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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Efetivitas tablet Fe dalam meningkatkan kadar hemoglobin ibu hamil Mila Syari; Rahmi Fitria; Elvina Sari Sinaga; Harahap Harahap; Yuka Oktafirnanda
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.208

Abstract

Introduction: Iron deficiency is when a person has a low number of red blood cells (erythrocytes) in the blood, causing anaemia. Anaemia occurs due to a lack of haemoglobin, which means a lack of oxygen supply throughout the body. Lack of oxygen can cause the body to become weak, lethargic, and lacking energy. In pregnancy, anaemia can occur because the increase in plasma volume is greater than the increase in haemoglobin levels. Purpose: This study aims to determine the effectiveness of Fe tablets in increasing Hb levels in pregnant women at the Amaliun Health Center. Methods: This study used an analytical, quantitative method with a pre-experimental design using a one-group pre-test and post-test design. Data was collected using a questionnaire and data analysis using the T-Dependent test. The research sample consisted of 38 pregnant women. Results: The results showed that the average difference in Hb levels before and after being given Fe tablets was 1.5 gr% ± 0.57 gr%. The statistical test results showed a value of p = 0.00, which means that Fe tablets have an effect on increasing haemoglobin levels in pregnant women. Conclusion: This study concluded that Fe tablets had a significant effect with p=0.00. Therefore it is expected that the puskesmas will provide counselling and health counselling to prevent anaemia during pregnancy.
Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat Asyrun Alkhairi Lubis; Muhammad Yunus; Jefri Naldi; Muhammad Andry; Pricella Ginting; Fira Safitri; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.209

Abstract

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
Uji Aktivitas Produk Sediaan lipgloss dari buah kesumba keling (Bixa orellana L) sebagai pewarna alami Christica Ilsanna Surbakti; Artha Yuliana Sianipar; Cut Masyitah Thaib
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.214

Abstract

The general of kesumba keling fruit is one of the potential plants as natural dyes.Moreover,kesumba keling fruit also useful for diuretic,antipiretic,and neutralizing toxins in the body.One of the plants that can be made in lip coloring is kesumba keling fruit one of the most used cosmetic product is lipgloss..lipgloss in using be easy to apply and give a shiny impression.The purpose of this research is to know if kesumba keling fruit skin extract can be used as natural dye substitute for synthetic dyes on lipid dye preparations.On day 1 to 30 color prepararion on change.Lipgloss with consentration of kesumba keling 10% light yellow,12% giving dark yellow,14% consentration giving a reddish yellow color.Lipgloss preparation is the distinctive smell of kesumba keling fruit extract that is most preffered by panelist with concentration of 12%,because the preparation of lipgloss from kesumba keling fruit extract doesn’t cause irritation.Conclusions : Point out the difference between icreasing concentration of the kesumba celing fruit extract to used in formula then the more consentrated color of the lipgloss produced increased.Lipgloss with 10% concentration are light yellow,lipgloss preparation with 12% concentrated are dark yellow,lipgloss preparation with 14% conceration are reddish yellow and on days1 to 30 preparation on change.
Evaluasi Pengujian mutu biji pepaya (Carica papaya L.) yang di ekstraksi secara maserasi dengan pelarut etanol 70% Christica Ilsanna Surbakti; Modesta Tarigan; Grace Anastasia Ginting
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.215

Abstract

Background : In papaya seed (Carica papaya L.) the bitter taste is caused by carpain alkaloid content. Carpain is an alkaloids free class of alkaloids. This carpain alkaloid can lower blood pressure, kill amoeba, bladder stones, urinary tract, and worms. But often found traditional medicine that does not produce the expected effect, generally due to not meet the quality standard or it could be due to misinformation and mistaken assumption against traditional medicine. In terms of side effects it is recognized that traditional medicine has relatively small side effects compared to modern medicine. Therefore, researchers are interested to make a quality and efficacious extract, thus the herbal products can be maintained quality, quality and efficacy that can cure various diseases. Objectives : To find out the percentage of yield of extract after maceration of papaya seed extraction, secondary metabolite identification and characterization of papaya seed by using 70% ethanol solvent. Method : The samples used in this research are Bangkok papaya fruit seeds from Jl. Student, Ex. Marindal, Kec. Patumbak, Kab. Deli Serdang, North Sumatra. Sampling is done purposively without comparing with the same sample from other regions. This research uses experimental laboratory experimental design consist of several stages including: sample collection, making simplicia, making of extract, identification of secondary metabolite compound, and quality test of papaya seed extract (Carica papaya L.) by maceration method. Results : In result of rendement have obtained extract of ethanol thick with percentage of rendement extract equal to 15,672% from 500 gram simplicia papaya seeds. In phytochemical screening test, the compounds contained in the extract of ethanol papaya seeds seeds are alkaloids, flavonoids, saponins, steroids / triterpenoids, and tannins and on the characterization test of papaya seed extract obtained water content of 1.15%, water soluble juice content of 46.35 %, ethanol soluble content of 18.61%, total ash content of 7.25% and 0.92% acid soluble ash content that meets the extract requirements set by MMI. Conclusion : It is known that the yield after the paperasi seed extraction is done, the secondary metabolite results show negative results only on the cyanogenic glycoside test, and the characterization test has met the requirements set by MMI.
Analisis kadar vitamin C pada buah naga putih (Hylocereus undatus) dan buah naga merah (hylocereus polyrhizus) dengan perbandingan metode spektrofotometri uv dan titrasi iodimetri Claudy Friesta Melanie; Gabena Indrayani Dalimunthe; Ridwanto; Fathur Rahman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.216

