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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 235 Documents
Correlation Analysis Study between Hearing Loss Occurence and Duration of Type 2 Diabetes Mellitus in Sultan Agung Islamic Hospital Semarang Risyudhanti, Citta Arunika; Sulistyanto, Agung; Suparmi, Suparmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1013.653 KB) | DOI: 10.30659/sainsmed.v6i1.338

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Introduction: Hearing impairment due to cochlear damage is one complication of Type 2 Diabetes Mellitus (DM2). Objective: This study aims to determine the relationship between duration of DM2 with hearing impairment.Method: The analytic observasional study with the cross sectional design using the medical record of DM2 outpatient in internal clinic of Islamic Sultan Agung Hospital Semarang and also pure tone audiometric examination’s record in Otorynolaryngology clinic of Islamic Sultan Agung Hospital Semarang.31 medical records of DM2 patients were meeting the inclusion and exclusion criteria. The data consist of 18 medical records of patients with less than6 years duration of DM2, and 13 medical records of patients with more than 6 years duration of DM2. The pure tone audiometry was used to classified the hearing impairment. The data analysis was conducted using SPSS 20.0. The correlation between the duration of DM2 and hearing impairment was analyzed using Chi Square test. The significance relation between the duration of DM type 2 and hearing impairment was analyzed using cooficient contigency, with significance of < 0.05. Result: hearing impairment’s distribution frequency on tested ears in Sultan agung Islamic Hospital Semarang were 27 ears having SNHL type (43,5%), 19 ears having CHL (30,6%) and 16 ears were normal (25,8%), p = 0,02 (p < 0,05). Conclusion: There is a weak correlation between the DM 2 duration and the incidence of hearing impairment in Sultan Agung Islamic Hospital Semarang.
CORRELATIONS BETWEEN ATTITUDES AND RATIONAL USE OF ANTACID IN SELF MEDICATION (Study on Health Students of Universitas Muhammadiyyah Malang) Husniar, Witri Rochaeni; Pristianty, Liza; Hidayati, Ika Ratna
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): June 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v9i1.1060

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Intoduction: Self-medication is the selection and use of modern drugs, herbs, and traditional medicines by individuals to overcome diseases or symptoms of disease. One mild disease that can be treated with self-medication is gastritis. The over-the-counter medication which is frequently used in treating gastritis in self- medication is antacid.Objective: To determine the correlation between attitudes and antacid rational use in self-medication among health students at the Universitas Muhammadiyah Malang.Methods:  observational analytic method using questionnaire was used for this study. The sample consist of 97 people who met inclusion criteria. Sampling was done by purposive sampling method, then the data were analyzed using Rank Spearman analysis using SPSS. This research was conducted at the campus II, Universitas Muhammadiyah Malang.Results: The results showed that 97 students of health had negative attitudes of 42% (41) and positive attitude of 58 % (56). The rational use of antacid drugs as much as 60% (58), the irrational use of drugs is 40% (39). Results of analysis using Spearman rank correlation test values were rcount 0.680 > rtable 0.202.Conclusion: The results of this study indicated that there is a significant correlation between a positive attitude to the antacid rational use in self-medication on Health Students of Universitas Muhammadiyah Malang
Komponen Senyawa Aktif pada Udang Serta Aplikasinya dalam Pangan Ngginak, James; Semangun, Haryono; Mangimbulude, Jubhar C.; Rondonuwu, Ferdy S.
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.761 KB) | DOI: 10.30659/sainsmed.v5i2.354

