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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "Vol 4, No 2 (2024): August 2024" : 10 Documents clear
Studi In Vitro Aktivitas Antibakteri Ekstrak Etanol Penawar Sampai (Tinospora crispa L.) terhadap Staphylococcus epidermidis Martani, Natalia Sri; Turnip, Oktaviani Naulita; Hanasia, Hanasia; Nawan, Nawan
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1074

Abstract

Kulit merupakan jaringan terluar di tubuh manusia yang menjadi pertahanan pertama dari masuknya patogen. Kulit dihuni oleh berbagai flora normal, salah satunya adalah Staphylococcus epidermidis. S. epidermidis adalah patogen oportunistik yang menjadi penyebab infeksi nosokomial yang menetap pada perangkat medis. Kasus infeksi nosokomial banyak terjadi baik di negara maju maupun negara berkembang. Infeksi nosokomial karena S. epidermidis tergolong sulit diatasi karena adanya kemampuan spesies ini dalam membentuk biofilm dan resistensi antibiotik yang menyebabkan kasus nosokomial berujung kematian. Penelitian ini mengujikan ekstrak dari tanaman penawar sampai atau brotowali terhadap S. epidermidis guna mendeteksi adanya aktivitas antibakteri. Batang penawar sampai dimaserasi dan diuapkan menjadi ekstrak kental dengan konsentrasi 20, 50, 75, dan 100%. Ekstrak kental batang penawar sampai diujikan terhadap S. epidermidis dengan metode difusi cakram. Interpretasi kemampuan ekstrak dalam menekan pertumbuhan S. epidermidis dapat diamati dari diameter zona hambat yang terbentuk di sekitar cakram. Konsentrasi terendah dalam menekan pertumbuhan S. epidermidis dihasilkan pada penelitian ini adalah konsentrasi ekstrak 20%. Hal ini mengindikasikan adanya potensi dari ekstrak penawar sampai sebagai antibakteri terhadap S. epidermidis yang tergolong dalam bakteri Gram positif.The skin is the outermost tissue in the human body and the first line of defense against pathogen entry. The skin is inhabited by a variety of normal flora, one of which is Staphylococcus epidermidis. S. epidermidis is an opportunistic pathogen that causes nosocomial infections that persist in medical devices. Cases of nosocomial infections are common in both developed and developing countries. Nosocomial infections due to S. epidermidis are relatively difficult to overcome due to the ability of this species to form biofilms and antibiotic resistance which causes nosocomial cases to lead to death. This study tested extracts from the antidote to brotowali plant against S. epidermidis to detect antibacterial activity. The stem was macerated and evaporated into thick extracts with concentrations of 20%, 50%, 75%, and 100%. The thick extracts were tested against S. epidermidis using disc diffusion method. Interpretation of the ability of the extract to suppress the growth of S. epidermidis can be observed from the diameter of the inhibition zone formed around the disc. The lowest concentration in suppressing the growth of S. epidermidis produced in this study was 20% extract concentration. This indicates the potential of the extract as an antibacterial against S. epidermidis which is classified as Gram-positive bacteria.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Lip Balm dari Ekstrak Etanol Umbi Wortel (Daucus carota L.) dengan Metode DPPH (2,2-dipheny 1-picrylhydrazyl) Azima, Azima; Wahyuningsih, Sri; Agung, Yusfin Cesiana; Ilyas, Ika Lismayani
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1145

