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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 698 Documents
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Aktivitas Kombinasi Ekstrak Etanol Daun Kersen (Muntingia calabura L.) dan Kloramfenikol Terhadap Salmonella typhi Maharani, Shafira Arifah; Munawaroh, Rima
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1299

Abstract

Background: Typhoid fever, caused by Salmonella typhi, remains a significant health burden. Chloramphenicol is a first-line antibiotic for its treatment; however, increasing bacterial resistance necessitates alternative therapeutic strategies. Combining antibiotics with natural compounds is a potential approach to overcome resistance and reduce antibiotic doses. Kersen leaves (Muntingia calabura L.) have been reported to contain bioactive compounds with antibacterial properties. Objective: This study aimed to evaluate the in vitro interaction between ethanolic extract of kersen leaves and chloramphenicol against Salmonella typhi using the checkerboard assay method. Methods: The ethanolic extract was obtained through maceration. Phytochemical constituents were analyzed qualitatively using tube tests and Thin-Layer Chromatography (TLC) with silica gel GF254 as the stationary phase and a chloroform:methanol (8:2 v/v) mobile phase. The antibacterial activity, expressed as Minimum Inhibitory Concentration (MIC), was determined for both the single extract and chloramphenicol using the microdilution method with resazurin indicator. The interaction between the two agents was assessed using the checkerboard assay, and the Fractional Inhibitory Concentration Index (FICI) was calculated. Results: Phytochemical screening revealed that the ethanolic extract of kersen leaves contained alkaloids, steroids, flavonoids, tannins, and saponins. The MIC value of chloramphenicol alone was 19.5 µg/mL, while the extract alone showed an MIC of >1000 µg/mL against S. typhi. The checkerboard assay results indicated an increase in the MIC of chloramphenicol in combination with the extract; however, the FICI value could not be definitively determined due to the inability to establish the extract's MIC in the combination. Conclusion: The ethanolic extract of kersen leaves contains various secondary metabolite groups. While chloramphenicol exhibited antibacterial activity, the extract alone did not show inhibitory activity at the tested concentrations. The combination test suggested a potential alteration in the effectiveness of chloramphenicol, but the interaction type (synergistic, additive, indifferent, or antagonistic) could not be conclusively classified. Further investigation using fractionated or isolated compounds from the leaves is recommended.
Suplementasi Butirat dan Modulasi Epigenetik melalui Inhibisi Histon Deacetylase pada Diabetes Melitus Tipe 2: Suatu Tinjauan Naratif dengan Perspektif untuk Indonesia Ainaputri , Aliza Salsabila; Kasasiah, Ahsanal; Malau , Jekmal; Aprillia , Cantika; Siboro , Dewi Pratiwi Purba; Apriyanti , Endeh; Nugraha , Afif Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1301

Abstract

Type 2 diabetes mellitus is a multifactorial metabolic disorder characterized by insulin resistance, chronic inflammation, and epigenetic dysregulation. Emerging evidence indicates that butirat supplementation may improve metabolic homeostasis through histon deacetylase inhibition and modulation of gene expression involved in insulin signaling and inflammatory pathways. This review aims to evaluate preclinical and clinical evidence on the role of butirat as an epigenetic modulator in type 2 diabetes mellitus and to discuss its translational relevance, including perspectives for Indonesia. A structured literature search was conducted to identify original research articles published between 2015 and 2025. The selected studies demonstrate that butirat enhances insulin sensitivity, improves glycemic control, and attenuates inflammatory responses through increased histon acetylation. However, direct clinical evidence remains limited. In Indonesia, available data are largely derived from dietary or probiotic interventions that increase endogenous butirat production. Therefore, well designed controlled clinical trials are required to evaluate the therapeutic potential of direct butirat supplementation in populations with type 2 diabetes mellitus.
Studi Perbandingan Antara Maserasi dan Accelerated Solvent Extraction (ASE) terhadap Hasil Ekstrak Daun Kalangkala (Litsea angulata) Akbar, Nabila Hadiah; Buih , Putri Helena Junjung; Muslimawati , Khoirunnisa; Putra , Aditya Maulana Perdana; Amalia , Adhindha; Putri , Dhea Juliana
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1305

