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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Analisis sensitivitas pengaruh liter air dan bumbu marinasi pada ayam broiler menggunakan mesin tumbling Pryanto, Edy; Putra, Andhika; Sinaga, Kurniawan; Purwosiswoyo, Purwosiswoyo
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.294

Abstract

Tumbling is a marination method that combines the process of stirring and homogenizing so that the taste of spice from the marinade is optimally distributed into the meat. Based on the advantages of the tumbling machine, which can stabilize the texture and increase the weight of the carcass that has been cut, this can occur well. So, the researchers wanted to measure the amount of remaining spices in the tumbling machine and measure the yield (weight) before and after marinating. The research method used was a completely randomized design method using five treatments. The results obtained in this research for the 10% increase treatment obtained good results for use; for the 10% decrease treatment, the results were not good for use; for the 20% increase treatment, the results were good for use; and for the 20% decrease treatment, the results were not good for use.
Analisis mutu bubuk kopi arabika gayo yang dijual di toko oleh-oleh khas Kabupaten Bener Meriah Provinsi Aceh Zarwinda, Irma; Elfariyanti, Elfariyanti; Zakaria, Nurmalia; Humaira, Humaira
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.311

Abstract

Gayo Arabica coffee is a typical coffee produced from plantations in the Gayo area of Aceh Province, especially Bener Meriah Regency. This research aims to determine the quality of packaged coffee powder that does not have a distribution permit, which is sold in souvenir shops in Bener Meriah Regency, Aceh Province. The method used in this research is quantitative analytical descriptive. The sample used in this research was coffee powder that did not have a distribution permit, which was taken as a total sampling in 5 souvenir shops in 4 sub-districts in Bener Meriah Regency. The results of organoleptic observations on coffee powder with codes P1, P2, P3, and P4 were in the form of coarse powder, while P5 was in the form of fine powder. P1 and P2 coffee grounds are dark brown, and P3, P4, and P5 are brown. The taste of coffee powder P1, P2, P3, and P5 has no taste, and P4 tastes bitter. The overall aroma of the sample is typically aromatic. The water content test results were 0.74%, 0.66%, 0.58%, 0.14%, and 1.40%, respectively. The ash content test results were obtained: 4.60%, 4.47%, 4.37%, 44.65%, and 4.50%, respectively. The coffee essence levels were 23.97%, 25.80%, 25.70%, 25.10%, and 30.2%, respectively. The results of the quality analysis of Gayo Arabica coffee powder in the souvenir shop of Bener Meriah Regency, province, have met the quality requirements by SNI 01-3542-2004.
Uji kadar total polifenol buah asam kandis (Garcinia xanthochymus Hook.f.ex T.Anderson) dengan metode spektrofotometri UV-VIS dan LCMS Winata, Hanafis Sastra; Faisal, Hendri; Andry, Muhammad; Naziyah, Syifa; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.320

Abstract

Background: Kandis tamarind has various activities, such as antioxidant, cytotoxic, anti-inflammatory, and antimicrobial. This study aimed to determine the total polyphenol content of kandis acid fruit and the types of phenolic compounds contained in kandis acid fruit. This type of research was experimental, using 70% ethanol solvent. The research method used was a polyphenol qualitative test, UV-Vis spectrophotometry, and LC-MS. The results of qualitative measurements showed that the samples contained polyphenolic compounds. The results of the polyphenol test on the kandis acid fruit sample on 1% FeCl3 reagent and diazo reagent got positive results, while the Millon reagent got negative results. The study's results show that the determination of the levels of polyphenol content in kandis acid fruit extract was measured using UV-VIS spectrophotometry by adhering to the working principle of Folin-Ciocalteau. The proof of polyphenol content used the Folin-Ciocalteau reagent because this reagent can react with a group of polyphenolic compounds to form a concentrated solution whose absorbance can be measured. The higher the sample concentration, the higher the absorbance value. The results of determining the polyphenol content of the kandis acid fruit extract using uv-vis spectrophotometry had a polyphenol compound component of 61.1015 mg GAE/g sample. The results of the LC-MS analysis for the highest phenolic compound, namely the type of vanillic acid, amounted to 14.21%.  
Formulasi sediaan body butter ekstrak etanol bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab kulit Diana, Vivi Eulis; Abadi, Hafizhatul; Andry, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.321