Abstract

Umbi wortel (Daucus carota L.) mengandung banyak senyawa kimia salah satunya yaitu β-karoten. β-karoten berfungsi sebagai antioksidan alami. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan sediaan lip balm dari ekstrak etanol umbi wortel dengan metode DPPH. Pada penelitian ini, kestabilan sediaan diketahui melalui evaluasi sebelum dan sesudah cycling test meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji titik lebur dan uji kelembapan yang sesuai standar kestabilan untuk sediaan lip balm serta metode dalam uji aktivitas antioksidan sediaan lip balm ekstrak umbi wortel menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa sediaan lip balm ekstrak umbi wortel stabil secara fisika dan kimia setelah melalui tahapan evaluasi sediaan dan menunjukkan hasil pada IC50 yang diperoleh berturut-turut pada formula 1 yaitu 29,18 ppm, formula II yaitu 20,18 ppm, dan formula III yaitu 10,47 ppm sedangkan pada kontrol positif lip balm viva memiliki nilai IC50 yaitu 3,60 ppm. Kesimpulan dari penelitian ini yaitu, sediaan lip balm ekstrak umbi wortel dikategorikan stabil secara fisika dan kimia serta mempunyai nilai IC50 yang paling baik pada formula III (6%) dengan nilai IC50 yaitu 10,47 ppm.Carrot tubers (Daucus carota L.) contain many chemical compounds, one of which is β-carotene. β-carotene functions as a natural antioxidant. This research was conducted to determine the antioxidant activity of lip balm preparations from the ethanol extract of carrot tubers using the DPPH method. In this study, the stability of the preparation was determined through evaluation before and after the cycling test, including the organoleptic test, homogeneity test, pH test, spreadability test, melting point test, and humidity test in accordance with stability standards for lip balm preparations as well as methods for testing the antioxidant activity of lip preparations. carrot tuber extract balm using the DPPH method. The research results showed that the carrot tuber extract lip balm preparation was physically and chemically stable after going through the preparation evaluation stages and showed the IC50 results obtained respectively in formula 1, namely 29.18 ppm, formula II, namely 20.18 ppm, and formula III, namely 10.47 ppm, while the positive control Viva lip balm has an IC50 value of 3.60 ppm. The conclusion of this research is that the carrot tuber extract lip balm preparation is categorized as physically and chemically stable and has the best IC50 value in formula III (6%) with an IC50 value of 10.47 ppm.
Identifikasi Senyawa Flavonoid Fraksi Etanol Bintang Laut (Linckia laevigata) di Perairan Bolaang Mongondow Mappa, Moh. Rivaldi; Bahi, Rizky Resvita R.; Sarman, Sarman; Fauzan, Moh Rizki; Begum, Nanda Sayyida
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1103

Abstract

Bintang laut merupakan organisme laut yang menghasilkan senyawa bioaktif, salah satunya flavonoid. Flavonoid berkhasiat sebagai antioksidan, anti-penuaan, anti-inflamasi, antivirus, dan lain sebagainya. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa flavonoid dari fraksi etanol bintang laut yang diperoleh dari pesisir pantai Desa Maelang Kabupaten Bolaang Mongondow menggunakan uji kualitatif pereaksi kimia dan metode kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa bintang laut yang diperoleh dari pesisir pantai Desa Maelang Kabupaten Bolaang Mongondow positif mengandung senyawa flavonoid yang ditandai dengan perubahan warna dari jingga ke hijau kehitaman pada uji menggunakan pereaksi kimia dan terbentuknya pola noda berwarna hijau dengan nilai Rf 0,8 pada pelat KLT yang dibandingkan dengan baku standar kuersetinStarfish are marine organisms that produce bioactive compounds, one of which is flavonoids. Flavonoids are efficacious as antioxidants, antiaging, anti-inflammatory, antiviral and so on. This research aims to identify the content of flavonoid compounds from the ethanol fraction of starfish obtained from the coast of Maelang Village, Bolaang Mongondow Regency using qualitative tests of chemical reagents and the thin layer chromatography (TLC) method. The results of the research showed that starfish obtained from the coast of Maelang Village, Bolaang Mongondow Regency were positive for containing flavonoid compounds which were characterized by a color change from orange to blackish green in the test using chemical reagents and the formation of a green stain pattern with an Rf value of 0.8 on the TLC plate which was compared with the standard quercetin
Uji Efektivitas Ekstrak Etanol Daun Pepaya (Carica papaya L.) terhadap Peningkatan Trombosit pada Mencit Jantan (Mus musculus) yang diinduksi Kloramfenikol Idris, Zulfiah; SR, Muhammad Asri; Wahyuningsih, Sri; Sudirman, Agriawan; Kartika, Amaliah
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.488