Abstract

Kalangkala (Litsea angulata) is an endemic plant of Kalimantan that has long been used in local traditional medicine to manage various health conditions. Phytochemical reports indicate that Kalangkala contains diverse secondary metabolites, including phenolics, flavonoids, alkaloids, tannins, saponins, terpenoids, steroids, and carotenoids. Therefore, selecting an appropriate extraction method is essential to maximize metabolite recovery while minimizing degradation. This experimental study compared the extraction yield of Kalangkala leaf extract obtained using maceration and ASE (Accelerated Solvent Extraction) methods. Each method was performed in three replicates and the percentage yield was calculated. Maceration produced yields of 2.10-2.18%, whereas ASE produced higher yields of 13.25-14.01%. the mean yield of maceration was 2.14 ± 0.04% (95% Cl: 2.04-2.24), while ASE achieved 13.64 ± 0.38% (95%Cl: 12.69-14.58). A two-tailed Welch’s t-test confirmed a statistically significant difference between methods (p = 0.00032), with a mean difference of 11.49% (95% Cl: 10.56-12.42). In conclusion, ASE provided a higher extraction yield than maceration under the conditions evaluated in this study.
Kemajuan Bioteknologi dalam Diagnosis Tuberkulosis: Perkembangan Global dan Penerapannya di Indonesia Aprillia, Cantika; Zahra , Aliya Azkia; Malau , Jekmal; Ainaputri , Aliza Salsabila; Siboro , Dewi Pratiwi Purba; Apriyanti , Endeh; Nugraha , Afif Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1309

Abstract

Tuberculosis (TB) remains a major global health burden, and Indonesia is among the countries with the highest incidence and mortality rates. Early and accurate diagnosis is essential for effective TB control; however, conventional diagnostic methods such as sputum smear microscopy, culture, chest radiography, and the tuberculin skin test continue to face limitations in sensitivity, specificity, turnaround time, and operational feasibility. This narrative review synthesizes global biotechnological developments in TB diagnostics and evaluates their potential applicability within the Indonesian healthcare system. A structured literature search was conducted using PubMed, ScienceDirect, and Google Scholar, applying Population, Intervention, Comparison, and Outcome (PICO) based inclusion and exclusion criteria. Key advances in molecular diagnostics include conventional polymerase chain reaction (PCR), real-time PCR, automated nucleic acid amplification test (NAAT) platforms such as GeneXpert, Xpert Ultra, and Truenat, as well as loop-mediated isothermal amplification (LAMP). Emerging innovations including CRISPR-based assays, biosensor platforms, microfluidic lab-on-chip devices, and nanotechnology-enhanced systems demonstrate improved sensitivity, portability, and testing speed, with potential for point-of-care implementation, although many require further field-based validation. No single diagnostic tool is universally optimal, as suitability depends on infrastructure availability, workforce capacity, and population needs. In Indonesia, persistent challenges include limited laboratory networks, high diagnostic costs, supply-chain constraints, and variability in human resource competence. Strengthening diagnostic systems, expanding decentralized testing, integrating digital health technologies, and supporting local production of diagnostic materials are critical to enable sustainable adoption and accelerate progress toward national TB elimination targets.
Kelengkapan Terapi Medis Sesuai Pedoman dan Dampaknya terhadap Luaran Terapi pada Pasien Angina Pektoris Tidak Stabil: Penelitian di Rumah Sakit Rujukan Tersier di Indonesia Saufi, Muhammad Rifki; Cholisoh, Zakky
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1357

