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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Pelapisan (Edible Coating) Kitosan Cangkang Bekicot terhadap Mutu Fisikokimia Terung Belanda (Solanum betaceum) Humairah, Dwina Angelina; Ridwanto, Ridwanto; Dalimunthe, Gabena Indrayani; Pulungan, Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.908

Abstract

Background: Chitosan, a natural polysaccharide derived from chitin deacetylation, shows potential as a natural edible coating to extend the shelf life of perishable fruits. Utilizing giant African snail (Achatina fulica) shells as a chitosan source offers a sustainable solution to reduce biological waste while replacing synthetic chemicals in food preservation. Objective: This study aimed to analyze the effectiveness of snail shell chitosan as an edible coating in maintaining the physicochemical quality of tamarillo (Solanum betaceum) during storage. Methods: Chitosan was isolated from snail shells and applied at concentrations of 10%, 20%, and 30%. Antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was tested using the disc diffusion method. Physicochemical parameters including weight loss, moisture loss, color, pH, total acidity, vitamin C content, and total soluble solids (TSS) were measured over 7 days of storage. Results: Chitosan demonstrated strong to very strong antibacterial activity, with the largest inhibition zones at 30% concentration (29 mm for S. aureus; 33.8 mm for P. aeruginosa). The 30% chitosan treatment yielded optimal results: lowest weight loss (3.15%), moisture loss (5.75%), pH (7.72), total acidity (16.44%), and TSS (1.350). Vitamin C retention was significantly higher in the 30% chitosan group (551.47 mg/100g) compared to control (416.53 mg/100g), confirming its effectiveness in inhibiting oxidation. Conclusion: 30% snail shell chitosan proved effective as an edible coating for maintaining tamarillo's physicochemical quality, while providing a natural and sustainable solution for the food industry.
Formulasi dan Uji Mutu Fisik Krim Antiperspirant dari Ekstrak Kunyit Putih (Curcuma zedoaria (Berg.) Roscoe) Syafira, Nona; Dalimunthe , Gabena Indrayani; Lubis, Minda Sari; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.916

Abstract

Background: Curcuma zedoaria (Berg.) Roscoe, commonly known as white turmeric, is a plant from the Zingiberaceae family that contains bioactive compounds such as curcumin, flavonoids, alkaloids, saponins, and tannins. These compounds have potential as natural antiperspirants due to their astringent and antimicrobial properties, which can reduce sweat production and prevent body odor. The use of synthetic antiperspirants containing aluminum chloride often causes skin irritation, highlighting the need for safer, natural alternatives. Objective: This study aims to formulate an antiperspirant cream using white turmeric (Curcuma zedoaria (Berg.) Roscoe) extract with good physical quality and to evaluate the effectiveness of various concentrations in inhibiting sweat production. Methods: This experimental study involved extracting white turmeric using 96% ethanol through maceration, followed by concentration with a rotary evaporator. The antiperspirant cream was formulated with varying extract concentrations. Physical quality evaluations included organoleptic testing, homogeneity, pH, stability, viscosity, adhesion, spreadability, cream type, as well as irritation and antiperspirant tests on volunteers. Results: Phytochemical screening showed that the white turmeric extract contains alkaloids, flavonoids, saponins, and tannins. The cream with a 17.5% extract concentration demonstrated the highest antiperspirant effectiveness compared to 7.5% and 12.5% concentrations. All formulations met physical quality standards, including pH (4.5–6.5), viscosity (2,700–23,020 cP), and 14-day stability without significant changes. Conclusion: The white turmeric-based antiperspirant cream met physical quality standards and exhibited significant antiperspirant effects, particularly at a 17.5% concentration. This study demonstrates the potential of white turmeric as a safe and effective natural active ingredient in antiperspirant formulations.
Formulasi dan Karakterisasi Nanokomposit Polyvinyl alkohol-Na CMC dengan Penambahan Antibiotik Ciprofloxacin sebagai Balutan Luka Wound Dressing Annisa, Nabilah Shafa; Imanto, Teguh
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.918