Abstract

Telah dilakukan penelitian tentang uji aktivitas ekstrak etanol daun pepaya (Carica papaya L.) terhadap peningkatan trombosit pada mencit jantan (Mus musculus) yang diinduksi kloramfenikol. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun pepaya serta dosis efektifnya dalam meningkatkan jumlah trombosit pada mencit jantan yang diinduksi kloramfenikol. Pada penelitian ini dilakukan perlakuan pertama pemberian pakan selama 14 hari, perlakuan kedua dengan pemberian kloramfenikol dosis 30mg/30g BB peroral selama 7 hari dan pakan standar selama 7 hari, perlakuan ketiga pemberian kloramfenikol dosis 30mg/30g BB peroral dan ekstrak etanol daun pepaya 1,5% selama 7 hari, perlakuan keempat pemberian kloramfenikol dosis 30mg/30g BB peroral dan ekstrak etanol daun pepaya 3% selama 7 hari. Hasil penelitian menunjukkan bahwa ekstrak etanol daun pepaya menunjukkan efek dalam meningkatkan jumlah trombosit pada mencit jantan yang diinduksi kloramfenikol.Research has been conducted on the activity test of ethanol extract from papaya leaves (Carica papaya L.) on increasing platelet count in male mice (Mus musculus) induced with chloramphenicol. The purpose of this study was to determine the effect of ethanol extract from papaya leaves and its effective dosage in increasing platelet count in male mice induced with chloramphenicol. In this study, the first treatment involved feeding for 14 days, the second treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally for 7 days along with standard feed for 7 days, the third treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally along with 1.5% ethanol extract of papaya leaves for 7 days, and the fourth treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally along with 3% ethanol extract of papaya leaves for 7 days. The results showed that the ethanol extract of papaya leaves exhibited an effect in increasing platelet count in male mice induced with chloramphenicol.
Efektivitas Penyembuhan Luka Sediaan Patch Kombinasi Beberapa Spesies Sirih Secara in Vivo Ranti, Dalia; Trinovita, Elsa; Praja, Rian Ka; Frethernety, Agnes; Widayati, Ratna
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.960

Abstract

Luka merupakan permasalahan kesehatan dengan tingkat kejadian yang sering terjadi di Indonesia. Pemberian terapi berbahan herbal dapat menjadi salah satu alternatif dalam penyembuhan luka. Sirih merah (Piper crocatum) dan sirih hijau (Piper betle L.) mempunyai berbagai senyawa metabolit sekunder yang berperan dalam penyembuhan luka sayatan pada kulit. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau terhadap penyembuhan luka sayat. Hewan coba dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif (plaster povidone iodine), kontrol negatif patch tanpa ekstrak, dan kelompok dengan ekstrak pada beberapa konsentrasi (7,5%, 15% dan 30%). Beberapa parameter yang dilakukan dengan pengukuran panjang luka, pengamatan waktu penyembuhan luka dan infeksi lokal berdasarkan kriteria Nagaoka. Sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau secara statistik tidak menunjukkan perbedaan bermakna terhadap efektivitas dalam penyembuhan luka yang dinilai berdasarkan kriteria Nagaoka dengan beberapa parameter penilaian luka. Namun, pengamatan secara makroskopis pada kelompok K2 (konsentrasi 15%) menunjukkan terjadinya penyembuhan luka yang lebih baik dibandingkan dengan kelompok plaster povidone iodine. Wounds are a health problem that is a frequent occurrence in Indonesia. Providing herbal therapy can be an alternative for healing wounds. Red betel (Piper crocatum) and green betel (Piper betle L.) have various secondary metabolite compounds that play a role in healing wounds of skin incisions. This study aims to determine the effectiveness of a combination patch preparation of red betel leaf extract and green betel leaf in healing cuts on the skin. The experimental animals were divided into five treatment groups: positive control (povidone-iodine plaster), negative control patch without extract, and groups with extract at several concentrations (7.5%, 15%, and 30%). Several parameters were measured by measuring wound length and observing wound healing time and local infection based on the Nagaoka criteria. The combination patch preparation of red betel leaf extract and green betel leaf extract did not statistically show a significant difference in effectiveness in wound healing as assessed based on the Nagaoka criteria with several wound assessment parameters. However, macroscopic observation in the K2 group (concentration 15%) showed better wound healing compared to the povidone-iodine plaster group.
In Silico Exploration of Suruhan Leaves (Peperomia pellucida) for Triple-Negative Breast Cancer Therapy Targeting AURKA Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1119