Abstract

Dragon fruit is natural source of antioxidants. We can consume not only dragon fruit flesh, but the skin is also very beneficial for health, in reality it is only considered as waste that has not been used properly. This study aims to analyze the levels of vitamin C in white dragon fruit and red dragon fruit with a comparison of uv spectrophotometry and iodimetric titration methods. The stages of the research included extracting from dragon fruit, screening phytochemicals, testing levels of vitamin C using iodimetric titration, testing levels of vitamins using UV spectrophotometry. The results showed that red dragon fruit contains alkaloids, flavonoids, saponins, tannins, triterpenoids and glycosides, while white dragon fruit contains alkaloids, flavonoids, saponins and steroids. Determination of vitamin C levels by iodimetric titration method on red dragon fruit skin was 9.240 ± 3.029 mg, on red dragon fruit flesh was 11.587 ± 1.893 mg and vitamin C levels on white dragon fruit skin was 9.827 ± 3.933 mg, on white dragon fruit flesh was 13.347 ± 3.143 mg in 100 gram sample. While the spectrophotometric method obtained vitamin C levels in white dragon fruit flesh, namely 332.93 mg/100g, in red dragon fruit flesh, 24.99 mg/100g, while red dragon fruit skin, which was 16.59 mg/100g, in white dragon fruit skin, namely 10.47 mg/100g.
Uji Aktivitas Ekstrak Etanol Daun Labu Siam (Sechium edule Jacq. Swartz) sebagai Antibakteri Mycobakterium smegmatis Christel Sambou; Douglas N. Pareta; Sarah Sambow; Wilmar Maarisit; Jabes Kanter; Jeane Mongi; Hanna M. Rumagit; Selvana Tulandi; Joke L. Tombuku; Reky R. Palandi; Nerni O. Potalangi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.217

Abstract

The membrane structure of Mycobacterium smegmatis is similar to that of Mycobacterium tuberculosis, allowing TB testing to be performed on Mycobacterium smegmatis without directly testing on Mycobacterium tuberculosis. Antibacterial testing uses the paper disc method with several treatments, namely extract concentrations of 1 µg/disc, 2 µg/disc, and 4 µg/disc, as well as positive control streptomycin 2 µg/disc and negative control 70% ethanol. The research results obtained at Extract Concentrations of 1, 2, and 4 µg/disc have moderate antibacterial activity seen from the inhibitory zone diameter, namely 8.73 mm, 9.17 mm, and 9.73 mm, and the positive control is strong because it has a zone diameter of 13.27 and the negative control does not give a zone. The conclusion is that the extract of siam pumpkin leaves has moderate antibacterial activity.
Formulasi sediaan pasta gigi ekstrak etanol buah takokak (Solanum torvum Sw.) dan tulang ikan tuna sirip kuning (Thunnus albacares) terhadap bakteri Streptococcus viridans dan bakteri Escherichia coli Hendri Faisal; Hanafis Sastra; Muhammad Andry; Melia Sari; Adek Chan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.218

