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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 698 Documents
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Sediaan Larutan Nanopartikel Dari Fraksi Etil Asetat Daun Sungkai (Peronema Canescens Jack) Hartesi , Barmi; Ratih, Hestiary; Nugraha , Sabina Azahra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1158

Abstract

Sungkai leaves (Peronema canescens Jack) are known to contain secondary metabolite compounds such as alkaloids, polyphenols, flavonoids, quinones, and steroid-triterpenoids, which have potential as immunostimulants. This study aims to determine the effect of the ratio of chitosan and NaTPP on the stability of nanoparticle solutions from the ethyl acetate fraction of sungkai leaves. Sungkai leaves were extracted using the maceration method with 70% ethanol, then fractionated using the liquid-liquid estraction method using n-hexane, ethyl acetate, and n-butanol solvents. The ethyl acetate fraction selected to be made into nanoparticle solutions used the ionic gelation method with variations in the ratio of chitosan:NaTPP consisting of 3 formulas, namely F1 (5:1), F2 (10:1), F3 (20:1). Characterization of the nanoparticle solution was carried out by organoleptic testing, measuring % transmittance, particle size with a Particle Size Analyzer (PSA), and measuring the zeta potential value. The results showed that F3 (Chitosan:NaTPP 20:1) produced an average particle size of 953.6 nm, a polydispersity index of 0,338, and a zeta potential of 43.2 mV, indicating relatively better stability compared to the other formulas. However, the percent transmittance obtained was still below the optimum (80-100%), which was 68.88%. In conclusion, increasing the chitosan:NaTPP ratio affected the environmental stability of the nanoparticles, and formula. F3 was the most stable formula in this study.
Analisis Kandungan Merkuri dan Hidrokuinon dalam Krim Pemutih Wajah Daring Menggunakan Spektrofotometer Serapan Atom dan Kromatografi Cair Kinerja Tinggi Kusmiyati, Mimin; Tronovani , Elvi; Sulaeman , Agus; Musyarrofah, Laila; Fitriani , Hani Sri; Khotimah , Enung Nur; Mirta, Surya Bin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1176

Abstract

The skin is the outermost organ of the human body and plays an important protective and physiological role. Currently, fair skin is often regarded as a beauty standard desired by both men and women. Mercury and hydroquinone are active ingredients commonly used in whitening products due to their ability to inhibit melanin formation; however, their use can cause serious toxic effects. This study aimed to determine the presence of mercury and hydroquinone qualitatively and quantitatively in facial whitening creams sold online in Bandung City. Samples showing positive results were further analyzed quantitatively to determine their concentrations. For mercury analysis, samples were digested using a microwave digestion method to eliminate organic substances. The color reaction test for mercury employed KI 0.5 N, HCl 6 M, and NaOH 2 N reagents. Based on qualitative testing, samples labeled D and N were positive for mercury. Quantitative determination of mercury was conducted using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 253.7 nm. For hydroquinone analysis, qualitative color tests were carried out using FeCl₃ 5%, phenanthroline, and Benedict reagents, while quantitative analysis was performed using High-Performance Liquid Chromatography (HPLC). Of the 17 samples tested, two (D and N) contained mercury at concentrations of 2,776 ±  0,036 μg/g and 4,277 ± 0,021 μg/g, respectively, and two others (E and H) contained hydroquinone 2,3745% and 2,4798%.
Teh Herbal Daun Kelakai (Stenochlaena palustris) sebagai Potensi Fitoestrogen Untuk Produksi ASI : Terinspirasi dari Kearifan Lokal Suku Anak Dalam Jambi Intami, Eprina; Mustakim , Ardi; Rahmadevi, Rahmadevi; Mulyati , Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1177

