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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Pengaruh Edukasi DAGUSIBU terhadap Pengetahuan Kader Desa Dasan Borok Oktresia, Erma Ewisa; Gemantari, Baiq Maylinda
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p51-55

Abstract

The inadequate knowledge about drugs usage might be leading to emerging the unwanted effect of drugs. Ikatan Apoteker Indonesia, the committee of pharmacists in Indonesia, by their DAGUSIBU program make an attempt to overcome that problem. To increase the public knowledge, DAGUSIBU is implemented by educate public about four principal of drugs usage as how to get; how to use; how to store; and how to dispose the drugs. By establishing this program especially for the cadre of posyandu program, it is hoped the cadre might have impactful role to arising the public awareness and knowledge about drugs usage. This research is aimed to increase the knowledge of the cadre in Dasan Borok Vilage about drugs usage by DAGUSIBU program. This research was designed as quasi experimental using pretest-posttest analysis by questionnaire and education treatment as instrument research. There were 30 cadres take this program as participants. As the results, its was known that education treatment significantly enhance participants knowledge about drugs usage proven by pretest and postest analysis using marginal homogeneity test.
PENGARUH FABRIKASI BERUPA PERBANDINGAN PRODUK OBAT PATEN PANADOL DAN SANMOL Rahmawati, Shinta; Aryzki, Saftia
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p56-59

Abstract

Availability is a measure of the rate and amount of a therapeutically active drug that reaches the general circulation. As for bioequivalence requirements, a requirement made by the Food and Drug Administration (FDA) for in vitro and/or in vivo testing of certain medicinal products, these requirements must be met as a condition for marketing. Bioequivalence of a medicinal product is pharmaceutical equivalent or an alternative is a preparation whose rate and amount of absorption do not differ significantly when given at the same dose and experimental conditions. Several drugs that have the same amount of absorption but differ in absorption rate can be considered pharmaceutical equivalent if the difference in absorption rate does not cause a significant difference in clinical effects.
Identifikasi Boraks pada Jajanan Bakso Tusuk di Lombok Timur Gemantari, Baiq Maylinda; Fatmayanti, Baiq Risma; Ramadhan, Leny
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p60-64

Abstract

Meatballs are a processed meat-based food commonly processed by adding chemical preservatives. Many reports find the usage of borax as the chemical preservative in meatballs sold in large markets on Lombok Island. However, the use of borax in the type of meatball consumed as snacks called skewered meatballs has not been identified thoroughly in East Lombok. This study aimed to identify borax in skewered meatballs in East Lombok qualitatively by curcumin paper test and flame test colors using sodium tetraborate as standard. The result showed that 4 samples confirmed positive for borax through the curcumin paper test. Two of those four samples showed the same flame color as standard corresponding to the presence of borax as a preservative in skewered meatballs tested. These results indicate that the curcumin paper test and flame color test were compatible in identifying borax in skewered meatball samples qualitatively.
AKTIVITAS EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) PADA SEDIAAN SALEP BASIS ABSORPSI TERHADAP BAKTERI Propionibacterium acne Maulana, Restu; Prabandari, Rani; Nawangsari, Desy
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p65-77

Abstract

Moringa leaves contain flavonoids, alkaloids, saponins and tannins that can inhibit bacterial growth. In order to make the use of moringa leaves more practical, an absorption base ointment formulation was made. Ointment preparations were chosen because they are suitable for medicinal purposes on the skin because the drug contact with the skin is longer. This study aims to determine the physical properties, stability and antibacterial activity of absorption base ointment preparations of moringa leaf ethanol extract. The research method is experimental laboratory. The extract concentrations used were F0 (base), F1 (15%), F2 (20%) and F3 (25%). Physical quality testing is seen from organoleptic, homogeneity, pH, spreadability and stickiness. The pH test results were sequentially obtained as 6.33 ± 0.15, 5.9 ± 0.1, 5.6 ± 0.1 and 5.56 ± 0.15. The spreadability test sequentially obtained 2.87 ± 0.07, 2.9 ± 0.05, 3.05 ± 0.05 and 3.25 ± 0.1 cm. The stickiness test was 17.60 ± 0.60, 17.59 ± 0.46, 16.87 ± 0.47 and 16.18 ± 0.56 seconds. The results were analyzed using SPSS 26 with One Way ANOVA, there were significant differences in pH values, spreadability and adhesiveness with a significance value of <0.05. The results of the stability test with the Cycling test method analyzed by T-test there was no significant difference from each formula between day 0 and day 12 with a 2-tailed value >0.05 which means that the formulas made are all stable in the stability test. Formula 1, 2 and 3 can inhibit Propionibacterium acne bacteria with an average inhibition zone of F1 10.34 ± 1.86 mm, F2 13.77 ± 3.43 mm and F3 16.67 ± 0.97 mm. It can be concluded that the three formulas have strong inhibition.
Gambaran Karakteristik Kepatuhan Penderita Hipertensi Dengan Di Puskesmas Ngaliyan Kota Semarang Farizi, Gilang Rizki Al; Aprilia, Eka Rosita; Gloria, Fransisca; Dewi, Rissa Maharani; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p218-224

