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Patricia Wulandari
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INDONESIA
Scientific Journal of Pediatrics
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 30256224     EISSN : 30256224     DOI : https://doi.org/10.59345/sjped
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Focus Scientific Journal of Pediatrics (SJPed) focused on the development of medical sciences especially pediatrics and child health for human well-being. Scope Scientific Journal of Pediatrics (SJPed) publishes articles which encompass all aspects of basic research/clinical studies related to the field of pediatrics and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 25 Documents
 1   2   3 
Analysis of Risk Factors for Dengue Hemorrhagic Fever in Children: An Observational Study in Batang Regency, Indonesia Jaya Maulana; Restu Mastuti, Dewi Nugraheni; Yasmin Meida
Scientific Journal of Pediatrics Vol. 2 No. 2 (2024): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i1.137

Abstract

Dengue hemorrhagic fever (DHF) is a significant public health problem in Indonesia, including in Batang Regency. This study aims to analyze the risk factors associated with the incidence of dengue fever in children in Batang Regency, Indonesia. A cross-sectional observational study was conducted on 258 child subjects in Batang Regency. Data was collected through structured interviews with parents or guardians, direct observation of the home environment, and laboratory tests to confirm the diagnosis of dengue fever. Data analysis included univariate, bivariate (Chi-square test), and multivariate (logistic regression) analyses to identify independent risk factors. Univariate analysis showed a relationship between the incidence of dengue fever and age, gender, parental education, parental occupation, residential density, presence of mosquito larvae in water reservoirs, habit of hanging clothes, history of mosquito bites, and nutritional status. Bivariate analysis identified several statistically significant risk factors, including high residential density (OR=2.87; 95% CI: 1.65-5.01), presence of mosquito larvae (OR=3.21; 95% CI: 1.89-5.45), habit of hanging clothes (OR=2.87; 95%CI:1.32-5.21), and history of mosquito bites (OR=2.54; 95%CI: 1.48 -4.36). Multivariate analysis confirmed that high residential density and the presence of mosquito larvae were independent predictors of dengue incidence. High residential density and the presence of mosquito larvae in the home environment are the main risk factors for the incidence of dengue fever in children in Batang Regency. Public health interventions that focus on vector control and improving environmental sanitation are critical to reducing the dengue burden in this area.
The Gut Microbiome in Early Childhood Obesity: Exploring the Role of Diet and Probiotics - An Observational Study in Palembang, Indonesia Wulandari, Aleisha
Scientific Journal of Pediatrics Vol. 2 No. 2 (2024): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i1.152

Abstract

Introduction: Early childhood obesity is a growing public health concern, with the gut microbiome emerging as a potential contributing factor. Diet and probiotics hold promise in modulating the gut microbiome and potentially influencing obesity risk. This study investigated the associations between dietary patterns, gut microbiome composition, and the use of probiotics in early childhood obesity in Palembang, Indonesia. Methods: An observational study was conducted in Palembang, involving 150 children aged 2-5 years, categorized into obese and non-obese groups based on WHO growth standards. Dietary intake was assessed using a 3-day food record, gut microbiome composition was analyzed via 16S rRNA sequencing of fecal samples, and probiotic use was documented through questionnaires. Statistical analyses, including multivariate regression and microbiome diversity metrics, were employed to explore associations. Results: Obese children displayed significantly lower gut microbiome diversity compared to non-obese children (p < 0.05). Dietary patterns rich in processed foods and sugary drinks were associated with altered gut microbiome composition, characterized by increased abundance of Firmicutes and decreased Bacteroidetes (p < 0.01). Probiotic use was associated with improved gut microbiome diversity and a trend towards reduced obesity risk (p = 0.07). Conclusion: This study provides evidence linking dietary patterns, gut microbiome composition, and probiotic use to early childhood obesity in Palembang, Indonesia. Promoting healthy dietary choices and considering probiotic supplementation may offer potential strategies for obesity prevention in this population. Further research is warranted to establish causality and explore the long-term impact of interventions targeting the gut microbiome in early childhood obesity.
Longitudinal Study of the Association Between Screen Time and Childhood Obesity in Singapore Eng, Robert; Badrool Nizham
Scientific Journal of Pediatrics Vol. 2 No. 2 (2024): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i1.153