Abstract

This study was conducted in response to the problem of low breast milk production among some breastfeeding mothers, which may adversely affect infant growth and development. One approach to enhancing breast milk production is the utilization of natural substances containing phytoestrogens. Kelakai leaves (Stenochlaena palustris) are a plant traditionally used by the Suku Anak Dalam community as part of local wisdom to support maternal health during the postpartum period. This study aimed to develop kelakai leaf herbal tea as a natural source of phytoestrogens with potential to support increased breast milk production. The research employed a quasi-experimental design using a one-group pre-test and post-test with control group approach, complemented by laboratory analyses including identification of active compounds, simplicia processing, herbal tea formulation, phytochemical screening, and phytoestrogen content analysis. The results demonstrated that kelakai leaves contain flavonoids, saponins, and phytoestrogenic compounds that may contribute to the stimulation of prolactin and oxytocin secretion. Statistical analysis revealed a p-value of 0.000 (p < 0.05), indicating a significant effect of kelakai herbal tea administration on breast milk production among breastfeeding mothers. Based on these findings, it can be concluded that kelakai herbal tea has potential as an alternative herbal beverage derived from local wisdom that may support the success of exclusive breastfeeding programs.
Interaksi Obat Pada Pasien Geriatri: Kajian Berbasis Evidence Tentang Kombinasi Antihipertensi dan Obat Non Steroidal Anti-Inflammatory Alya, Rahma; Khuriyah, Khuriyah; Ananda, Meisya Dwi; Putra, Hasan Etanov; Adzkia, Muhammad Adit; Putri, Mukarromah Dita; Hilmi, Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1182

Abstract

The number of elderly individuals continues to increase globally, accompanied by a high prevalence of chronic diseases, particularly hypertension and musculoskeletal disorders. This condition makes geriatric patients vulnerable to polypharmacy, which increases the risk of drug interactions, one of which is between antihypertensives and non-steroidal anti-inflammatory drugs (NSAIDs). Such interactions can potentially reduce therapy effectiveness, cause electrolyte disturbances, and lead to acute kidney injury (AKI). This study aims to comprehensively examine the interaction between antihypertensives and NSAIDs in geriatric patients and its impact on therapy safety. The method used is a literature review by selecting national and international articles published between 2015 and 2025, written in either Indonesian or English, specifically investigating interactions between antihypertensives (β-blockers, ACE inhibitors, ARBs, diuretics, and CCBs) and NSAIDs. The review results indicate that most interactions are pharmacodynamic, involving either antagonism or negative synergism. NSAIDs can reduce the effectiveness of antihypertensive therapy through mechanisms such as sodium retention, afferent arteriolar vasoconstriction, and decreased renal perfusion. In certain combinations, such as the triple whammy phenomenon (NSAIDs, diuretics, and RAAS inhibitors), the risk of AKI and hyperkalemia increases significantly. This risk is higher in geriatric patients with decreased kidney function, comorbidities, and concurrent use of multiple drugs. In conclusion, the interaction between antihypertensives and NSAIDs in the elderly population is an important clinical issue. Therefore, close monitoring of kidney function and electrolytes, using the lowest effective dose for the shortest possible duration, and patient education to avoid self-medication are necessary to ensure therapy safety.
Ekstraksi kombinasi ultrasonik dan enzimatis untuk senyawa asam klorogenat dari Cascara Kopi Arabika Kerinci Lestari , Siti Marwah; Rahmaha, Vindi Annisa; Khairunnisa , Selda Vira; Salsabilla , Tiskha; Fadillah , Nur
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1220

Abstract

Arabica Coffee Cascara (CKA) has high potential as a source of bioactive compounds such as chlorogenic acid, which has antioxidant activity. The release of active compound can be optimized by combining ultrasonic and enzymatic methods, which are more efficient and environmentally friendly. The aim of this study was to examine the effectiveness of ultrasound-enzymatic-assisted extraction (UEAE) using water as a solvent for chlorogenic acid compound from CKA using Response Surface Methodology Box-Behnken Design (RSM_BBD). Three extraction parameters, such as sonication temperature (35-45°C), enzyme concentration (10-20 mg/g), and enzymolysis temperature (40-60°C), were designed to obtain optimal chlorogenic acid content. Based on the general trend data, results indicated that the highest chlorogenic acid content was 42.55 mg/g of dry extract, and was achieved under specific conditions: a sonication temperature of 40°C, an enzyme concentration of 10 mg/g, and an enzymolysis temperature of 60°C. Verification tests showed a value of 44.17 mg/g dry extract within the model’s prediction range with a 95% confidence level. The current quadratic RSM model with the existing factor design is not yet a reliable predictive tool and only serves to explore the range of operational extraction conditions.
Penetapan Kadar Asam Retinoat Pada Krim Anti Acne di Kabupaten Blora dengan Spektrofotometri UV Andieni , Herdania Puan; Kusumowati, Ika Trisharyanti Dian
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1243

