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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 193 Documents
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Analisis Drug Related Problems (DRPs) Pada Pasien Angina Pektoris RS X Kota Cirebon Tahun 2023 Efriani, Like; Irawan, Ade; Anwar, Mahfud
Jurnal Farmasi (Journal of Pharmacy) Vol 13, No 2 (2024)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v13i2.318

Abstract

Angina pektoris ialah salah satu gejala penyakit jantung yang menjadi permasalahan serta pemicu utama kematian di Indonesia ditandai dengan nyeri dada. Prevalensi angina bertambah tiap tahunnya dikarenakan berbagai faktor resiko seperti usia, gaya hidup serta riwayat penyakit terdahulu seperti diabetes, kolesterol, maupun hipertensi. Penggunaan obat dalam jumlah banyak pasien rawat inap beresiko mengalami permasalahan terkait obat. Drug Related Problems (DRPs) ialah permasalahan pengobatan baik secara langsung ataupun tidak langsung mempengaruhi hasil terapi yang sudah ditentukan. Tujuan penelitian ini yaitu menganalisis kejadian DRPs aktual ataupun potensial pada penderita angina pektoris. Penelitian ini bersifat observasional non-eksperimental. Pengumpulan data diambil dari 66 rekam medis pasien angina pektoris periode Januari- Desember 2023 yang memenuhi kriteria inklusi. Kejadian DRPs dianalisis dengan metode deskriptif kualitatif berdasarkan literatur. Hasil analisis menunjukkan DRPs terjadi pada 61 (92%)  pasien angina pektoris rawat inap. Adanya DRPs pada kategori interaksi obat (60,77%), duplikasi kelompok obat (20,26%), underdosis (12,05%), overdosis (5,13%), serta obat tidak tepat (1,79%). Kemudian hasil analisis tidak menunjukan adanyanya hubungan yang signifikan antara penyakit penyerta dan polifamasi terhadap DRPs. Dapat disimpulkan kejadian DRPs pada pasien angina pektoris rawat inap tergolong cukup besar (92%) perlu peran farmasis dalam mencegah dan mengatasi DRPs yang dialami pada pasien angina pektoris rawat inap.
FORMULASI DAN UJI STABILITAS FISIK MASKER GEL PEEL OFF EKSTRAK METANOL ALGA MERAH (Eucheuma cottonii) VARIASI KONSENTRASI POLIVINIL ALKOHOL (FILM FORMING) Arifin, Arfiani
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.312

Abstract

Red algae is a type of seaweed that has many biological activities. One of the compounds that acts as an antioxidant from red algae is phenolic compounds. The aim of this research is to determine the optimal concentration of polyvinyl alcohol to produce a red algae (Eucheuma cottonii) methanol extract peel-off gel mask that meets the physical stability test requirements. The extraction method used is maceration using methanol solvent. The formulation was made using varying concentrations of PVA FI (8%), FII (9%) and FIII (10%). Based on the research results, it was found that the most optimal PVA concentration and fulfilled the physical stability test requirements before and after storage was obtained at FIII with a PVA concentration (10%). 
ANALISIS GAMBARAN TERAPI DAN INTERAKSI OBAT PADA PASIEN MIXED ANXIETY AND DEPRESSIVE DISORDER DI RUMAH SAKIT ISLAM ARAFAH KOTA JAMBI TAHUN 2021-2023 Andriani, Medi; Sanuddin, Mukhlis; Umairoh, Sarah
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.331