Abstract

Introduction: Childhood obesity is a growing public health concern in Singapore. Excessive screen time has been identified as a potential risk factor for childhood obesity. This longitudinal study aims to investigate the association between screen time and the development of childhood obesity in a Singaporean cohort. Methods: A prospective cohort study was conducted involving 500 children aged 6-12 years in Singapore. Screen time data was collected through questionnaires at baseline, 1 year, and 3 years. Anthropometric measurements were taken at the same time points to assess body mass index (BMI) and obesity status. Multivariate regression analysis was used to examine the association between screen time and obesity, adjusting for potential confounders. Results: Increased screen time was significantly associated with an increased risk of developing obesity. Each additional hour of screen time per day at baseline was associated with a 1.2-fold increased risk of obesity at 3-year follow-up (OR: 1.2, 95% CI: 1.05-1.37). The association remained significant after adjusting for age, gender, socioeconomic status, physical activity, and dietary habits. Conclusion: This study provides evidence for a longitudinal association between screen time and childhood obesity in Singapore. Interventions targeting screen time reduction should be considered as part of a comprehensive strategy to prevent childhood obesity in Singapore.
Impact of Surfactant Therapy on Preterm Neonates: A Meta-Analysis Evaluating Respiratory and Hemodynamic Outcomes Ayudimartini, Ni Luh
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.166

Abstract

Introduction: Surfactant deficiency is a major contributor to neonatal respiratory distress syndrome (RDS) in preterm infants. Surfactant replacement therapy has become a cornerstone in managing RDS, but its impact on broader respiratory and hemodynamic outcomes remains an area of active investigation. This meta-analysis aimed to comprehensively evaluate the effects of surfactant therapy on preterm neonates, encompassing both respiratory and hemodynamic parameters. Methods: A systematic search of electronic databases (PubMed, Embase, Cochrane Library) was conducted to identify randomized controlled trials (RCTs) and observational studies evaluating surfactant therapy in preterm neonates. Studies reporting on respiratory outcomes (need for mechanical ventilation, duration of ventilation, oxygen requirement) and hemodynamic outcomes (patent ductus arteriosus (PDA) incidence, blood pressure, cerebral blood flow) were included. Data extraction and quality assessment were performed independently by two reviewers. Meta-analyses were conducted using random-effects models. Results: A total of 35 studies (22 RCTs, 13 observational studies) involving 4,875 preterm neonates were included. Surfactant therapy was associated with a significant reduction in the need for mechanical ventilation (RR 0.72, 95% CI 0.65-0.80, p<0.001), duration of mechanical ventilation (MD -1.8 days, 95% CI -2.5 to -1.1, p<0.001), and oxygen requirement (MD -5%, 95% CI -7 to -3, p<0.001). A trend towards reduced incidence of PDA was observed (RR 0.85, 95% CI 0.71-1.02, p=0.08). Surfactant therapy also led to improvements in blood pressure parameters and cerebral blood flow. Conclusion: Surfactant therapy in preterm neonates confers significant benefits in respiratory outcomes, including reduced need for and duration of mechanical ventilation, and decreased oxygen requirement. A potential beneficial effect on PDA incidence warrants further investigation. These findings underscore the critical role of surfactant therapy in improving the respiratory and hemodynamic status of preterm neonates.
Corticosteroids in Pediatric Bacterial Meningitis: A Meta-Analysis of Randomized Controlled Trials Comparing Dexamethasone and Adjunctive Therapies Ayudimartini, Ni Luh
Scientific Journal of Pediatrics Vol. 2 No. 1 (2024): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v3i1.167

Abstract

Introduction: Bacterial meningitis remains a significant cause of morbidity and mortality in children. Adjunctive corticosteroid therapy, particularly dexamethasone, has shown promise in reducing inflammation and improving outcomes. This meta-analysis aimed to evaluate the efficacy and safety of dexamethasone compared to placebo or other adjunctive therapies in pediatric bacterial meningitis. Methods: A systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials was conducted from January 2013 to October 2024. Randomized controlled trials (RCTs) comparing dexamethasone with placebo or other adjunctive therapies in children with bacterial meningitis were included. Primary outcomes were hearing loss, neurological sequelae, and mortality. Secondary outcomes included adverse events. Data were pooled using a random-effects model, and the risk ratio (RR) with 95% confidence intervals (CI) was calculated. Results: Six RCTs met the inclusion criteria, comprising 2,840 children. Dexamethasone was associated with a significant reduction in hearing loss (RR 0.57, 95% CI 0.45-0.71, p=0.005) and neurological sequelae (RR 0.66, 95% CI 0.56-0.78, p=0.006) compared to placebo. No significant difference in mortality was observed (RR 0.78, 95% CI 0.49-1.27, p=0.32). The incidence of adverse events, including gastrointestinal bleeding and hyperglycemia, was similar between the dexamethasone and placebo groups. Conclusion: Adjunctive dexamethasone therapy in pediatric bacterial meningitis significantly reduces hearing loss and neurological sequelae without increasing mortality or the risk of serious adverse events.
The Influence of Personal Hygiene on the Prevalence of Soil-Transmitted Helminths (STH) in Children: A Case Series in a Remote Indigenous Community in Indonesia Nur Laela Alydrus; Ka’bah; Rugayyah Alyidrus; Risky Nurul Fadlila RN; Fika Andriani
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.172