Abstract

Takokak (Solanum torvum Sw.) is a traditional plant used as vegetables, fruits, ornamental plants and medicinal purposes. Takokak fruit contains secondary metabolites of alkaloids, flavonoids, saponins, tannins and steroids. Tuna fish bones are one of the biggest wastes from the tuna processing industry. Tuna fish bones contain minerals that are quite high compared to other parts of the body because the main elements of fish bones are calcium, phosphorus and carbonate. This study aims to make toothpaste preparations of ethanol extract of large chili fruit and yellowfin tuna bones and to determine the inhibition zone against Streptococcus viridans and Escherichia coli bacteria. This type of research is done experimentally. This type of research includes the manufacture of toothpaste preparations with concentrations of F1 (10%), F2 (15%), F3 (20%). Preparation evaluation included organoleptic test, homogeneity test, spreadability test, foam formation test, pH test, viscosity test, extrudability test and activity test for Streptococcus viridans and Escherichia coli bacteria. The results of the research were carried out to evaluate the physical preparations of toothpaste with ethanol extract of large chili fruit and yellow fin tuna bones, each toothpaste formulation met the organoleptic requirements, homogeneity, spreadability, foam formation, pH, viscosity and extrudability. Toothpaste preparations of ethanol extract of takokak fruit and yellow tuna bones have antibacterial effectiveness on Streptococcus viridans F1 (9.85 ± 0.32), F2 (11.85 ± 0.45), F3 (13.05 ± 0.34) and Escherichia coli F1 (3.15 ± 0.73), F2 (3.75±0.40), F3 (4.5±0.25). One way Anova data analysis showed a sig value of 0.00 <0.05 meaning that each concentration was significantly different, so that the results of the bacterial inhibition zone affected each concentration of toothpaste preparations.The conclusion of this study is that the ethanol extract of large chili fruit and yellow fin tuna bones can be formulated as a toothpaste preparation and effectively inhibits the growth of Streptococcus viridans and Escherichia coli bacteria in the weak, medium and strong categories.
Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus) Lilik Septiana; Rida Evalina Tarigan; Muhammad Andry; Vannissa Andriani Irawan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.220

Abstract

Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.
Penetapan Kadar Kafein Ekstrak Daun Teh Hijau Dan Putih Camellia Sinensis (L.) Dengan Kromatografi Cair Kinerja Tinggi Selfia Lestary; Muhammad Amin Nasution; Ridwanto Ridwanto; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.199

Abstract

Tea, a widely popular and frequently consumed beverage, is integral to daily routines. Despite the potential long-term risks associated with excessive caffeine consumption, such as hypertension, heart disease, and stroke, caffeine is a prominent choice among a diverse spectrum of individuals in society. The objective of this research endeavour is to discern the caffeine content present in extracts derived from green and white tea leaves by applying the high-performance liquid chromatography (HPLC) method. The research procedure encompasses a series of stages, encompassing the preparation of botanical materials, extraction employing ethanol solvent, characteristic analysis, phytochemical screening, and quantification of caffeine levels within the green and white tea leaf extracts utilising the HPLC technique. The extraction process of green and white tea leaves entails maceration utilising 96% ethanol, followed by concentration via a rotary evaporator. The determination of caffeine concentrations is executed using the high-performance liquid chromatography method. A phytochemical screening analysis of ethanol extracts derived from green and white tea leaves unveiled a myriad of chemical compound classes, including alkaloids, flavonoids, saponins, tannins, and steroids. The quantification of caffeine content within the samples is ascertained by calculating the area under the curve (AUC) on the chromatograms of green and white tea extracts. The quantification results for caffeine content in the green tea extract reveal a value approximately equivalent to 98.4278069571 mg/g. The white tea extract demonstrates a content value of approximately 136.131488681 mg/g.
Uji aktivitas antioksidan ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan metode DPPH Selfiani Selfiani; M. Pandapotan Nasution; Anny Sartika. D; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.200

Abstract

Antioxidant compounds are substances that can absorb or neutralize free molecules so they can prevent degenerative diseases such as heart disease and cancer. Antioxidants are able to donate electrons to stop free radical chain reactions that can damage the body. Jasmine flower leaves contain bioactive substances such as flavonoids, alkaloids, and tannins which are potential ingredients as natural antioxidants. One method to measure or determine free radical scavenging antioxidants is the DPPH (1,1-Diphenyl-2-Picrylhidrazyl) method. This study aims to determine the antioxidant activity of the ethanol extract of jasmine leaves based on the IC value50. The methods used in this study included examination of simplicia characteristics, phytochemical screening and antioxidant activity tests using the DPPH method (1,1-Diphenyl-2-picrylhidrazyl) using a UV-Vis spectrophotometer. The results of this study revealed that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) showed that the extract contained chemical compounds of alkaloids, flavonoids, saponins, tannins, and steroids. In addition, this study also revealed that the ethanol extract of jasmine leaves has antioxidant activity with an IC value50 namely 56.05 µg/mL and for vitamin C the IC value was obtained50 3.70 µg/mL. This shows that the ethanol extract of jasmine leaves positively contains secondary metabolites and has the potential as an antioxidant with a strong classification compared to vitamin C, which is an antioxidant with a very strong classification.

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