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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 698 Documents
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Hubungan Kualitas Pelayanan Kefarmasian Terhadap Kepuasan Pasien Rawat Jalan RS Bhayangkara TK. III Banjarmasin Lisdawati , Maulina; Su’aida , Nily; Fadillah , Aris
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1286

Abstract

Background: The quality of pharmaceutical services is a crucial factor in the success of treatment and patient satisfaction. Objective: This study aims to analyze the relationship between the quality of pharmaceutical services and the satisfaction of outpatients at RS Bhayangkara TK. III Banjarmasin. Methods: This study employs a descriptive quantitative method with a survey approach, where data is collected through questionnaires distributed to patients receiving services at the hospital’s pharmacy department. Results: The results indicate a significant relationship between the quality of pharmaceutical services and patient satisfaction (p–value = 0,000 ≤ 0,05) analyzed through five dimensions of service quality: tangibility, reliability, responsiveness, assurance, and empathy. The Chi-Square test analysis showed that all these dimensions positively contribute to patient satisfaction. Additionally, this study evaluated the waiting time for both compounded and non-compounded medications, revealing that the hospital’s pharmacy services comply with the time standards set by the Ministry of Health. Conclusions: This study confirms the significant relationship between the quality of pharmaceutical services and outpatient satisfaction at Bhayangkara level III Hospital. Higher service quality, greater outpatient satisfaction, highlighting the need for continuous improvement in pharmaceutical services.
Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior (Jack)) Terhadap Gambaran Histopatologi Lambung Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diindukasi Streptozotocin Palipadang, Matra Novalia; Alaydrus , Syafika; Tandi , Joni; Islamiati , Utami; Toding, Ficanata Adhiguna; Managanta , Vianda
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1293

Abstract

Background: Hyperglycemia induced by streptozotocin (STZ) increases oxidative stress and inflammatory responses that may lead to gastric mucosal damage. Kecombrang flower (Etlingera elatior (Jack)) contains flavonoids and other secondary metabolites with antioxidant, anti-inflammatory, and antihyperglycemic properties that are potentially gastroprotective. Objective: This study aimed to evaluate the effect of ethanol extract of kecombrang flower on the histopathological profile of the stomach in male white rats (Rattus norvegicus) induced by streptozotocin and to determine the most effective dose. Methods: This experimental in vivo study employed a posttest-only control group design. Twenty-five male rats were divided into five groups (n=5): normal control, negative control (STZ-induced), positive control (STZ + glibenclamide), extract 50 mg/kg body weight (BW), and extract 100 mg/kg BW. Streptozotocin was administered intraperitoneally at 40 mg/kg BW. Gastric tissues were examined histopathologically using hematoxylin-eosin staining and assessed based on degeneration, necrosis, and inflammation scoring. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney test with Bonferroni correction (p<0.05). Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins in the extract. Statistical analysis showed significant differences among groups in degeneration (p=0.013) and inflammation (p=0.047), but not in necrosis (p=1.000). The 100 mg/kg BW dose demonstrated the most prominent protective effect, with lower degeneration and inflammation scores and an average gastric damage score of 1, comparable to the positive control group. Conclusion: Ethanol extract of kecombrang flower at a dose of 100 mg/kg BW effectively reduced gastric histopathological damage in streptozotocin-induced male rats, indicating its potential gastroprotective activity through antioxidant and anti-inflammatory mechanisms.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Formulasi Dan Uji Aktivitas Gel Fraksi Aktif Biji Kopi Robusta (Coffea Canephora L.) terhadap Stapylococcus aureus sebagai Terapi Ulkus Diabetik Tarigan, Putri Diana Br; Sembiring , Novitaria Br; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1334

