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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Optimasi Sediaan Toner Wajah Daun Pegagan (Centella Asiatica) Sebagai Anti Acne Dengan Variasi Polisorbat 20 Dan Gliserin Menggunakan Metode Simplex Lattice Design Sabiti, Farroh Bintang; Juarti, Ika Buana; Alfa, Zahra Syani
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p134-140

Abstract

One common issue that arises from insufficient facial hygiene is acne. Treatment of acne using synthetic drugs, such as antibiotics and retinoids, is usually administered topically in the form of ointments. However, the use of these drugs often results in side effects such as skin irritation. Therefore, there is a need for herbal remedies that can address this issue, one of which is the use of gotu kola leaves. Gotu kola (Centella Asiatica) is a plant that has many benefits, with numerous studies indicating its impact on inhibiting the growth of bacteria that cause acne, such as S. aureus, Proteus vulgaris, and Escherichia coli. Hence, further research is needed to determine the optimal formula for a facial toner preparation containing gotu kola leaves (Centella Asiatica) as an alternative therapy for acne-prone skin, with variations of polysorbate 20 and glycerin.This study aims to determine the optimum formula for a facial toner preparation containing gotu kola leaves (Centella Asiatica) that meets the physical parameters of the preparation and to determine the optimal concentrations of polysorbate 20 and glycerin that can produce the optimum formula for the facial toner preparation containing gotu kola leaves (Centella Asiatica). This research employs laboratory experimental methods, and the results indicate that the optimum formula for the gotu kola leaf toner preparation (Centella Asiatica) has concentrations of Polysorbate 20 at 10% and Glycerin at 5%. Organoleptic testing, homogeneity testing, viscosity testing, and pH testing of the optimum formula meet the range of parameters and requirements for evaluating the physical properties of a good toner preparation.
OPTIMASI FASE GERAK KROMATOGRAFI CAIR KINERJA TINGGI PADA PENETAPAN KADAR PIPERIN BUAH CABE JAWA (Piper Retroofactum Vahl.) Christina, Odilia Dea; Nurul, Aisiyah; Ina, Ayu
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p187-191

Abstract

Piperine is the main alkaloid compound found in various types of pepper, including long pepper (Piper retrofractum Vahl.). Determining the piperine content in natural materials and processed products is important in the context of quality control and pharmaceutical research. The analytical method frequently used for determining piperine content is High-Performance Liquid Chromatography (HPLC). One critical factor in HPLC analysis is the selection and optimization of the mobile phase. This study aims to optimize the mobile phase in HPLC analysis to determine piperine content. The mobile phases used were acetonitrile:methanol:distilled water (60:10:30) and acetonitrile:methanol:distilled water (65:5:30). The results showed that the optimal mobile phase for determining piperine content using HPLC is a mixture of acetonitrile:methanol:distilled water in the ratio of 65:5:30 (v/v)
Uji Efektivitas Penyembuhan Luka Bakar dari Sediaan Gel Ekstrak Daun Jarak Pagar (Jatropha Curcas L) pada Tikus Putih Jantan (Rattus Norvegicus) Mesak, Ivan; Christina, Odilia Dea; T.I., Angelina
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p172-178

Abstract

The occurrence of burns on the skin is a type of injury that requires fast and appropriate treatment in order to achieve an optimal level of healing. Handling burns using medicinal plants can be done. One of the plants that can be used is Jatropha leaves. Jatropha leaves contain active substances such as saponins, tannins, alkaloids, and flavonoids that are efficacious as antibacterial, antioxidant, anticancer and antiinflammatory. The purpose of this study was to determine the effectiveness of Jatropha curcas leaf extract gel preparations with concentrations of 10%, 15%, 20% on burn wound healing. This study is an experimental study by comparing the effectiveness of burn wound healing in rats in each test group, namely negative control given gel base, positive control given Bioplacenton gel, and three test control groups with each given Jatropha leaf extract gel concentrations of 10%, 15% and 20%. The test results show that the most effective Jatropha leaf extract gel preparation heals rat burns, namely the 20% concentration compared to the positive control with a P>0.914 value (P>0.05).
Analisis Proteksi Radiasi Ruang Terkontrol Cath-Lab Selama Tindakan Pemeriksaan Di RSUD Murjani Sampit Manik, Jhon Wesly; Hakim, Luqman
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p65-69