Abstract

Unstable angina pectoris (UAP) is a major cause of cardiovascular hospitalization and requires complex inpatient pharmacological management. Variability in the completeness of core guideline-recommended acute pharmacotherapy may influence inpatient therapeutic outcomes, including length of hospital stay (LOS). This study aimed to evaluate the completeness of core guideline-recommended pharmacotherapy and its association with LOS among hospitalized patients with unstable angina pectoris at a tertiary referral hospital in Indonesia. A descriptive observational study with a retrospective design was conducted using secondary data from medical records. Of 214 hospitalized patients screened, 144 adult patients diagnosed with unstable angina pectoris met the inclusion criteria. Data collected included demographic characteristics, smoking status, comorbidities, LOS, and pharmacological therapy administered during hospitalization. Pharmacotherapy completeness was operationally defined based on the documented use of three core disease-modifying drug classes recommended for the acute management of unstable angina pectoris: antiplatelet therapy (single or dual), statin therapy, and beta-blocker therapy based on core acute-phase recommendations in the ESC 2023 and AHA/ACC 2023 guidelines, at any time during the inpatient stay. Descriptive statistics were used to summarize patient characteristics and medication use, while bivariate analysis was performed to assess the association between pharmacotherapy completeness and LOS. Most patients were male (62.5%) and aged 40–59 years (47.9%) or ≥60 years (43.1%), with a median LOS of 4 days (interquartile range 3–5). The most frequently prescribed drug classes were statins (92.4%), beta-blockers (91.7%), aspirin (88.2%), and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (86.1%). Dual antiplatelet therapy was administered in 66.7% of patients, and anticoagulants in 28.5%. Bivariate analysis showed no statistically significant association between pharmacotherapy completeness and length of hospital stay (p = 0.642). In conclusion, hospitalized patients with unstable angina pectoris generally received pharmacological therapy aligned with core guideline-recommended acute-phase management. However, the absence of a significant association between pharmacotherapy completeness and LOS suggests that LOS is a multifactorial outcome influenced by clinical and organizational factors beyond pharmacological management. These findings highlight the importance of comprehensive inpatient care and structured medication review, including the role of clinical pharmacists, in optimizing treatment for patients with UAP.
Optimasi Formula Sediaan Lip Cream Sari Buah Stroberi Kering (Fragaria x ananassa) dan Minyak Jarak dengan Metode Simplex Lattice Design Risyafa, Jihan; Suprapto, Suprapto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1363

Abstract

Strawberries (Fragaria x ananassa) contain striking red anthocyanin pigments that can serve as natural colorants for lip cream preparations and also as antioxidants. The emollient properties of castor oil can rehydrate dry skin, allowing it to function as a moisturizer for the skin and lips. This study aims to obtain the optimal formula for lip cream combining strawberry fruit strawberry juice powder as a natural colouring agent and castor oil as a moisturizer. Both ingredients were optimized using Design Expert V13 Simplex Lattice Design method, resulting in 5 formulas in 8 runs. The lip cream preparations were evaluated based on organoleptic, homogeneity, pH, viscosity, adhesion, spreadability, irritation, hedonic, and antioxidant tests to obtain the optimal formula. Verification of the optimal formula was carried out to ensure the validity of the results. The results of the study obtained an optimal formula with a composition of 33.15 g of strawberry juice powder and 13.85 g of castor oil with a desirability value of 0.524. The optimal formula produced a pH response of 5.6; viscosity of 17686.7 cP; adhesion of 4.06 seconds; spreadability of 6.57 cm; hedonic properties in terms of colour, aroma, and spreadability of 4.7, 4.7, and 4.8, respectively; and antioxidant activity with an IC₅₀ value of 21.31 ppm. The results of the verification formula on the parameters of pH, viscosity, adhesive power and spread power did not show significant differences.  
Deteksi Bahan Kimia Obat (BKO) Pada Jamu Sesak Napas Yang Beredar Di e-Marketplace Melalui Kombinasi Metode KLT dan FTIR. Girvin, Aulia Garnida; Hanwar , Dedi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1372

Abstract

The circulation of herbal medicines through e-marketplaces raises serious safety concerns due to the illegal addition of chemical drug substances to provide rapid therapeutic effects. This study aimed to detect chemical drug substances, specifically theophylline and chlorpheniramine maleate, in herbal medicines marketed for shortness of breath using a combination of thin-layer chromatography (TLC) and Fourier transform infrared spectroscopy. Qualitative analysis was conducted through optimization and validation of TLC using two mobile phase systems, followed by two-dimensional chromatography to enhance separation selectivity. The optimized systems demonstrated adequate separation with acceptable resolution values. The results showed that all herbal medicine samples had retention factor (Rf) values comparable to the standard. FTIR confirmation showed typical absorption bands of chlorpheniramine maleate (CTM) and theophylline, so that all samples (5 of 5) were declared positive for containing chemical drugs, with CTM identified in samples 1 and 4 and theophylline in samples 2, 3, and 5. These findings indicate that some herbal medicines circulating in e-marketplaces contain chemical drugs, which are not in accordance with the provisions of traditional medicine regulations.
Peramalan Kebutuhan Obat Kronis Berdasarkan Data Klaim BPJS Kesehatan Menggunakan Model ARIMA di Kabupaten Gunungkidul, Daerah Istimewa Yogyakarta, Indonesia. Syarifuddin, Annisaul Karimah; Diana, Ina Kusuma; Verdiana, Antokalina Sari; Kristina, Susi Ari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1379