Abstract

Abstract: Hypertension is a disease that is often found in Indonesia. A person is said to have hypertension if systolic blood pressure >140 mmHg and diastolic pressure >90mmHg. Adherence to the use of drugs plays an important role in the long-term treatment of hypertension in order to reduce the risk of complications. This study aims to determine the characteristics of compliance of hypertension patients at the Ngaliyan Health Center, Semarang City. This study used a quantitative design with observational research and cross sectional data collection using patient health medical record data for the period January - April 2023. The instruments used were MMAS-8 and Health Beliefe Model with 240 respondents who met the inclusion criteria. The results of the description of the characteristics of compliance in patients with hypertension) can be concluded that most have a moderate level of compliance as many as 130 respondents (54.2%) while respondents who have a low level of compliance are 77 respondents (32.1%) and those with high compliance are 33 respondents (13.8%).
Analisis Aktivitas Antioksidan Pada Fraksi Aktif Kacang Lebui Lombok (Cajanus cajan) Febriani, Yuyun; Habibatusshalihah, Habibatusshalihah
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p78-87

Abstract

Cajanus cajan or known as lebui is one of the local plants of Lombok which is used as a side dish and in some places empirically used as a treatment. This study aims to identify and analyze the antioxidant activity of the active fraction of lebui beans with various solvent variations. The design of post-test was used this study. The extract used was 96% ethanol extract with liquid-liquid fractionation method in various solvents such as methanol, n-hexane, and ethyl acetate. The results obtained were tested by thin layer chromatography with a standard comparison of vitamin C (ascorbic acid) in the eluent composition of ethyl acetate: methanol: formic acid (8:2:0,5). The antioxidant activity test used two tests, namely qualitative testing by spraying DPPH on the TLC plate and quantitative testing using UV-Vis’s spectrophotometer. The TLC test results obtained that the Rf value of lebui bean extract was 0.8, the Rf value for fraction I (n-hexane) was 0.8, the Rf value for fraction II (ethyl acetate) was 0.8, the Rf value for fraction III (methanol) was 0.2 and the standard Rf value for vitamin C was 0.8. The results of the qualitative test showed that fraction I and fraction II contained antioxidants. Further quantitative testing showed that the IC50 value of fraction I (N-Hexane), fraction II (Ethyl Acetate, and standard respectively were 148 ppm, 88.4 ppm, and 48 ppm. Based on this, it can be concluded that lebui beans have antioxidant activity in the category of strong antioxidant activity and more fracted on more polar solvent
Aktivitas Antibakteri Ekstrak Etanol Daun Mangga (Mangifera indica L. var. Arum Manis) Terhadap Bakteri Streptococcus pyogenes Hilda, Nabila Husnaini; Mulangsri, Dewi Andini Kunti
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p99-104

Abstract

Mango leaves contained active compounds such as tannins, flavonoids, phenols, and saponins. Its absorbed in ethanol extract and acted as antibacterial against Streptococcus pyogenes bacteria. The purpose of this study was known active compounds and the antibacterial activity against Streptococcus pyogenes bacteria of ethanol extract of mango leaves (Mangifera indica L. var. Arum Manis). Ethanol extract of arum manis mango leaves (EEAML) was obtained by maceration method with 96% ethanol solvent that was tested for phytochemical screening such as alkaloid, flavonoid, phenolic, tannin and saponin. Serial of EEAML concentration has made at 5, 7.5, 10 (%) with DMSO solvent that was tested for antibacterial activity by disk diffusion method and gradually incubated at 37° C for 48 hours then at room temperature for up to 60 hours in anaerobic jars. Positive and negative control were used erythromycin 15 µg/disk and DMSO solvent respectively. The data, that resulted from phytochemical screening test and antibacterial activity test, was analyzed by descriptively. The results of phytochemical screening test of EEAML was contained as flavonoids, phenolics, tannins, and saponins.The EEAML was showed antibacterial activity all of concentrations with zone of inhibition diameters values at 13.03 mm, 16.83 mm and 18.27 mm.
Optimasi Formula Sediaan Toner Tea Tree Oil (Melaleuca alternifolia (Maaiden & Betche) Chell) dengan Variasi Gliserin Dan Propilen Glikol Menggunakan Metode Simplex Lattice Design Adityas, Hanung Puspita; Wulansari, Eka; Fitria, Sabila Nur
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p88-98