Abstract

Continuous exposure to radiation on Cah Lab equipment during procedures can produce significant environmental radiation. Therefore, the safety of medical worked and the public is very important and must comply with PERKA BAPETEN No. 4 of 2020 which sets a radiation exposure limit of 20 mSv/year for radiation workers and 1 mSv/year for the environment or community. This research focused on measuring radiation exposure at three different points in the Cath Lab control room, namely point 1 on the operator's glass, point 2 on the top door, and point 3 on the bottom door. The measurement method uses a Gamma Surveymeter which is placed at a distance of 30 cm from each measurement point, then the radiation background value is recorded and each measurement point is carried out 30 times during exposure during the inspection, with variations in kV and mA. The measurement results show that the radiation exposure value at point 1 (glass) is 0.183 mSv/year, point 2 (the upper door which is parallel to the organ area) is 0.045 mSv/year, and point 3 (the bottom door which is parallel to the organ area reproduction) is 0.102 mSv/yr. All these measurement results are still within the safe limits set in accordance with PERKA BAPETEN No.4 of 2020.
Pengaruh Layanan SMS Gateway Terhadap Kepatuhan Minum Tablet Tambah Darah Pada Anggota Teman Sebaya Tanggap Anemia Di Puskesmas Bangsri Kabupaten Jepara Suwarni, Sri; Khotimah, Devi Syahrilia; Nahak, Martinus; Widyastuti, Rini
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p70-75

Abstract

Based on the data from the Basic Health Research (Riskesdas) in 2018, 80,9% of female teenagers received blood tablets in their schools while 19.1% of them did not receive the tablets from their schools. From the number of the female students who got blood tablets, furthermore, it was found that the number of the tablets taken was only <52 tablets or as many as 98,6%; which means only 1,4% of female students who took ≥52 tablets (Kemenkes, 2016). Teman Sebaya Tanggap Anemia (friends of the same age responsive to anemia) is the special term for a group of people considered as the blood tablet recipients. Some interventions can be conducted to improve the patients’ medical compliance such as medical information service, distributing medical leaflets, sending short reminders, and utilizing alarm (Susanto, 2017). The purpose of this research is to measure the medication compliance level of Teman Sebaya Tanggap Anemia (TSTA) in taking blood tablets at Puskesmas Bangsri, Jepara Regency and to comprehend the influence of the Short Message Service (SMS) gateway on such compliance. The quasi-experimental was employed in this research, and the prospective data were collected from February to April 2019. The data were then analyzed using the Chi Square test and the Wilcoxon test. The result showed that the percentage of compliance was only 34.57% before the treatment was given, and the SMS gateway service gave significant influence on the compliance of TSTA (p 0.00 < 0.05) In addition, the Wilcoxon test result also showed the same result (p 0.00 < 0.05), and it proved that there was significant difference in the compliance before and after the treatment; therefore the SMS gateway service was effectively proven in improving the medication compliance percentage from 34.57% to 87.23%.
Analisis Hubungan Tingkat Pengetahuan Tentang COVID-19 Dan Penggunaan Imunbooster Karyawan PT Phapros Tbk Semarang Suwarni, Sri; Aryanti, Destryana; Ayuningtyas, Nurista Dida; Ikhsan, Muhammad; Wulandari, Ratna
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p76-84

Abstract

Corona virus Disease 2019 (COVID-19) as a new type of disease that has never been identified before in humans with signs and symptoms including symptoms of acute respiratory disorders such as fever, cough and shortness of breath. COVID-19 can be prevented by improving the body's resistance to respiratory infections. Knowledge is an important domain for the formation of a person's behavior because actions based on knowledge will be more important than actions or behaviors that are not based on knowledge. This study aims to determine the relationship between the level of knowledge about COVID-19 and the use of Immunbooster as a form of infection prevention for employees at PT Phapros Tbk. The research method carried out was descriptive-analytic with a crosssectional research design. The sample in this study was employees at PT Phapros Tbk who met the inclusion and exclusion criteria based on purposive sampling method. For data in this study using primary data from research questionnaires filled out online. Data analysis of the results of the study was carried out using Spearman's rank correlation test. The results showed that there is a relationship between the level of knowledge of COVID-19 and the use of Immunbooster in employees of PT Phapros Tbk Semarang. as evidenced by the spearman's test value obtained value of 0.000 <0.050. The strength of the relationship is moderate as seen from the correlation coefficient value of 0.589 and the test results produce a correlation coefficient value has a positive direction, so it can be said that if COVID-19 knowledge increases, the behavior of using immunbooster will also increase or get better.
Perbandingan Kadar Total Flavonoid Ekstrak Daun Ketapang (Terminalia catappa L) berdasarkan Kekeringan Simplisia dengan Metode Spektrofotometri UV-Vis Pratiwi, Anastasia Eka; Bulu, Atalia Tamo Ina; Sawal, Rizky Ardian Hartanto; Pitarisa, Agustina Putri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p203-209

