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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim Nur Ain Thomas; Robert Tungadi; Dizky Ramadani Putri Papeo; Andi Makkulawu; Yuni Sarah Manoppo
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13532

Abstract

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
Uji Toksisitas Ekstrak Metanol Daun Kecubung (Datura metel L) Menggunakan Metode BSLT (Brine Shrimp Lethality Test) A. Mu’thi Andy Suryadi; Moh Adam Mustapa; Muhammad Taupik; Beby Bestari
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13272

Abstract

Amethyst plant (Datura metel L.) is often used by people as traditional medicine. This plant contains alkaloids, flavonoids, saponins, tannins, and steroids. Meanwhile, some of these compounds with certain levels can be cytotoxic. Toxicity test using the Brine Shrimp Lethality Test (BSLT) method is an initial screening to test a plant that has cytotoxic potential for the development of anticancer drugs. The purpose of this study was to determine the toxicity of the methanol extract of the leaves of Amethyst (Datura metel L.) to shrimp larvae (Artemia salina Leach) using the BSLT method. The test was carried out using several concentration variations, which are 10, 20, 40, 80, and 160 μg/Ml, and a control solution with 3 replications. Each concentration used 10 larvae, and observations were made for 24 hours on larval mortality. Thus, the findings found that the methanol extract of the amethyst leaf (Datura metel L) was potentially very toxic with an LC50 value of 46.1636 μg/mL.
Gambaran Interaksi Obat Pada Pasien Gagal Ginjal Kronik Dalam Proses Hemodialisis Siti Alfanda Makmur; Madania Madania; Nur Rasdianah
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13333

Abstract

Chronic Kidney Disease (CKD) is a condition in which there is a decrease in kidney function due to the presence of chronic and irreversible renal parenchyma. Patients with chronic disease often require a combination of several drugs. The administration of drugs combination is generally expected to have a beneficial effect. However, in some cases, drug interactions resulted in ineffective treatment and the emergence of unexpected events. This research aimed to determine drug interactions in patients with chronic kidney disease who are undergoing hemodialysis in the Inpatient Installation of Dr. M.M Dunda Limboto Hospital. This research was observational using a cross-sectional design and retrospective data collection. The sampling technique used was a purposive sampling technique with a total of 51 patient who met the inclusion criteria during the July-Desember 2020 period. Drug interaction data analysis was based on the Drug Interaction Checker and Drug Interaction Facts. The results showed that the most widely used drugs in patients with chronic kidney disease at Dr. M.M Dunda Limboto Hospital were anti-hypertensi drugs (17%), vitamins and minerals (13.30%), and gastrointestinal (11.32%). Drugs interactions with pharmacodynamic mechanisms were 31 cases (53.45%), pharmacokinetics were 21 cases (36.21%), and 6 cases were unknown (10.34%). The level of clinical significance in patients with chronic kidney disease was 75.86% moderate, 13.80% minor, and 10.34% major.
Formulasi Sabun Cair Cuci Tangan Antibakteri Ekstrak Etanol Daun Cabe Rawit (Solanum frutescens.L) Aina fatkhil haque; Elly Mulyani; Jimmy Hendick
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.15510

Abstract

Several studies have shown that cayenne pepper (Solanum frutescens.L) leaf extract has antimicrobial properties In this study, the extraction was carried out by the maceration method. The liquid soap formulation that will be made contains cayenne pepper leaf extract with 0.5%, 1%, 2%. Of all the parameters of the physical properties test carried out. It is known that the ethanol extract of cayenne pepper leaves can be made into liquid soap preparations. Variations in the concentration of ethanol extract of cayenne pepper leaves used in the study showed its effect on organoleptic tests in the form of color and aroma. In the pH test, the pH varied from 9.41-10.65 and the foam height obtained at the 5th minute was 91%, 92%, 93%. For the hedonic test, it was found that the panelists preferred Formula 2 to Formula 1 and Formula 3. Based on the results of the evaluation of the formulation, the best formula is obtained in formula 3.
The Formulation and Stability Test of The Balm Emprit Ginger (Zingiber officinale var. amarum) Essential Oil Ferna Indrayani; Nurul Hikma
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15863