Abstract

Background: Body butter is a semi-solid preparation with the highest fat content, so it is very thick and has a consistency very similar to butter, and has a better ability to nourish the skin than body lotion. In addition, body butter itself is perfect for eliminating reddish lines that usually appear on the skin or commonly called strechmarks. Objective: To test the physical quality stability of the concentration of rosella flower ethanol extract formula (Hibiscus sabdariffa L.) in body butter preparations that have been made. Method: The method used is laboratory experimental. Research includes plant extraction, plant identification, making simplisia, phytochemical screening, making ethanol extract, body butter preparation formulation, and quality stability testing of preparations. The sample used in this study was Rosella Flower (Hibiscus sabdariffa L). The research data was analyzed using the SPSS program, namely the Anova test. Result: Rosella flower ethanol extract (Hibiscus sabdariffa L.) has a semisolid form, homogeneous no coarse particles, with a pH value of the preparation ranging from 6.3-6.4, non-irritating, and can moisturize the skin. But it is not stable with cycling test method storage and stable at room temperature for 4 weeks. The best formula of body butter preparation from ethanol extract of rosella flower (Hibiscus sabdariffa L.) to moisturize the skin is a concentration of 3%. Conclusion: Rosella flower ethanol extract (Hibiscus sabdariffa L.) can be formulated in body butter preparations. It is recommended that future researchers formulate it into other preparations in the same concentration using the same plant from rosella flowers (Hibiscus sabdariffa L.).
Isolasi senyawa flavonoid dari daun bakung (Crinum asiaticum L.) Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.322

Abstract

Introduction Sprains and fractured bones are treated with spider lily leaves (Crinum asiaticum L.). Alkaloids, flavonoids, tannins, steroids, and triterpenoids are among the chemical components found in spider lily leaves. The most significant phytochemicals in plants with wide biological advantages for humans are bioactive flavonoids. The purpose of: The study aimed to isolate flavonoid components from spider lily leaves. Methods: This study was descriptive, using the following steps: plant material collection and preparation, sample processing, simplicia characterization, extract preparation, phytochemical screening, hydrolysis, fractionation, analysis using paper chromatography (KKt), and compound isolation using preparative paper chromatography. The isolates were tested for purity using one-way and two-way KKt, and they were identified using UV-Vis spectrophotometry with a shear reagent. The results: The results of the characterization showed that the water content was 7.21%, the water-soluble extract was 11.21%, the ethanol-soluble extract was 9.23%, the total ash content was 1.99%, and the acid-insoluble ash content was 0.81%. The screening findings indicated the presence of flavonoid chemicals. The KKt analysis results revealed that the best mobile phase was 5% acetic acid with ammonia vapor specks, and the preparative KKt isolation results yielded a single blue isolate, which was then identified by UV-Vis spectrophotometry using a shear reagent, resulting in maximum wavelength absorption (max) at band II of 253nm, presumably identifying the isoflavone group of flavonoids. Conclusion: The conclusion showed the ethyl acetate fraction of spider lily leaves could be separated using paper chromatography and that identification by spectrophotometry UV-Vis using a shear reagent wasolate, which was assumed to be an isoflavone group component.
Daya terima nugget ikan depik dengan substitusi tepung mocaf Lestari, Wanda; Maisyarah, Maisyarah; Purba, Tuty Hertati; Angkat, Abdul Hairuddin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.323

Abstract

Nuggets are processed meat product that can increase the use and storage values of the meat itself. Making nuggets from depik fish with the substitution of mocaf flour increases the selling values of the depik fish. The aim is to determine the acceptability and hedonic quality and nutritional content of the best formulas vor nugget products. Experimental research using a completely randomized design (CRD) approach to the formulation of the basic material for making nuggets with the addition of depik fish with mocaf flour substitution that is four treatments and two repilications to obtain 8 experimental units, the data were analyzed by One Way ANOVA with Duncan test. The results based on hedonic tests show that F3 (60% Mocaf Flour + 40% Wheat Flour) averaged 3,81 the best-selected formula. Whereas the hedonic quality test showed that F3 was the best formulation with a total value of 3.74 with a grayish-white color clarification, depik fish aroma, savory taste and chewy texture. Water content is 12.24%, ash content is 7.38% and protein content is 5.16%. Conclusion:  the best depik fish nuggets formula is F3 formula.
Uji aktivitas antibakteri formulasi sediaan gel antijerawat ekstrak etanol kulit buah alpukat (Persea americana Mill) terhadap bakteri Staphylococcus aureus Novi Yuliandari; Yayuk Putri Rahayu; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.327

Abstract

The avocado peel contains flavonoids, saponins, tannins, steroids, and glycosides and has antimicrobial properties. Staphylococcus aureus is a gram-positive bacteria and typical skin microorganism that causes acne. It produces lipase, which breaks down free fatty acids from skin lipids. The gel preparation was chosen. It is better used in treating acne because it does not contain oil or affect acne. This study aimed to determine whether the ethanol extract of avocado peel can be used as an anti-acne gel and to choose the inhibitory power of the gel preparation against Staphylococcus aureus. The ethanol extract of avocado peel was prepared using the percolation method; the extract was formulated into anti-acne gel with 10%, 20%, and 30%. Then, a physical evaluation of the preparation was carried out by assessing organoleptic, homogeneity, pH, viscosity, adhesion, spreadability, irritation, skin moisture, and syneresis. Then, the activity of Staphylococcus aureus bacteria was tested on gel preparations. The result is that the ethanol extract of avocado peel can be formulated into gel preparation. It has a distinctive aroma, is homogeneous, has a pH range of 6,2-6,9, has a value of viscosity, spreadability, and good adhesion, does not irritate, can moisturize the skin, and does not cause syneresis. The gel preparation had antibacterial activity against Staphylococcus aureus, namely a concentration of 10% inhibition of 14.56 mm, 20% inhibition of 19.46 mm, and 30% inhibition of 21.2%, so the interpretation of the inhibition zone was included in the susceptible category.
Pengaruh konsumsi jus wortel terhadap perubahan tekanan darah pada ibu menopause penderita hipertensi di klinik Pratama Hanum Medan Wardani, Fina Kusuma; Wulan, Mayang; Aisyah, Siti
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.329

