaranthus tricolor L) which can reduce glucose levels. Qualitative analysis shows that red spinach leaf extract contains flavonoids and phenols. Quantitative analysis was carried out using UV-Vis spectrophotometry at a wavelength of 744 nm and an operating time of 25 minutes. Based on the data obtained, it shows that red spinach leaf extract has the potential to reduce glucose levels with an EC50 value of 11.0069 ppm
Evaluation of Aseptic Actions of Pharmaceutical Technical Staff in the Process of Reconstitution and Storage of Antibiotic Injection in the Inpatient Room of UNS Hospital Eka Rahma Noviyanti; Lusia Murtisiwi
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.182

Abstract

aseptic dispensing, reconstitution and storage of antibiotic injection
Determination of SPF value in Serum Preparation of Ethyl acetat fraction ethanol extract of Roselle Petals (Hibiscus sabdarifa L.) Vivin Nopiyanti; Reslely Harjanti; Siti Aisiyah
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.163

Abstract

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations..
Antioxidant Activity Test Of Water, Ethyl Acetat, And N-Heksan Fraction Of Ethanolic Extract Of Sarang Semut (Myrmecodia Pendens Merr. & Perry) Agus Suprijono; Ariani Hesti Wulan; Arini Dyah Pratiwi
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.167

Abstract

Sarang Semut (Myrmecodia pendens Merr. & Perry) is a medical plant contains of flavonoids, tannins, phenolic compounds, polyphenols, and vitamin E. Those substances are potent antioxidants. This research refers to previous research that the ethanol extract of Sarang Semut (Myrmecodia pendens Merr. & Perry) provided antioxidant activity with a mean EC50 of 3.8021 µg/ml. The purpose of this research was to determine the antioxidant activity of the fractions of ethanolic extract of Sarang Semut  (Myrmecodia pendens Merr. & Perry) and to determine the highest antioxidant activity of them expressed by EC50. Sarang Semut (Myrmecodia pendens Merr. & Perry) was extracted by soxhletation method using 96% ethanol solvent, then the ethanolic extract partitioned by liquid-liquid fractionation with water, ethyl acetate, and n-hexane. Each fraction at a concentration of 0.9 µg/ml, 1.0 µg/ml, 2.0 µg/ml, 3.0 µg/ml, 4.0 µg/ml, and 5.0 µg/ml were tested by the DPPH method (1,1-diphenyl-2-picrylhidrazyl ) using a spectrophotometer at λ 515 nm and operating time 35 minutes. The result shows the fraction of ethyl acetate has the highest antioxidant activity with a mean EC50 of 2.8821 µg/ml. While the average EC50 fraction of water is 3.8830 µg/ml and n-hexane is 259.9872 µg/ml. From the statistical t test is known that the fraction of water and ethyl acetate have significantly different rates of EC50, while the average of n-hexane fractions were not analyzed statistically because the percentage  antioxidant activity of its fraction is not stable.
The Reduction Of Water Level In Used Cooking Oil Using Bagasse Charcoal (Saccharum officinarum) Kharisma Islamia Nanda Giovani; Purwati Purwati
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 1 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i1.168

Abstract

Recycling technology processes used cooking oil into reusable oil using bagasse as an absorbent material,  to determinate the decrease in water content in used cooking oil using bagasse chacoal. the reseach method is experimental. The sample used is used cooking oil. Water level before the addition of bagasse charcoal was 0,3%. This results after the additional of bagasse charchoal with variation of immersion time 1x24 hours, 2x24 hours and 3x24 hours was 0,1%, 0,03%, and 0,02%.There is reducing in water level after soaking using bagasse charcoal. Water level from used cooking oil more smaller after the addition of soaking time by bagasse charcoal.

Page 11 of 19 | Total Record : 189

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