Abstract

Breast cancer is the most common type of cancer worldwide. One of the most widely used chemotherapeutic agents in the treatment of breast cancer is doxorubicin. However, doxorubicin has been reported to cause side effects. Suruhan (Peperomia pellucida) contains bioactive compounds that might protect against breast cancer cells. This study aims to analyze the bioactive compound activity of Suruhan leaves in triple-negative breast cancer in silico. The study was conducted by reviewing published literature on bioactive compounds in Suruhan leaves, predicting the protein target, analyzing the gene expression in triple-negative breast cancer (TNBC) patients, analyzing the protein interactions, and examining patient survival. There are five common bioactive compounds in Suruhan leaves, including peperomin A; 6,8-dihydroxy kaempferol 3,6,7,4'-tetramethyl ether 8-neohesperidoside; dillapiole; carotol; and pellucidin A. AURKA is a target protein for bioactive compounds that are also overexpressed in TNBC patients. AURKA has strong interactions with many proteins, including TPX2, NEDD9, CCNB2, CDC20, PLK1, BIRC5, INCENP, TACC3, TP53, and MYCN. The AURKA has emerged as a promising target for TNBC therapy.
Identifikasi dan Penetapan Kadar Flavonoid Ekstrak Etil Asetat Daun Mimba (Azadiractha indica A. Juss) Metode Spektrofotometri UV- Vis Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; Mus, Suwahyuni; Jariah, Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1049

Abstract

Flavonoid terdiri dari 15 molekul yang tersusun dalam susunan C6-C3-C6 yang merupakan senyawa polifenol. Senyawa ini berbentuk kerangka karbon dan terurai menjadi dua set: C6 dan C3. Daun mimba (Azadiractha indica A. Juss) mengandung flavonoid yang memiliki sifat antioksidan, antibakteri, dan antikanker. Penelitian ini bertujuan untuk mengidentifikasi kelompok senyawa dalam daun mimba (Azadirachta indica A. Juss) dan menentukan kadar flavonoidnya. Ekstraksi dilakukan menggunakan teknik maserasi dengan pelarut etil asetat untuk mendapatkan ekstrak yang kemudian diuji melalui skrining fitokimia. Pengukuran kadar flavonoid dilakukan dengan metode spektrofotometri UV-Vis. Dari hasil ekstraksi, diperoleh rendemen ekstrak sebesar 5,83%. Hasil skrining fitokimia menunjukkan adanya kandungan flavonoid dan alkaloid. Kadar flavonoid ditentukan menggunakan kuersetin sebagai standar pembanding, dengan persamaan garis y = 0,0739x + 0,0776. Kesimpulannya, ekstrak etil asetat mengandung flavonoid dengan kadar 1,183 ± 0,018%.Flavonoids consist of 15 molecules arranged in a C6-C3-C6 configuration, which are polyphenolic compounds. These compounds form a carbon framework and are divided into two sets: C6 and C3. Neem leaves (Azadirachta indica A. Juss) contain flavonoids that have antioxidant, antibacterial, and anticancer properties. This study aims to identify the group of compounds in neem leaves (Azadirachta indica A. Juss) and determine their flavonoid content. Extraction was carried out using the maceration technique with ethyl acetate as a solvent to obtain an extract that was then tested through phytochemical screening. Flavonoid content was measured using the UV-Vis spectrophotometric method. The extraction process yielded an extract with a percentage of 5.83%. Phytochemical screening results indicated the presence of flavonoids and alkaloids. The flavonoid content was determined using quercetin as a reference standard, with the equation y = 0.0739x + 0.0776. In conclusion, the ethyl acetate extract contains flavonoids with a concentration of 1.183 ± 0.018%.
Current Understanding of Mycobacterium tuberculosis Drug Resistances and Diagnostics in Indonesia: A Review Rahayu, Ayu; Rovik, Anwar; Turnip, Oktaviani Naulita
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1121