Abstract

Acne is a skin disorder characterized by chronic inflammation involving the sebaceous glands and excessive bacterial colonization. Management of acne generally requires external treatment, focusing on maintaining facial hygiene using facial cleansers supported by the use of anti-acne products. Anti-acne creams are cosmetic products formulated with active ingredients that help prevent and treat acne. One of the active ingredients commonly used in such products to improve acne-prone skin conditions is retinoic acid. Based on BPOM RI 2007, that use of retinoic acid requires a doctor’s prescription. The purpose of this study to identify the levels of retinoic acid in anti-acne cream product circulating in the Blora regency area. Qualitative testing using Thin Layer Chromatography (TLC) method obtained 1 sample out of 5 containing retinoic acid. Based on the calculating of validation parameters, the equation Y = 0.1488x – 0.0026 with a correlation coefficient (r)of 0.993, exLOD 0.554 ppm, LOQ 1.681 ppm, %RSD 1.8895% and %Recovery 83.823 – 109.503%. The calculating of the levels in sample that positive for containing retinoic acid, sample E obtained at 0.103036%, which exceeds the limit established in the National Formulary.
Aktivitas Antidiabetes Infusa Buah Mengkudu (Morinda Citrifolia L.) pada Mencit Jantan terinduksi Aloksan Mulki, Munir Alinu; Amelia , Tiara Cinta
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1247

Abstract

Noni (Morinda citrifolia L.) is traditionally consumed for diabetes, yet in vivo evidence for water-based infusion remains limited. This study aimed to evaluate the antihyperglycemic effect of a standardized noni fruit infusion in alloxan-induced male mice. Dried fruit simplicia were quality-controlled according to the Indonesian Herbal Pharmacopoeia. Mice were induced with alloxan (140 mg/kg, i.p.) and randomized (n=5/group) to vehicle (0.5% Na-CMC), metformin (1.3 mg/20 g BW), or noni infusion at low (103), normal (123), or high (144 mg/20 g BW) for 21 days in two divided doses per day. Fasting blood glucose was measured at baseline, day 0, and days 7, 14, and 21. Paired t-tests assessed within-group changes, while between-group comparisons used one-way ANOVA with Levene’s test (Tukey HSD) and Welch ANOVA as sensitivity analysis. Phytochemical screening indicated alkaloids, saponins, triterpenoids, and flavonoids. All groups showed significant reductions from day 0 to day 21 (p<0.05). From day 0 to day 14, the normal-dose infusion decreased glucose by 45.7% (172.8 to 93.8 mg/dL), compared with 33.3% for metformin (134.0 to 89.4 mg/dL). By day 21, reductions were 48.3–49.6% in the normal/high-dose infusion groups and 36.4% with metformin. Between-group differences were evident at days 7 and 14 but not at day 21 (p>0.05). Standardized noni infusion exhibits antihyperglycemic activity in the alloxan model; confirmation of mechanisms, additional metabolic endpoints, and subchronic safety evaluation are required before clinical relevance can be inferred.
Formulasi Minyak Angin Aromaterapi Dengan Menggunakan Kombinasi Minyak Chamomile (Matricaria recutita) dan Minyak Mawar (Rosa alba) Prawesti, Camelia Ayu; Wulansari, Eka; Putri, Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1276

