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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 164 Documents
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Onycholysis in an elderly woman: Proposal for treatment with Coix seed extract administration Horiuchi, Yasuhiro
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Abstract

Background: The exact etiology of onycholysis, which is characterized by the painless separation of the nail from the nail bed, remains unclear. Currently, there are no established effective treatments for this condition. Coix seed extract (C-S extract), a traditional Chinese medicine, is recognized for its various biological properties. Case Illustration: This report describes a case of onycholysis affecting the left index finger of a 62-year-old female patient, with initial symptoms appearing three months prior. Despite ongoing internal administration of C-S extract, the patient experienced a recurrence of onycholysis on both the index finger and pinky finger of the left hand a few months later. Notably, both the initial occurrence and the relapse were resolved with the use of oral C-S extract. Discussion: C-S extract is commonly utilized in both medicinal and cosmetic application; however, its underlying biological mechanism remain largely unexplored. It has been suggested that the extract may serve as an effective anti-aging agent for the skin. Nonetheless, it is perceived that the potency of C-S extract is relatively limited. Conclusion: Therefore, further scientific evaluation of the biological function of C-S extract is warranted. While it shows promise as an anti-aging agent and has a favorable safety profile, its overall efficacy appears to be moderate.
Comparison of quality of life, anxiety, and depression levels based on acne vulgaris severity Husna, Annisaul; Yenny, Satya Wydya; Desmawati, Desmawati; Akhyar, Gardenia; Masrul, Masrul; Yulistini, Yulistini
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Acne vulgaris is a chronic inflammation of the pilosebaceous unit. Although acne vulgaris is not fatal, it can cause psychological effects. This study aimed to compare the quality of life, anxiety, and depression levels based on the severity of acne vulgaris among medical students at Andalas University. Methods: This was an observational-analytic study with a cross-sectional design. It was conducted from May to June 2023. The population included the third-grade students of the Medical Study Program of the Faculty of Medicine, Andalas University, who had acne vulgaris. The respondents were 70 people, recruited with consecutive sampling techniques. This research used Lehmann classifications to classify acne severity, the Cardiff Acne Disability Index (CADI) to assess quality of life, and the Depression Anxiety Stress Scale (DASS-21) to assess anxiety and depression. The statistical analysis used the Kolmogorov-Smirnov test. Results: Most female respondents, aged 20 years old, experienced mild acne vulgaris (84.3%). Additionally, the respondents predominantly had mild quality of life disorders (80%), normal anxiety level (32.9%), and normal depression level (52.9%). The Kolmogorov-Smirnov test found no relationship between the severity of acne vulgaris with quality of life (p = 0.076), anxiety level (p = 0.623), and depression level (p = 0.751). Conclusion: The results showed that most respondents had mild acne vulgaris, mild impairment in quality of life, normal anxiety level, and normal depression level. Statistical tests revealed no significant association between the severity of acne vulgaris and these variables.
Dermoscopy and 30% potassium hydroxide direct examination as diagnostic tools for distal lateral subungual onychomycosis Gaol, Evangelina Lumban; Miranda, Eliza; Sirait, Sondang Pandjaitan
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Culture and histopathological examination are gold standards for diagnosing onychomycosis. However, these examinations are subject to several limitations. Dermoscopy has the potential to become a promising diagnostic tool for onychomycosis. Direct examination of potassium hydroxide (KOH) also has advantages similar to dermoscopy. Knowing the accuracy of both examinations can help clinical decision-making. Our objectives are to assess the diagnostic value of dermoscopy, KOH examination, and their combination for distal lateral subungual onychomycosis compared to culture or histopathology. Methods: This was a cross-sectional diagnostic study of nails with suspected distal lateral subungual onychomycosis. Sixty nails were included in this study. Results: The sensitivity and specificity of the KOH examination were 89.6% and 66.7%, respectively. On dermoscopy, the sensitivity of jagged-edge-with-spikes, longitudinal striation, and discoloration were 89.6%, 93.8%, and 97.9%, respectively. Only the aurora borealis dermoscopic feature provided good specificity (91.7%). The positive predictive values of these four dermoscopic features were 75.0%–79.7%. Combination with KOH examination increased the positive predictive value of dermoscopy (90.9%–92.7%). Conclusion: Since they were superior in terms of sensitivity, dermoscopy and KOH examinations are good screening tools to determine which suspected onychomycosis cases need further examination. Additionally, an increased positive predictive value was observed when the two examinations were combined. Hence, these procedures can help establish a diagnosis in settings where mycologic examinations are unavailable.
