Jurnal Farmasi dan Sains Indonesia (JFSI)
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
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<![CDATA[PENGUJIAN STABILITAS DAN MUTU FISIK LIPSTIK DARI EKSTRAK UMBI WORTEL (Daucus carota L.) ]]>
<![CDATA[Lutsina, Novi Winda]]>;
<![CDATA[Kristyanti, Yulia]]>;
<![CDATA[More, Evanisia]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p1-5
<![CDATA[Lipstick is a cosmetic preparation used to color lips with an artistic touch so as to give an aesthetic impression in cosmetology. The dyes used in lipstick preparations must be paid attention to because they are very likely to be ingested with saliva or the food and drinks consumed, for this reason, it must be ensured that lipstick dyes are made from natural dyes and are not dangerous. Carrots are one of the natural ingredients as a source of antioxidants because they contain the active compound β-carotene which has an intensity of orange to orange color. The purpose of this research is to formulate lipstick from natural carrot root dyes. The extraction method used in this study was carrot root extract obtained from carrot powder maceration with a solvent ratio of methanol and n-hexane. Lipstick formulations were made into 3 kinds of formulations with each extract concentration of 0% in formula I, 5% in formula II, and 10% in formula III. Each lipstick formula was tested for physical quality including an organoleptic test, smear test, melting point test, pH test, and stability test. The results of this study indicate that the color of the lipstick produced in carrot root extract is dark orange-orange. This orange color can come from carrot root juice which can be used as a natural dye. The results of the stability test of the preparations showed that all formulations had a good shape, remained hard, not soft, and not runny or slimy. Formulation II is the formulation with the best stability because at a concentration of 10% carrot root extract the shape is good, not watery, the hardness level does not decrease and it is not easily broken.]]>
<![CDATA[Validasi Metode Analisis Senyawa Enhidrin Dalam Ekstrak Daun Yakon Menggunakan Kromatografi Lapis Tipis (KLT) - Densitometri ]]>
<![CDATA[Nugroho, Ardi]]>;
<![CDATA[Prasasti, Syita Shevia]]>;
<![CDATA[Tamhid, Hady Anshory]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p6-10
<![CDATA[Before using medicinal plant products, quality control is required to determine their quality and consistency. Yacon leaves (Smallanthus sonchifolius) in preclinical trials have pharmacological effects to lower postprandial glucose with enhydrin as the marker compound. This study aimed to develop and validate a TLC-Densitometry method for determining enhydrin in Yacon leave extract. The stationary phase was TLC plates of silica gel GF254, while a mobile phase was the mixture of chloroform:hexane in the ratio of 10:1 was selected for the chromatographic system. Then, the TLC separation was followed by densitometric analysis at 210 nm. The method was validated in terms of linearity, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ), and found to be linear, with a correlation coefficient (R2) 0.9998. The LOD and LOQ values calculated from the calibration curve were 80.57 and 244.1µg/mL, respectively. The method also exhibited acceptable precision, with relative standard deviation values lower than 3%. The accuracy of the method was evaluated based on the recovery percentages, and found to be within an acceptable range (97–107%).]]>
<![CDATA[ANALISIS LOGAM TIMBAL (Pb) PADA PENSIL ALIS YANG BEREDAR DI KABUPATEN TULUNGAGUNG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) ]]>
<![CDATA[Rosyidah, Semi]]>;
<![CDATA[Harmastuti, Nuraini]]>;
<![CDATA[Rejeki, Endang Sri]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p179-186
<![CDATA[Eyebrow pencil is a cosmetic that is used to correct less symmetrical eyebrows. The colors marketed are very diverse. Lead is also obtained from tools used during the production process. This study aims to determine the lead content in eyebrow pencils and to determine the lead levels in eyebrow pencils circulating in Tulungagung by atomic absorption spectrophotometry (AAS) still meets the requirements of BPOM No. 12 of 2019. Sampling using a purposive sampling technique. Preparation samples were carried out using the dry deconstruction method. The research began with chemical and physical qualitative analysis. The determination of lead levels using AAS at a wavelength of 283.3 nm was then determined. The AAS analytical method is suitable for lead based on the results of method verification meeting the requirements including linearity with a value of r = 0.9929, accuracy of 102%, LOD 0,1189 mg/L, but did not meet the LOQ of 0.3964 mg/L. The results showed that 3 out of 5 samples were positive for lead with levels ranging from 4.9339-5.4896 mg/kg. The results still meet the BPOM contamination limit requirements, which are not more than 20 mg/kg, thus all samples are still within safe limits according to the requirements set by BPOM.]]>
<![CDATA[Analisis Tingkat Pengetahuan Ibu terhadap Obat Diare Akut pada Pasien Anak di RS Umum Daerah Drs. Jocobus Luna,M.Si ]]>
<![CDATA[Nadilla, Nadilla]]>;
<![CDATA[Purwanti, Nera Umilia]]>;
<![CDATA[Wahdaningsih, Sri]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p11-16