Abstract

Introduction: Soil-transmitted helminths (STHs) are a major public health concern, especially in remote indigenous communities with limited access to clean water and sanitation. This study aimed to investigate the influence of personal hygiene practices on the prevalence of STH infections in children in the Ammatoa Kajang community of Bulukumba Regency, Indonesia. Methods: An observational case series was conducted among children aged 3-13 years in the Ammatoa Kajang community. Data on personal hygiene practices were collected through questionnaires and interviews, while stool samples were examined for STH infections using the Kato-Katz method. Data were analyzed using correlation tests to determine the relationship between personal hygiene and STH prevalence. Results: The prevalence of STH infection was 45%, with Ascaris lumbricoides being the most common (30%), followed by Trichuris trichiura (10%) and hookworm (5%). Poor personal hygiene practices, such as infrequent handwashing, not using soap after defecation, and not wearing footwear, were significantly associated with an increased risk of STH infection. Conclusion: Personal hygiene plays a crucial role in the prevalence of STH infections among children in the Ammatoa Kajang community. Health promotion programs focused on improving personal hygiene practices, along with improved sanitation facilities, are essential for reducing the burden of STH infections in this remote indigenous community.
Non-Invasive Neuromodulation for Drug-Resistant Epilepsy in Children: A Randomized Controlled Trial of Transcranial Magnetic Stimulation (TMS) versus Vagus Nerve Stimulation (VNS) in Jakarta, Indonesia Febria Suryani; Rinna Azrida; Linda Purnama; Vania Delma; Desiree Montesinos
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.173

Abstract

Introduction: Drug-resistant epilepsy (DRE) significantly impacts the quality of life in children. While vagus nerve stimulation (VNS) is an established treatment, repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive alternative. This study aimed to compare the efficacy and safety of rTMS versus VNS in a pediatric DRE population in Jakarta, Indonesia. Methods: This was a single-center, randomized, controlled, open-label trial conducted at Private Hospital, Jakarta. Children aged 5-18 years with DRE, defined as failure to achieve seizure freedom despite adequate trials of two appropriate antiepileptic drugs (AEDs), were randomly assigned (1:1) to receive either rTMS or VNS. The primary outcome was the percentage reduction in seizure frequency at 6 months post-intervention compared to baseline. Secondary outcomes included responder rate (≥50% seizure reduction), quality of life (QoL) using the PedsQL, cognitive function (using standardized neuropsychological tests), and adverse events. Results: A total of 60 children were randomized (30 rTMS, 30 VNS). At 6 months, the mean percentage reduction in seizure frequency was significantly greater in the rTMS group (48.5%, SD 15.2%) compared to the VNS group (35.2%, SD 12.8%) (p = 0.001). Responder rates were 63.3% for rTMS and 46.7% for VNS (p = 0.17). PedsQL scores showed a significant improvement in the rTMS group compared to baseline in the psychosocial health summary score (p = 0.005), but not the VNS group (p=0.1). No significant differences were observed in cognitive function between the groups. Adverse events were generally mild and transient in both groups, though VNS was associated with more voice alteration and coughing. Conclusion: rTMS demonstrated superior efficacy in reducing seizure frequency compared to VNS in this Indonesian pediatric DRE population. While VNS is an established method, rTMS may present a non-invasive and potentially more effective therapeutic alternative. Further, larger, multicenter studies are warranted to confirm these findings and explore long-term outcomes.
Predictive Value of Drug-Induced Sleep Endoscopy (DISE) in Pediatric Obstructive Sleep Apnea: A Multicenter Cohort Study in Indonesia Sarah Istiqomah; Annisa Annisa; Dessy Agustina; Abhimanyu Putra; Zainal Abidin Hasan; Johan Wirahadi Putro; Venny Melinda; Nabila Saraswati; Made Swastika
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.174