Port-wine stain treatment with 577-nm laser: Treatment outcomes of superficial versus deep lesions Siskawati, Yulia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Abstract

Background: Port-wine stains (PWS), or capillary malformations (CM), are congenital vascular anomalies characterized by gradual enlargement of the superficial cutaneous vascular plexus, leading to low-flow malformations in the skin. Laser therapy remains the preferred treatment for PWS. The 577-nm vascular laser system is particularly suited for treating cutaneous vascular disorders. This study evaluates the efficacy of the 577-nm vascular laser for both superficial and deep PWS lesions. Case Illustration: Three adult patients, all aged over 17 years old, were treated with the 577-nm laser. In the first case with deeper PWS, four treatment sessions resulted in flattening of hypertrophic areas, leaving residual red patches. In the second case, complete clearance of the PWS was achieved after eight treatment sessions. In the third case, additional treatment with the 577-nm laser was administered after a device targeting deeper vascular structures was employed. Discussion: The 577-nm vascular laser is safe for use in dark-skinned patients, with a short downtime and low risk of scarring and post-inflammatory erythema. For lesions deeper than 0.8 mm, other treatment modalities should be considered. Early intervention can help prevent the development of hypertrophic or nodular components. Multiple 577-nm laser sessions can minimize progression and provide significant improvement. Treatment success depends on clinical conditions, appropriate laser parameters, and timing. Conclusion: The 577-nm vascular laser is effective and safe for treating PWS, particularly in dark-skinned individuals. Early intervention and multiple sessions are the key to preventing progression and achieving optimal results. Deeper lesions may require alternative laser modalities.
Comparing Sodium Fusidate and Petrolatum for Electrosurgery-related Wound Healing: A Double-blind Randomized Controlled Trial Parrol, Firman; Wibawa, Larisa Paramitha; Sitohang, Irma Bernadette Simbolon; Saldi, Siti Rizny Fitriana
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Electrosurgery is a common surgical technique used to treat skin tumors. This procedure produces necrotic skin, which might impair the wound healing process, prompting physicians to prescribe topical antibiotics to prevent infection. This study aims to analyze the efficacy of sodium fusidate ointment compared to petrolatum for wound healing after electrosurgery. Methods: We conducted a double-blind, randomized, controlled study with a within-person design. The inclusion criteria were adult subjects with seborrheic keratosis or acrochordon with a size of 4 mm to 10 mm on the face and neck, with a minimum of 2 lesions. Electrodessication was performed on the subject lesions. The patients were then randomized to receive and sodium fusidate ointment or petrolatum. Follow-up was done for up to 14 days, during which wound healing score, erythema, edema, crusts, re-epithelialization, incidence of infection, and subjective symptoms were assessed. This study is registered in ClinicalTrials.gov (NCT05353374). Results: Twenty-two subjects with 90 wounds were enrolled. The subjects had a mean age of 48.18 ± 11.25 years old and 86.4% of them had seborrheic keratosis. Statistical analysis revealed no significant difference in erythema, edema, crusts, re-epithelialization, infection, subjective symptoms, and total wound healing score appearance on days 3, 7, and 14 following the procedure. Conclusion: Both sodium fusidate ointment and petrolatum showed similar efficacy for wound healing after electrosurgery.