Abstract

Tuberculosis is a significant global infectious disease cause of mortality, with 25% of the world's population caused by Mycobacterium tuberculosis (Mtb). The highest case recorded was 821,200 cases in 2023 over one decade. Drug resistance significantly impacts tuberculosis treatment and has been observed since the first drug discovery, streptomycin. In Indonesia, drug-resistant tuberculosis (DR-TB) is a significant public health issue, with an estimated 24,666 cases recorded in 2022. A comparative literature search was conducted using various articles, including research studies, guidelines, narrative reviews, reports, and meta-analyses, with the inclusion criteria for reference sources including ten years of published articles. Drug resistance in TB can reduce treatment success rate and increase therapy duration. In the result, several general mechanisms proposed for drug resistance in Mtb include efflux pump, enzyme inactivation, permeability barrier, mutations in drug-target genes, and epigenetics. Currently, TB treatment in Indonesia involves combination therapy using three or more types of drugs, such as rifampicin and isoniazid. The International Standard for TB Care (ISTC) serves as the basis for TB diagnosis in Indonesia, which involves a combination of clinical and laboratory tests. Early diagnosis and universal access to the Drug Susceptibility Test (DST) are crucial for TB resistance. In Indonesia, several diagnostic methods, such as sequencing, PCR testing, Gene Xpert, and culture, can be used to identify TB resistance. Understanding the mechanisms of drug resistance and developing effective diagnosis strategies for TB resistance is crucial for managing global infection.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Paper Soap Ekstrak Etanol Daun Bidara Arab (Ziziphus spina-christi L.) Terhadap Bakteri Staphylococcus epidermidis Junita, Nurfitria; Awaluddin, Nurhikmah; Nadjamuddin, Mirfaidah; Wahid, Hilmiati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1043

Abstract

Daun bidara Arab (Ziziphus spina-christi L.) mengandung senyawa kimia berupa saponin, alkaloid, tanin dan flavonoid yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui apakah ekstrak daun bidara Arab dapat diformulasikan dalam bentuk sediaan paper soap dan melihat serta mengukur aktivitas antibakteri terhadap pertumbuhan bakteri Staphylococcus epidermidis. Desain penelitian ini merupakan penelitian eksperimen laboratorium dengan evaluasi uji mutu fisik yang melalui Cycling Test serta pengujian aktivitas antibakteri dengan metode difusi teknik paper disk dengan menggunakan 3 konsentrasi yaitu 5%, 10%, 15% dan dua kontrol pendukung yaitu kontrol negatif dimana sediaan tanpa ekstrak juga kontrol positif yaitu paper soap. Hasil penelitian uji mutu fisik sediaan paper soap menunjukkan bahwa sediaan memenuhi syarat standar sediaan sabun dan memiliki aktivitas antibakteri dengan konsentrasi paling efektif yaitu konsentrasi 15% dengan diameter zona hambat yang terbentuk 6,9 mm termasuk kategori sedang.Ziziphus spina-christi L. contain chemical compounds such as saponins, alkaloids, tannins, and flavonoids that have antibacterial properties. This study aims to determine whether extracts from Ziziphus spina-christi L. leaf can be formulated into paper soap preparations and to assess whether these preparations exhibit antibacterial activity against the growth of Staphylococcus epidermidis. The design of this research is a laboratory experimental study, evaluating physical quality tests through the Cycling Test and testing antibacterial activity using the paper disk diffusion method with three concentrations: 5%, 10%, and 15%, as well as two control groups: a negative control (preparation without extract) and a positive control (paper soap). The results of the physical quality test of the paper soap preparation indicate that it meets the standard criteria for soap preparations and exhibits antibacterial activity, with the most effective concentration being 15%, which formed an inhibition zone diameter of 6.9 mm, classified as moderate.
Indeks Massa Tubuh Berhubungan dengan Hiperurisemia pada Pasien Tuberkulosis Paru Putra, Oki Nugraha; Mufarridan, Syagafa; Saifudin, Muhammad Arif; U, Shafira Maulida Fitria; Kurniawati, Aisyah Fitri
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1106