Abstract

Introduction: Obstructive sleep apnea (OSA) is a significant pediatric health concern in Indonesia, but diagnostic and treatment pathways are often resource-constrained. Drug-induced sleep endoscopy (DISE) offers a dynamic assessment of upper airway obstruction, but its predictive value for treatment outcomes in Indonesian children remains unclear. This study aimed to evaluate the predictive value of DISE findings for polysomnography (PSG)-determined OSA severity and surgical outcomes in a multicenter cohort of Indonesian children. Methods: A prospective, multicenter cohort study was conducted at three tertiary hospitals in Indonesia. Children aged 2-18 years with suspected OSA underwent DISE and overnight PSG. DISE findings were classified using the VOTE (Velum, Oropharynx, Tongue base, Epiglottis) classification system. The primary outcome was the correlation between DISE findings and the apnea-hypopnea index (AHI) on PSG. Secondary outcomes included the prediction of surgical success (defined as a postoperative AHI < 5 and >50% reduction from baseline) after adenotonsillectomy (T&A). Statistical analyses included Spearman's rank correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression. Results: 250 children (mean age 8.2 ± 3.5 years, 60% male) were included. A significant positive correlation was found between the total VOTE score and AHI (ρ = 0.62, p < 0.001). Tongue base obstruction (VOTE-T) showed the strongest correlation with AHI (ρ = 0.58, p < 0.001). The area under the ROC curve (AUC) for the total VOTE score predicting severe OSA (AHI ≥ 10) was 0.85 (95% CI, 0.79-0.91). In the subgroup of 180 children who underwent T&A, a higher total VOTE score (particularly VOTE-T and VOTE-E scores) was significantly associated with a lower likelihood of surgical success (OR 0.45, 95% CI 0.28-0.72, p = 0.001). Conclusion: DISE, using the VOTE classification, demonstrates good predictive value for OSA severity and surgical outcomes in Indonesian children. Tongue base and epiglottic obstruction are particularly important predictors. DISE can be a valuable tool for guiding treatment decisions in resource-limited settings.
Early Childhood Feeding Practices and the Development of Severe Early Childhood Caries (S-ECC): A Prospective Cohort Study in Medan, Indonesia Andhika Kurnianta Kusuma; Muhammad Ashraf; Yi-Fen Huang; Aprilia Sari; Firman Hadi; Sohyuk Kim
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.175

Abstract

Introduction: Severe early childhood caries (S-ECC) is a significant public health problem, particularly in developing countries like Indonesia. Early childhood feeding practices are recognized as major risk factors, but prospective data from specific regions like Medan, Indonesia, are limited. This study aimed to investigate the association between various feeding practices and the development of S-ECC in a cohort of children in Medan. Methods: A prospective cohort study was conducted involving 450 mother-child dyads recruited from Posyandu (integrated health posts) in Medan, Indonesia. Baseline data on maternal demographics, socioeconomic status, oral health knowledge, and infant feeding practices were collected via questionnaires and interviews. Children were followed up at 6-month intervals for 36 months. Dental examinations were performed by calibrated dentists using the dmft index (decayed, missing, filled teeth) to diagnose S-ECC. Cox proportional hazards regression was used to analyze the association between feeding practices and S-ECC development, adjusting for potential confounders. Results: The incidence of S-ECC at 36 months was 38.2% (n=172). Prolonged bottle feeding (beyond 12 months) (Hazard Ratio [HR] = 2.15; 95% Confidence Interval [CI]: 1.55-2.98; p<0.001), nocturnal bottle feeding with sweetened liquids (HR = 2.85; 95% CI: 2.01-4.03; p<0.001), and frequent consumption of sugary snacks/drinks (≥3 times/day) (HR = 1.92; 95% CI: 1.38-2.67; p<0.001) were significantly associated with an increased risk of S-ECC. Exclusive breastfeeding for the first 6 months showed a protective effect (HR = 0.62; 95% CI: 0.45-0.86; p=0.004), even after adjusting for socioeconomic status and maternal oral health knowledge. Conclusion: This study confirms the significant impact of early childhood feeding practices on S-ECC development in Medan, Indonesia. Prolonged and nocturnal bottle feeding, particularly with sweetened liquids, and frequent consumption of sugary snacks/drinks were key risk factors. Promoting exclusive breastfeeding for the first six months and educating mothers about appropriate feeding practices are crucial for S-ECC prevention in this population.
The Relationship between Feeding Patterns and Stunting Incidence in Toddlers Aged 12-59 Months in the Working Area of Pembina Health Center, Plaju, Palembang, Indonesia Hidayat, Rachmat
Scientific Journal of Pediatrics Vol. 1 No. 1 (2023): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v1i1.196

Abstract

Introduction: Stunting is a linear growth disorder caused by malnutrition and chronic infectious diseases. The food intake of a child is very highly influenced by parental feeding patterns. The more optimal the feeding of a child, of course, the more optimal the growth and development of the child, where the factor of nutrition greatly affects the growth of a child's body. This study aimed to determine the relationship between feeding patterns and the incidence of stunting in toddlers aged 12-59 months in the working area of Pembina Health Center, Plaju, Palembang, Indonesia. Methods: This study is a cross-sectional analytic observational study. A total of 100 research subjects participated in this study. Analysis of sociodemographic data and feeding patterns was carried out using SPSS software univariate and bivariate. Results: The study results show that the majority of the subject with poor feeding patterns have a greater proportion of stunting events. Meanwhile, research subjects with good feeding patterns had a smaller proportion of stunting events. The results of this study indicate that the pattern of feeding in children is related to the incidence of stunting, p<0.05. Conclusion: The pattern of feeding children is related to the incidence of stunting in toddlers aged 12-59 months in the working area of Pembina Health Center, Plaju, Palembang, Indonesia.

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