<![CDATA[Diarrhea is a collection of symptoms of infection that occurs in the human digestive tract caused by several organisms, namely bacteria, viruses and parasites. The aim of this study was to analyze the mother's level of knowledge and determine the influence of the mother's level of knowledge on acute diarrhea medicine in pediatric patients at the Drs Regional General Hospital. Jocobus Luna, M.Sc. The research method is prospective descriptive with a cross sectional research design. The tool used in the research was a questionnaire sheet and processed using SPSS. Sample selection used non-probability sampling techniques and a total of 100 respondents were obtained who met the inclusion criteria. The research results obtained were as many as 49 cases of child diarrhea, with the majority of mothers aged 26-35 years as much as 49%, having a history of education at high school level as much as 60% and 50% of mothers having jobs as housewives, and the highest level of mother's knowledge was in the sufficient group (40%). The conclusion of the research is that the P-Value value is 0.000, so there is an influence between the mother's level of knowledge and the incidence of diarrhea in children.]]>
<![CDATA[Formulasi Orally Disintegrating Tablet (ODT) Furosemide Menggunakan Fast Disintegrant Crospovidone dan Croscarmellose Sodium dengan Metode Kempa Langsung ]]>
<![CDATA[Prastika, Delia Ayu]]>;
<![CDATA[Rejeki, Endang Sri]]>;
<![CDATA[Priyanto, Widodo]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p17-27
<![CDATA[Orally Disintegrating Tablets (ODT) are tablets that disintegrate or break down in less than one minute. Furosemide is a potent diuretic (loop diuretic) used in the treatment of edema associated with hypertension, congestive heart disease, heart failure, liver cirrhosis and kidney disease. Crospovidone is a fast disintegrating agent which is very porous so it can speed up the tablet disintegration time. Croscarmellose sodium is able to absorb water and expand quickly, thereby accelerating the disintegration of the tablet. The aim of this research was to determine the effect of the fast disintegrants crospovidone and croscarmellose sodium on the physical properties and dissolution profile of furosemide ODT, and to find out which fast disintegrant is better in producing good furosemide ODT. This study used seven formulas, namely three formulas with variations of crospovidone 1%, 3% and 5%, three formulas with variations of crosscarmelosse sodium 1%, 3% and 5% and one formula as a control. Furosemide ODT is made by direct compression method. Evaluation of the physical properties of furosemide ODT includes hardness test, brittleness test, and disintegration time test. Tablet dissolution profile testing was carried out in-vitro. The data obtained were analyzed using the one way ANOVA test with a confidence level of 95%. The results showed that the addition of rapid disintegrating crospovidone and croscarmellose sodium at a concentration of 5% was able to influence the hardness, friability and disintegration time of the tablet, as well as increasing the dissolution profile. A better rapid disintegrating agent that produces good furosemide ODT is croscarmellose sodium.]]>
<![CDATA[Formulasi Lotion Sari Buah Mangga (Mangifera Indica L.) Sebagai Pelembab Kulit ]]>
<![CDATA[Karphiawati, Aldilla Shalsa]]>;
<![CDATA[Zuniarto, Ahmad Azrul]]>;
<![CDATA[Pandanwangi TW, Siti]]>;
<![CDATA[Karsidin, Bambang]]>;
<![CDATA[Nafi'ah, Rahma]]>;
<![CDATA[Zakiah, Fitri]]>;
<![CDATA[Dewi, Komala]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p28-34
<![CDATA[Making mango juice lotion (Mangifera indica L.) using various concentration variations is expected to produce mango juice lotion (Mangifera indica L.) which meets the requirements for a good lotion and tests skin moisture against the mango juice lotion formula (Mangifera indica L.). This study aims to determine the best concentration of mango (Mangifera indica L.). In this study, mango juice was obtained by extortion, made in the form of lotion and tested for skin moisture using a Skin Analyzer. Data analysis in the form of SPPS (Statistical Product and Service Solution) tables. The results showed that the addition of the concentration of mango juice (Mangifera indica L.) had an effect on the resulting skin moisture. The selected formula of Mango juice lotion (Mangifera indica L.), namely formula 1 with a concentration of 5%, has a skin moisture value of 70,55%, and Mango fruit juice lotion (Mangifera indica L.).]]>
<![CDATA[Uji Aktivitas Antidiare Ekstrak Etanol Daun Ramania (Bouea macrophylla) Terhadap Mencit Betina Galur Swiss Webster ]]>
<![CDATA[Aryzki, Saftia]]>;
<![CDATA[Safitri, Ayu]]>;
<![CDATA[Yesika, Yesika]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p35-44