Abstract

Emprit ginger (Zingiber officinale var. amarum) is a rhizome plant that is much of the time tracked down in the locale. Tanasitolo, Kab. Wajo. Its utilization is most generally utilized as a cooking zest, defeating joint inflammation, muscle torment, treating colds, treating hacks, as a characteristic cell reinforcement and warming the body. The compound parts contained in emprit ginger (Zingiber officinale var. amarum) are zingiberene, shagaol, sap, and gingerol which are adequate as cancer prevention agents and mitigating or then again reflexology. This study aims to decided how to of ginger emprit (Zingiber officinale var. amarum) as a salve form of a natural balm. This type of research is a direct observation in the laboratory using the distillation method to obtain the essential oil in ginger emprit (Zingiber officinale var. amarum) was then made in the form of a balm with different concentrations of essential oils, namely F1 (0 g), F2 (1.5 g), and F3 (2 g) using accelerated stability testing on the balm preparation, stored for 6 days with 3 cycles (40C and 400C) the observations included organoleptic tests (shape, smell, and colour), homogeneity test, pH test, spreadability test, adhesion test, and specific gravity.. This study indicate that a stable balm preparation that meets the standard requirements based on SNI with accelerated stability testing is formula F3 with a concentration of 2 grams of ginger essential oil. Emprit ginger (Zingiber officinale var. amarum) can be formed in a balm preparation.
Formulating Oil Emulgel of Nyamplung (Calophyllum inophyllum L) with Variations of HPMC and Activity Testing for Incision in Rabbit New Zealand Erinda Risma Puspita Cahya; Dewi Ekowati; Dwi Ningsih
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15455

Abstract

Emulgel is an emulsion of both O/W and W/O which is made into a gel by mixing it with a gelling agent. One of the gelling agents that is often used is HPMC because it can produce a clear gel, easily soluble in water, and has low toxicity. Nyamplung oil has wound healing activity by stimulating cell proliferation and the production of collagen and GAG (glycosaminoglycans). The purpose of this study was to find out that nyamplung (Calophyllum inophyllum L) oil can be made into a good emulgel preparation, has the effect of healing cuts, to determine the effect of variations in HPMC concentration on the physical quality and stability of the emulgel, and in accelerating the healing of cuts. This study used three formulas containing 1%, 2%, and 3% HPMC plus one control formula. Emulgel is made by mixing emulsion with gel and contains 1% nyamplung oil, then physical quality tests are carried out : organoleptic, homogeneity, pH, adhesion, dispersibility, viscosity test, emulgel type test, stability test. The wound healing activity test was carried out on the back of New Zealand rabbits. The percentage of treatment results were statistically analyzed. The results showed that all nyamplung oil emulgel formulas could be made ini emulgel preparations, had good physical quality and stability and had the effect of wound healing. The effect of gelling agent concentration affects the speed of wound healing. The result of the most optimal wound healing activity test is the formula 2.
Evaluasi Pemeriksaan Tes Buta Warna Menggunakan Metode Ishihara Berbasis Google Form Menggunakan Buku Ishihara Syahril Saini; Elvie Febriani Dungga; Ita Sulistiani
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.15855

Abstract

This article background about the availability of ishihara book is very rare in rural areas because of its quite expensive price. Therefore, in this current research, the researcher uses the Google Form-based  ishihara book method which is relatively new which can make it easier to do a color blindness test. The research design employs an analytical survey method with a cross sectionl multisite study approach. The samples are 178 active students in 8th semester in faculties on campus 1 UNG where they are determined by accidental sampling. The research findings show that the color blindness test using ishihara book and google form is carried out on 178 (100%) active students in 8th semester of the total samples, 174 (97,7%) do not experience color blindness whereas 4 student (2,3%) have partial green color blindness. In conclusion, the results of evaluation of the sensitivity and specificity of google form towards the golden standard of ishihara book are 100% sensitivity and 100% specificity.
Formulation and Antibacterial Potential Activity Test of Antiseptic Transparent Soap Preparations Srikaya Leaf (Annona squamosa L.) Ari Dwidayati; Muhammad Asri; Adinda Putri; Nurfitria Junita
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15658

