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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Formulasi Krim Fraksi Ekstrak Daun Kemangi (Ocimum sanctum L) Sebagai Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Saptawati, Tunik; Nurwidianingsih, Silvia; Girsang, Valentina; Aldila, Silvy
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p112-120

Abstract

Dermatosis vesiculobullosa is a public health issue that frequently affects Indonesian society and even the world. Current treatment often involves topical application of a cream to the infected area, utilizing chemical substances and traditional medicine. One of the plants that has antibacterial properties is basil. This study determined the excellence of hexane fraction cream made from basil leaves to kill Staphylococcus aureus and Escherichia coli bacteria. This experimental study used the maceration method with 96% ethanol is used for extraction, while the liquid-liquid extraction method for fractionation. The well diffusion method examined the antibacterial activity. The concentration of the n-hexane fractions is 15%, 30%, and 45%. The physical characteristic tests of the cream include organoleptic, homogeneity, pH, spreadability, adhesion, and viscosity. The researcher conducted a one-way Anova statistical analysis using the post hoc Duncan test. Basil leaf cream with n-hexane fractions at 15%, 30%, and 45% concentrations has an antibacterial activity of 20.09 mm (very strong), 21.47 mm (very strong), and 22.43 mm (very strong) against Staphylococcus aureus. It has an antibacterial activity of 20.10 mm (very strong), 22.83 mm (very strong), and 23.76 mm. The cream formulations with 30% and 45% n-hexane fraction effective at stopping the growth of Staphylococcus aureus and Escherichia coli, with a significance value of 0.000 (p<0.05).
Aktivitas Daya Ingat Ekstrak Daun Pecut Kuda (Stachtarpheta jamaicensis L. (Vahl) Pada Mencit Putih (Mus musculus) Dengan Metode Radial Arm Maze Septiarini, Anita Dwi; Pratama, Kharisma Jayak; Andhika, Intan Fatna
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p173-177

Abstract

Alzheimer's disease is the most common type of dementia. Horse whip leaves contain flavonoid compounds which are widely used both in physiological aging studies and in rat model research, to research the cure of neurodegenerative diseases. The purpose of this study was to determine the activity of giving horse whip leaf extract and the effective dose of horse whip leaf extract in improving the memory power of mice. Horse whip leaf extract was extracted using 96% ethanol solvent by maceration method. Memory activity testing was carried out on male mice which were divided into 5 groups, namely the negative control group, the positive control group, the horse whip leaf extract test group at doses of 5, 10 and 20 mg/kg BW. The test was carried out using the radial arm maze method. The results showed that horse whip leaf extract had memory enhancing activity. Test animals that have been induced given treatment are known to experience a decrease in latency time which can be stated as test animals experience an increase in memory activity. The effective extract dose was a dose of 20 mg/kgBW with a difference in latency time of 49.80 second.
PENERAPAN SISTEM INFORMASI PENJUALAN DAN PEMBELIAN OBAT DI APOTEK X SEMARANG Toyo, Eleonora Maryeta; Oktaviyani, Triana; Wulandari, Agustina Ratna
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p160-166

Abstract

Information systems play an important role in managing and supporting various operational activities, including the process of selling and purchasing drugs. At X Pharmacy Semarang, the system has been computer-based with the use of the SID Apotek PRO application. This application is expected to assist pharmaceutical officers in carrying out the drug sales and purchase system and improve the quality of service to customers. This study aims to understand the drug sales and purchase information system at X Semarang Pharmacy. The methodology used was non-experimental qualitative descriptive research with the research population involving all pharmaceutical officers. The total sampling technique was applied with the entire population being the research sample. The results showed that the information system has not yet supported the drug purchasing process, but can already be used for drug sales. This indicates that the implementation of a drug sales information system helps improve the efficiency of services to patients.
Stability Test and Antioxidant Test of Peel-off Gel Mask of Butterfly Pea Flower Extract (Clitoria ternatea L.) Against Physical Characteristics Setiyaningsih, Wahyu; Sudarsono, Agustina Putri Pitarisa; Istianingrum, Elisa
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p218-222