<![CDATA[Diarrhea is still one of the leading causes of morbidity and mortality in almost all geographical regions of the world. All age groups are susceptible to diarrhea, but severe disease with high mortality is especially common among infants and children. In developing countries, children suffer from diarrhea more than 12 times per year and it accounts for 15 - 34 percent of all deaths. The ramania plant is green when young, and is often consumed as a salad or a mixture of ramania chili sauce. Ramania leaf extract contains several secondary metabolites, one of which is tannin, which has activity as antidiarrheal with the mechanism that the broken down tannate protein will bind to hydrolyzed tannin and pass through the intestine so that it can reduce the secretion of the small intestine and cause constipation. This research method is true experimental with pre-post test design with randomized control group design method with female Swiss Webster mice. The results suggest that the extract has met the parameters of simplisia standardization and extract standardization. The extract is proven to contain flavonoids, tannins, alkaloids, saponins, anthraquinones, phenolics, and terpenoids. Ramania leaf extract is proven to have antidiarrheal activity with a concentration of 400mg / kgBB against oleum ricini-induced mice based on the parameters of diarrhea onset time, decreased diarrhea frequency, and duration of diarrhea. Ethanol extract of ramania leaves at a dose of 400 mg/kgBB provides the best antidiarrheal activity against mice induced by oleum ricini.]]>
<![CDATA[Uji Aktivitas Analgetika Ekstrak Daun Mahang (Macaranga bancana) Terhadap Mencit Putih (Mus musculus L.) Jantan ]]>
<![CDATA[Mukti, Yusuf Anggoro]]>;
<![CDATA[Oktavia, Nadia]]>;
<![CDATA[Andrian, Ine]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p45-50
<![CDATA[According to The International Association for the Study of Pain (IASP) pain is an unpleasant sensory and emotional experience due to damage or threat of tissue damage. When there is damage to body tissue, such as surgery, it will produce damaged cells with the consequence of releasing algesic chemicals that can cause pain. Most clinical guidelines recommend NSAIDs as first-line treatment for pain. The use of NSAID drugs has several side effects including increasing the risk of impaired renal function, bleeding in the gastrointestinal tract, myocardial infarction and stroke. Various side effects caused by using NSAID drugs, then treatment using herbal medicine to treat pain is still an alternative treatment that is expected to have smaller side effects. One plant that is very useful as a medicine is the mahang plant. Based on the results of research, the methanol extract of mahang leaves contains alkaloid, flavonoid, polyphenol and terpenoid/steroid compounds. Flavonoids are secondary metabolite compounds contained in mahang leaf extract which are thought to have pharmacological effects as analgesic agents. The purpose of this study was to evaluate the presence or absence of analgesic activity of mahang leaf extract. This research method is the Tail Flick Test Method using heat as a pain inducer. The administration of mahang leaf extract (Macaranga bancana) to male white mice (Mus musculus L.) can reduce pain due to hot water stimulation as indicated by the extension of the tail flick response time. The optimum concentration of mahang leaf extract that gives analgesic effect is the concentration of mahang leaf extract 400mg/KgBB.]]>
<![CDATA[Pengaruh Edukasi DAGUSIBU terhadap Pengetahuan Kader Desa Dasan Borok ]]>
<![CDATA[Oktresia, Erma Ewisa]]>;
<![CDATA[Gemantari, Baiq Maylinda]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p51-55
<![CDATA[The inadequate knowledge about drugs usage might be leading to emerging the unwanted effect of drugs. Ikatan Apoteker Indonesia, the committee of pharmacists in Indonesia, by their DAGUSIBU program make an attempt to overcome that problem. To increase the public knowledge, DAGUSIBU is implemented by educate public about four principal of drugs usage as how to get; how to use; how to store; and how to dispose the drugs. By establishing this program especially for the cadre of posyandu program, it is hoped the cadre might have impactful role to arising the public awareness and knowledge about drugs usage. This research is aimed to increase the knowledge of the cadre in Dasan Borok Vilage about drugs usage by DAGUSIBU program. This research was designed as quasi experimental using pretest-posttest analysis by questionnaire and education treatment as instrument research. There were 30 cadres take this program as participants. As the results, its was known that education treatment significantly enhance participants knowledge about drugs usage proven by pretest and postest analysis using marginal homogeneity test.]]>
<![CDATA[PENGARUH FABRIKASI BERUPA PERBANDINGAN PRODUK OBAT PATEN PANADOL DAN SANMOL ]]>
<![CDATA[Rahmawati, Shinta]]>;
<![CDATA[Aryzki, Saftia]]>
<![CDATA[ Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024) ]]>
Publisher : <![CDATA[LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera ]]>
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DOI: 10.52216/jfsi.vol7no1p56-59
<![CDATA[Availability is a measure of the rate and amount of a therapeutically active drug that reaches the general circulation. As for bioequivalence requirements, a requirement made by the Food and Drug Administration (FDA) for in vitro and/or in vivo testing of certain medicinal products, these requirements must be met as a condition for marketing. Bioequivalence of a medicinal product is pharmaceutical equivalent or an alternative is a preparation whose rate and amount of absorption do not differ significantly when given at the same dose and experimental conditions. Several drugs that have the same amount of absorption but differ in absorption rate can be considered pharmaceutical equivalent if the difference in absorption rate does not cause a significant difference in clinical effects.]]>