Validity and Reliability of the Indonesian Version of Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) Paramita, Listya; Waskito, Fajar; Prawiratama, Dikky; Indrastuti, Niken; Rayinda, Tuntas; Febriana, Sri Awalia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Epidemiological data on occupational hand eczema in Indonesia is still limited, partly because there are no valid and reliable instruments in the Indonesian language as a means of survey. This study aims to translate the Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) into the Indonesian language and assess the validity and reliability of the Indonesian NOSQ-2002 as an instrument for epidemiological surveys and screening of occupational hand eczema. Methods: The original English version of NOSQ-2002 was translated into the Indonesian language following the standard procedure of translation. The Indonesian NOSQ-2002 version, which had been collectively approved, was subsequently completed by a group of 194 textile employees from PT. Panca Persada Mulia-PANDATEX in Magelang, Central Java, Indonesia. Validity was assessed using Pearson correlation for each question with the total score. Reliability was evaluated using Cronbach's alpha values. The sensitivity and specificity of the Indonesian NOSQ-2002 screening were determined by comparing results with those of examination by the examining physician as the gold standard. Results: Pearson correlation values for each question range from 0.252 to 0.905, all surpassing the r table value, indicating questions in NOSQ-2002 are valid. Reliability NOSQ-2002 rated good (reliable), with a Cronbach's alpha of 0.933. The Indonesian NOSQ-2002 version demonstrates a sensitivity of 93.3% and specificity of 98.8% for screening occupational hand eczema. Conclusion: The Indonesian version of NOSQ-2002 is a valid and reliable instrument for use in epidemiological surveys and screening of occupational hand eczema.
Factors Associated with the Severity of Erythema Nodosum Leprosum Reactions Anggraini, Ita; Esti, Prima Kartika; Komarasari, Eka
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Leprosy is a chronic infection caused by Mycobacterium leprae. Leprosy reactions, including erythema nodosum leprosum (ENL), are induced by immune responses. ENL can cause neurological damage and deformities that result in disabilities. This study aimed to identify factors associated with the severity of ENL to help control the leprosy reactions. Methods: This was an analytical study on 148 patients with ENL reactions, who were divided into two groups based on the severity of their reactions. A retrospective cross–sectional study was conducted in the medical record unit of Sitanala Hospital, Tangerang, Banten, Indonesia, from May 2022 to April 2024. Data evaluated included age, gender, leprosy types, treatment status, duration of illness, clinical manifestations, involvement of other organs, disability, comorbidities, acid-fast bacilli, and laboratory examination. Categorical data was analyzed with chi-square test or Fisher’s exact test, and numerical data was analyzed with the Mann-Whitney test. Significance is determined at p < 0.05. Results: Characteristics including age, neuritis, skin ulcers, and comorbidities differ significantly between mild and severe ENL (p = 0.034; < 0.001; < 0.001; and 0.003, respectively). Severe ENL reactions tend to occur more frequently in older patients, and is associated with higher bacterial index (p = 0.004) and lower sodium and albumin levels (p = 0.014 and < 0.001, respectively). Conclusion: Age, neuritis, skin ulcer, comorbidities, bacterial index, as well as sodium and albumin levels were associated with the severity of ENL reactions. Appropriate management is required to prevent further complications.
Combination of 1064 nm QS Nd:YAG Photoacoustic Technology and Exosome for Facial Rejuvenation Setiawan, Stanley; Putranto, Samuel Septrian; Linata, Angela Maria; Salim, Stephanie; Mertosono, Novia Sari Andriati; Nobel, Shelly; Wardianti, Flora Asri; Anggraini, Ita; Rahmawati, Zulaikha Rizqina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Facial rejuvenation has become a global trend in cosmetic and aesthetic dermatology to restore youthful skin. The combination of 1064 nm Q-Switched Neodymium:Yttrium Aluminum Garnet (QS Nd:YAG) laser and exosomes as a facial rejuvenation procedure restores youthfulness by increasing collagen and elastin. Case Illustration: This case series evaluated the effectiveness of 1064 nm QS Nd:YAG laser with and without human amniotic fluid stem cell-derived exosomes (hAFSC-exo) for facial rejuvenation in six adults aged 24–39 years with Fitzpatrick skin types III-IV. Participants were randomized to receive either laser treatment alone or combined with intradermal hAFSC-exo injections every two weeks for three sessions, with outcomes assessed through blinded objective and subjective evaluations. Objective assessments using a skin analyzer showed improvements for both groups, with consistently greater improvement in the combination therapy group. Meanwhile, subjective evaluations using the GAIS scale indicated that combination therapy recipients experienced “very much improved” outcomes, minimal side effects, and good overall tolerance. Discussion: Facial rejuvenation using 1064 nm QS Nd:YAG laser and hAFSC-exo was evaluated in this case series. Both treatments improved skin quality, but combination therapy demonstrated superior results. However, improvements in pigmentation were limited, and subjective assessments may have been influenced by response bias. The short follow-up period limited the evaluation of long-term skin changes; extended studies are warranted to assess sustained outcomes. Conclusion: Combination therapy of 1064 nm QS Nd:YAG laser and exosomes has a favorable result for facial rejuvenation.