Abstract

Srikaya leaf (Annona squamosa L.) is a plant that contains several active compounds including flavonoids, saponins, alkaloids and tannins which have antibacterial properties. Transparent antiseptic extract of srikaya leaf (Annona squamosa L.) has antibacterial activity against Staphylococcus aureus. This research method is an experimental study with physical and chemical evaluation of the preparation as well as testing of antibacterial activity using the paper disc technique diffusion method at concentrations of 1%, 2%, 3%, negative control and positive control. The results of the study at concentrations of 1%, 2% and 3% met the physical and chemical requirements as well as the antibacterial activity test with a concentration of 1% inhibition zone 15.6 mm (Strong), 2% inhibition zone 19.6 mm (Strong) and 3% zone of inhibition 21.2 mm (Very strong). It was concluded that for a concentration of 3% with an inhibition zone diameter of 21.2 mm (Very strong) the most effective.
Perbandingan Kadar Kafein pada Jenis Kopi Hasil Perkebunan Bengkulu dengan Metode Spektrofotometri Ultraviolet elly mulyani; Herlina Herlina; Dewi Winni Fauziah; Aina Fatkhil Haque
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15492

Abstract

Bengkulu is a province that is in the top five as a coffee producer in the archipelago. The survey proves that Bengkulu has a fairly large potential for producing coffee with many local coffee products from Bengkulu city plantations that are already circulating in the market. Caffeine is a type of alkaloid found in coffee beans, tea leaves, and cocoa beans. This study aims to determine the caffeine content of Bengkulu plantations (Rejang Lebong, Kepahiang, Seluma) using Ultraviolet Spectrophotometry. The results showed that the coffee samples at the Bengkulu Plantation contained caffeine with levels, namely: 0,00144 mg (Seluma coffee sample), 0,011928 mg (Rejang Lebong coffee sample), 0,019,144 mg (Kepahiang coffee sample). Of the three data, the highest plantation caffeine content was found in Kepahiang coffee.
Antipyretic Activity Test of Combination of Peperomia pellucida Extract and Andrographis paniculata in Mice (Mus musculus) Khairil Pahmi; Muhammad Ricky Ramadhian; Gabena Indrayani Dalimunthe
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15654

Abstract

Pepper elder (Peperomia pellucida) and green chiretta (Andrographis paniculata) are plants that have been used empirically to reduce fever. Fever is a symptom of a disease characterized by a significant increase in body temperature. This study aimed to determine the antipyretic effect of the combination of pepper elder herbal extract (P. pellucida) and green chiretta herbal extract (A. paniculata) (80:20) in the male house mice (Mus musculus). Extraction was conducted through maceration using ethyl acetate solvent. The total of 25 male mice were divided into 5 groups, namely a negative control group (Na-CMC 1%), a positive control group (paracetamol), and a treatment group induced by a combination of pepper elder herbal extracts and green chiretta herbal extract at the dose of (80 + 20), (40 +10), and (20 + 5) mg/kg BW. DPT vaccine 0.2 ml was used intramuscularly as a fever inducer. The observation was carried out at 30, 60, 90, and 120 minutes after treatment. The data obtained were analyzed using one-way ANOVA followed by the LSD test to determine the differences between groups. The results showed that variations in the dose of the combination of pepper elder and green chiretta herbal extracts had an antipyretic effect where the most effective dose was (80 + 20) mg/kg BW due to its stable temperature reduction power and effectiveness that are equivalent to paracetamol. The combination of suruhan herb extract (P. pellucida) and sambiloto herb (A. paniculata) has potential as an antipyretic

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