Abstract

Introduction: Hypertension is one of the most significant causes of mortality in the world, especially in developing countries. Hypertension does not know the age of young or old, but women in menopause are prone to hypertension because estrogen levels decrease. Objective: To ascertain the impact of carrot juice on blood pressure variations in menopausal mothers who suffer from hypertension in the Clinic Pratama Hanum Medan. Method: The study was a quantitative research with Quasy Experimental, One Group Pre-Post Test. The population was 15 Menopause mothers who had hypertension in Hanum Clinic. The sample was 15 people with a mother's menopause. The data analysis is a t-test, then presented as tabulated frequency data. Results of the study, the average blood pressure of postmenopausal women who had hypertension before being given carrot juice was 159.67/92 mmHg. After consuming carrot juice, the mean blood pressure of hypertensive menopausal mothers was measured. 136.67/81.67 mmHg. The results of the Wilcoxon test found that the systolic blood pressure variable obtained a value = 0.001, and diastolic pressure received a p-value = 0.000. The conclusion showed there was an effect of giving carrot juice to change blood pressure in post-menopausal women who experienced hypertension at Hanum Clinic Medan. It is recommended that health workers apply non-pharmacological therapy to reduce hypertension with KIE consumption of carrot juice two times a day with 200 grams of carrots and 250 ml of water.
Faktor resiko kejadian anemia pada remaja putri di SMAN 2 Moro’o Demitri, Athira; Waruwu, Dirman Wati; Nababan, Agnes Sry Vera; Purba, Tuty Hertaty
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.332

Abstract

Anaemia occurs when haemoglobin levels in the blood fall below the typical 12 g/dl. The lack of iron, folic acid, vitamin B12, or protein can cause anaemia. Anaemia is mainly caused by low erythrocyte production and bleeding. This study aims to determine the risk factors of anaemia among female adolescents at SMAN 2 Moro'o. This study employed observational analytics using a case-control design. The population of this study was female adolescents, with a sample size of 64 respondents consisting of a case group of 32 respondents and a control group of 32 respondents, sampled using random procedures with a simple random sampling approach. The data was analysed using univariate analysis and bivariate analysis using the chi-square test and odds ratio. The results showed that there was a risk of knowledge p-value = 0.020 and OR 4.048, iron intake p-value = 0.016 < 0.05 and OR 12.130, menstruation p-value = 0.045 < 0.05 and OR 3.215, and obedience Fe tablets consumption p-value = 0.000 < 0.05 and OR 93.000. This research concludes that knowledge, iron intake, menstruation, and obedience to Fe tablets consumption are the risk factors for anaemia among adolescent females at SMAN 2 Moro'o.
Potensi kemopreventif fraksi n-heksan biji kebiul (Caesalpinia bonduc (L) Roxb.) Bengkulu pada chorioallantoic membrane yang diinduksi bFGF Hayati , Risda; Nadia, Nadia; Karini , Amey Putri; Shavitry, Ayyu; Romdani, Ayu Nadiyah Permatasari; Wulandari, Septi
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.333

Abstract

Cancer is the growth or swelling of a mass of abnormal, uncontrolled and malignant cells. With the formation of these blood vessels, antiangiogenesis is needed because without a blood supply, cancer cells will die. The kebiul seed plant (Caesalpinia bonduc (L) Roxb.) contains secondary metabolites as anticancer. This research uses experimental methods, namely making N-Hexane extracts and fractions, Phytochemical Tests, and Antiangiogenesis Tests. The yield of kebiul seeds was 13.608%. In the phytochemical test, the n-hexane fraction of kebiul seeds gave positive results for alkaloids, flavonoids, triterpenoids and tannins. In the blank paper disc group, paper discs with DMSO solvent and paper discs induced by bFGF the average score was 0 (not active). The N-Hexane fraction with a concentration of 02 mg/ml is the most active and has the greatest and best antiangiogenesis effect with an average score of 1.66 (Good), at a concentration of 0.1 mg/ml with an average score of 1.33 (good) and at a concentration of 0.05 mg/ml with an average score of 0.83 (weak). Macroscopic observations showed that kebiul seed extract inhibited the growth of new blood vessels in the bFGF-induced CAM of chicken embryos depending on the concentration given.

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