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Indonesian water area is vast and has a great potential of natural resources. Most of the Indonesian people working as fisherman describes that oceanis place of making a living. Watery area resources Indonesian watery area is vast and has a great potential incude shrimps, fish, and other organism tosupport human life. Ocean organism has been known to contain nutrition which is good for human’s health. Shrimps contains omega 3, mineral, fat,citin, carotenoide (astaxanthin) and vitamin. The active compound have an ability to prevent disease and meet the nutritional need of body. Omega3 andastaxantin for example are active compounds found in shrimps. These compound play a role as antioxidant and free radicals scavenger can be supplementfor pregnant women and baby. Omega 3 and antaksantine are found in various shrimps and fish. Thus, the development of product from this organismincludes supplement, margarine, cake, souse, bread, kerupuk, flour and salt. In this review, the writer describes the the functional compound and itsusage as food product.
Factors Related to HIV/AIDS Prevention Behavior Among Female Sex Workers in Padang in 2018 Yuliza, Wilda Tri; Hardisman, Hardisman; Nursal, Dien Gusta Anggraini
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.989 KB)

Abstract

Background: HIV/AIDS has a huge risk transmitted through sexual intercourse with multiple partners, including Female from Sexual Workers and customers due to perform unsafe sexual behavior. The increasing prevalence of HIV/AIDS among female sex workers in Indonesia related to the health prevention behaviors were too low.Objective: To determine the factors related to the behavior of HIV/AIDS prevention at the FSW.Methods: This study uses a quantitative approach by the cross-sectional design. Researchers took a sample of 50 female sex workers in Padang using Consecutive Sampling method. Analysis of the data in this study using univariate, bivariate, and multivariate analyzes.Results: Results showed 66% of FSW have a good preventive behavior, there is a significant relationship between education (p= 0.024), knowledge (p= 0.002), attitude (p= 0.0001), specificity (p= 0.006), support fellow of FSW (p= 0.027), and support officers (p= 0.013) to conduct HIV/AIDS prevention at the FSW. Whereas the availability of condoms, access to information and support pimps have no meaningful relationship to the behavior of HIV/AIDS prevention. The most dominant factor related to the behavior of HIV/AIDS prevention is the attitude (OR= 82.877 CI: 7.717-89.079).Conclusion: Factors in themselves greatly influence the behavior of female sex workers in preventing HIV/AIDS coupled with the support of the closest people such as friends, pimps, and officers who make female sex workers feel comfortable and feel cared for.  
The Effect of Exercise on Elderly Body Balance which Measured By Romberg Test Study in Plamongansari Pedurungan Semarang Annafisah, Zuhaida; Rosdiana, Ika
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.225 KB) | DOI: 10.30659/sainsmed.v4i2.370

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Background: Balance disorders is a major cause which often lead elders to fall easily. Body balance reduction of elders can be helped by many variety of balance exercises, one of them is elders exercise. There have been many researches on the assessment of body balance. But a research carrying a Romberg Test to assesses static balance by closing and opening eyes as a visual organ has not been done. This study aims to determine the effect of exercise on elderly body balance which measured by Romberg Test.Design and Method: Analytic observational research with cross-sectional approach was conducted to elderly who routinely do exercises and to them who don’t. There were 82 samples, consisted of 41 elderly do exercises and 42 elderly who don’t. Body balances of both groups were measured using the Romberg test. The data were analyzed by chi-square.Result: Among the 41 elderly who do exercise, consisted of 12 men and 29 women, showed 97.56% balanced and 2.44% unbalanced. While 41 elderly aged over 60 years who don’t do exercise, consisted of 15 men and 26 women, showed 46.34% balanced and 53.66% unbalanced. The results of chi-square test showed p = 0.000; r = 0.495.Conclusion: The elderly exercises influence the body balance as measured using the Romberg Test to healthy elderly, with a moderate degree of correlation (Sains Medika, 4(2):142-146).
The Difference between the Effect of Green Tea Cream and Tocopherol on Decreasing Level of Tyrosinase Enzyme and Amount of Melanin in Rattus norvegicus Exposed to UVB Rays Riyanto, Anwar; Nasihun, Taufiqurrachman; Sumarawati, Titiek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1045.643 KB) | DOI: 10.30659/sainsmed.v11i1.4347

