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Jurnal Ilmu Kedokteran (Journal of Medical Science)
Published by Universitas Riau
ISSN : 1978662X     EISSN : 27154467     DOI : https://doi.org/10.26891/JIK
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health
Journal of Medical Science receives a script from health and medical lecturer, undergraduate, residents, hospital staff and those who interested in writing scientific papers. The scientific articles posted on JIK include: literature reviews, research article, case report and EBCR (Evidence Based Case Report). Article preferably basic science of medicine and health.
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 255 Documents
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Pengaruh Pemberian Esomeprazole Terhadap Ekspresi Imunohistokimia Soluble Fms-Like Tyrosine Kinase (Sflt-1) Dan Soluble Endoglin (Seng) Pada Tikus Dengan Model Preeklamsia Andri, Sofyan; Aldiansyah, Dudy; Dina, Sarah; Marpaung, Johny; Adenin, Ichwanul; Faradina, Dwi
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.66-76

Abstract

Preeclampsia is a systemic disorder affecting approximately 3–8% of pregnant women, occurring during or after pregnancy. The exact cause and underlying mechanisms of this condition remain unclear. It is believed that the anti-angiogenic molecules soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), which are excessively produced by the placenta in preeclampsia, play a significant role in endothelial dysfunction. Recent studies suggest that esomeprazole, a proton pump inhibitor, is generally well tolerated in preeclamptic patients. This study aimed to evaluate the effect of esomeprazole administration on the reduction of sFlt-1 and sEng expression in a preeclampsia-induced rat model using an analytical approach with a quasi-experimental design. The research was conducted at two laboratories within the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at Universitas Sumatera Utara: the Anatomical Pathology Laboratory and the Biology Laboratory. The study subjects consisted of 30 healthy and active female laboratory rats (Rattus norvegicus), aged 10 weeks, modeled to resemble preeclamptic conditions. The study was carried out in May 2021. After the intervention, significant differences were observed between the intervention and control groups in systolic blood pressure, diastolic blood pressure, and mean arterial pressure (MAP) (p = 0.001; p = 0.014; p = 0.001). Additionally, the proportion of proteinuria was lower in the intervention group than in the control group. The mean expression levels of sFlt-1 and sEng also showed statistically significant differences between the intervention and control groups (p = 0.002; p = 0.001). The findings indicate statistically significant changes in MAP, systolic and diastolic blood pressure, and proteinuria across all groups following the intervention. A comparison of sFlt-1 and sEng expression levels among the negative control, positive control, and intervention groups revealed statistically significant differences. Esomeprazole administration at a dosage of 4.68 mg/kgBW/day significantly reduced sFlt-1 expression, demonstrating the therapeutic potential of esomeprazole in suppressing anti-angiogenic factors in preeclampsia.
Genetic Variation and Antifungal Susceptibility Profile of Candida auris Adrir, Mutia Syarifah; Setianingrum, Findra; Adawiyah, Robiatul; Hasyim, Ammar Abdurrahman; Rozaliyani, Anna
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.1-13

Abstract

Candida auris is an invasive yeast that has spread worldwide since it was first identified in Japan in 2009. C.auris has spread through four genetic clades that emerged between 2008 and 2013 and caused nosocomial outbreaks. The mortality rates of C.auris infections vary significantly between regions, ranging from 30 to 60%. C.auris infections can cause fungemia, invasive candidiasis, and spread to various organs. C.auris has a defense mechanism against the innate immune response and virulence factors that are not fully understood. High thermal and salinity tolerance, excretion of protease enzymes, and the ability to form biofilms are the main virulence factors that influence the pathogenicity of C.auris. Due to limited facilities, the diagnosis of C.auris infections is still hampered in some countries. Accurate strain identification methods are essential to prevent the rapid spread of this pathogen. Molecular techniques, including PCR and sequencing of the D1/D2 region of 28s rDNA or internal transcribed spacer using specific primers, are recommended for faster and more accurate identification. Genetic analysis revealed single-nucleotide polymorphisms (SNPs) that differed between clades, especially in the nuclear and mitochondrial genomes. C.auris exhibits high resistance to fluconazole, amphotericin B, and echinocandins, with some strains being resistant to all three. Resistance mechanisms include ERG11 gene mutations, Erg11p overexpression, and efflux pump activity. The rise of multidrug-resistant strains and high genetic variation complicates infection management, requiring heightened attention to prevent further spread.
Subdural Hematoma in Chronic Myelocytic Leukaemia Pinzon, Rizaldy Taslim; Fedora, Gusti Ayu Jacinda Amanda
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.100-103