Abstract

Background: Ineffective wound care and bacterial infections are among the major barriers to optimal wound healing. Conventional wound dressing often fail to maintain proper moisture and lack antimicrobial activity, requiring the development of more advanced alternatives. Objective: This study aimed to develop and evaluate a modern nanocomposite-based wound dressing system combining PVA, Na-CMC, and ciprofloxacin as a local antibacterial agent. Methods: Nanocomposite films were formulated using polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (Na-CMC), and ciprofloxacin. Three formulas were developed with varying concentrations of PVA and Na-CMC. The formulations were evaluated through surface morphology analysis using Scanning Electron Microscopy (SEM), swelling test, biodegradation, mechanical strength, antibacterial activity against Staphylococcus aureus, and ciprofloxacin entrapment efficiency. Results: The formula with the highest Na-CMC content showed the best performance, with the largest pore size (52.74 nm), the highest swelling ratio (432.13%), the widest inhibition zone (3.65 ± 0.05 mm), and the highest entrapment efficiency of ciprofloxacin (91.95%). Conclusion: The developed nanocomposite film exhibits favorable physical and biological characteristics, supporting its potential use as a modern wound dressing to accelerate healing and prevent bacterial infections.
Isolasi Gelatin dari Tulang Ikan Gulamah (Johnius trachycephalus) dan Aplikasinya Pada Permen Jelly Sindi, Sindi; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.936

Abstract

Background: Gelatin, as a product of partial collagen hydrolysis, is typically derived from pig bones or skin, creating halal compliance issues for Indonesia's Muslim population. Objective: This study aimed to isolate halal gelatin from gulamah fish bones (Johnius trachycephalus) and apply it as a gelling agent in jelly candy production. Methods: The gelatin isolation process involved: (1) degreasing through immersion in boiling water, (2) demineralization using 5% acetic acid for 48 hours, (3) extraction at 60-75°C for 12 hours, and (4) oven drying at 50°C. Gelatin was characterized using FTIR and tested for quality parameters (yield, moisture content, ash content, pH) according to SNI standards. Jelly candies were formulated with two gelatin concentrations (F1=5g; F2=10g) and evaluated for physical properties and hedonic quality. Results: The study achieved a gelatin yield of 7.32% with SNI 06-3735 compliant characteristics: 10.2% moisture content, 1.24% ash content, pH 6.28, and FTIR identification of characteristic functional groups (-OH, C=O, N-H, C-H, and C-N). Formula F2 (10g gelatin) received the highest preference scores for texture (2.93), aroma (2.93), and taste (4.63). Conclusion: Gulamah fish bones show potential as a halal gelatin source meeting quality standards, with optimal application at a 10g concentration in jelly candy formulations
Uji Efektivitas Flavonoid Total Ekstrak Etanol Kulit Batang Nangka (Artocarpus heterophyllus Lam) Terhadap Penyembuhan Luka Sayat Pada Ayam Broiler (Gallus domesticus) Kemalasari , Nurisma; Sumardi, Sumardi; Febriani , Yessi
Journal of Pharmaceutical and Sciences JPS Volume 1 Nomor 1 (2018)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v1i1.1

Abstract

Jackfruit (Artocarpus heterophyllus Lam) is a local plant found in various regions in Indonesia. This jackfruit tree is usually used as traditional medicine. This study aims to examine the ethanol extract of jackfruit bark against wound healing on broiler skin and determination of total flavonoid content using the calorimetry method. This study began with identification of plants, taking jackfruit bark, processing of jackfruit bark simplicia, making ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam), measuring the total flavonoid content of ethanol extract of jackfruit bark, preparation of test animals, wound cutting on chicken skin, effectiveness test of total flavonoid ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam) on wound healing in broiler chickens (Gallus domesticus), data analysis. The results showed that the administration of ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam) to wound healing on the skin of broiler chickens (Gallus domesticus) had a better healing effect than negative controls. The results of applying 4 times in 24 hours provide the fastest healing effect on cuts on the skin of broiler chickens (Gallus domesticus). Based on statistical results there are 86.1% of flavonoids that affect the area of the curve and affect the healing of the area of incisions in chickens.
Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan pada Varian Seduhan Teh dan Varian Teh Kombucha Secara Spektrofotometri Visible Maghfirah , Dini; Pulungan , Ainil Fithri; Ridwanto, Ridwanto; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.952

