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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Studi Penggunaan Natrium Bikarbonat pada Pasien Penyakit Ginjal Kronik dengan Asidosis Metabolik Andilusia, Sindy; Hasmono, Didik; Kusumaningtyas, Atika Putri; Syifa', Nailis
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p100-105

Abstract

Chronic Kidney Disease (CKD) is defined as a condition in which there are abnormalities in kidney performance, and occurs for at least 3 months. Metabolic acidosis is a disturbance of acid-base balance resulting in a decrease in plasma sodium bicarbonate concentration with a decrease in blood pH. Metabolic acidosis patients are characterized by (arterial pH <7.35, PCO2 <35 mmHg, and HCO3- <22 mEq/L [mmol/L]). Sodium bicarbonate increases plasma bicarbonate, and increases blood pH. This study aims to identify the pattern of sodium bicarbonate use in CKD patients who experience metabolic acidosis including type, dose, route, interval, and duration of drug administration at Universitas Muhammadiyah Malang Hospital. This study was conducted in the form of observational research by analyzing descriptively and retrospectively collecting data using Health Record data of patients who underwent hospitalization in the period 01 January 2022 – 31 December 2022. Based on the research that has been carried out, it is concluded that patients who meet the therapeutic targets are 23 patients (96%), indicated by the pattern of sodium bicarbonate use only used singly in all CKD patients with metabolic acidosis as many as 24 patients (100%), the most dose is (3x500mg) po as many as 20 patients (83%), with a duration of administration ≤ 5 days as many as 19 patients (79%). The suggestions that researchers convey are research that has been carried out, can be used as a reference and further guidance.
Pengaruh Kombinasi Minyak Jelantah Dan Asam Stearat Pada Sediaan Lilin Aromaterapi Kopi Arabika (Coffea arabica) Anggraini, Cristine; Kurniasih, Trifonia Rosa
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p67-73

Abstract

Waste cooking oil is cooking oil that has been used repeatedly. Indiscriminate disposal of used cooking oil has the potential to pollute soil and water. If used cooking oil is not managed properly, it can seep into the soil and cause the soil to become infertile. Efforts can be made to reduce the negative impact of used cooking oil by converting used cooking oil into raw materials for making aromatherapy candles. This study aims to utilize waste cooking oil as a base material for making candles with arabica coffee aroma and to obtain a formula that has good physical evaluation results. This type of research is pure experiment. This research was conducted by making three formulas with different ratios of used cooking oil and stearic acid, namely formula I (1:1), formula II (1:4) and formula III (3:5). Data were not normally distributed (α<0.05) so it was continued using the Kruskal-Wallis test to compare between groups with 95% confidence level. Based on the evaluation of physical properties, namely organoleptic test, melting point test and burn time test, formula III showed good physical properties compared to formula I and formula II. Formula III (3:5) produced solid candles, no cracks, homogeneous dark brown color, highest melting point 55.33 ± 0.33 SE, longest burning time 253.45 ± 8.13 compared to formula I and II. The combination of waste cooking oil and stearic acid has a significant effect on burn time. Overall, the aromatherapy candle preparations produced have meets the SNI criteria for candle preparations.
UJI AKTIVITAS ANTIOKSIDAN KOMBINASI EKSTRAK ETANOL DAUN TEH HIJAU (Camellia Sinensis L.) DENGAN EKSTRAK ETANOL KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) MENGGUNAKAN METODE DPPH Illah, Galuh Sekar Rahma; Rejeki, Endang Sri; Pramukantoro, Ganet Eko
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p178-185

Abstract

Red dragon plant (Hylocereus polyrhizus) and green tea (Camellia Sinensis L.) are plants that have benefits as antioxidants. Antioxidant compounds are able to reduce free radicals so that they become harmless substances. The purpose of this study was to determine the potential antioxidant activity of the combination of green tea leaves and red dragon fruit peels by making three comparisons, namely 1:1, 1:2, 2:1. Extraction was carried out by maceration using 96% ethanol solvent to obtain a thick extract. The extract was subjected to phytochemical screening, then the viscous extract was made into 3 combination variations, namely 1:1, 1:2, and 2:1. In testing the antioxidant activity using the DPPH method spectrophotometrically. The results of data on the percentage of antioxidant activity were tatistically analyzed using SPSS with the one way ANOVA method. The research results show that the combination of green tea leaves and red dragon skin has strong antioxidant activity. The IC50 value at a 1:1 ratio is 13.25 ppm, at a 1:2 ratio is 12.15 ppm, and at a 2:1 ratio is 11.40 ppm. The 2:1 ratio is the strongest combination.
STUDI ETNOFARMASI PENGGUNAAN TUMBUHAN OBAT BERKHASIAT PENYEMBUH LUKA DI SUKU BADUY, LEBAK, BANTEN. Susanti, Kharisma Dewi Fadia; Peranginangin, Jason Merari; Boedirahardja, Partana
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p121-129