Abstract

The telang flower plant (Clitoria ternatea L.), especially its flowers, contains high antioxidants. This antioxidant activity can inhibit free radicals and can function as anti-aging. Antioxidants are one of the components in cosmetics that are needed to be anti-radical. Therefore, researchers want to know the correct formulation for butterfly pea flower extract (Clitoria ternatea L.) as an antioxidant in peel-off gel mask preparations with varying concentrations of Polyvinyl Alcohol (PVA) and Hydroxypropyl Methylcellulose (HPMC). The research method used is an experimental method. This research includes extracting butterfly pea flowers using the maceration method with 70% ethanol. The manufacturing method is developed using hot aqua PVA and HPMC which is formulated into a Peel-Off gel mask. The peel-off gel mask preparations that have been made are tested for quality control which includes organoleptic test, homogeneity test, pH test, viscosity test, spreadability test, stickiness test, dry time test, and preference test. Peel-off masks with a variety of PVA and HPMC bases affect the viscosity, spreadability, adhesion and dry time test of peel-off gel mask preparations with ethanol extract of butterfly pea flowers.
PERBANDINGAN KUALITAS KITOSAN PADA LIMBAH CANGKANG RAJUNGAN (Portunus pelagicus) REBUS DAN MENTAH DITINJAU DARI % N-DEASETILASI Yudhantara, Sandi Mahesa; Sugiyo, Warlan; Buanasari, Buanasari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p200-204

Abstract

Chitosan is chitin that is deacetylated as much as possible whose quality can be measured by the value of % N-Deacetylated. Chitosan has the potential to be used in various industrial and health fields, so its needs are influenced by its quality standards. Crab shells, which are one of the sources of chitosan-making materials, have not yet been fully utilized, especially shells from consumption waste (restaurants). Researchers intend to test Chitosan derived from raw and cooked crab shells to compare their quality. The process of making chitosan goes through three main stages, namely deproteination, demineralization and deacetylation, while at the analysis stage using the base line method using an FT-IR spectrophotometer. As a result, the %N-Deacetylated price was obtained at 74.8640% in the raw crab shell sample (A), while in the cooked crab shell sample (B), the %N-deacetylation price was 68.9313 %. The difference between sample A and sample B is only 5.9327%.
UJI AKTIVITAS ANTIINFLAMASI KOMBINASI EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight) Walp) dan EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP UDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN Syahputra, Dhika Adhil; Samodra, Galih; Prabandari, Rani
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p1-6

Abstract

Inflammation or inflammation is the body's normal response to tissue damage caused by physical trauma, chemical and microbial damage. Plants that are thought to have anti-inflammatory properties are bay leaves (Syzygium polyanthum (Wight) Walp). Which acts as an anti-inflammatory in bay leaves and papaya leaves are flavonoids. Bay leaf and papaya leaf extracts were extracted using 70% ethanol by maceration method. The test animals were divided into 7 groups, namely a negative control group (Na CMC), a positive group (Diclofenac Sodium 50 mg), a single dose group of 100 mg/kgBW bay leaf extract, a single dose group of 100 mg/kgBW papaya leaf extract, and a combination group of leaf extracts. salam and papaya leaf extract 50mg/kgBB: 50mg/kgBB, 150mg/kgBB: 100mg/kgBB, 250mg/kgBB: 200mg/kgBB. Treatment 1 hour after the hind legs of rats was induced by subplantar carrageenin. The results showed that the combination of bay leaf and papaya leaf extracts had anti-inflammatory activity. The results of the calculation of the inflammatory power in the combination group showed inflammatory activity.
Pengaruh Interaksi Simvastatin dan Perasan Buah Jeruk Bali (Citrus maxima Merr.) Terhadap Efek Antikolesterol Mencit Jantan Humaidah, Daffa; Widodo, Gunawan Pamudji; Widyasti, Jena Hayu
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p7-13

Abstract

Consumption of drugs together with herbal medicine at the same time can affect its efficacy. Cholesterol can be treated with simvastatin and herbal medicine such as grapefruit (Citrus maxima Merr.) which contains phenols and flavonoids as anticholesterol and furanocoumarins. This study aims to determine whether the consumption of simvastatin and grapefruit together will affect the anticholesterol effect. Male mice of 35 Swiss strains were divided into 7 groups, each consisting of 5 mice. Without treatment, negative control Na-CMC 0.5%, positive control I simvastatin 5.2 mg/kgBW mice, positive control II grapefruit juice 26 mL/kgBW mice, interaction I, II and III simvastatin 5.2 mg/ kgBW of mice and grapefruit juice were 13 mL/kgBW, 19.5 mL/kgBW, and 26 mL/kgBW of mice, respectively. All groups except without treatment were given a high-fat diet consisting of lard, duck egg yolk, and chicken liver and were induced with 0.1% propylthiouracil solution for 28 days before treatment. Total cholesterol levels were measured after 28 days of induction and 35 and 42 days after treatment. The interaction of simvastatin and grapefruit juice can affect the anticholesterol effect in the form of increasing the effect of reducing total cholesterol levels in the blood of mice. The effective interaction dose was the interaction dose I (simvastatin 5.2 mg/kg BW of mice and grapefruit juice 13 mL/kg BW of mice) which had an anticholesterol effect compared to the single dose group of simvastatin and grapefruit juice.
UJI EFEK ANTIDIARE EKSTRAK ETANOL KULIT BUAH PISANG AMBON (Musa acuminata Colla) TERHADAP MENCIT JANTAN (Mus Musculus L.) YANG DIINDUKSI MINYAK JARAK (Oleum Ricini) Serang, Yithro; Wijayanti, Maria Widya Riska
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p20-25