Abstract

Chronic diseases require continuous pharmacotherapy and generate sustained demand for essential medicines, particularly within universal health coverage systems. In Indonesia, pharmaceutical utilization under the National Health Insurance program is documented through administrative claims data, which provide an important basis for demand analysis and planning. This study aims to forecast chronic drug demand in Gunungkidul Regency, Special Region of Yogyakarta, using health insurance claims data and a time-series forecasting approach. A retrospective analysis was conducted using weekly aggregated claims data. Drug utilization patterns were examined, and demand forecasting was performed using the Autoregressive Integrated Moving Average model following standard time-series procedures. Forecast accuracy was assessed by comparing predicted values with observed utilization. The results indicate that the model effectively captures weekly demand patterns and short-term fluctuations, producing forecasts that closely align with actual utilization trends. These findings demonstrate that time-series forecasting based on claims data can provide reliable estimates of chronic drug demand. The study highlights the potential value of integrating forecasting models into pharmaceutical inventory planning to support timely drug availability and improve logistics efficiency within regional health insurance implementation.
Potensi Antimikroba Ekstrak Infus Daun Pedada (Sonneratia caseolaris L) Mandeh, Sumatera Barat Jannah, Mifthahul; Nurlaili , Nurlaili; Harsachatri , Deasy Ovi; Novia, Novia; Larasati , Julia Veronika; Arfan , Alya Rahmaditya; Pangestika , Yuliandini; Habibi , Alif Rahman; Agustien , Anthoni
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1385

Abstract

The increasing emergence of antibiotic-resistant bacteria poses a serious global health threat, highlighting the need for alternative antimicrobial sources derived from natural products. Pedada mangrove (Sonneratia caseolaris L.), widely distributed in the coastal area of Mandeh, West Sumatra, has been traditionally used as a medicinal plant. This study aimed to evaluate the antimicrobial potential of leaf infusion extracts of Sonneratia caseolaris and to determine the effect of heating time variation on antimicrobial activity. Leaf infusion extracts were prepared using boiling water with heating durations of 10, 15, and 30 minutes. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, and Candida albicans using the disc diffusion method. The results showed that all infusion extracts exhibited antimicrobial activity with varying inhibition levels. The optimal heating time was 10 minutes, resulting in inhibition zone diameters of 10.5 mm against E. coli, 10 mm against S. aureus, and 10 mm against C. albicans. These findings indicate that Sonneratia caseolaris leaf infusion extract has potential as a natural antimicrobial agent, with shorter heating time being more effective in preserving antimicrobial activity.
Menelusuri Perkembangan, Kondisi Terkini, dan Prospek Masa Depan Pengujian DNA dalam Aplikasi Forensik Manusia dan Non-Manusia: Tinjauan Naratif Siboro, Dewi Pratiwi Purba; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Malau, Jekmal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Nugraha, Afif Tri; Aprianti, Endeh
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1389

Abstract

DNA typing has become a cornerstone of modern forensic science, profoundly influencing criminal investigations, forensic human identification, and non-human forensic applications. Since its introduction in the mid-1980s, forensic DNA analysis has evolved from restriction fragment length polymorphism-based methods to polymerase chain reaction-based short tandem repeat profiling, and more recently to sequence-based approaches enabled by massively parallel sequencing, resulting in substantial improvements in analytical sensitivity, robustness, and discriminatory power. This narrative review aims to trace the historical development, examine the current state, and explore future directions of DNA typing in both human and non-human forensic contexts, with particular emphasis on empirical case studies from Asia. A narrative review methodology was employed through a comprehensive analysis of peer-reviewed literature published between 2015 and 2026, sourced from major scientific databases including Google Scholar, PubMed, and ScienceDirect, with studies selected based on forensic relevance, methodological rigor, and regional significance. The review highlights the extensive application of DNA typing in routine criminal casework, disaster victim identification, missing persons investigations, wildlife forensic genetics, food fraud detection, and biosecurity, and documents emerging technologies such as portable DNA systems and CRISPR-based detection. Despite these advances, significant challenges remain related to data interpretation, validation requirements, contamination control, ethical and legal governance, and uneven forensic capacity across regions. Overall, this review underscores the continuing evolution of forensic DNA typing and emphasizes the importance of standardized protocols, interdisciplinary collaboration, and region-specific validation to ensure the reliable and responsible application of DNA evidence in modern forensic science.

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