Abstract

Mixed Anxiety and Depressive Disorder (MADD) adalah kondisi individu yang mengalami gejala kecemasan dan depresi secara bersamaan, namun tidak memenuhi semua kriteria diagnostik untuk gangguan ansietas dan gangguan depresi. Saat gejala ansietas dan depresi muncul bersamaan akan menyebabkan penurunan fungsi yang signifikan terhadap penderita. Pada tahun 2015, diperkirakan lebih dari 300 juta orang di seluruh dunia menderita depresi dan ansietas. Berdasarkan data Kementerian Kesehatan Republik Indonesia prevalensi depresi di Provinsi Jambi adalah 1,8%. Selama pandemi COVID-19 didapatkan prevalensi ansietas sebanyak 32,2%. Penelitian ini bertujuan untuk menganalisis gambaran terapi dan potensi interaksi obat pada pasien MADD di Rumah Sakit Islam Arafah Kota Jambi. Sampel penelitian merupakan pasien yang didiagnosa MADD pada tahun 2021-2023 berjumlah 153 pasien. Pengambilan data pada penelitian menggunakan metode retrospektif yaitu penelusuran data sekunder rekam medis. Hasil Penelitian menunjukan bahwa resep racikan banyak diresepkan pada tahun 2021-2023 yaitu berturut-turut sebanyak 52%, 52% dan 50%. Golongan obat yang diresepkan pada penderita MADD pada tahun 2021-2023 berupa antidepresan dan benzodiazepine. Golongan obat pada pasien yang memiliki penyakit penyerta paling banyak diresepkan adalah antipsikotik berturut-turut sebanyak 16%, 17% dan 18% dan golongan antihipertensi sebanyak 3% pada tahun 2021-2023. Obat yang paling banyak diresepkan pada tahun 2021-2023 adalah sertraline sebanyak 14%, 14%, 11% dan alprazolam sebanyak 13%,13% dan 15%. Dosis sertraline yang diresepkan yaitu 50 mg dan alprazolam 0,25 mg, 0,5 mg dan 1 mg. Frekuensi sertraline yang diresepkan yaitu 1x perhari dan 2x perhari.  Frekuensi alprazolam yang diresepkan yaitu 1x perhari dan 2x perhari. Kasus interaksi obat paling banyak yaitu pada tingkat moderat (aripiprazole-sertraline) sebanyak 7% dan 8% pada tahun 2021 dan 2022, sementara pada tahun 2023 sebanyak 9% (alprazolam-aripiprazole).
Identifikasi Kualitatif Ekstrak, Fraksi n-Heksan, Fraksi Etil Asetat, Fraksi Air Herba Bandotan (Ageratum conyzoides L.) Palupi, Dwi Ayu; Pratimasari, Diah; Dhurhania, Crescentiana Emy
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.333

Abstract

Bandotan (Ageratum conyzoides L.) is a plant that grows in subtropical and tropical regions and has high growth and adaptability. Some studies have shown that Bandotan herb has good activity as an antibacterial, anti-inflammatory, antioxidant, and antidiabetic agent. Existing research is limited to the content and activity of Bandotan herb extracts. However, some extracts that undergo fractionation are known to enhance their activity. Therefore, this study aims to identify the flavonoid and phenolic compounds in the polar, semi-polar, and non-polar fractions of Bandotan herb. The research started with macerating the Bandotan herb using ethanol as a solvent and concentrating it to obtain a thick extract. This thick extract was then suspended in warm water and fractionated successively using n-hexane and ethyl acetate solvents. The extracts and fractions obtained were analyzed for their content using tube tests and Thin Layer Chromatography (TLC). The tube test results indicated that the extract, ethyl acetate fraction, and water fraction were positive for flavonoids, while the n-hexane fraction was negative for flavonoids. TLC results showed variations in the compound profiles among the extract and its different fractions.
TINGKAT KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK ARMADA KABUPATEN WONOGIRI Keysha, Keysha Geffi
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.305