Abstract

Indonesian people use a lot of traditional medicinal plants as wound healers, one of them is the Baduy tribe. The use of medicinal plants in the Baduy tribe has not been well invented. This research aims to find out about the nutritious plants, how to soften and the use of plants as wound healers in the Baduy tribe.The research uses qualitative, quantitative methods and snowball sampling techniques with open-ended interviews to obtain data on medicinal plants that are useful as wound healers. The data obtained was processed using bioprospective analysis to find UV and ICF values. The most commonly used plants are rumput jariji, mata ayam, jarak jintir, pakis merak, and pacing tawar. The most common types of wounds suffered by the Baduy tribe were scratch wounds, dry wounds or scratches, bone fractures, scorpion bites, insect bite wounds. Methods of grinding and use on some plants by stopping, smoothing, peeling, diolizing or gluing directly to the skin. The highest Use Value value is rumput jariji with a number 1 as wound healing and the highest or most frequently experienced Informant concensus factor value by the Baduy tribe obtained a number of 0.66 which is wound from sharp objects.
Identifikasi Drug Related Problems (DRPs) Pada Kasus Diare Anak Pasien Rawat Jalan di UPT. Puskesmas X Kudus Setyoningsih, Heni; Latifah, Siti Nor; Adiningsih, Retnowati; Wijaya, Hasty Martha
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p78-85

Abstract

Diarrhea is still a health problem in developing countries, including Indonesia. Diarrhea is a potential endemic disease of Extraordinary Events (KLB) accompanied by death that often occurs in Indonesia. Drug Related Problems (DRPs) are unwanted events experienced by patients and actually or potentially interfere with the desired therapeutic results. This study aims to determine Drug Related Problems (DRPs) including drug selection, drug form, dose selection, duration of treatment and drug interactions in cases of diarrhea in outpatients at UPT. X Kudus District Health Center for the period January - June 2020. Non-experimental research with observational methods conducted by collecting data retrospectively and analyzed descriptively quantitatively. The sampling technique used was total population sampling by purposive sampling with clear and complete inclusion criteria for outpatient medical records with a diagnosis of diarrhea aged 0-11 years at UPT. X Kudus District Health Center for the period January - June 2020. The results of the study obtained 79 patients who met the inclusion criteria. This study showed that the most common types of DRPs were drug interactions (12%), drug selection (10%), and dose selection (8%). The amount of drug use did not significantly affect the incidence of DRPs in the drug interaction category (P = 0.019). The results showed that there had been DRPs in pediatric diarrhea patients at UPT. X Kudus District Health Center for the period January - June 2020.
Penentuan Nilai SPF Sediaan Lotion Tabir Surya dari Ekstrak Hasil Maserasi Bertingkat Daun Asam Jawa (Tamarindus indica L.) Dewi, Serlyna Mutiara; Suhartinah, Suhartinah; Nopiyanti, Vivin
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p47-55

Abstract

Tamarind leaves contain compounds that have conjugated chromophore groups from aromatic rings such as phenol and its derivatives that can absorb ultraviolet radiation at a wavelength of 200-400 nm. Lotion is a form of sunscreen preparation that is comfortable to use because it has a lower oil content. This research aims to determine whether tamarind leaves extract obtained through multilevel maceration can be made into a sunscreen lotion with good physical stability and quality, determine the SPF value of each and compare them. Multilevel maceration is used to extract tamarind leaves. Solvents used are in sequence from non-polar, semi-polar and polar. Three formulas containing n-hexane extract, ethyl acetate extract, and 70% extract; and one more as a negative control. The three formulas contain tamarind leaves extract have the same concentration, 5%. Each formula is then tested to determine its qualities by physically. The SPF value was measured using UV-Visible spectrophotometer instrument at a wavelength of 290-320 nm with 5 nm intervals. The research results showed that the lotion preparation with tamarind leaf extract had good physical quality and maximum ultraviolet protection category, with SPF value for Formula 1 namely 9,81±0,07; Formula 2 namely 11,65±0,17; and Formula 3 namely 12,32±0,52. Formula 3 has the best physical quality and SPF value among the other formulas.
Pengaruh metode ekstraksi biji kewer roasting dan komponen senyawa aktifnya Mariani, Ria; Martiani, Isye; Noviyanti, Noviyanti; Avini, Fitni
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p92-99