Abstract

Chronic subdural hematoma is an old collection of blood between the arachnoid and dura mater that covers the brain surface. This condition is a common neurological emergency and commonly caused by craniocerebral trauma. Chronic subdural hematoma caused by leukaemia was rarely reported, and its pathogenesis and strategies for clinical treatment remain controversial. We report a rare case of chronic subdural hematoma caused by chronic myelocytic leukaemia (CML) in blast crisis. The patient was diagnosed as CML 8 months ago after ischemic stroke. The bone marrow cytology, flow cytology, and haematology consultation suggested chronic myelocytic leukaemia. The patient admitted again with headache and right side weakness. The routine blood examination showed blast crisis. The emergency neurosurgical consultation was performed, but the patient's condition deteriorated quickly after admission. The platelet levels continued to decrease after admission. In this case, early diagnosis and multidisciplinary treatment are important to minimalized the outcome and poor prognosis.
Diluted Liquid Dishwashing Soap Effectively Displace Xylol in The Deparaffinization Process of Hematoxylin Eosin Staining Lianita, Viona; Burhannudin, Burhannudin
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.44-48

Abstract

This study aimed to determine the optimal concentration of Liquid dishwashing soap (LDS) in the deparaffinization process. The study analyzed 27FFPE of liver from Wistar rats (Rattus norvegicus) divided into three groups. Xylol as a control (C), LDS concentrations of 1.7% (P1) and 2% (P2) as treatments. The quality of hematoxylin Eosin staining results was evaluated using scoring, analyzed using Kruskal-Wallis and Mann-Whitney statistical tests (SPSS 26.0). The results showed a significant difference between xylol and 2% LDS concentration but no significant difference with 1.7% LDS concentration. Surfactant bind tightly with both water and paraffin to dissolve paraffin out. However, the lower viscosity solution made pulling paraffin inside the tissue easier. The study found that a lower concentration of LDS (1.7%) was more effective than a higher concentration (2%) in removing paraffin from tissue samples. Therefore, it is recommended to use 1.7% LDS as an alternative deparaffinization agent to xylol.
Karakteristik Pasien Nyeri Punggung Bawah di Poliklinik Saraf RSUD Arifin Achmad Provinsi Riau Maryanti, Yossi; Darmawi, Darmawi; Zikra, Izza Fattalia; Khairussyifa, Najmi; Arenja, Regina Trisya; Aini, Sabrina
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.77-83

Abstract

Low back pain (LBP) is defined as discomfort felt between the lower costal margin and the inferior gluteal fold, and it is one of the most common complaints that bring people to seek medical attention. The World Health Organization (WHO) in 2017 reported that LBP ranked second as a global cause of disability in musculoskeletal system issues, and according to WHO data from 2022, 619 million people worldwide suffer from LBP. This study aims to identify the characteristics of patients with low back pain who seek treatment at the Neurology Polyclinic Arifin Achmad General Hospital of Riau Province. The characteristics examined include age, gender, work duration, body mass index (BMI), waist-hip ratio (WHR), pain severity, and disability level in daily activities. This is a descriptive observational study with a cross-sectional design, conducted at the Neurology Polyclinic Arifin Achmad General Hospital of Riau Province, from July to September 2024. Data were collected through guided interviews using structured questionnaires, the numeric rating scale (NRS), and the oswestry disability index (ODI), as well as anthropometric measurements. The frequency distribution of each characteristic was analyzed using SPSS. The sample was collected, consisting of 50 patients. The results showed that the majority of low back pain patients were aged 35-55 years (54%), female (62%), worked ≥ 8 hours per day (58%), had a BMI in the obese category (54%), had a WHR in the central obesity category (52%), experienced severe pain (52%), and had a severe disability (58%).
The Effect of Platelet-Rich Plasma Injection as Therapy for Stress Urinary Incontinence Cases Sumarlin, Sofi; Lubis, Munawar Adhar; Fakhrizal, Edy
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.14-18

Abstract

Women frequently have stress urinary incontinence (SUI), which has a major negative influence on their quality of life. A non-surgical method of enhancing SUI that shows potential is platelet-rich plasma (PRP) therapy, by improving urethral tissue strength and enhancing the urethral closure mechanism. The usefulness of PRP in increasing urethral resistance and lowering SUI symptoms has been examined in recent literature studies conducted between 2019 and 2023. Although the first results are encouraging, more investigation is required to validate long-term advantages and clinical efficacy in broader groups, as well as to comprehend possible adverse effects and related difficulties. For SUI patients looking for non-surgical options, PRP offers an alluring treatment option with the potential to lessen the need for invasive surgical procedures. However, further development and broader clinical studies are necessary to strengthen these findings and support the clinical use of PRP in the management of SUI to improve quality of life. 
Hubungan Inisiasi Menyusu Dini dengan Keberhasilan ASI Eksklusif Pada Anak Baduta Di Kota Pekanbaru Nurhasanah, Nurhasanah; Hermawan, Angga Rizki
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.49-53