Abstract

Aromatherapy is a form of complementary therapy that utilizes plant-derived essential oils to support physical and mental health. Chamomile essential oil (Matricaria recutita) possesses a characteristic calming aroma and has been reported to exhibit various pharmacological activities, including antipyretic, anti-inflammatory, antispasmodic, and sedative effects. Rose essential oil (Rosa alba) is also known for its antidepressant and anxiolytic properties, as well as its potential to reduce blood pressure and alleviate sleep disorders, migraines, and stress. This study aims to determine the optimal composition of chamomile and rose essential oils in an aromatherapy medicated oil formulation based on its physical characteristics. The formulation employed olive oil and red palm oil as carrier bases due to their high antioxidant content, particularly vitamin E and carotenoids. Optimization was conducted using a Simplex Lattice Design (SLD) approach with eight combination formulations. The prepared formulations were evaluated for pH, specific gravity, and displaced volume. The results demonstrated that the combination of chamomile and rose essential oils significantly influenced the physical characteristics of the formulation. Based on the optimization of physical parameters (pH, specific gravity, and displaced volume) the optimal formulation was obtained with a composition of 1.5% chamomile essential oil and 1.5% rose essential oil. This formulation exhibited acceptable physical characteristics.
Uji Hepatoprotektif Fraksi N-Heksana Kulit Batang Jamblang (Syzygium Cumini (L.) Skeels) Ditinjau Dari Kadar Ast, Alt, Dan Albumin Amal, Surya; Hidayah, Himyatul; Gunarti , Neni Sri; Mangunsong , Dhavid Twua
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1291

Abstract

The liver plays an important role in the metabolism and detoxification of harmful substances in the body. One of the drugs that can cause liver damage if used excessively is paracetamol. Liver damage due to paracetamol is characterized by an increase in the levels of AST (aspartate aminotransferase) and ALT (alanine aminotransferase) enzymes as well as a decrease in albumin levels in the blood. The bark of the jamblang tree (Syzygium cumini) contains flavonoid compounds, tannins, and triterpenoids that have antioxidant properties and may possess hepatoprotective effects. This study aims to evaluate the effect of the n-hexane fraction of jamblang bark on liver function parameters in male Wistar strain white rats induced with paracetamol, and to determine the most effective dose. This study involved 20 rats divided into five treatment groups: negative control (paracetamol 1000 mg/KgBB), positive control (silymarin 50 mg/KgBB), and three test groups that were given n-hexane fraction at graded doses (50, 100, and 200 mg/KgBB). The treatment was given for 21 days, while paracetamol was administered from day 15 to day 21. The results showed that the levels of AST and ALT were significantly affected by the n-hexane fraction of jamblang bark at a dose of 50 mg/KgBB with p < 0.0001 for AST and p = 0.0002 for ALT. Meanwhile, albumin levels were significantly affected at a dose of 200 mg/KgBB with p = 0.0411. From the results, it can be concluded that the n-hexane fraction of jamblang bark has the potential as a hepatoprotective agent, especially at a dose of 50 mg/KgBW.
Analisis Kualitas Yogurt Santan Kelapa Dengan Penambahan Tepung Kolang Kaling Selama Penyimpanan Nasution, Rizki Amelia; Tambunan, Efrida Pima Sari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1298

Abstract

The addition of flour from kolang kaling in this research aims to act as a stabilizer and improve the quality of fermented drinks (yoghurt) made from coconut milk. This research aims to analyze the quality of coconut milk yogurt with the addition of kolang kaling flour by testing its physicochemical properties. Experimental research with coconut milk yogurt samples with the addition of 1% kolang kaling flour and without the addition was stored at 40C for 14 days and analyzed for pH, viscosity and total LAB, as well as testing the research samples for water content using the distillation method (thermovolumetric), protein using the method Kjeldahl, fat using Soxhlet extraction, carbohydrate (starch) content testing using the UV Visible spectrophotometric method, and total acid using the titration and organoleptic method with 9 hedonic scales. Research shows that the results of adding palm fruit flour have an effect on the analysis parameters and are in accordance with SNI, namely pH reaches 5-3.94, carbohydrates decrease during H14 fermentation by 20.1%, protein reaches 6.5%, fat around 3%, water content is very low, namely 49%, The viscosity is very low, namely 2.8cP, the acid number is sufficient according to SNI in H14, namely 2%, %, as well as the hedonic results during storage which show statistical test results which are significantly different (P<0.05) on day 7 and day 14. The research can be concluded based on physicochemical analysis and conformity with SNI that the quality of coconut milk yogurt with the addition of kolang kaling flour during storage is good and in accordance with food standards.

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