Abstract

One of the most widely consumed aromatic beverages in the world is tea. Tea shoots are rich in polyphenolic compounds that function as antioxidants. Not many people know that tea can be fermented with a type of bacteria and yeast culture that can be consumed as a drink for health known as kombucha tea. The health benefits of consuming kombucha tea as anti-carcinogenic, anti-diabetic, detoxification, increased immune response, treating stomach ulcers and lowering cholesterol levels as well as high blood pressure. The purpose of this study was to determine the total phenolic content and antioxidant activity as well as the comparison of total phenolic content and antioxidant activity in tea brewing variations with kombucha tea variations. The methods carried out include testing the total phenolic content and antioxidant activity using the DPPH method on tea brewing variants and kombucha tea variants by visible spectrophotometry.mThe results of total phenolic content in black tea, green tea, and oolong tea were 24,480 mgGAE/g, 26,538 mgGAE/g, and 38,427 mgGAE/g, respectively, while kombucha black tea, green tea, and oolong tea were 39,264 mgGAE/g, 58,581 mgGAE/g, and 64,299 mgGAE/g, respectively. Brewed black tea, green tea, and oolong tea have antioxidant activity with IC50 values of 105,68 ppm in teh moderate category, 81,59 ppm in teh strong category, and 56,25 ppm in the strong category, respectively. In kombucha black tea, green tea, and oolong tea have antioxidant activity with IC50 values respectively 101,60 ppm with moderate category, 55,82 ppm with strong category, and 39,69 ppm with very strong category. While teh vitamin C comparator has antioxidant activity with an IC50 value of 3,22 ppm with a very strong category.
Pengaruh Ekstrak Etanol Daging Buah Pala (Myristica Fragrans Houtt) Pada Histopatologi Jantung Tikus Wistar Hiperglikemik Nur, Amran; Fiskia, Ermalyanti; Hi Yusuf, Muhammad Fakhrur Rajih; A. Disi, Muhammad Zulfian; Mursin, Nita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.517

Abstract

The heart is an organ significantly impacted by diabetes mellitus problems, as elevated free radical generation and oxidative stress from hyperglycemia activate the apoptosis and necrosis pathways in cardiac myocytes. This study aimed to ascertain the histological characteristics of the cardiac tissue in rats subjected to hyperglycemia following the administration of ethanol extract from nutmeg fruit flesh (Myristica fragrans Houtt). This study employed rice as a diabetes inducer in 25 rats, categorized into 5 treatment groups: group 1 received Na-CMC, group 2 received metformin, group 3 received a dosage of 100 mg/KgBW, group 4 received a dosage of 200 mg/KgBW, and group 5 received a dosage of 300 mg/KgBW. The detected data included alterations in body weight, blood glucose levels, organ mass, and cardiac histology. The data were evaluated employing the One-Way ANOVA test at a 95% confidence level (p<0.05). The findings indicated that all groups treated with nutmeg fruit flesh ethanol extract exhibited a substantial enhancement in the histopathology of rat hearts compared to the negative control group 0,03 (p<0.05). The administration of nutmeg fruit flesh extract can ameliorate histopathological damage to the hearts of hyperglycemic rats at doses of 100 mg/KgBW, 200 mg/KgBW, and 300 mg/KgBW, indicating that nutmeg fruit flesh may serve as a cardioprotective drug in diabetic subjects.
Analisis Logam Berat pada Jamu Pegal Linu yang Beredar di Kota Banda Aceh Farida, Mutia; Safrina, Nurul; Kurniaty, Rina; Azhari, Saiful; Mahmudi, Mahmudi; Yusuf , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.606