Abstract

The high infant mortality rate (IMR) is one of the problems facing the world. One of the efforts that can be done to suppress the IMR is to give colostrum contained in breast milk as soon as possible in order to increase the immunity and immunity of the neonate. After the first breastfeeding is done, it can be continued with exclusive breastfeeding until the baby is 6 months old. The success of exclusive breastfeeding starts from the optimal implementation of early initiation of breastfeeding (EIBF). The purpose of this study was to determine the relationship between EIBF and the success of exclusive breastfeeding in children under two years old. This type of research is analytic with case control method. Data were taken using a direct interview questionnaire, the research sample amounted to 120 people obtained by purposive sampling technique. Chi-square test was performed to determine the association between EIBF and exclusive breastfeeding. The results showed that most of the breastfeeding mothers aged 26-35 years (63.3%), had EIBF (52.5%), graduated from high school (67.5%), and had moderate knowledge (57.5%), and there was a significant association between EIBF and exclusive breastfeeding (p<0.05) with Odds Ratio (OR) 18.077 (95% CI 7,236 - 45,158).
Skabies di Antara Penyakit Kulit: Studi Prevalensi di Klinik Pratama Soedirman Tahun 2024 Firinda, Rizma Haidif; Wicaksono, Madya Ardi; Sinensis, Rizki Amelia; Nafiisah, Nafiisah; Kusdaryanto, Wahyu Dwi; Ihtiaringtyas, Suci
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.84-89

Abstract

Scabies is a skin disease caused by infestation of the parasitic mite Sarcoptes scabiei, which penetrates the skin and reproduces by laying eggs. Although often regarded as a common and non-severe condition, scabies is classified as a neglected skin disease on a global scale. This study aims to determine the prevalence of scabies in relation to the total number of skin diseases diagnosed at the Soedirman Primary Outpatient Clinic. A descriptive research method was employed, utilizing patient medical records from March to September 2024. Data were collected based on ICD-10 diagnostic codes, including both scabies and other dermatological conditions. The results showed that there were 13 recorded cases of scabies (5.05%) out of a total of 257 diagnosed skin diseases. This prevalence closely aligns with the national prevalence of scabies in Indonesia. Variations in prevalence may be influenced by social and environmental factors, with higher transmission rates occurring in densely populated areas and among individuals with frequent close contact. Preventive measures include health education, personal hygiene, and improved environmental sanitation.
Unveiling Burnout: How Psychological Well-Being and Quality of Life Shape Female Lecturers' Resilience Ambarsarie, Riry; Dinda, Rofifah; Saki, Vernonia Yora; Euleryn, Norevia; Ashan, Hesty Rhauda
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.29-34

Abstract

Female lecturers are more vulnerable to burnout due to biological and emotional factors, as well as the dual roles they often manage. Psychological well-being (PWB) and quality of life (QOL) are critical factors that can influence the occurrence of burnout. This research aims to determine the relationship between PWB and QOL with the level of burnout syndrome among female lecturers at University of Bengkulu. This study employed an observational cross-sectional design, consisted of 86 female lecturers at the University of Bengkulu selected through stratified random sampling. The variables were assessed by using Ryff’s Psychological Well-Being Scale, WHOQOL-BREF questionnaire, and Maslach Burnout Inventory Educators Survey. Data were analyzed using univariate, bivariate and multivariate analysis. The results showed that the majority of respondents were aged 36-45 years (34.9%), married (83.7%), and held a Master's degree (68.6%), have a high PWB level (86%) with good QOL (58.1%) and have a mild burnout syndrome (91.9%). The Pearson chi-square test analysis results show p = 0.0001 (p ≤ 0.05) for both PWB and QOL. From the multiple linear regression analysis, it was found that both the PWB and QOL variables have a negative and significant effect on burnout syndrome among female lecturers. Each increase both PWB and QOL will reduces burnout by 0.255 (PWB) and 0.829 (QOL). With appropriate interventions, it is hoped that a healthier and more productive work environment can be created, supporting professional development and the emotional well-being of educators, especially with female lecturers.
Karakteristik Elektrolit Pada Anak Pasca Operasi yang Dirawat di PICU RSUD Arifin Achmad Tahun 2018-2020 Pasaribu, Hotber Edwin Rolan; Razan, Sabila
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.54-60

Abstract

Electrolytes have the ability to conduct electricity, because electrolytes have two charges, namely cations and anions. The main cations are sodium, potassium, calcium, and magnesium. The main anions are hydrogen bicarbonate, chloride and phosphate. Postoperative pediatric patients have the possibility of experiencing electrolyte disturbances in sodium, potassium, calcium, and chloride. Electrolyte levels can be affected by age, gender, number of surgeries based on surgery site, and type of fluid. The purpose of this study was to determine the characteristics of electrolytes in postoperative pediatric patients treated at the PICU of Arifin Achmad Hospital in 2018-2020. This study used a retrospective descriptive design with a total sample of 136 people. The results showed that the most age was infant and the most gender was male. Preoperative electrolyte levels were normonatremia, normokalemia, normocalcemia, and normochlorinemia and the most postoperative electrolyte levels were normonatremia, normokalemia, normocalcemia, and hyperchlorinemia. The majority of the surgery is conducted on the abdomen. The most common administered type of fluid is crystalloid.

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