Herpes Zoster Reactivation Following COVID-19 mRNA Vaccination in an Elderly Patient: A Case Report Sarah, Ratu Siti Khadijah; Hapsari, Yari Castiliani; Yusharyahya, Shannaz Nadia; Miranda, Eliza; Edwar, Sarah Qanita
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Latent varicella-zoster virus (VZV) in nerve ganglia may reactivate into herpes zoster infection. The coronavirus disease (COVID-19) vaccine is suspected of triggering VZV reactivation, although the exact cause is unclear. This case report aims to raise awareness of the potential complications induced by the COVID-19 mRNA vaccine, particularly in elderly patients. Case Illustration: A 62-year-old woman complained of itchy and painful unilateral dermatomal herpetiform blisters six days after mRNA COVID-19 vaccination. The vesicle first appeared on the left breast, spreading to the back. The patient has a history of hypertension. After the administration of 800 mg of acyclovir five times a day for seven days, the vesicles dried up, and no new vesicles emerged. Discussion: The incidence of herpes zoster has been widely reported to occur within 5-7 days after the COVID-19 vaccination, mostly due to the mRNA vaccine. The dysregulated cell-mediated immune system may trigger VZV reactivation. The vaccines have been shown to induce a cellular response with increased CD8+ T-cells and T-helper type 1 CD4+ T cells. The VZV-specific CD8+ cells cannot control VZV after the massive shift of naïve CD8+ T-cells in the setting of COVID-19 vaccination. Hypertension is also allegedly the main comorbid factor for herpes zoster reactivation after COVID-19 vaccination. Conclusion: Increased awareness and early recognition of potential COVID-19 vaccine-related complications, especially in elderly individuals with comorbidities, are important for timely management and prevention of further issues.
Topical Application of Exosomes in a Patient with Acne Conglobata: A Case Report Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Acne conglobata (AC) is a rare and severe acne characterized by interconnected nodules, cysts, and abscesses. Mesenchymal stem cell-derived exosomes (MSC-exosomes) have immunosuppressive properties that alleviate inflammation and immunological reactions. We present a case of AC in a patient who received topical administration of exosomes. Case Illustration: A 20-year-old male was diagnosed with AC, presenting as inflammatory papules and cysts covered with yellowish crusts that had been present for five months. Exosomes (ASCE+®, Seoul, South Korea) were topically administered at a dose of 5 mL, applied evenly to the face. The patient underwent three treatment sessions, with a one-week interval between sessions. Photographic images were captured before treatment, immediately after the final session, followed by one week and then three weeks after the final treatment session. The patient expressed complete satisfaction with the implemented treatment and disclosed no adverse effects. Discussion: The present case report illustrates the therapeutic advantages associated with the use of exosomes in a patient with AC. The therapeutic targeting of inflammatory regulators is crucial in treating AC. Studies have shown that MSCs possess inherent immunosuppressive properties that can help alleviate inflammation and immunological reactions. MSC-exosomes offer additional benefits, including angiogenic capacity and collagen synthesis. The study's limitations include the short follow-up duration and the lack of a control group. Conclusion: Exosomes have the potential to serve as cosmeceutical in the treatment of AC, due to their anti-inflammatory, regenerative, and antimicrobial properties.

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