Abstract

Service quality is an essential element in the utilization of healthcare services. Evaluating good service quality not only focuses on the physical healing of diseases but also involves the attitude, knowledge, and skills of the staff in providing services. Moreover, effective communication, accurate information, politeness, punctuality, responsiveness, and the availability of adequate facilities and physical environment are equally important. This study employs a descriptive approach with a survey method, examining five dimensions of service quality: reliability, responsiveness, assurance, empathy, and tangible aspects. The population of this study includes all patients who redeem medications and healthcare products at Apotek Armada. Samples were selected using purposive sampling, with the sample size calculated using Cochran's formula, resulting in 385 samples collected in February 2024. The results showed that patient satisfaction levels at Apotek Armada for the reliability dimension were 85.17% (very satisfied), responsiveness 86.97% (very satisfied), assurance 87.39% (very satisfied), empathy 89.27% (very satisfied), and tangible aspects 84.75% (very satisfied). The average satisfaction across all dimensions was 86.71%, categorized as very satisfied. In conclusion, the level of patient satisfaction with pharmaceutical services at Apotek Armada is classified as very high.
Optimasi Formula Sediaan Losion Ekstrak Bunga Rosella (Hibiscus sabdariffa L.) Sebagai Antioksidan dengan Box-Behnken Design Shofiani, Della; Tanjung, Yenni Puspita; Akmal, Tubagus
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v%vi%i.368

Abstract

Ekstrak bunga rosella memiliki senyawa flavonoid dan fenolik yang berfungsi sebagai antioksidan dan dapat digunakan untuk menghambat radikal bebas sehingga efektif mencegah kerusakan pada kulit. Kandungan antioksidan dalam bunga rosella dapat dimanfaatkan dalam suatu sediaan kosmetik seperti sediaan losion. Penelitian ini bertujuan untuk memperoleh formula optimum sediaan losion dengan variasi konsentrasi emulgator Olivem®900, Cetearyl alcohol, dan TEGO®Care 165. Optimasi formula optimum basis dilakukan dengan Box-Behnken Design sebagai desain eksperimen menggunakan perangkat lunak Design-Expert 13.05.0 dengan respon uji yaitu pH, viskositas, dan daya sebar. Pengujian stabilitas sediaan dilakukan selama 28 hari pada suhu ruang dan dianalisis menggunakan perangkat lunak Graphpad Prism versi 10.4.0. Proses optimasi basis dilakukan dengan 15 rekomendasi formula dan hasil formula optimum basis yang diperoleh dengan presentase komponen Olivem®900 1,6%, Cetearyl alcohol 4,2%, dan TEGO®Care 165 9% dengan nilai desirabilitas sebesar 1. Formula optimum yang diperoleh digunakan sebagai basis untuk sediaan losion ekstrak bunga rosella. Hasil analisis uji stabilitas menunjukkan nilai signifikan dengan nilai p<0,05 pada uji pH dan nilai tidak signifikan dengan nilai p>0,05 pada uji viskositas dan daya sebar. Pada respon uji menunjukkan kenaikan dan penurunan selama uji stabilitas, namun hasil yang ditunjukkan masih memenuhi persyaratan sediaan losion yang baik.  
Analysis of Flavonoid, Phenolic Content, and Antioxidant Activity in Chili Pepper (Capsicum frutescens L.) Fruit Stem Extract Fadhli, Haiyul; Putra, Diova Yuswidia; Trihardiyanto, Agus; Frasesa, Roscha Ulfa
Jurnal Farmasi (Journal of Pharmacy) Vol 14, No 1 (2025)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v14i1.360

Abstract

Cayenne pepper (Capsicum frutescens L.) is known to have many medicinal properties, especially its fruit. However, cayenne pepper fruit stalks have not been studied in depth and are only considered waste. This study aimed to ascertain the total flavonoid concentration, phenolic content, and antioxidant activity of the extract derived from cayenne pepper fruit. Sample extraction using multistage maceration with the help of sonication. Using 3 different solvents, namely n-hexane, ethyl acetate, and ethanol in a ratio of 1:4 (b/v), and then sonicated (30 minutes, 20-25 °C, 42 kHz). The calorimetric technique was used to determine the total flavonoid content (KTF). The Folin-Ciocalteu method was used to determine the total phenolic content (KTFe). And the DPPH method with a microplate reader was used to determine the antioxidant activity of ethanol extract. Total flavonoid content of 30.333 ± 1.32 mgQE/g extract, total phenolic content of 16.333 ± 0.89 mgGAE/g extract, and IC50 of 544.82 ± 0.01 µg/mL showed that ethanol extract of chili fruit stalk had weak antioxidant activity.
Sintesis 2,5-bis(4-hidroksibensilidin) siklopentanon dari p-hidroksibenzaldehid dan Siklopentanon dengan Katalis Asam Sulfat Murtisiwi, Lusia; Lusia Murtisiwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