Abstract

Background: Jamu pegal linu (traditional Indonesian herbal medicine for muscle and joint pain) is widely consumed to relieve muscle and bone discomfort. However, there are concerns about heavy metal contamination, particularly lead (Pb) and mercury (Hg), in some products circulating in Banda Aceh City. Such contamination poses serious health risks, including organ damage and poisoning, necessitating thorough analysis to ensure product safety. Objective: This study aimed to detect and measure Pb and Hg levels in jamu pegal linu samples sold on Diponegoro Street, Banda Aceh, and compare them with the safety limits set by the Indonesian Food and Drug Authority (BPOM RI). Methods: A total of 23 samples were qualitatively analyzed using KI, NaOH, and HCl reagents (for Pb) and HNO₃ and KI (for Hg). Positive samples were further analyzed quantitatively using Atomic Absorption Spectrophotometry (AAS). Method validation included linearity, precision, accuracy, LoD, and LoQ assessments. Results: Qualitative testing revealed Pb and Hg contamination in 12 samples. Pb levels ranged from 1.45–9.17 mg/kg (below BPOM’s threshold of ≤10 mg/kg), while Hg levels ranged from 0.14–1.37 mg/kg, with six samples exceeding the safe limit (≤0.5 mg/kg). The highest Hg concentration (1.37 mg/kg) was found in an unregistered product. Conclusion: Most jamu pegal linu products in Banda Aceh contain heavy metals, particularly Hg, at unsafe levels. Strict regulatory oversight, especially for unregistered products, is crucial to safeguard public health.
Efektivitas Media Video dan Leaflet dalam Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) dan Beyond Use Date: Studi Kuasi-Eksperimen Hasanah , Fenny; Lubis, Salmah Handayani; Dasopang , Eva Sartika; Aisyah, Teti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.644

Abstract

Background: The increasing practice of self-medication and home drug storage carries the potential for medication management errors, including improper drug disposal. Lack of public understanding of DAGUSIBU (Acquire, Use, Store, Dispose) protocols and Beyond Use Date (BUD) may lead to drug misuse and environmental contamination due to improper disposal methods that violate the Drug Awareness Family Movement (Gerakan Keluarga Sadar Obat/GKSO) guidelines. Objective: To examine the impact of educational interventions on public knowledge of DAGUSIBU and BUD, and to compare the effectiveness of video versus leaflet media. Methods: A quasi-experimental study with pretest-posttest design was conducted. Purposive sampling was used to select 100 respondents from Kotamatsum I Subdistrict. Data were analyzed using Wilcoxon test (educational impact), Chi-Square test (demographic correlations), and Mann-Whitney test (media comparison). Results: The educational intervention significantly improved participants' knowledge of DAGUSIBU and BUD (p < 0.001). Gender significantly influenced knowledge improvement (p = 0.005), while age, education level, and occupation showed no significant effects. Video proved more effective for DAGUSIBU content (mean score 53.94 vs 47.06), whereas leaflets showed marginally better results for BUD material (50.56 vs 50.44).Conclusion: Both video and leaflet-based education effectively enhanced community knowledge. Videos are recommended for DAGUSIBU campaigns, while leaflets serve as suitable supplementary materials for BUD education.  
Uji Efektivitas Sediaan Facial Wash Acne Gel Ekstrak Etanol Daun Nangka (Artocarpus heterophyllus Lamk.) Terhadap Bakteri Staphylococcus aureus Athaillah, Athaillah; Pritiwanti, Venni; Chandra, Putra; Affan Silalahi, Ali
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.787

Abstract

Background: Jackfruit leaves (Artocarpus heterophyllus Lamk.) contain antimicrobial compounds such as flavonoids, tannins, and saponins, which can damage bacterial cytoplasmic membranes and denature cellular proteins. This potential supports the development of a facial wash gel using jackfruit leaf extract as a natural antibacterial alternative. Objective: This study aimed to evaluate the effectiveness of a facial wash gel containing jackfruit leaf extract (Artocarpus heterophyllus Lamk.) in inhibiting the growth of Staphylococcus aureus ATCC® 25923. Methods: This experimental study included sample preparation, identification, extraction, phytochemical screening, and gel formulation evaluation (organoleptic test, homogeneity, spreadability, foam height, pH, irritation, and cycling test). Antibacterial activity was tested against S. aureus, with a positive control (Himalaya (Brand) Facial Wash) and a negative control (DMSO). Results: The extract yield was 11.26%, positively detecting flavonoids, saponins, tannins, steroids, and triterpenoids. The gel formulations (F1-F3) were semi-solid, dark green, and had a characteristic jackfruit leaf aroma, with a pH of 5–6. Homogeneity tests confirmed uniform consistency, with the highest foam height in F3 (3.7 cm) and optimal spreadability in F1-F2 (6 cm). No irritation was observed, and the gel remained stable in cycling tests. The antibacterial test showed the highest inhibition at 12% extract concentration (92.3%), while the formulated gel also effectively inhibited S. aureus growth. Conclusion: Jackfruit leaves can be successfully formulated into a stable and safe facial wash gel with effective antibacterial activity against Staphylococcus aureus.

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