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Introduction: Green tea and tocopherol are potent antioxidants used to treat melasma. However, whether green tea or tocopherol is superior remains unclear. Objective: To compare the effectiveness between green tea and tocopherol in decreasing the amount of melanin and tyrosinase level in wistar rats exposed to UVB rays.Methods: The experimental study took 30 male Wistar rats randomly and divided them into 3 groups. The control group (C-G) was given basic topical cream, GT-G was given green tea topical cream and TC-G was given tocopherol topical cream. All rats were exposed to UVB every Monday, Wednesday and Friday for 4 weeks, whereas topical creams were smeared every day. Topical creams smearing on the same day with UVB exposure was performed 20 minutes before exposure and 4 hours after UVB exposure. The doses of UVB were 50 mJ/cm2 in first week, 70mJ/cm2 in the second week and 80mJ/cm2 in the third and fourth weeks. The amount of melanin was measured using pixel method and the tyrosinase level was measured using ELISA.Results: Anova analysis indicates that the amount of melanin and tyrosinase level are significantly different between groups, p<0.05. Post Hoc LSD analysis indicates that the amount of melanin in GT-G and TC-G are significantly lower than that of C-G, p<0.05. The amount of melanin in GT-G is lower than that of TC-G, p<0.05. The tyrosinase level in GT-G is significantly lower than that of C-G and TC-G, p<0.05. Meanwhile, the tyrosinase level in TC-G is lower than that of C-G but insignificantly, p>0.05.  Conclusion: Green tea topical treatment is significantly capable of decreasing the amount of melanin and tyrosinase level better than tocopherol.
The Effect of Curcuma domestica Val Extract on Phagocytic Activity of Macrophage in Listeria monocytogenes Inoculated BALB/C Mice Pangestika, Dini; Mirani, Erna; Mashoedi, Imam D.
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.582 KB) | DOI: 10.30659/sainsmed.v4i1.387

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Background: Cellular imunological respond is started by macrophage activity as Antigen Presenting Cell, processing antigen in such a way that emerge interactions among immune cells. Listeria monocytogenes infection often used as an example to demonstrate the immune response to the intracellular bacteria. Curcuma has been proven in vitro to have immunomodulatory effect to improve the function of T cell, NKcell, macrophage, and splenocyte. Thus, it is presumed that curcuma extract may influence macrophage phagocytic activity. The aim of this research is to find out whether there is a difference between macrophage of mice inoculated with Listeria monocytogenes after treatment of curcuma extract in stepped dose compared with control.Design and Method: This laboratory experimental research used a Post-Test Only Control Group Design method. The samples were 20 males of balb/c mice. The mice were divided into 4 groups adopted for a week before the treatments for 20 days. The groups consist of control group, group I (receiving 0.13mg/day of curcuma extract), group II (receiving 0.26 mg/day of curcuma extract, group III (receiving 0.52mg/day curcuma extract). Mice were inoculated with Listeria monocytogenes on day 15. After isolation, the macrophage was desensitized using latex beads and observed under the microscope. The data were analyzed using One way Anova test was followed by Post hoc test using SPSS 15 programme.Result: Index of macrophage phagosytosis in control group, group I, II,II were 0.914±0,27, 1.940±0,42, 2.914±0.56, 1.30±0.31 respectively. One Way Anova test showed a difference among each of groups P<0.05 except for group I and II.Conclusion: Curcuma treatment can increase macrophage phagocytic activity on balb/c mice inoculated with Listeria monocytogenes (Sains Medika, 4(1):63-70).
Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever Kustiyah, Azizah Retno; Soemantri AG, Soemantri AG
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.269 KB) | DOI: 10.30659/sainsmed.v3i1.403