2,5-bis(4-hydroxybenzilidene)cyclopentanone is one of curcumin analog compound. The aim of this research is to synthesize 2,5-bis(4-hydroxybenzilidene)cyclopentanone               from              p- hydroxybenzaldehyde and cyclopentanone using sulfuric acid as a catalyst. Persumably, sulfuric acid, a diprotic acid can be used as a catalyst in synthesizing 2,5-bis(4-hydroxybenzilidene)cyclopentanone. The The research could be clasified as the descriptive explorative non-analytic research with the succedd of synthesizing of 2,5-bis(4- hydroxybenzilidene)-cyclopentanone as the parameter. The research was done by reacting 0,06 mol p-hydroxybenzaldehyde and 0,03 mol cyclopentanone in methanol solution with sulfuric acid as a catalyst. The analysis was occupied with two ways, they were qualitative and quantitative. The qualitative analysis was done in a series of test. They were organoleptic test, solubility test, thin layer chromatography (TLC) test, melting point estimation, elucidation of synthesized compound with infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy. The quantitative analysis was done by estimating the yield of synthesized compound. The research result showed that synthesized compound was a yellowish powder, specified odor, tasteless but it has specified effect on tongue. The melting point of synthesized compound was more than 300˚C. The TLC test showed that synthesized compound has an Rf as much as 0,73 which was different with p-hydroxybenzaldehyde that was 0,84. The IR, 1H-NMR and 13C-NMR spectra showed that the synthesized compound was 2,5-bis(4-hydroxybenzilidene)- cyclopentanone with yield for about 10,64%.  
Pentingnya Interaksi Hidrogen dengan Nitrogen Backbone di Situs FS918 pada VEGFR2 Berdasarkan Analisis 31 Struktur Kristal VEGFR2 Maranantan, Fandriastika; Christy, Anintia Mara
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Polar interactions was observed from 31 VEGFR2 crystal structure using PyMOL 1.2r1.The interactions was seen in form of direct and indirect interactions. From visual observation shows that  nitrogen  backbone  direct  interaction  in  site  FS918  is important  because  approximately  87%  of  the  entire  VEGFR2 crystal structure has this interaction (from 31 crystal structure only 4 that has not interaction)
HUBUNGAN PENGETAHUAN DAN SIKAP IBU SERTA DUKUNGAN KELUARGA TERHADAP PEMANFAATAN PELAYANAN ANTENATAL Ariyanti, Lilik; Nugroho P, Priyadi; Irene Kartasurya, Martha
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

The high maternal mortality rate in Indonesia is related to the low result of the implementation of Ante Natal Care (ANC). The result of the programe in Godog reported is still for compared to the target decided ramely, first visit K1 reported was 68,75% and fourth visit K4 reported was 57,14%. This study aimed to determined the relationship of mother’s knowledge and attitude and family support to the utilization of antenatal services. Kind of this research was explanatory research with cross sectional desain. Data collection by structured quesioner interview. Sample of this study are 45 by using simple random sampling technique. Data analysis for relation test used Chi-Square with 5% significance level. Dependent variable was utilization of health services, and independent variable were knowledge, attitude and family support. The quesioner of knowledge, attitude and family support tested in validitas and reabilitas before. Respondent in Godog Village had a good knowledge (46,7%), positive attitude to antenatal services utilization (66,7%) and got family support (73,3%).The result showed that antenatal services utilization was about 75,6%. Knowledge (=0,001) and family support (=0,044) were significantly associated to antenatal services utilization. Others factor, attitude was not significantly associated. In conclusion that better knowledge and the presence family support could improve the antenatal services utilization.

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