Abstract

Utilization of plants as a treatment for diarrhea is an alternative to traditional medicine. Ambon banana peel is one of the plants that can be used as an antidiarrheal because it contains flavonoid compounds, tannins and saponins. This study aimed to determine the antidiarrheal effect of the ethanol extract of Ambon banana peel on male mice induced by Oleum Ricini and to determine the dose of ethanol extract of Ambon banana peel that gave the best antidiarrheal effect. Ambon banana peel was extracted by maceration method. The research method used was a laboratory experimental study using 25 male mice which were divided into 5 groups, namely the negative control group (given CMC Na 1%), the positive control group (given Loperamide HCl 2 mg), the treatment group with ethanol extract of Ambon banana peel. with varying doses of 300 mg/KgBW, 600 mg/KgBW and 900 mg/KgBW. The antidiarrheal effect was observed every 30 minutes for 4 hours with the parameters used were diarrhea frequency, stool weight and stool consistency. Based on the results of the study, the ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW showed diarrhea frequency and stool weight results which were almost the same as the Loperamide HCl treatment group. The results of statistical analysis using ANOVA obtained p<0.05, this indicates that there is a significant difference. The ethanol extract of Ambon banana peel at a dose of 900 mg/KgBW had the best antidiarrheal effect compared to the ethanolic extract of Ambon banana peel at a dose of 300 mg/KgBW and a dose of 600 mg/KgBW.
FORMULASI KRIM WAJAH EKSTRAK PELEPAH POHON AREN (Arenga pinnata Merr.) SEBAGAI ANTI ACNE Fauzi, Rizky Mohammad; Nugraha, Davit; Wahlanto, Panji
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p26-31

Abstract

Aren (Arenga pinnata Merr.) is a biological resource believed to have antioxidant abilities and is easily found throughout Indonesia. It is widely used by the populace, for example in midrib flour as a traditional medicine to relieve itching and scars on the skin. The purpose of this study was to determine whether the palm leaf extract (Arenga pinnata Merr.) could be formulated into cream preparations and was of good quality. The research method used is experimental by formulating the extract into three formulations, namely the extract concentration of 1%, 3%, 5%. Data analysis was performed using qualitative analysis including organoleptic test, homogeneity test, and quantitative analysis including pH test, dispersion test, adhesion test, viscosity and using one-way ANOVA statistics. The results of the analysis showed that there was no significant difference in the concentration of palm midrib cream in pH with a sig value of 0.542 (sig. > 0.05), a dispersion of 0.504 (sig. > 0.05) and a Adhesion of 0.717 (sig. > 0.05) gave > 0.05) and the viscosity meets the standard of good cream viscosity which is between (2000 - 50000 cps). Data analysis of the results showed that the three variations of extracts could be formulated into cream preparations and had quality standards for cream preparations that met the requirements, there was no effect of variations in the concentration of arene (Arenga pinnata Merr.) on the physical quality of cream preparations. The best wording is found in F2 (3%). Further research is expected to modify the formula for preservatives and fragrance additives, create new dosage forms such as lotions.
Identifikasi Senyawa Sibutramin Hidroklorida Pada Jamu Pelangsing Fakhriah, Siti Nurintan; Rahmadani, Rahmadani; Mahdiyah, Dede
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p32-37

Abstract

Dissatisfaction with the current body causes women to try to change their appearance by losing weight quickly which results in switching to slimming herbal products that can be trusted to lose weight instantly. With the current progress in the circulation of slimming herbal products, medicinal chemicals (BKO) are added. Slimming herbal products are prohibited from containing medicinal chemicals. Sibutramine Hydrochloride is one of the BKOs found in slimming herbs because Sibutramine HCl is a hard drug that works by inhibiting norepinephrine, serotonin and dopamine, which can suppress appetite so it can be used to lose weight. The study was conducted to identify the compound Sibutramine Hydrochloride in slimming herbs circulating in Tanah Grogot. The method used is pre-experimental with one shot case study. Sampling was done by purvosive sampling technique. The sample from the study was 10 slimming herbs circulating in Tanah Grogot. The results of the TLC method identified 10 samples, only 1 sample was positive for Sibutramine HCl because it had the same Rf value as the comparison standard, which was 0.95. The UV-Vis Spectrophotometry method obtained the sample results showing the levels of Sibutramine HCl exceeding the dose of 15mg with the sample content containing % Sibutramine HCl content, namely S4 0.59%. The results of this study are that there are slimming herbs with a BPOM permit that contain the medicinal chemical Sibutramine HCl.

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