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Background: Mortality in Dengue patients hospitalized in Dr. Kariadi Hospital, Semarang is very high. The most common cause of death were bleeding and Multiple Organ Dysfunction including pulmonary dysfunction that manifest as Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The previous study have shown the incidence of ARDS in DSS but the incidence of pulmonary dysfunction in dengue hemorrhagic fever is unknown.Design and Methods: An analytical observational study was performed in Non DSS and DSS patients. Researsh subjects were patients, aged 3-14 years old, with DHF according to WHO criteria 1999 hospitalized in the pediatric ward and Pediatric Intensive Care Unit (PICU) Dr. Kariadi Hospital Semarang from February 2003 until August 2005.Result: Forty patients were included for analysis consisting of 20 Non DSS and 20 DSS. Mann-Whitney analysis showed a significant differences in the incidence pulmonary dysfunction between Non DSS and DSS patient (p < 0,05). Kendall’s Tau_b analysis showed a relationship between PEI value and pulmonary dysfunction, the low total protein plasma level with pulmonary dysfunction and the low albumin plasma level with pulmonary dysfunction with r = 0.552; 0.540; 0.353 respectively, (p= 0.01).Conclusion: The study showed that pulmonary dysfunction occured more frequent in DSS than Non DSS. There were relationships between vascular leakage factors (PEI, total protein level, albumin level) with incidence of pulmonary dysfunction in DHF patients (Sains Medika, 3(1):1-15).
Formulation and Physical Test of Ethanolic Extract Sambiloto Leaves (Andrographis paniculata) Ointment Dewi, Indri Kusuma; Lestari, Titik; Rofi'ah, Siti Nur
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.162 KB) | DOI: 10.30659/sainsmed.v6i2.603

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Introduction: Andrographis paniculata had known contained active substance such as andrographolida, atsiri oil, flavonoid, tannin, alkaloid, and saponin which functions as antibacterial, antitoxic, analgesic, and anti-pyretic. Based on its antibacterial properties, an ointment form of Andrographis paniculata leaf is then formulated, for practical usage. Ointment formula is semi solid for topical use in the skin or mucosal membranes. Objectives: to know the result of ointment physical test of etanolic extract Andrographis paniculata leaf. Methods: physical tests contain organoleptic test, pH, homogenity, adhesion test and dispersive test. Results: Ointment shaped semi solid, blacky green and special smell of Andrographis paniculata, pH 6, homogenity test obtained homogenous results, adhesion test was 82 second and dispersive test was 5.6 cm. Conclusion: the result of physical tests of etanolic Andrographis paniculata leaf extract ointment appropriate with quality standard.
Red Ginger (Zingiber officinale var. Amarum) Infusion Increases Concentration of Luteinizing Hormone and Testosterone in Male Rats Nihayah, Alida; Nasihun, Taufiqurrahman; Isradji, Israhnanto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (494.36 KB) | DOI: 10.30659/sainsmed.v7i2.1174

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Introduction: Herbal remedies have been developed as a complementary therapy to increase sex hormones. The administration of the ethanolic extract of red ginger (Zingiber officinale var. Amarum) has been shown to increase spermatogenic cells, motility and morphology of sperm in mice. However, the effect of red ginger infusion on the level of testosterone and luteinizing hormone (LH) has not been done. Objective: to examine the effect of red ginger infusion on LH and testosterone levels of male Wistar rats.Methods: The study was designed as an experimental post-test only control group design. Twenty four male Wistar rats of 200-250 g body weight aged + 3-4 months were divided into four groups. a control group (G-1) was given distilled water 2 ml/day. Group 2 (G-2), Group 3 (G-3), and group 4 (G-4) were treated with 10%, 20%, and 40% infusion by dissolving 2 ml of ginger in distilled water. On day 15, blood samples were taken and assayed for LH and testosterone.Results: The one-way ANOVA test showed difference in levels of LH and testosterone between groups (p <0.001). Post Hoc LSD test results showed that the levels of LH of G-1 (0350) was significantly lower than that of G-2 (1082), G-3 (1 253), and G-4 (0923), p <0.005. While the levels of testosterone in the G-1 (0.2718) significantly lower than the G-2 (0.7797), G-3 (0.8285), and the G-4 (0.9142) (p <0.005).Conclusion: red ginger infusion for 14 days can increase the levels of LH and testosterone in male rats.