Abstract

Introduction: Diabetes mellitus is one of the health problems that deserves attention worldwide. Diabetes mellitus causes complications in various organs of the body. One of the complications of diabetes mellitus for sufferers is the appearance of diabetic wounds or gangrene and ulcers that cause susceptibility to bacterial infections. One of the bacteria that causes diabetic wounds is Staphylococcus aureus, which can be found on the skin surface as normal flora. Objective: This study aims to formulate the active fraction of robusta coffee beans (Coffea Canephora L.) into a gel preparation and evaluate its antibacterial activity against Staphylococcus aureus. Methods: This experimental study involved the extraction of robusta coffee beans with 96% ethanol maceration, phytochemical screening, and fractionation using n-hexane, ethyl acetate, and water solvents. Furthermore, the fraction results were tested using the disk diffusion method to determine the active fraction in robusta coffee beans to be formulated into gel preparations with concentrations of 12.5%, 25%, and 50% and physical stability tests were conducted. Based on the results of the study, the water fraction and gel preparation of robusta coffee beans showed inhibition of antibacterial activity against Staphylococcus aureus, with the greatest inhibition at a concentration of 50%. Therefore, the active fraction gel of robusta coffee beans has the potential as a treatment for diabetic wounds. Organoleptic testing of the gel showed a distinctive honey smell, brown color, and a slightly acidic pH of formula 1.
Uji Total Flavonoid Dan Aktivitas Antioksidan Fraksi Aktif Biji Kopi Robusta (Coffea canephora L. ) Sebagai Diabetik Ulcer Perangin-Angin, Elpina Br; Sembiring , Novitaria Br; Kaban , Vera Estefania
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1342

Abstract

Diabetes mellitus is a chronic metabolic disease frequently accompanied by serious complications, including diabetic foot ulcers, which require comprehensive management and supportive therapies derived from natural sources. Robusta coffee beans (Coffea canephora L.) contain various bioactive compounds with potential antioxidant properties that may support wound healing. This study aimed to determine the total flavonoid content and evaluate the antioxidant activity of active fractions of robusta coffee beans. An experimental laboratory design was applied, involving maceration using 96% ethanol followed by solvent fractionation with n-hexane, ethyl acetate, and water. Total flavonoid content was determined using ultraviolet–visible spectrophotometry with quercetin as the reference standard, while antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl assay with vitamin C as a comparator. The results showed an extraction yield of 14.33%, and phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolic or tannin compounds, saponins, and triterpenoids. All fractions exhibited very strong antioxidant activity, with the ethyl acetate fraction demonstrating the highest activity, comparable to vitamin C, whereas the highest total flavonoid content was observed in the n-hexane fraction. In conclusion, robusta coffee beans possess strong potential as a natural antioxidant source and may be developed as a supportive alternative therapy for diabetic wound management.
Genetika dan Farmakogenomika untuk Kinerja Atletik: Tren Terkini dan Arah Masa Depan di ASEAN Nugraha, Afif Tri; Malau , Jekmal; Kasasiah , Ahsanal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Siboro , Dewi Pratiwi Purba
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1375

Abstract

The integration of sport genomics and pharmacogenomics has become a central pillar of precision sports medicine, enabling individualized training, nutrition, and medication/supplement strategies for athletes. This structured narrative review synthesizes literature published between 2015 and 2025 from PubMed, ScienceDirect, and Google Scholar, with particular emphasis on implementation relevance in ASEAN, especially Indonesia. Findings are organized into three major themes: (1) genetic contributions to strength and endurance phenotypes, body composition, recovery, and injury susceptibility; (2) pharmacogenomic implications for drug selection, dose optimization, therapeutic safety, and potential exercise with drug interactions (e.g., NSAIDs, inhaled bronchodilators, caffeine, and creatine); and (3) ethical, privacy, equity, and gene-doping considerations. Athletic performance is inherently polygenic; variants in genes such as ACTN3, ACE, PPARGC1A, PPARA, and VEGF-A contribute to the power–endurance spectrum and vascular–metabolic adaptation, while pharmacogenes including CYP2C9, CYP1A2, ADORA2A, and ADRB2 may modulate therapeutic efficacy and adverse-effect risk. Moreover, physical activity itself may influence drug metabolism and pharmacodynamic responses, underscoring the limitations of one-size-fits-all protocols. Overall, genetic information should be positioned as a complementary decision-support layer rather than a deterministic predictor in sports medicine practice. Strengthening implementation in ASEAN requires larger, well-characterized athlete cohorts, standardized marker panels, longitudinal data integration, and robust ethical–regulatory frameworks to ensure safe and evidence-based genomic application.
Efektivitas Antijamur Kombinasi Ekstrak Bajakah (Uncaria acida) dan Bandotan (Ageratum conyzoides) pada Mencit dengan Onikomikosis yang Terinfeksi Trichophyton rubrum Najhah, Nor Rezqiyatun; Rohmadi, Mukhlis; Indahsari, Lilin Ika Nur
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1392