Abstract

Toner formulation is created using a combination of glycerin and propylene glycol. Glycerin can activate transglutaminase activity in the stratum corneum, increase the corneocyte maturation process and reduce scaling in xerotic skin. Propylene glycol is a penetration enhancer so it is usually used as a solvent and carrier for substances that are not soluble in water. As part of the formulation developement, the product is formulated as a toner. This research aims to determine the optimum composition of the toner formula with variation in the concentrations of glycerin and propylene glycol to achieve the optimal formula. This research uses the Simplex Lattice Design method. The evaluation tests carried out were organoleptic, specific gravity, viscosity, pH, transferred volume and hedonic tests. The organoleptic test results are white with a liquid texture and a distinctive aroma of tea tree oil. The specific gravity results meet the range between 1.01-1.1. The panelists' hedonic test results preferred the color and texture/shape of the tea tree oil toner, while the aroma preferred the comparison toner. Optimizing the optimum formula resulted in 12% glycerin and 8% propylene glycol with predicted values of pH 5.91, viscosity 3.70, and volume transferred 95.84. The optimum formula shows an average replication of 1.2 and 3 in the pH test of 5.84, viscosity of 3.76 and volume transferred 96. The results of the optimum formula and predicted values were analyzed using the One Sample T-Test, and the results showed that there were no significant differences. (p>0.05) namely pH test 0.981; viscosity 0.899; and the volume moved was 0.408. The conclusion of this research is that the tea tree oil toner preparation obtained an optimum formula with a ratio of 12% glycerin and 8% propylene glycol.
Optimasi Formula Sediaan Minyak Telon Bayi Tree Tea Oil (Melaleuca alternifolia Cheel) dengan Variasi VCO dan Olive Oil dengan Metode Simplex Lattice Design Adityas, Hanung Puspita; Wulansari, Eka; Sari, Rizka Noviana
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p118-127

Abstract

One of the plants that can be used as a natural medicine is the tea tree plant (Melaleuca alternifolia Cheel) which is generally known as the tea tree. The tea tree plant contains essential oils which are useful as antimicrobial and anti-inflammatory. Another plant that can be used as a natural ingredient is the fennel plant (Foeniculum vulgare Mill) which contains essential oils which are useful as antimicrobials. In order to develop the preparation, a telon oil preparation was formulated. The use of additional ingredients in the formulation of telon oil preparations, namely VCO and Olive Oil as vegetable oils which function as solvents for essential oils, can certainly affect the physical properties of telon oil preparations, so a method is needed to find an optimum formula that meets the good physical properties of the preparation. This research aims to determine the optimum formula composition of telon oil preparations with variations of VCO and Olive Oil using the Simplex Lattice Design method by looking at the results of evaluation tests of the physical properties of telon oil preparations which include organoleptic tests, homogeneity tests, pH tests, specific gravity tests, viscosity tests and displaced volume test. The results of organoleptic tests, homogeneity, pH, specific gravity, viscosity and transferred volume have met the requirements. Analysis using SLD showed that the optimal preparation formula for baby telon tree tea oil (Melaleuca alternifolia Cheel) was obtained with a VCO and Olive Oil composition of 78.4% and 19.6% with a specific gravity response value of 0.906 gr/ml, viscosity 36.84 cp and volume transferred 57.33 ml. In the hedonic testing of baby telon oil preparations, tree tea oil (Melaleuca alternifolia Cheel) with variations of VCO and olive oil from the optimum formula in terms of color was preferred more by the panelists.
Formulasi Sediaan Krim Ekstrak Etanol Lobak Tengger (Raphanus Raphanistrum L.) Dan Uji Aktivitas Antijamur Terhadap Candida Albicans ATCC 10231 Aziz, Yaya Sulthon; Novitasari, Heni; Wulandari, Septiana Indah Ayu
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p105-111

Abstract

The seaweed plant (Rhapanus raphanistrum L) has been used as a traditional medicine due to its many pharmacological effects. The tree is known to have benefits for treating fever, typhoid, syphilis, and diarrhea due to its important contents, including saponins, flavonoids, and polyphenols. The aim of this study is to standardize the extracts and make a cream preparation with a type M/A ethanol extract of the Tengger Shell (Rhapanus raphanistrum L), which can stop the development of the fungus Candida albicans. Laboratory experiments are this kind of research. The sample was taken by random sampling to test the resistance to Candida Albicans ATCC 10231. The results of this study showed that the ethanol extract of Tengger Rye (Rhapanus raphanistrum L) was obtained from the dried tengger rye bulbs using a method of maseration with 96% ethanol. The extract is thick, brownish, characteristic smell, and bitter taste, and has chemical content like flavonoids, saponins, and tannins. The resulting randomness was 13.57%. Non-specific parameters resulting from a drying suspension of 2.03%, extract type weight of 0.27%, water content of 3.26%, total ash of 14.28%, and acid insoluble ash of 2.67% meet the established quality standards. Antifungal activity suggests that the preparation of the cream ethanol extract of Tengger (Raphanus raphanistrum L.) has the ability to inhibit the fungus Candida albicans. The average diameter of formula I is 5 mm, formula II is 5mm, formula III is 10mm, and formula IV has a maximum barrier zone of 11mm. The results of research and data analysis showed that the cream ethanol extract of Tengger Shrimp (Raphanus raphanistrum L.) inhibits the fungus Candida albicans.

Page 15 of 25 | Total Record : 244

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