Abstract

Traditional treatment remains one of the widely used treatment methods to this day. One of the plants with potential as conventional medicine is the Ketapang leaf (Terminalia catappa L), which belongs to the Combretaceae family. Ketapang leaves contain various compounds such as flavonoids, alkaloids, tannins, and saponins, with flavonoids known for their high antioxidant properties. This study aims to compare the total flavonoid content in fresh and dried Ketapang leaf extracts. The extraction method used is maceration with 96% ethanol solvent. Evaluation includes organoleptic tests, moisture content, drying shrinkage, phytochemical screening, and thin-layer chromatography (TLC). Total flavonoid content testing is conducted using the colorimetric method with UV-Vis spectrophotometry at a wavelength of 430 nm, with quercetin as the standard. The results show that the yield of fresh Ketapang leaves was 8.74% w/w, while dried Ketapang leaves were 8.40% w/w. In the TLC tested, the Rf values of fresh and dried Ketapang leaf extracts were 0.95 and 0.94, respectively. The total flavonoid content in fresh Ketapang leaf extract was 24.19 mgQE/gram, while for dried Ketapang leaf extract it was 16.84 mgQE/gram. Statistical analysis with an independent sample t-test showed a significant difference (p<0.05) between fresh and dried Ketapang leaf extracts.
Skrining Fitokimia & Aktivitas Antibakteri Ekstrak Bunga Telang (Clitoria ternatea L.) terhadap Bakteri Staphylococcus epidermidis Sesilia, Riana; Priamsari, Margareta Retno; Akbar, Nanda Dwi
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p232-239

Abstract

Telang flowers contain secondary metabolite compounds that have benefits as antibacterial or antiseptic compounds including flavonoids, tannins, alkaloids and saponins. This research was an experimental research. Telang flower extract was obtained using 70% ethanol solvent by remaceration method then it tested like phytochemical content. Antibacterial activity testing with variaty concentrations media MHA (Mueller Hinton Agar) 15, 30, 45, 60, and 75% against Staphylococcus epidermidis. The positive control was Klindamycin. The obtained data were analyzed by Statistical Package for the Social Sciences (SPSS). The results shown that telang flower extract with concentrations 15, 30, 45, 60 and 75% had an average inhibition zone activity against Staphylococcus epidermidis were respectively 4.45 (15%); 4.63 (30%); 4.35 (45%); 5.47 (65%); and 7.02 mm (75%). The SPSS results show that the p value is <0.05 at the 95% confidence level, which indicates that there is a significant difference in antibacterial activity between butterfly pea flower extracts between concentrations of 15, 30, 45, 60, and 75%. Post hoc tests using LSD showed that there was a difference in antibacterial activity between concentrations of 75% and concentrations of 15, 30, 45, and 60%, but there was no difference in antibacterial activity between concentrations of 15, 30, 45, and 60%.Minimal inhibitor concentration of telang flower extract was obtained at 15%
Variasi Konsentrasi Kombinasi Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sirih (Piper betle) Menggunakan Metode Hidroekstraksi Seabagai Antibakteri Seara In Vitro Tilarso, Dara Pranidya; Muadifah, Afidatul; Khusna, Mursyidah Lathifatul
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p1-9

Abstract

Infectious diseases caused by bacteria are diseases that often arise in society. Bacteria that cause infection include Staphylococcus aureus and Escherichia coli. Bacterial growth can be inhibited with antibiotics. However, some microbes have become resistant to antibiotics so that the use of antibacterials from natural ingredients has begun to be used. Star fruit (Averrhoa bilimbi L.) contains flavonoids, tannins, saponins which are useful as antibacterials. Betel leaf (Piper betle) contains saponins, tannins, flavonoids and phenolic compounds which have activity in inhibiting bacteria. The purpose of this study was to determine the antibacterial activity of a combination of star fruit and betel leaf extracts. The method used in this study was the hydroextraction method with various concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. Antibacterial activity testing using disc diffusion. The results showed that the combination of star fruit and betel leaf extracts had optimum inhibitory activity at a concentration of 100% with an inhibition diameter of 11.05 mm for Staphylococcus aureus which was strong and with a diameter of 9.17 mm for Escherichia coli which was moderate.
Profil Penggunaan Obat Antibiotik di Apotek X Karanganyar Pambudi, Risma Sakti Pambudi
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p74-77

Abstract

A drug is a compound that is used to treat disease. Antibiotics from the hard drug class can be obtained using a prescription from a doctor. The availability of pharmaceutical preparations is important in supporting public health so it needs to be managed well. Therefore, it is necessary to know the profile of drug use as a basis for making drug plans. The aim of this research is to find out the percentage of antibiotic drug use in Karanganyar x pharmacies. This research method is included in the type of descriptive research with retrospective data collection based on stock card records and sales records and prescriptions at the Rizky Peni Farma Pharmacy. The samples in the study were all antibiotics sold in January-December 2023 at the Rizky Peni Farma Pharmacy. The results show that the use of 6 types of antibiotics at the Rizky Peni Farma pharmacy in the January-December 2023 period was used as a sample. In Antibiotic Sales, it was found that the three antibiotics that were frequently used were Cefadroxil 500 mg (42.92%), Amoxicillin (20.52%) and Metronidazole 500 mg (16.27%). Over a period of 12 months, Cefadroxil 500 mg was sold to 182 drugs, Amoxicilin to 87 drugs, and Metronidazole 500 mg to 69 drugs.

Page 17 of 25 | Total Record : 244

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