Abstract

Onychomycosis is a fungal infection of the nail predominantly caused by Trichophyton rubrum and requires safer alternative therapies compared to synthetic antifungal agents. The combination of plant extracts may produce synergistic effects through interactions among bioactive compounds with complementary antifungal mechanisms. This study aimed to evaluate the effectiveness of a combined extract of Bajakah root (Uncaria acida) and Bandotan leaf (Ageratum conyzoides) as a topical therapy in T. rubrum–induced Balb/c mice. The selection of this combination was based on the presence of flavonoids, tannins, alkaloids, terpenoids, and saponins in both plants, which are theoretically associated with antifungal activity. Extracts were obtained by 96% ethanol maceration and formulated into ointments at concentrations of 25%, 50%, 75%, and 100%. Clinical parameters observed included periungual swelling, lesion diameter, nail discoloration, and nail brittleness. Phytochemical analysis confirmed the presence of major bioactive secondary metabolites in both extracts. The results demonstrated clinical improvement in all treatment groups, with the most pronounced effects observed at concentrations of 75–100%. Kruskal–Wallis analysis revealed significant differences among treatments (p < 0.05) for all parameters, which were further confirmed by Dunn’s post hoc test. Overall, the combined extracts of U. acida and A. conyzoides effectively reduced the severity of T. rubrum–induced onychomycosis and show potential as a natural antifungal candidate derived from local plant resources.
Permasalahan Terkait Obat pada Pasien Skizofrenia Rawat Inap: Tinjauan Sistematik Mengenai Prevalensi dan Intervensi Fatimah , Salma Auliya; Harjaningsih , Woro; Budiman , Bambang Hasta Yoga Legawa; Kurniawati , Fivy
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1458

Abstract

Schizophrenia is a severe mental disorder with increasing prevalence. Treatment for schizophrenia is chronic and often leads to Drug-Related Problems (DRPs), especially in hospitalized schizophrenia patients. This systematic review aims to map the prevalence and most common types of DRPs and evaluate the impact of clinical pharmacist involvement in addressing DRPs. A literature search was conducted across six electronic databases (Scopus, PubMed, ScienceDirect, Web of Science, ProQuest, and Springer Nature) for publications published between January 2009 and December 2024. Eleven studies met the inclusion criteria, consisting of nine cross-sectional studies and two quasi-experimental studies, with a total of over 61,000 hospitalized schizophrenia patients. The prevalence of DRPs has been reported to range from 52.8% to 100%, depending on the study design and the DRP identification method. Studies using structured medication reviews reported a higher DRP burden, at 0.75–2.5 DRPs per patient. The most frequently identified types of DRPs include polypharmacy, drug interactions, inappropriate medication selection, and dosing problems (overdose and underdose). QTc prolongation was reported in 2.5–8.26% of patients. Clinical pharmacist involvement was reported in three studies, with physician acceptance of recommendations ranging from 49 to 50%. DRPs are a common problem in hospitalized patients with schizophrenia, and clinical pharmacist involvement has the potential to improve the rationality and safety of drug therapy.

Page 70 of 70 | Total Record : 698

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