Abstract

Pirazinamid merupakan salah satu obat antituberkulosis yang digunakan pada fase intensif. Salah satu efek samping pirazinamid yaitu peningkatan kadar asam urat yang seringkali disertai dengan nyeri sendi. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan hiperurisemia dan faktor-faktor yang berpengaruh terhadap nyeri sendi pada pasien tuberkulosis (TB) paru fase intensif. Penelitian ini menggunakan desain kohort prospekif. Penelitian ini dilakukan di Puskesmas Perak Timur dan Puskesmas Wonokusomo, Surabaya selama bulan Februari hingga Juli 2023. Tiga ml darah pasien TB paru diambil untuk pemeriksaan kadar asam urat sebelum dan setelah dua bulan pengobatan fase intensif. Dua puluh pasien TB paru yang memenuhi kriteria inklusi dimasukkan ke dalam penelitian. Sebanyak 13 (65%) pasien mengalami peningkatan kadar asam urat yang signifikan di akhir fase intensif, dari 5,25 ± 1,98 mg/dl menjadi 9,43 ± 1,98 mg/dl, p-value 0,000. Delapan (61,5%) dari 13 pasien dengan peningkatan kadar asam urat disertai dengan nyeri sendi. Indeks massa tubuh (IMT) berhubungan dengan hiperurisemia (p-value 0,024, r = 0,624). Kadar asam urat ≥ 6,5 mg/dl secara signifikan berpengaruh terhadap terjadinya nyeri sendi, p-value 0,017. IMT berhubungan dengan hiperurisemia pada pasien TB. Kadar asam urat ≥ 6,5 mg/dl menjadi satu-satunya variabel yang berpengaruh terhadap terjadinya nyeri sendi pada pasien TB yang menjalani pengobatan pada fase intensif. Pengukuran asam urat secara periodik diperlukan terutama pada pasien TB dengan IMT yang besar (gemuk atau obesitas).Pyrazinamide is one of the antituberculosis drugs used in the intensive phase. One of the side effects of pyrazinamide is an increase in uric acid levels, often accompanied by joint pain. This study aims to analyze the factors associated with hyperuricemia and the factors that affect joint pain in pulmonary tuberculosis (TB) patients in the intensive phase. It was a prospective cohort study. This study was conducted at Puskesmas Perak Timur and Puskesmas Wonokusomo, Surabaya, from February to July 2023. Three ml of blood from pulmonary TB patients was withdrawn to measure uric acid levels before and after two months of intensive phase treatment. Twenty pulmonary TB patients who met the inclusion criteria were included in the study. Thirteen (65%) patients significantly increased uric acid levels at the end of the intensive phase, from 5.25 ± 1.98 mg/dl to 9.43 ± 1.98 mg/dl, P-value 0.000. Eight (61.5%) of the 13 patients with elevated uric acid levels were accompanied by joint pain. Body mass index (BMI) was associated with hyperuricemia (p-value 0.024, r = 0.624). Uric acid levels ≥ 6.5 mg/dl significantly influenced the occurrence of joint pain, with a P-value of 0.017. BMI is associated with hyperuricemia in TB patients. A uric acid level ≥ 6.5 mg/dl is associated with joint pain in TB patients undergoing treatment in the intensive phase. Periodic uric acid measurements are needed, especially in TB patients with a high BMI (overweight or obese).

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