Abstract

Cassia occidentalis Linn. or kewer is a plant that is commonly found in tropical and subtropical climates. Cassia occidentalis seed extract is safe for consumption after roasting the seeds and extracting them using a water solvent. Drink from the roasted seeds of this plant is known as Negro coffee or Senna coffee. In Indonesia, including the Garut area, there are communities who usually consume boiled Cassia occidentalis seeds that have been roasted as a refreshing drink. It calls kewer tea. Cassia occidentalis seeds contain phenolic compounds. Phenol compounds are one of the secondary metabolites that have antioxidant activity. Behalf of that this research aims to determine the antioxidant activity of steeping, infusion and decoction of roasted Cassia occidentalis seed powder and to analysis the active compound content of three extracts. Antioxidant activity was tested using DPPH (2,2-diphenyl-1-picrylhidrazil) method, and active compounds were identified using LC-MS/MS analyses. The results of the antioxidant activity test showed that the roasted kewer seed steeping had the highest antioxidant activity compared to the infusion and decoction, with an IC50 value of 57.864 µg/ml. The results of compound content analysis using LC-MS/MS indicated 13 compounds in the steeping, 15 compounds in the infusion, and 16 compounds in the decoction. It is suspected that compounds that play a role in antioxidant activity in steeping include flavonoids, lignans, and stilbenes, which are lost or reduced in levels in infusions and decoctions.
Mutu Simplisia Kulit Buah Nanas (Ananas comosus (L) Merr.) Hasil Pengeringan Oven dan Sinar Matahari Yunitasari, Norainny; Djamaludin, Nur Farikhah Abya; Tiadeka, Pemta
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p106-111

Abstract

Pineapple is a tropical plant and can help cure several health disorders. In general, pineapple has active compounds, such as alkaloids, tannins, and flavonoids. The success of identifying the presence of the active compound cannot be separated from whether the sample preparation stage was good or not, one of which was the drying stage. This research aims to determine the length of the oven and sunlight drying process for making good simplicia and determine the results of organoleptic, microscopic, and water content tests. This type of research is experimental. The sample used was pineapple skin. The quality test of the simplicia uses organoleptic, microscopic, and water content tests. The study's results showed that oven drying at a temperature of 60⁰ was carried out for 1 day with a time of 10 hours and sunlight drying was carried out for 110 hours (22 days) with a time per day of 4-5 hours. The results of the organoleptic test showed that the simplicia from the oven drying method was dark brown and the sun drying method was light brown, in the form of fine powder, had a sour and bitter taste, and a distinctive aromatic odor. The microscopic test results showed the presence of parenchymal tissue, stone cells, needle-type calcium oxalate crystals, and vascular bundles. The results of the water content test from both drying methods did not meet the quality requirements of the simplicia, namely 14.2% oven and 15% sun drying.
Uji Aktivitas Enzim Fibrinolitik Dari Makanan Fermentasi Kacang Koro (Mucuna Pruriens) Metode Clot Lysis In Vitro Pamungkas, Bayu Aji; Indrayati, Ana; Pramukantoro, Ganet Eko
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p153-159

Abstract

Fibrinolytic enzymes are a group of serine proteases that can destroy blood clots (fibrin) in various thrombosis diseases. This study aims to determine the activity of fibrinolytic enzymes contained in jack bean tempeh using the in vitro clot lysis method. First, crude extraction of the jack bean tempeh enzyme was carried out by centrifugation to produce pellets and supernatants. Then purification using 70% ammonium sulfate salt, determination of enzyme protein levels using the Lowry method and fibrinolytic potential testing using the in vitro clot lysis method. The variations in extract concentrations used in the test were 12.5; 25; 50 and 100% with positive control Natokinase and negative control aquadest. This study showed the results of pellets after purification as much as 26.78 gr. Then it also showed an increase in protein level activity between before purification 22,515 µg / mL and after purification 27,215 µg / mL. In vitro clot lysis testing was carried out with several variations showing the most optimal variation in destroying blood clots was at 100% variation after purification with a lysis percentage of 61%. The most optimal results were also in the Two Way Anova test with a value of 63,592 samples after 100% concentration purification.
Eksplorasi Pengetahuan Suku Tolaki terhadap Penggunaan Tumbuhan sebagai Obat di Desa Iwoimendaa, Ladahai, Lambopini, Lawolia, Tamborasi, Ulukalo dan Watumelewe Kecamatan Iwoimendaa Kabupaten Kolaka Safaruddin, Safaruddin; Ariati, Widya; Sastrawati, Andi Nila; Amin, Rahmasinar
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p186-201

Abstract

Biodiversity has value in the health sector, one of which is in the use of plants as medicine. Medicinal plants are closely related to traditional medicine by local communities. Exploration of local knowledge regarding the use of natural materials as medicines is carried out in order to obtain information about data on traditional herbal medicines used by ethnic groups in Indonesia. The Tolaki tribe is one of the ethnic groups that are widely spread in the province of Southeast Sulawesi, including in the Iwoimendaa sub-district, Kolaka district. This study aims to explore local knowledge related to the types of medicinal plants, parts of plants used as medicine and how to process plants as medicine by the Tolaki tribe in the villages of Iwoimendaa, Ladahai, Lambopini, Lawolia, Tamborasi, Ulukalo and Watumelewe, Iwoimendaa sub-district, Kolaka district. The results of the study showed that the diversity of plant species based on the families used by the Tolaki tribe in the Iwoimendaa sub-district consisted of 68 species and 41 families, where the most widely used were from the Zingiberaceae family. The most widely used parts of the plant are the leaves, followed by the fruit, rhizome, herbs, tubers, roots, exudates/sap, stems and seeds. The most common way of processing plants is boiling. Other processing methods include brewing, grating, pounding, chewing, smearing, dripping, kneading, applying, sticking, squeezing and without mixing.

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